Gleevec, a cancer drug first approved for sale in 2001, has dramatically changed the lives of people with chronic myeloid leukemia. This form of cancer was once regarded as very difficult to combat, but survival rates of patients who respond to Gleevec now resemble that of the population at large.  Gleevec is also a medicine developed with the help of federally funded research. That support helped scientists better understand how to create drugs targeting the BCR-ABL oncoprotein, the cancer-causing protein behind chronic myeloid ...

UC Riverside researchers have discovered a piece that was missing in previous descriptions of the way Earth recycles its carbon. As a result, they believe that global warming can overcorrect into an ice age.   The traditional view among researchers is that Earth’s climate is kept in check by a slow-moving but reliable natural system of rock weathering.  In this system, rain captures carbon dioxide from the air, hits exposed rocks on land – especially silicate rocks like granite – and slowly dissolves ...

The genetic culprits responsible for the spread of multidrug resistance (MDR) in bacteria have been identified by new research mapping 100 years of bacterial evolution. Experts at the Wellcome Sanger Institute, the University of Bath, the UK Health Security Agency (UKHSA) and their collaborators1, analysed over 40,000 plasmids from historical and present-day bacterial samples taken across six continents, the largest dataset of its kind. Plasmids are transferable structures in bacteria that allow different strains to share genetic information. In this study, published today (25 September) in Science, researchers found that a minority of plasmids causes most of the multidrug ...

Amid high expectations for quantum technology, a new paper in Science reports proven quantum advantage. In an experiment, entangled light lets researchers learn a system's noise with very few measurements. Researchers at the Technical University of Denmark (DTU) and international partners have demonstrated that entangled light can cut the number of measurements needed to learn the behaviour of a complex, noisy quantum system by an enormous factor. "This is the first proven quantum advantage for a photonic system," says corresponding author Ulrik ...

New research from Memorial Sloan Kettering Cancer Center (MSK) highlights the importance of tumor location in metastasis; shows how regulatory T cells work with sensory nerves in the skin to restrain pain and inflammation; explores whether a large language model can adequately summarize cancer patients’ experiences with pain; and finds proton therapy is effective at treating leptomeningeal metastasis. In metastasis, genetics meet geography, study finds Mutations that drive the growth and survival of cancer cells can help a primary tumor spread to new sites, but the extent to which they help sustain tumor growth at these metastatic sites has been unclear. An MSK-led ...

Philadelphia, September 25, 2025 – A new study published in the Journal of Nutrition Education and Behavior, published by Elsevier, highlights the development of a culturally-informed approach to screening for food insecurity among patients at Northern Navajo Medical Center (NNMC) in Shiprock, New Mexico. The alternative screener aims to reduce stigma, improve patient comfort, and reflect local food traditions and community food access better. American Indian households experience food insecurity at disproportionately ...

Depression and psychosis are more common in women after childbirth than before, but the risk of suicide attempts decreases. This is shown by two new studies from Karolinska Institutet. The results suggest that national guidelines for screening can help women get help earlier. Mental ill health in connection with pregnancy and childbirth can have long-term consequences for women's health. During this period, major biological and psychosocial changes occur that can increase vulnerability to depression, anxiety, ...

Brazilian researchers, in partnership with French institutions, have developed a tool that can predict how patients will respond to natalizumab, one of the most commonly used drugs for treating multiple sclerosis. Despite its effectiveness, about 35% of users do not respond completely to therapy and experience a return of symptoms within two years of starting treatment. Additionally, while it helps reduce the frequency and severity of outbreaks and slows disease progression, it can cause adverse reactions such as an increased ...

Lignin, a renewable aromatic biopolymer with complex three-dimensional networks and diverse functional groups, represents a promising sustainable feedstock for value-added chemicals and fuels. However, its structural heterogeneity and poor solubility pose significant challenges for efficient valorization. Oxidative depolymerization has emerged as a particularly effective approach for producing carbonyl-containing aromatic compounds under mild conditions. Polyoxometalates serve as ideal bifunctional catalysts, combining acidic and oxidative sites while enabling oxygen-mediated regeneration. Current limitations involve the high ...

CAMBRIDGE, MA -- Mucus is more than just a sticky substance: It contains a wealth of powerful molecules called mucins that help to tame microbes and prevent infection. In a new study, MIT researchers have identified mucins that defend against Salmonella and other bacteria that cause diarrhea. The researchers now hope to mimic this defense system to create synthetic mucins that could help prevent or treat illness in soldiers or other people at risk of exposure to Salmonella. It could also help prevent “traveler’s diarrhea,” a gastrointestinal infection caused by consuming contaminated food or water. Mucins are bottlebrush-shaped polymers made of complex sugar ...

ITHACA, N.Y. – An analysis of commercial raw cat foods detected disease-causing microbes, including some that are resistant to antibiotics, creating risks for both pets and their owners, according to a new Cornell University study. The paper, published in Communications Biology, found Salmonella, Cronobacter and E. coli in such foods as raw or partially cooked meat sold frozen, refrigerated and freeze-dried in stores and online. These pathogens can transfer from pets to humans and are of special concern for young children, and people who are old, pregnant and ...

Tampa, FL, USA – September 25, 2025 – With global attention shifting away from mpox after recent declines in case counts, the Global Virus Network (GVN) is warning against complacency and urges accelerating efforts to strengthen outbreak readiness. Through its Mpox Action Committee and Centers of Excellence, GVN has initiated one of the first coordinated, multi-country evaluations of rapid point-of-care mpox diagnostics, a critical step to prevent resurgence and ensure the world is better prepared for future epidemics. Despite recent improvements, health experts caution that gaps in surveillance and diagnostics leave communities vulnerable to new flare-ups. In ...

With $3M in new federal funding over two years, University of Ottawa Faculty of Medicine molecular virologist Dr. Marc-André Langlois and a multidisciplinary team of collaborators will be a vital part of Canada’s ability to respond effectively to infectious disease threats & future pandemics. With this investment from the Canadian Institutes of Health Research (CIHR), the national network of experts led by Dr. Langlois will be able to support large-scale scientific research, protect vulnerable communities, and strengthen the country’s ability ...

People who suspect that their sense of smell has been dulled after a bout of COVID-19 are likely correct, a new study using an objective, 40-odor test shows. Even those who do not notice any olfactory issues may be impaired. Led by the National Institutes of Health’s RECOVER initiative and supported by its Clinical Science Core at NYU Langone Health, a team of researchers from across the country explored a link between the coronavirus that causes COVID-19 and hyposmia — the reduced ability to smell. The results revealed that 80% of participants who reported a change in their smelling ability after having COVID-19 earned low scores on ...

More marine life is living on some World War II munitions disposed of on the Baltic Sea’s seabed than on the sediment surrounding it. The findings, reported in a paper in Communications Earth & Environment, show that some marine organisms can tolerate high levels of toxic compounds if there is a hard surface for them to inhabit. The results also demonstrate how detritus from human conflict can provide habitats for wildlife, which is similarly shown in a Scientific Data study mapping a fleet of World War I shipwrecks in Maryland, USA. Prior ...

About The Study: This cohort study of schools matched to child and adolescent patient medical records from a large network of community health organizations found that school participation in the Community Eligibility Provision was associated with a net reduction in blood pressure outcomes. These findings add to mounting evidence that universal free school meals may be associated with improved child health. Corresponding Author: To contact the corresponding author, Anna M. Localio, PhD, MPH, email alocalio@uw.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.33186) Editor’s ...

About The Study: The findings of this analysis suggest that the individualized treatment effect of low-dose aspirin on cancer prevention in older adults varies by participant characteristics. Further study is needed to fully understand the implications of these findings.  Corresponding Author: To contact the corresponding author, Le Thi Phuong Thao, PhD, email thao.le@monash.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaoncol.2025.3593) Editor’s Note: Please ...

About The Study: This cohort study examines the presence, severity, and patterns of olfactory dysfunction in U.S. adults with and without prior SARS-CoV-2 infection. Corresponding Author: To contact the corresponding author, Leora I. Horwitz, MD, MHS, email Leora.horwitz@nyulangone.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2025.33815) Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, ...

New York, NY [September 25, 2025] — A new study led by the Icahn School of Medicine at Mount Sinai offers one of the most comprehensive views yet of how brain cells interact in Alzheimer’s disease, mapping protein networks that reveal communication failures and point to new therapeutic opportunities. Published online in Cell on September 25, the study analyzed protein activity in brain tissue from nearly 200 individuals. The researchers discovered that disruptions in communication between neurons and supporting brain cells called glia—specifically astrocytes and microglia—are ...

The American Geophysical Union (AGU), the world’s largest association of Earth and space scientists, and the American Meteorological Society (AMS), the professional society for atmospheric and related sciences and services, invite contribution proposals for a joint special collection of research articles called the “U.S. Climate Collection: Informing Assessment of Risks and Solutions.”   This collaborative effort, first announced earlier this year in the wake of the dismissal of the Sixth National Climate Assessment (NCA) authors, aims to publish ...

Fischer-Tropsch synthesis (FTS) is an important technology for converting carbon-rich resources such as coal, natural gas, and biomass into clean fuels and high-value chemicals through synthesis gas. Iron-based catalysts are widely used in industrial applications due to their low cost and strong adaptability, especially for syngas derived from coal or biomass with low H2/CO ratios. However, the catalytic process is complicated by frequent phase transformations among metallic iron, iron oxides, and iron carbides, which ...

DALLAS, Sept. 25, 2025 — Six NFL (National Football League) club mascots are stepping up to inspire kids to move more to support mental and physical health. These NFL mascots are serving as members of the inaugural NFL PLAY 60 Ambassador class supporting the NFL and the American Heart Association’s work to help kids achieve a minimum of 60 minutes of moderate-to-vigorous physical activity each day. Rooted in the American Heart Association’s physical activity guidelines, NFL PLAY 60 supports the evidence-based guidance that students who are active learn better, focus more, think more ...

Background and Aims The causal biomarkers for metabolic dysfunction-associated steatotic liver disease (MASLD) and their clinical value remain unclear. In this study, we aimed to identify biomarkers for MASLD and evaluate their diagnostic and prognostic significance. Methods We conducted a Mendelian randomization analysis to assess the causal effects of 2,925 molecular biomarkers (from proteomics data) and 35 clinical biomarkers on MASLD. Mediation analysis was performed to determine whether clinical biomarkers mediated the effects of molecular biomarkers. The association ...

INDIANAPOLIS -- Chest pain ranks as the second most common reason for emergency department (ED) visits, making it a key concern for patients and doctors. However, 80 percent of these cases are considered low-risk and not related to heart disease, and for these patients, anxiety and panic disorders are frequent diagnoses. A new study led by the Indiana University School of Medicine and Regenstrief Institute researchers shows that many patients who visit the ED with low-risk chest pain might benefit more from treatment for underlying psychological conditions than from extensive cardiac testing. Anxiety is not only common among low-risk ...

Key Points: Microbiologists have previously studied the bacterial species found in subway stations, but fungi have often been overlooked. An international team of researchers collected monthly samples from subway stations in Beijing and found high fungal diversity, mostly non-pathogenic. Some opportunistic pathogens were also detected. Fungal communities were observed to vary significantly by season and station types. The work could guide better strategies for air quality control in urban transit systems. Washington, D.C. — Subways don’t just bring people together. They’re also ...