Bottom Line: In a retrospective study, the 313-SNP breast cancer polygenic risk score (PRS313) blood test could predict future incidents of breast cancer in women diagnosed with ductal carcinoma in situ (DCIS) or lobular carcinoma in situ (LCIS). Journal in Which the Study was Published: Cancer Epidemiology, Biomarker & Prevention, a journal of the American Association for Cancer Research (AACR) Author: Jasmine Timbres, clinical information analyst at King’s College London and the study’s lead author, and Elinor J. Sawyer, PhD, the study’s senior author and professor of clinical oncology at King’s College London in the United Kingdom. Background: ...

  Studying a person’s genetic makeup can predict if they will go on to develop invasive breast cancer after abnormal cells have been found in their breast tissue. For the first time, researchers at King’s College London have shown the connection between a person’s genetic risk score and their risk of developing the disease after irregular cells have been detected. The research, published in Cancer Epidemiology, Biomarkers & Prevention and funded by Breast Cancer Now, included over 2,000 women in the UK who had been tested for 313 genetic changes, known as a genetic risk score. These patients had already been diagnosed with either ductal carcinoma in situ (DCIS) ...

Even though many years have passed since the start of the COVID-19 pandemic, the effects of infection with SARS-CoV-2 are not completely understood. This is especially true for Long COVID, a chronic condition that can develop after COVID-19 that causes a variety of lasting symptoms. Among the most common and debilitating of these is cognitive impairment, often referred to as “brain fog,” which affects over 80% of people with Long COVID. Given the hundreds of millions of global cases, Long COVID represents a massive public health and socioeconomic challenge, as it severely ...

People who sleep poorly are more likely than others to have brains that appear older than they actually are. This is according to a comprehensive brain imaging study from Karolinska Institutet, published in the journal eBioMedicine. Increased inflammation in the body may partly explain the association. Poor sleep has been linked to dementia, but it is unclear whether unhealthy sleep habits contribute to the development of dementia or whether they are rather early symptoms of the disease. In a new study, researchers at Karolinska Institutet have investigated the link between sleep characteristics and how old the brain appears in relation ...

A new study published in The Lancet Infectious Diseases involving over 460,000 children and adolescents across 40 paediatric hospitals in the USA suggests that children who were infected with COVID-19 for the second time during the Omicron wave had more than double the risk of developing long COVID.   Conducted by researchers under the US National Institutes of Health (NIH)-funded RECOVER Initiative*, this is the largest study to date examining the long-term effects of COVID-19 reinfection in young people. The study analysed electronic ...

Children and adolescents were twice as likely to experience long COVID after catching COVID for the second time, compared to their peers with a single previous infection, according to a large study funded by the National Institutes of Health (NIH) and published in Lancet Infectious Diseases. These results run counter to the popular perceptions that COVID in children is "mild" and that reinfections with COVID do not carry the same risk of long COVID that initial infections do. Among the conditions ...

Previously, the primary endpoint results of the NRG-LU005 study assessing the addition of the immunotherapy drug atezolizumab to standard of care concurrent chemoradiation for limited-state small cell lung cancer was reported at the American Society for Radiation Oncology 2024 Annual Meeting. Those results showed that adding atezolizumab did not improve overall survival (OS) for this patient population.   At the same time, an exploratory analysis reported longer median OS among patients who received twice-a-day radiation, though RT schedule was ...

Previously, results from the photon cohort of the NRG-BN001, a signal seeking Phase II randomized trial, indicated that photon radiation dose intensification (75 Gy) did not demonstrate improvement in overall survival (OS) for patients with newly diagnosed glioblastoma (GBM). The recent analysis of the proton cohort revealed improved survival for patients receiving proton therapy at 75 Gy. Because this data met the pre-defined survival improvement threshold, they could be used to design and conduct a definitive phase III randomized ...

As part of its strategy and ongoing commitment to open science, ECMWF (The European Centre for Medium-Range Weather Forecasts) has been opening its extensive data catalogue and making its science more widely open and accessible. The organisation holds one of the world’s largest meteorological archives, exceeding 1.3 exabytes of data. Starting with historical data and charts, and ECMWF is now moving to make real-time forecast data openly available. By making its data openly available, ECMWF is supporting the UN’s Early Warnings for All initiative and enabling societies ...

Life beneath the waves can be a game of cat and mouse. Seals pursue swimming fish by following the tell-tale wakes and spinning vortices they leave behind, sensing the faint swirls with their sensitive whiskers. But fish might have a trick up their sleeves. Yvonne Krüger from University of Rostock, Germany, explains that escaping fish produce three jets of different sizes they dart away, squirting in individual directions almost simultaneously – at least two of which form into vortex rings, like smoke rings – which could confuse a seal. But might seals be able to see through the ...

Vienna, Austria: People who have a cardiac arrest in their own homes have similar neurological outcomes regardless of socioeconomic background, according to research presented at the European Emergency Medicine Congress today (Wednesday) [1]. However, the study of 676 patients who received treatment in the Department of Emergency Medicine at the Medical University of Vienna suggested that those who lived in lower-income areas may be less likely to receive cardiopulmonary resuscitation (CPR) from bystanders compared to people suffering a cardiac arrest (when the heart stops pumping blood around the body) in higher-income areas – a finding ...

MIAMI, FLORIDA (Sept. 30, 2025) -- Research findings from Sylvester Comprehensive Cancer Center, part of the University of Miami Miller School of Medicine, are being presented this week at ASTRO 2025 – the American Society for Radiation Oncology’s annual meeting in San  Francisco. Markus Bredel, M.D., Ph.D., professor and chair of the Miller School’s Department of Radiation Oncology, presented at the Presidential Symposium, focusing on “Precision Without Incision: The New Era of Functional Radiosurgery.” His session, “Classical Movement Disorders and Connectomics: Image-Guided ...

University of Miami scientists launch accessible global climate modeling framework Designed for education, adaptable for research—the new Python-based framework makes climate dynamics more approachable for students and researchers Miami, FL — A team of researchers at the University of Miami has developed a global atmospheric modeling framework that blends powerful research capabilities with accessibility for students and scientists alike. Written entirely in Python, a high-level, general-purpose programming language, and designed to run on an interactive Jupyter Notebook, the ...

A new platform developed by Illinois Grainger engineers demonstrates the utility of a ytterbium-171 atom array in quantum networking. Their work represents a key step toward long distance quantum communication. A new platform developed by Illinois Grainger engineers demonstrates the utility of a ytterbium-171 atom array in quantum networking. Their work represents a key step toward long distance quantum communication. Researchers from The Grainger College of Engineering at the University of Illinois Urbana-Champaign have introduced a scalable platform for quantum networking with a ytterbium-171 ...

A new battery recycling method developed by Illinois Grainger engineers removes scarce, expensive metals from old battery cathodes and coats them onto new cathodes in a single step. The result is significantly more affordable, less environmentally impactful and less risky to health than any recycling method currently in use. Battery cathodes – the positive part of the battery that helps to store electrical energy – often require rare, expensive metals such as cobalt. It is therefore crucial to develop effective means for recycling cathodes that reclaim the metals essential to their operation. Researchers in The Grainger College of Engineering at the University of Illinois ...

The most cost-effective way to conserve the dwindling waters of the Colorado River may not come from building new reservoirs, canals, or wells, but from changing how water is used on farms that consume most of it. That’s the conclusion of a comprehensive study by UC Riverside’s School of Public Policy, conducted with the Utah Rivers Council. Led by UCR graduate student Paloma Avila, the study examined 462 federally funded Colorado River conservation and supply projects, totaling about $1 billion (in 2023 constant dollars) between 2004 and 2024, using available spending data from the U.S. Bureau of Reclamation. It ...

UNIVERSITY PARK, Pa. — A looming deadline at work, a clogged toilet, an argument with a loved one — these daily hassles can make any day feel more stressful. When these demands pile up, it can feel overwhelming, like there’s no end in sight. Yet, the perception of control could make resolving these everyday inconveniences easier, according to a new study from a team including researchers from Penn State. The research team found that on days when people felt they had more control over stressors ...

We are honored to announce that the Municipal Finance Journal (MFJ) has joined the Chicago Journals publishing program. The journal is published in partnership with the Center for Municipal Finance at the University of Chicago Harris School of Public Policy. Launched in 1980, MFJ is a forum for research on the issues facing practitioners in state and local finance and tax-exempt financing. Articles address the complicated interplay of legal, market, economic, and political perspectives affecting public finance, ...

Antarctica’s Southern Ocean is one of the most demanding places on Earth when it comes to survival. Its waters plunge below freezing, long periods of darkness restrict growth and feeding, and food webs shift with relentless climate swings. Yet one group of fish — the notothenioids, or Antarctic icefish — not only survived here but flourished. From a single ancestor tens of millions of years ago, they evolved into dozens of species. Some cruise near the surface, others prowl the seafloor, and still others dart through the open water. A new ...

TAMPA, Fla. (Sept. 30, 2025) — Researchers at Moffitt Cancer Center have reported encouraging results from a phase 1B clinical trial showing that the immunotherapy drug avelumab, when combined with whole brain radiotherapy, may provide a safe and effective treatment option for patients with leptomeningeal disease, one of the most aggressive and difficult-to-treat complications of advanced cancer. The findings were published in Neuro-Oncology.  Leptomeningeal disease occurs when cancer cells spread to the membranes surrounding the brain and spinal cord. ...

Currently, the treatments for alcohol use disorder (AUD) work in one of two ways, explains Joseph Schacht, PhD, associate professor of psychiatry at the University of Colorado Anschutz School of Medicine — they either make the effects of alcohol less pleasurable, or they reduce cravings for alcohol. “Those are important things for alcohol and substance use disorders — reducing how good the drug makes you feel or how much you want to use it,” Schacht says. But is there another mechanism a drug could target to help people with alcohol use disorder? ...

Kansas City, MO — September 30, 2025 — Some of nature’s most important secrets are hidden in plain sight. David Stern, Ph.D., has spent his career unlocking such mysteries, from fruit fly genetics to the proteins insects use to hijack plants. The Stowers Institute for Medical Research is proud to announce Stern’s appointment as Investigator. Stern, a Senior Group Leader at Howard Hughes Medical Institute’s Janelia campus since 2011, will move his lab and HHMI appointment to Kansas City in February 2026. Stern and his lab pioneered research behind the battle between plants ...

A groundbreaking new study from the Alliance for Clinical Trials in Oncology aims to test whether digital tools and chatbot technology can help young adult cancer survivors get the genetic counseling they need to better understand future health risks to themselves and family members. Led by Alliance Study Chair Angela Bradbury, MD, Professor of Medicine in the Division of Hematology Oncology at the University of Pennsylvania Abramson Cancer Center, the AYA ACCESS (Alliance A232301CD) study will enroll participants to study ways to address longstanding gaps in genetic services for adolescents and young adults (AYA) aged 18 to 39, who often receive care in community settings ...

HOUSTON – (Sept. 30, 2025) – Atoms in crystalline solids sometimes vibrate in unison, giving rise to emergent phenomena known as phonons. Because these collective vibrations set the pace for how heat and energy move through materials, they play a central role in devices that capture or emit light, like solar cells and LEDs. A team of researchers from Rice University and collaborators have found a way to make two different phonons in thin films of lead halide perovskite interact with light so strongly that they merge into entirely ...

Human-caused biodiversity loss has accelerated over the past fifty years. An opinion article published September 30th in the open-access journal PLOS Biology by a team of renowned international authors, including Anne Larigauderie, former Executive Secretary of Intergovernmental Platform on Biodiversity and Ecosystem Services (IPBES), concludes that stopping biodiversity loss is contingent on transformative social and cultural changes across multiple scales. The IPBES Transformative Change Assessment is a 2024 report prepared by an interdisciplinary group of nearly 100 scientists and holders of Indigenous and local knowledge. It aims to inform the implementation ...