About The Study: The results of this post hoc analysis suggest that treatment with semaglutide, 2.4 mg, did not increase the risk of developing symptoms of depression or suicidal ideation/behavior vs placebo and was associated with a small but statistically significant reduction in depressive symptoms (not considered clinically meaningful). People with obesity should be monitored for mental health concerns so they can receive appropriate support and care.  Corresponding Author: To contact the corresponding author, Thomas A. Wadden, PhD, email wadden@pennmedicine.upenn.edu. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/  (doi:10.1001/jamainternmed.2024.4346) Editor’s ...

Large study included 47,307 well-child visits at 30 clinics in Michigan and Colorado Almost 50% of clinicians receiving a prompt plus added support delivered a secure firearm storage program during well visits versus just 22% of doctors receiving prompt only Firearm-related injuries are the leading cause of death for young people in the U.S.  ‘We can save lives’ with a brief program to support parents in secure storage CHICAGO --- If it takes a pediatrician less than one minute per visit to talk to parents about how to securely store their firearms and offer a free cable lock, why do only 2% of doctors report routinely doing so? Turns out, they ...

There has been concern that common diabetes drugs could increase the risk of suicide and self-harm. In a new study, led by researchers at Karolinska Institutet and published in Jama Internal Medicine, no such risk increase was observed. Drugs of the type GLP-1 analogues lower blood sugar levels and are used by millions of people worldwide. They are mainly used to treat diabetes, but drugs such as Ozempic have also been shown to be effective against obesity, which has increased their popularity. At the same time, both American and European drug authorities have warned that there may be risks associated with ...

An invasive, freshwater jellyfish is popping up in B.C. waters in the thousands and future sightings could increase rapidly, according to UBC research. The peach blossom jellyfish clones have been spotted in 34 places in B.C., its furthest northern range in North America, and a recent paper predicts sightings and the number of locations will increase by the end of the decade as climate change extends this range. Dr. Florian Lüskow, who completed the research during his postdoctoral fellowship ...

A new study using 10 years of data has provided the most comprehensive estimate of infertility rates to date in a threatened wild animal population Researchers from the University of Sheffield found infertility accounts for 17 per cent  of hatching failure in an endangered songbird, the hihi, with the majority of hatching failure being caused by embryo death This is the first study to find a link between small population size, sex ratio bias, and reduced fertilisation rates in wild animals By considering the impacts of population size and sex ratio on fertility, conservationists can better manage the numbers and composition of animals in populations ...

Each agency representative presented the status of their current involvement in current and future planning for missions to Apophis (including extended mission for OSIRIS-REx, renamed OSIRIS-APEX, for NASA and the RAMSES mission for ESA) as well as the existing partnerships and mutual involvement in other agency’s missions, e.g. the infrared camera provided by JAXA in ESA’s mission Hera. Concepts to fly to Apophis, as well as reuse of existing payloads, spare parts and hardware, coordination of arrival time at Apophis of the different spacecraft, techniques to be demonstrated, ...

OAK BROOK, Ill. – Researchers evaluating the performance of ChatGPT-4 Vision found that the model performed well on text-based radiology exam questions but struggled to answer image-related questions accurately. The study’s results were published today in Radiology, a journal of the Radiological Society of North America (RSNA). Chat GPT-4 Vision is the first version of the large language model that can interpret both text and images. “ChatGPT-4 has shown promise for assisting radiologists in tasks such as simplifying patient-facing radiology reports and identifying ...

A new study reveals nuanced findings on the neuropsychiatric risks of prenatal cannabis exposure. The research found a slight increase in the risk of ADHD and a heightened vulnerability to cannabis use in offspring. These results highlight the need for continued caution and further investigation into the long-term effects of cannabis use during pregnancy. A new study led by Prof. Ilan Matok and Hely Bassalov PharmD from the Department of Clinical Pharmacy at the School of Pharmacy in the Faculty of Medicine at Hebrew University in collaboration ...

Gun-free zones have often been blamed for making schools, malls and other public areas more attractive to shooters; however, there have been no quantitative studies examining those claims. Now, in a first of its kind study published in The Lancet Regional Health Americas, researchers at UC Davis Health and other institutions have shown that gun-free zones may, in fact, reduce the risk of mass shootings. "Our most significant finding is that gun-free zones don't attract active shooters,” said the study’s first author, Paul Reeping, ...

Darwin was puzzled by cooperation in nature—it ran directly against natural selection and the notion of survival of the fittest. But over the past decades, evolutionary mathematicians have used game theory to better understand why mutual cooperation persists when evolution should favour self-serving cheaters.    At a basic level, cooperation flourishes when the costs to cooperation are low or the benefits large. When cooperation becomes too costly, it disappears—at least in the realm of pure mathematics. ...

East Hanover, NJ – September 3, 2024 – Researchers at Kessler Foundation have published a new clinical protocol examining the combination of aerobic exercise and cognitive rehabilitation to improve learning and memory in individuals with multiple sclerosis (MS) who have mobility disability. The article, “Rationale and methodology for examining the combination of aerobic exercise and cognitive rehabilitation on new learning and memory in persons with multiple sclerosis and mobility disability: Protocol for a randomized controlled trial,” was published online and will appear in print in Contemporary Clinical Trials, ...

$75 million NIH grant could lead to the first effective drugs for a condition with few treatment options A clinical trial that will test three drugs concurrently, and could include more, represents new hope for patients with progressive supranuclear palsy (PSP), an incurable neurodegenerative disorder that usually kills within seven years after symptoms start.   Researchers hope the trial, which will be led by UC San Francisco and conducted at up to 50 sites nationwide, will lead to the development of new therapies. There are currently no drugs to stall the disease’s deadly progression. The ...

The Mass General Brigham Gene and Cell Therapy Institute (GCTI) today announced it has launched the RNA Therapeutics Core, a first-of-its-kind, state-of-the-art facility and resource to advance the use of RNA technologies within and beyond the Mass General Brigham research ecosystem. This new Core is dedicated to accelerating the exploration of novel therapeutic targets to effectively translate RNA-based medicines into clinical practice by leveraging advanced RNA vectors and delivery systems. Until now, a Core of this kind has not existed within an academic setting. With this launch, the RNA Therapeutics Core enables ...

Valley fever is an emerging fungal disease in the western United States that most often causes flu-like symptoms, but can also cause dangerous or even deadly complications. By analyzing data on reported cases of Valley fever in California, which have increased dramatically over the last two decades, researchers from University of California San Diego and University of California, Berkeley, have identified seasonal patterns that could help individuals and public health officials better prepare for future surges in Valley fever cases. The findings also have important implications for how the changing climate can exacerbate the threat of infectious diseases. The findings are published in The ...

Natural selection is an important evolutionary force that enables humans to adapt to new environments and fight disease-causing pathogens. However, the unique footprints of natural selection in our genome can be buried beneath those left by other evolutionary forces. Thus, by leveraging information about multiple evolutionary forces, researchers can identify signatures of natural selection in the human genome, and ultimately determine its role in human adaptation and disease. Low-cost DNA sequencing has ...

PULLMAN, Wash. -- When young adults first go off to college, more communication with parents generally leads to better relationships, but parents should avoid always initiating it, according to a study led by Washington State University researchers. In a paper published in the journal Emerging Adulthood, WSU Assistant Professor Jennifer Duckworth and co-authors found that phone, text, video or in-person communication made first-year students feel better about the relationship with their parents. Students also felt better about the relationship when parents offered support or advice, and when they discussed important topics, such as studying and friendships. However, researchers found ...

A modeling study suggests that one-sided interspecies cooperation can spontaneously emerge and persist over time, despite only one species benefitting. Evolutionary game theory, and the prisoner’s dilemma in particular, are often used to model the evolution of cooperation within a single species. In the prisoner’s dilemma, both parties benefit by cooperating, but the greatest benefit is earned by a defector who plays with a cooperator. The temptation to cheat tends to push players towards defection, ...

Prostate cancer is the second most common cancer among men worldwide, following lung cancer. In the United States alone, nearly 300,000 new cases are diagnosed annually. While reducing testosterone and other male hormones can be an effective treatment for prostate cancer, this approach becomes ineffective once the disease progresses to metastatic castration-resistant prostate cancer (mCRPC). At this stage, the cancer advances quickly and becomes resistant to conventional hormonal therapies and chemotherapy.   A clever strategy for fighting mCRPC is to exploit the ...

Around 4 billion years ago, an asteroid hit the Jupiter moon Ganymede. Now, a Kobe University researcher realized that the Solar System's biggest moon's axis has shifted as a result of the impact, which confirmed that the asteroid was around 20 times larger than the one that ended the age of the dinosaurs on Earth, and caused one of the biggest impacts with clear traces in the Solar System. Ganymede is the largest moon in the Solar System, bigger even than the planet Mercury, and is also interesting for the liquid water oceans beneath its icy surface. Like the Earth’s moon, it is tidally locked, meaning that it always shows the ...

A sweat-powered wearable has the potential to make continuous, personalized health monitoring as effortless as wearing a Band-Aid. Engineers at the University of California San Diego have developed an electronic finger wrap that monitors vital chemical levels—such as glucose, vitamins, and even drugs—present in the same fingertip sweat from which it derives its energy. The advance was published Sept. 3 in Nature Electronics by the research group of Joseph Wang, a professor in the Aiiso Yufeng Li Family Department of Chemical and Nano Engineering ...

Who killed the pregnant porbeagle? In a marine science version of the game Cluedo, researchers from the US have now accused a larger shark, with its deciduous triangular teeth, in the open sea southwest of Bermuda. This scientific whodunnit is published in Frontiers in Marine Science. “This is the first documented predation event of a porbeagle shark anywhere in the world,” said lead author Dr Brooke Anderson, a former graduate student at Arizona State University. “In one event, the population not only lost a reproductive female that could contribute to population growth, but it also lost all her developing ...

Belching is a common bodily function, but when it escalates to a level that interferes with daily life, it is defined as belching disorders. International surveys have reported that approximately 1% of adults have belching disorders, but the percentage in Japan and the factors involved often elude medical professionals. To examine the relationship between the rate of belching disorders, comorbidities, and lifestyles in Japan, a research team led by Professor Yasuhiro Fujiwara of Osaka Metropolitan University’s Graduate School of Medicine ...

Scientists from China have investigated how short peptide chains aggregate together in order to deepen our understanding of the process, which is crucial for drug stability and material development. Their study, published in JACS Au, provides valuable insights into how short proteins called peptides interact, fold, and function. These findings have significant implications for medicine, material science, and biotechnology. Peptides are short chains of amino acids that play essential roles in the body by building structures, speeding up chemical reactions, and supporting our immune system. The specific function of a protein is determined by how its amino acids interact with each other and ...

A national survey conducted as part of University of Exeter research has found huge variation in treatment for ADHD, highlighting the struggle many young adults face once they turn 18. Researchers have warned that the current system is failing many young adults as they transition from children’s to adult’s services - suddenly finding themselves unable to access treatment because services do not link up effectively. More than 750 people from across the country – including commissioners, healthcare professionals working ...

Embargoed for release until 5:00 p.m. ET on Monday 2 September 2024       Annals of Internal Medicine Tip Sheet        @Annalsofim       Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent.       ----------------------------       1. ...