About The Study: In this prespecified secondary analysis of the FINEARTS-HF randomized clinical trial, long-term treatment with the nonsteroidal mineralocorticoid receptor antagonist finerenone was estimated to extend event-free survival by up to 3 years among people with heart failure with mildly reduced or preserved ejection fraction.  Corresponding Author: To contact the corresponding author, Scott D. Solomon, M.D., email ssolomon@rics.bwh.harvard.edu. To access the embargoed study: Visit our For The Media website at ...

The University of Texas MD Anderson Cancer Center today announced its first-ever academic journal, Advances in Cancer Education & Quality Improvement (ACE-QI). The journal will publish research, training program summaries and quality improvement interventions for the oncology provider community. The open-access, peer-reviewed journal will feature research and professional perspectives focused on training health care providers to meet myriad challenges around prevention, diagnosis, treatment and survivorship in cancer care. “We envision this journal as a catalyst for critical conversations across the cancer care continuum," said Joshua Kuban, M.D., associate ...

PHILADELPHIA – Leading experts in radiation therapy from Penn Medicine’s Abramson Cancer Center and the Perelman School of Medicine will present new results from clinical trials and research studies at the American Society for Radiation Oncology's (ASTRO) 66th Annual Meeting, which will be held at the Walter E. Washington Convention Center in Washington, D.C., Sept. 29 through Oct. 2, 2024. At the meeting, Neha Vapiwala, MD, FACR, FASTRO, FASCO, the Eli Glatstein Professor in Radiation Oncology, will take office as president-elect of ASTRO as the first Penn faculty member to lead the premier society ...

University of Cincinnati Cancer Center experts will present research at the American Society for Radiation Oncology (ASTRO) Annual Meeting Sept. 29 through Oct. 2.  Osteoradionecrosis more common in patients with head and neck cancer that requires partial jaw removal  Following radiation treatment for head and neck cancer, some patients can experience osteoradionecrosis (ORN) when an area of exposed bone fails to heal after a three-month period.  “ORN of the mandible and maxilla (jaw bones) can be very debilitating, as it often causes severe pain, fistula formation, infection and susceptibility to fractures,” ...

Center for BrainHealth® at The University of Texas at Dallas has received a major match gift commitment from retired U.S. Navy four-star admiral and former University of Texas System chancellor William McRaven and his wife Georgeann. Adm. McRaven recently received the 2024 Bezos Courage & Civility Award presented by Amazon founder Jeff Bezos and Lauren Sánchez.   The $2 million challenge grant will support Optimal BrainHealth for Warfighters – including active-duty military, spouses and veterans. This program will help those with traumatic brain injury (TBI), post-traumatic stress (PTS) and similar issues, as well ...

Irvine, Calif., Sept. 27, 2024 — Research from the University of California, Irvine has revealed how disruption of the circadian clock, the body’s internal, 24-hour biological pacemaker, may accelerate the progression of colorectal cancer by affecting the gut microbiome and intestinal barrier function. This discovery offers new avenues for prevention and treatment strategies.   The study, published online today in the journal Science Advances, offers a more comprehensive understanding of how important changes occur in the function and composition of the gut microbiome when the circadian clock is disturbed in the presence ...

The University of Tennessee and the UT Institute of Agriculture have received a $434,038 Seeding Solutions grant from the Foundation for Food & Agriculture Research (FFAR) to develop and test a decision support tool for farmers to better manage crop production from risks of extreme weather events across the Tennessee River Basin and surrounding southeast US regions. UT is providing matching funds for a total investment of $966,119 over the three-year project. The U.S. Department of Agriculture estimates that extreme weather is responsible for 90% of crop losses. These estimates are generally based on annual climate conditions. ...

Researchers from three of Virginia’s premier universities, including the University of Virginia’s Homa Alemzadeh, aim to take the risk out of self-driving vehicles by overcoming inevitable computer failures with good engineering. The trio will share a $926,737 National Science Foundation award to identify when and where autonomous vehicle systems are most vulnerable to safety-critical failures. They plan to use this knowledge to design ways to efficiently mitigate potential safety hazards and enhance the overall system resilience.  Alemzadeh, an associate professor of electrical and computer engineering in UVA’s School of Engineering and Applied ...

Since the first sighting of the first-discovered and largest asteroid in our solar system was made in 1801 by Giuseppe Piazzi, astronomers and planetary scientists have pondered the make-up of this asteroid/dwarf planet. Its heavily battered and dimpled surface is covered in impact craters. Scientists have long argued that visible craters on the surface meant that Ceres could not be very icy.  Researchers at Purdue University and the NASA's Jet Propulsion Lab (JPL) now believe Ceres is a very icy ...

Researchers with McMaster University have discovered that the protein mutated in patients with Huntington’s Disease doesn't repair DNA as intended, impacting the ability of brain cells to heal themselves.    The research, published in PNAS on Sept. 27, 2024, found that the huntingtin protein helps create special molecules that are important for fixing DNA damage. These molecules, known as Poly [ADP-ribose] (PAR), gather around damaged DNA and, like a net, pull in all the factors needed for the repair process. In people with Huntington’s Disease, however, the research found that the mutated version of this protein doesn’t function properly ...

DURHAM, N.C. – Estrogens are known to drive tumor growth in breast cancer cells that carry its receptors, but a new study by Duke Cancer Institute researchers unexpectedly finds that estrogens play a role in fueling the growth of breast cancers without the receptors, as well as numerous other cancers.   Appearing Sept. 27 in the journal Science Advances, the researchers describe how estrogens not only decrease the ability of the immune system to attack tumors, but also reduce the effectiveness of immunotherapies that are used to treat many cancers, notably triple-negative breast cancers. Triple-negative ...

In December 2020 the space probe Hayabusa 2 brought samples of asteroid Ryugu back to Earth. Since then, the few grams of material have been through quite a lot. After initial examinations in Japan, some of the tiny, jet-black grains traveled to research facilities around the world. There they were measured, weighed, chemically analyzed and exposed to infrared, X-ray and synchroton radiation, among other things. At the MPS, researchers examine the ratios of certain metal isotopes in the samples, as in the current study. Scientists refer to isotopes as variants of the same element that differ only in the number of neutrons in the nucleus. Investigations ...

A new study shows how individual brain cells in the hippocampus respond to pronouns. “This may help us unravel how we remember what we read.” Read the following sentence: “Donald Trump and Kamala Harris walked into the bar, she sat down at a table.” We all immediately know that it was Kamala who sat at the table, not Donald. Pronouns like “she” help us to understand language, but pronouns can have multiple meanings. Depending on the context, we understand who the pronoun is referring to. But ...

Recently, a research group led by Prof. WANG Xianlong from the Hefei Institutes of Physical Science of the Chinese Academy of Sciences, successfully synthesized high-energy-density materials cubic gauche nitrogen (cg-N) at atmospheric pressure by treating potassium azide (KN3) using the plasma-enhanced chemical vapour deposition technique (PECVD). The research results were published in Science Advances. Cg-N is a pure nitrogen material consisting of nitrogen atoms bonded by N-N single bonds, resembling the structure of diamond. It has attracted attention because it has a high-energy-density and produces only nitrogen gas when it decomposes. ...

University of Maryland scientists uncovered evidence of an ancient seafloor that sank deep into Earth during the age of dinosaurs, challenging existing theories about Earth’s interior structure. Located in the East Pacific Rise (a tectonic plate boundary on the floor of the southeastern Pacific Ocean), this previously unstudied patch of seafloor sheds new light on the inner workings of our planet and how its surface has changed over millions of years. The team’s findings were published in the journal Science Advances on September 27, 2024. Led by geology postdoctoral researcher Jingchuan Wang, the team used innovative seismic imaging techniques to ...

As Mark Hasegawa-Johnson combed through data from his latest project, he was pleasantly surprised to uncover a recipe for Eggs Florentine. Sifting through hundreds of hours of recorded speech will unearth a treasure or two, he said. Hasegawa-Johnson leads the Speech Accessibility Project, an initiative at the University of Illinois Urbana-Champaign to make voice recognition devices more useful for people with speech disabilities. In the project’s first published study, researchers asked an automatic ...

NEW YORK, September 27, 2024 – Water scarcity, pollution, and the burden of waterborne diseases are urgent issues threatening global health and security. A recently published study in the journal Global Environmental Change highlights the pressing need for innovative economic strategies to bolster water security investments, focusing on the “enabling environment” that influences regional readiness for new business solutions. Initiated and led by researchers at the Advanced Science Research Center at the CUNY Graduate Center (CUNY ASRC), ...

The study, published in Lancet Neurology, detailed the “head-to-head” trial implemented by the researchers to test two drugs, mexiletine and lamotrigine, on people with the condition. The trial, which was conducted at the UCL Queen Square Multidisciplinary Centre for Neuromuscular Diseases and the National Hospital for Neurology and Neurosurgery, UCLH, involved 60 adults with confirmed non-dystrophic myotonia. Patients were randomly assigned to receive either mexiletine for eight weeks followed by lamotrigine for eight weeks, or the reverse order, with a seven-day ...

HOUSTON ― The University of Texas MD Anderson Cancer Center has posthumously awarded Michael Frumovitz, M.D., with the Julie and Ben Rogers Award for Excellence in Patient Care. The annual award recognizes employees who consistently demonstrate excellence in their work and dedication to MD Anderson’s mission to end cancer. The award’s focus rotates among the areas of patient care, research, education, prevention and administration, with this year’s award focusing on patient care.  Frumovitz dedicated more than 20 years of service to MD Anderson, most recently as chief patient experience officer and professor in Gynecologic ...

A University of Arizona College of Medicine – Phoenix researcher was recently awarded a $1.9 million National Institutes of Health grant to study the molecular mechanisms of how dilated cardiomyopathy progresses to heart failure, which could eventually lead to better preventive and treatment options for heart failure. Heart failure is inextricably linked with dilated cardiomyopathy, or DCM, a disease characterized by the progressive enlargement of the heart and reduced contractility reflected by reduced ejection fraction. ...

Clinical cancer research in the U.S. is increasingly dominated by pharmaceutical industry sponsors, study finds Study underscores need for increased investment in federally funded cancer clinical trials SEATTLE – September 27, 2024 – Researchers at Fred Hutch Cancer Center identified a substantial increase over the past decade in the proportion of patients with cancer in the U.S. who participate in pharmaceutical industry sponsored clinical trials compared to those conducted with federal government support. Published in The Journal of Clinical Oncology and presented at the ASCO Quality Care Symposium, these findings reveal trends of underinvestment in federally ...

A new study published in the journal Science suggests that an ordinary old log could help refine strategies to tackle climate change. A team of researchers led by University of Maryland Atmospheric and Oceanic Science Professor Ning Zeng analyzed a 3,775-year-old log and the soil it was excavated from. Their analysis, published on September 27, 2024, revealed that the log had lost less than 5% carbon dioxide from its original state thanks to the low-permeability clay soil that covered it. “The wood is nice and solid—you could probably make a piece of furniture out of it,” Zeng noted.  Understanding the ...

Preterm births have increased by more than 10 percent over the past decade, with racial and socioeconomic disparities persisting over time, according to a new study analyzing more than five million births. The study, published in the journal JAMA Network Open, also found that some factors that increase the risk for preterm birth—such as diabetes, sexually transmitted infections, and mental health conditions—became much more common over the past decade, while other factors that protect against preterm birth declined.  “Our findings not only show that preterm births are on the rise, but provide clues as ...

About The Study: The results of this cross-sectional study show that over the past 2 decades, menopausal hormone therapy use declined among U.S. postmenopausal women of all age and racial and ethnic groups. Women of racial and ethnic minority groups had lower prevalence of menopausal hormone therapy use compared to non-Hispanic white women.  Corresponding Authors: To contact the corresponding authors, email Lin Yang, PhD, (lin.yang@ahs.ca) and Adetunji T. Toriola, MD, PhD, MPH, (a.toriola@wustl.edu). To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamahealthforum.2024.3128) Editor’s ...

New research shows the connection between adverse childhood experiences (ACEs), such as physical or emotional abuse, and an increased risk of people growing up to be abusive against older generations. While generational trauma is known to be passed down from parent to child, the study showed that it can also reverberate upwards from parent to older generations. A survey of over 13,000 people in Japan found that about half had one or more ACEs. Of these, 8.5% self-reported committing some form of physical or verbal abuse against people aged over 65. An important contributing factor was the person’s mental and physical health, both of which are known to be affected by ...