Insilico Medicine(“Insilico”), a clinical-stage generative artificial intelligence (AI)-driven drug discovery company, has successfully delivered the second preclinical candidate compound (PCC) in its collaboration with Fosun Pharma in June 2024, a potential innovative therapeutic using synthetic lethal strategy for the treatment of solid tumors. Insilico expects to submit the pre-IND application for this candidate with the CDE in 2024 Q4. When initiating the collaboration, Fosun Pharma proposed four targets of interest, and the target of the PCC nominated in this program is one of them and plays a critical role in DNA damage repair mechanisms. Insilico’s ...

After three years of meticulous study, an international team of researchers has announced the discovery of a fossilised giant basal tetrapod in Namibia's arid heartland in Nature. A basal tetrapod is an early four-legged vertebrate with fingers and toes, which lived during the transition from water to land. These ancient carnivores are among the earliest ancestors of all modern animals. This nearly complete 3-meter-long skeleton of an adult, unearthed in the Ugab River valley in Damaraland, is the largest ever discovered. This discovery is significant because it challenges previous assumptions that these early four-legged vertebrates, which lived during ...

An ongoing research project into the impact of offshore windfarm electromagnetic fields on shark development reveals that the alternating electric currents produced by underwater windfarm cables seems not to disrupt the growth or survival of sharks. Offshore windfarms are one of the most common marine renewable energy (MRE) producers, and are seen as a pivotal technology in the global transition towards renewable energy and away from fossil fuels that contribute to climate change. However, their proliferation in marine environments raises new questions about their impacts on wildlife. Energy operators and ...

To perform quantum computations, quantum bits (qubits) must be cooled down to temperatures in the millikelvin range (close to -273 Celsius), to slow down atomic motion and minimize noise. However, the electronics used to manage these quantum circuits generate heat, which is difficult to remove at such low temperatures. Most current technologies must therefore separate quantum circuits from their electronic components, causing noise and inefficiencies that hinder the realization of larger quantum systems beyond the lab. Researchers in EPFL’s Laboratory of ...

Microbes that are used for health, agricultural, or other applications need to be able to withstand extreme conditions, and ideally the manufacturing processes used to make tablets for long-term storage. MIT researchers have now developed a new way to make microbes hardy enough to withstand these extreme conditions. Their method involves mixing bacteria with food and drug additives from a list of compounds that the FDA classifies as “generally regarded as safe.” The researchers identified formulations that help to stabilize several different types ...

Agroecology—a science, practice, and movement which seeks social, political, economic, and environmental sustainability in the global food system—is gaining momentum in the U.S., according to a new Dartmouth-led commentary in Nature Food. As the co-authors report, the approach requires coordination between scientists, farmers, and activists. "When it comes to sustainable food and agriculture, people in the U.S. tend to be more familiar with organic farming, the production of food without synthetic inputs, and regenerative agriculture, which primarily strives to restore soil health," says lead author Theresa Ong, an assistant professor of environmental studies ...

A mysterious remnant from a rare type of supernova recorded in 1181 has been explained for the first time. Two white dwarf stars collided, creating a temporary “guest star,” now labeled supernova (SN) 1181, which was recorded in historical documents in Japan and elsewhere in Asia. However, after the star dimmed, its location and structure remained a mystery until a team pinpointed its location in 2021. Now, through computer modeling and observational analysis, researchers have recreated the structure of the remnant white dwarf, a rare occurrence, explaining its ...

The Negev desert of southern Israel is renowned for its unique rock art. Since at least the third millennium BCE, the hunters, shepherds, and merchants who roamed the Negev have left thousands of carvings (‘petroglyphs’) on the rocks. These figures are mostly cut into ‘desert varnish’: a thin black coating on limestone rock, which forms naturally. Many represent animals such as ibexes, goats, horses, donkeys, and domestic camels, but abstract forms also occur. Now, a study published in Frontiers in Fungal ...

Pseudomonas aeruginosa – an environmental bacteria that can cause devastating multidrug-resistant infections, particularly in people with underlying lung conditions – evolved rapidly and then spread globally over the last 200 years, probably driven by changes in human behaviour, a new study has found. P. aeruginosa is responsible for over 500,000 deaths per year around the world, of which over 300,000 are associated with antimicrobial resistance (AMR). People with conditions such as COPD (smoking-related lung damage), cystic fibrosis (CF), and non-CF bronchiectasis, are particularly susceptible. How P. aeruginosa evolved from an environmental organism into a ...

An aerogel made from gelatin and DNA surpasses 100% solar reflectance, yielding exceptional radiative cooling, a new study reports. It is also biodegradable. The novel approach paves the way for high-performance next-generation radiative cooling materials, promoting environmentally friendly advancements in the field. Sustainable, energy-efficient, and environmentally conscious cooling technologies are crucial for adapting to our rapidly warming world. Compared to traditional refrigeration systems, passive radiative cooling technologies consume less energy and emit fewer greenhouse gasses, making them ...

The rapid influx of cerebral spinal fluid (CSF) and protein solutes released during cortical spreading depression (CSD) in the brain activates neurons to trigger aural migraine headaches, according to a new mouse study. The findings identify a novel non-synaptic signaling mechanism between the brain and peripheral sensory system important for migraine. They also suggest potential pharmacological targets for treating the painful disorder. Migraine with aura, or an aural migraine, is a distinct headache disorder that can include sensory disturbances, such as hearing- or vision-related symptoms that precede onset of ...

Although energy production from wind and solar has grown rapidly in the United States, its integration into the national electric grid has been impeded by poor grid interconnection policies, leaving thousands of new facilities for generating renewable energy waiting to be connected to the grid.  In a Policy Forum, Les Armstrong and colleagues highlight the interconnection problem and discuss whether federal grid policy reforms alone are enough to address it. Armstrong et al. argue that while the US Federal Energy Regulatory Commission’s (FERC) recent orders to improve this bottleneck are a step in the right direction, fundamental issues remain unaddressed. In the ...

In the gut, dozens of strains of bacteria exert different effects on the immune system that in turn impact our health – fending off pathogens, helping digest food and maybe even influencing behavior. But pinpointing which bacteria exert which effects has been challenging. Better understanding this process could lead to a powerful way to treat a host of diseases. For developing a method by which to zero in on individual gut bacterium’s impacts on T cells, Kazuki Nagashima, a senior research scientist at Stanford University, is the winner of this year’s NOSTER & Science Microbiome ...

New research describes for the first time how a spreading wave of disruption and the flow of fluid in the brain triggers headaches, detailing the connection between the neurological symptoms associated with aura and the migraine that follows. The study also identifies new proteins that could be responsible for headaches and may serve as foundation for new migraine drugs. “In this study, we describe the interaction between the central and peripheral nervous system brought about by increased concentrations of proteins released ...

Researchers led by Yasuhiro Murakawa at the RIKEN Center for Integrative Medical Sciences (IMS) and Kyoto University in Japan and IFOM ETS in Italy have discovered several rare types of helper T cells that are associated with immune disorders such as multiple sclerosis, rheumatoid arthritis, and even asthma. Published July 4 in Science, the discoveries were made possible by a newly developed technology they call ReapTEC, which identified genetic enhancers in rare T cell subtypes that are linked to specific immune ...

In recent years global warming has left its mark on the Antarctic ice sheets. The "eternal" ice in Antarctica is melting faster than previously assumed, particularly in West Antarctica more than East Antarctica. The root for this could lie in its formation, as an international research team led by the Alfred Wegener Institute has now discovered: sediment samples from drill cores combined with complex climate and ice-sheet modelling show that permanent glaciation of Antarctica began around 34 million years ago – ...

Curious bits of DNA tucked inside genomes across all kingdoms of life historically have been disregarded since they don’t seem to have a role to play in the competition for survival. Or so researchers thought. These DNA pieces came to be known as “selfish genetic elements” because they exist, as far as scientists could tell, to simply reproduce and propagate themselves, without any benefit to their host organisms. They were seen as genetic hitchhikers that have been inconsequentially passed ...

A previously unknown mechanism by which proteins from the brain are carried to a particular group of sensory nerves causes migraine attacks, a new study shows. This may pave the way for new treatments for migraine and other types of headaches. More than 800,000 Danes suffer from migraines – a condition characterised by severe headache in one side of the head. In around a fourth of all migraine patients, headache attacks are preceded by aura – symptoms from the brain such as temporary visual or sensory disturbances preceding the migraine attack by 5-60 minutes. While ...

The complexity of the melodies of the most popular songs each year in the USA — according to the Billboard year-end singles charts — has decreased since 1950, a study published in Scientific Reports suggests. Madeline Hamilton and Marcus Pearce analysed the most prominent melodies (usually the vocal melody) of songs that reached the top five positions of the US Billboard year-end singles music charts each year between 1950 and 2022. They found that the complexity of song rhythms and pitch arrangements decreased over this period as the average number of notes ...

Firstly, the authors provided a detailed explanation of the experimental methods and procedures. This study recruited 30 healthy subjects (15 males and 15 females), aged between 20 to 50 years, with an average age of 42 ± 6.58 years. All participants had no severe visual or auditory impairments and were right-handed. The subjects met the biometric standards for astronaut candidates and were rigorously screened. The experiment used Unity 3D to model the space station, simulating the internal scenes of the space station. The subjects started from the core node module and found the laboratory module I, where they operated the Space Raman Spectrometer ...

Plastic items from around the world are continuously washing ashore on Norwegian coastlines. This reflects a much larger systemic issue facing the nations of the world. Scientists have long reported the consequences of plastic pollution and the urgent need for intervention, but global plastic production and consumption continue to rise. This underscores the importance of Norway’s advocacy for a global agreement that guarantees stopping the flow of plastics into the environment. But Norway also has a responsibility in generating plastic pollution. In a study conducted ...

A new study of curriculum reading material at the University of Glasgow finds that 94% of recommended Tropical Ecology authors are white, and that 80% of authors are affiliated with universities outside of the tropics. Dr Stewart White, Senior Lecturer at the School of Biodiversity, One Health and Veterinary Medicine at the University of Glasgow, UK, intends to change that. “Tropical rainforest research was long the preserve of rich white men and the resulting literature was the same,” says Dr White. “This historical bias in tropical research and publication is still ...

New research reveals how the surprising internal anatomy of the helmeted hornbill’s casque allows it to withstand damage during aerial jousting battles with rivals. Researchers hope that this new understanding can help to conserve this critically endangered species, as well as provide new insights into developing impact-resistant bio-mimetic materials. “When I started in Hong Kong, I visited City University of Hong Kong (HKU)’s conservation forensics group to chat about their research and they introduced me to this amazing bird, to its ...

Researchers have discovered the unique nanostructures responsible for the electric blue spots of the bluespotted ribbontail ray (Taeniura lymma), with possible applications for developing chemical-free colouration. The team are also conducting ongoing research into the equally enigmatic blue colouration of the blue shark (Prionace glauca). Skin colouration plays a key role in organismal communication, providing life-critical visual clues that can warn, attract or camouflage. Bluespotted ribbontail ...

Painting roofs white or covering them with a reflective coating would be more effective at cooling cities like London than vegetation-covered “green roofs,” street-level vegetation or solar panels, finds a new study led by UCL researchers. Conversely, extensive use of air conditioning would warm the outside environment by as much as 1 degree C in London’s dense city centre, the researchers found. The research, published in Geophysical Research Letters, used a three-dimensional urban climate model of Greater London to test the thermal effects of different passive and active urban heat management systems, including painted “cool roofs,” rooftop solar panels, ...