The pathogen C. diff — the most common cause of health care-associated infectious diarrhea — can use a compound that kills the human gut’s resident microbes to survive and grow, giving it a competitive advantage in the infected gut.  A team led by investigators at Vanderbilt University Medical Center has discovered how C. diff (Clostridioides difficile) converts the poisonous compound 4-thiouracil, which could come from foods like broccoli, into a usable nutrient. Their findings, published March 25 in the journal Cell Host & Microbe, increase ...

DALLAS, March 25, 2025 — Understanding how to properly respond in a cardiac emergency when seconds matter is critical to everyone, everywhere. That is why the American Heart Association, devoted to changing the future to a world of healthier lives for all, and its Nation of Lifesavers™ national ambassador and Buffalo Bills safety, Damar Hamlin, are expanding the Chasing M’s Foundation cardiopulmonary resuscitation (CPR) tour to Tokyo during March 27-30. This work is supporting the American Heart Association’s impact goal to improve survival rates of out-of-hospital cardiac arrest[1]. “Our national Nation ...

New research led by American Cancer Society (ACS) researchers estimates more than 3.8 million lung cancer deaths were averted and a little over 76 million years of life gained in the United States during 1970-2022 due to substantial reductions in smoking prevalence driven by tobacco control. The study is published today in CA: A Cancer Journal for Clinicians. “The substantial estimated numbers of averted lung cancer deaths and person-years of life gained highlight the remarkable effect of progress ...

Background and Aims Cholesterol synthesis and gallstone formation are promoted by trimethylamine-N-oxide (TMAO), a derivative of trimethylamine, which is a metabolite of gut microbiota. However, the underlying mechanisms of TMAO-induced lithogenesis remain incompletely understood. This study aimed to explore the specific molecular mechanisms through which TMAO promotes gallstone formation. Methods Enzyme-linked immunosorbent assays were used to compare serum concentrations of TMAO, apolipoprotein A4 (APOA4), and ...

When the plasma inside a fusion system starts to misbehave, it needs to be quickly cooled to prevent damage to the device. Researchers at Commonwealth Fusion Systems believe the best bet is a massive gas injection: essentially, a well-timed, rapid blast of cooling gas inside their fusion system, which is known as SPARC. But how many gas valves does it take to quickly tame a plasma that is hotter than the sun? The team has to strike the perfect balance: with too few valves, some parts of SPARC might overheat. With too many, valuable space inside the ...

About 4.5 million workers in the United States quit their jobs in 2022, continuing a trend that began after the 2007 Great Recession. Despite better labor conditions and the pandemic’s decline, many adults are still less willing to return to work compared to previous recessions, making it harder for companies to attract and retain top talent. Moreover, voluntary turnover – when an employee quits their job as opposed to being fired or laid off – costs U.S. businesses more than $1 trillion each year. Beyond recruitment and training expenses, turnover disrupts operations, damages customer relationships, and often leads to further departures. Replacing an employee ...

LOS ANGELES — City of Hope®, one of the largest and most advanced cancer research and treatment organizations in the U.S. with its National Medical Center named top 5 in the nation for cancer by U.S. News & World Report, has opened a phase 1 trial seeking to one day transform rectal cancer from a mostly radiation-resistant disease to one that can be cured using radiation and chemotherapy. “Many cancers are cured through radiation therapy alone or radiation in combination with chemotherapy, including — but not limited to — prostate, head and ...

The rate of maternal mortality related to cardiovascular causes more than doubled between 1999 and 2022 in the United States, according to a study being presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). The finding is concerning, especially as the U.S. has the highest overall rate of maternal mortality among all developed countries, researchers said. Since cardiovascular problems are a leading cause of death around the time of pregnancy and childbirth, the new findings shed light on the drivers behind recent trends and draw attention to particularly high rates of mortality seen among ...

Tiny fragments of plastic have become ubiquitous in our environment and our bodies. Higher exposure to these microplastics, which can be inadvertently consumed or inhaled, is associated with a heightened prevalence of chronic noncommunicable diseases, according to new research being presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). Researchers said the new findings add to a small but growing body of evidence that microplastic pollution represents an emerging health threat. In terms of its relationship with stroke risk, for example, microplastics concentration ...

Compared with those who spent most of their time in a single room, people with heart failure with preserved ejection fraction (HFpEF) who were able to travel outside of their home without assistance were significantly less likely to be hospitalized or die within a year, according to a study being presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). The findings underscore the value of supporting holistic care and encouraging people with heart failure to maintain an active lifestyle and engage with others ...

In addition to causing several types of cancer, human papillomavirus (HPV) appears to bring a significantly increased risk of heart disease and coronary artery disease, according to a study being presented at the American College of Cardiology’s Annual Scientific Session (ACC.25). Evidence that HPV is linked with heart disease has begun to emerge only recently. This new study is the first to assess the association by pooling data from several global studies, totaling nearly 250,000 patients. Its findings bolster the evidence that a significant relationship exists ...

A new peer-reviewed studyi* published in Frontiers in Nutrition provides compelling evidence that pork can play a beneficial role in sustainable diets. The research, conducted by scientists at William & Mary, modeled the environmental and economic impacts of substituting various protein sources with pork in a nationally representative sample of U.S. adults.   The findings suggest that pork performs similarly to poultry, seafood, eggs and legumes across key sustainability and agricultural resource indicators with a ± 1% change in land use, fertilizer nutrient use and pesticide use.   Modeled ...

Imagine a robot that can walk, without electronics, and only with the addition of a cartridge of compressed gas, right off the 3D-printer. It can also be printed in one go, from one material.  That is exactly what roboticists have achieved in robots developed by the Bioinspired Robotics Laboratory at the University of California San Diego. They describe their work in an advanced online publication in the journal Advanced Intelligent Systems. To achieve this feat, researchers aimed to use the simplest technology available: a desktop ...

Mill Valley, CA – March 25, 2025 – The SynGAP Research Fund (SRF) dba Cure SYNGAP1 501(c)(3) announced a $130,000 grant to Dr. Vikaas Sohal at The Regents of The University of California, San Francisco. The grant supports research into new therapies for reversing cognitive deficits in SYNGAP1-related disorders (SRD) by enhancing key brain functions. Dr. Sohal’s research focuses on cognitive flexibility—the ability to adapt behavior in response to environmental changes—a ...

Autism spectrum disorder (ASD) is a growing global concern, affecting approximately 2.8% of children in the United States and 0.7% in China. ASD is characterized by challenges in social interaction, communication difficulties, and repetitive behaviors, making early diagnosis critical for improving outcomes. However, current diagnostic methods rely primarily on behavioral observations, which may delay early interventions. Despite ongoing research, the structural and functional brain differences between children with ASD and typically developing (TD) children remain poorly understood. Now, in a recent study published in NeuroImage and made available online on February ...

Siberia, a province located in Russia, is a significant geographical region playing a crucial role in the world’s carbon cycle. With its vast forests, wetlands, and permafrost regions (permanently frozen grounds), Siberia stores a considerable amount of carbon on a global scale. But climate change is rapidly altering Siberia’s landscape, shifting its vegetative distribution and accelerating the permafrost thaw. Classifying land cover is essential to predict future climatic changes, but accumulating land cover data in regions like ...

Life has evolved over billions of years, adapting to the changing environment. Similarly, enzymes—proteins that speed up biochemical reactions (catalysis) in cells—have adapted to the habitats of their host organisms. Each enzyme has an optimal temperature range where its functionality is at its peak. For humans, this is around normal body temperature (37 °C). Deviating from this range causes enzyme activity to slow down and eventually stop. However, some organisms, like bacteria, thrive in extreme environments, such as hot springs or freezing polar waters. These extremophiles have enzymes adapted to function in harsh conditions. For ...

Obesity is linked to numerous health complications, including diabetes, cardiovascular disease, and fatty liver disease. In a world where obesity rates continue to climb, researchers are constantly seeking effective, accessible solutions to this global health crisis. Interestingly, over the past few decades, scientists have begun to focus not only on what we eat but also on how we eat it. While much attention has indeed focused on dietary content and caloric intake, emerging research suggests that eating behaviors—including meal duration, chewing speed, and number of bites taken—may ...

A new study published in The Journal of Immunology found that a high-salt diet (HSD) induces depression-like symptoms in mice by driving the production of a protein called IL-17A. This protein has previously been identified as a contributor to depression in human clinical studies.  “This work supports dietary interventions, such as salt reduction, as a preventive measure for mental illness. It also paves the way for novel therapeutic strategies targeting IL-17A to treat depression,” shared Dr. Xiaojun Chen, a researcher at Nanjing ...

Along with nitrogen and carbon, phosphorus is an essential element for life on Earth. It is a central component of molecules such as DNA and RNA, which serve to transmit and store genetic information, and ATP (adenosine triphosphate), which cells need to produce energy. Phosphorus may also have played a key role in the origin of life. Certain conditions are needed to trigger the start of the biochemical processes that precede life. One of these is the presence of sufficient phosphorus. Its availability regulates the growth and activities of organisms. Unlike nitrogen or carbon, however, phosphorus is relatively ...

The findings come from the most comprehensive computer model of brain metabolism to date, which incorporates more than 16,800 biochemical interactions between proteins and chemicals across brain cells, supporting cells, and the blood. Scientists can now use this open-source model to find ways to prevent age-related diseases, such as dementia.“This study provides an x-ray view into the battery that powers the brain,” said Henry Markram, Professor of Neuroscience at École Polytechnique Fédérale de Lausanne (EPFL), Switzerland, the senior author of the study. “We can now track ...

A full slide deck of findings is available at the Box link here TAMPA, Fla. (March 18, 2025) – A groundbreaking new study of young people’s digital media use has revealed surprising results, including evidence that smartphone ownership may actually benefit children. The study also suggests a link between social media posting and various negative outcomes, as well as data connecting cyberbullying to depression, anger and signs of dependence on digital media. The Life in Media Survey, led by a team of researchers at the University of South Florida in collaboration with The Harris Poll, conducted a survey of ...

In vertebrate retinas, specialized photoreceptors responsible for color vision (cone cells) arrange themselves in patterns known as the “cone mosaic”. Researchers at the Okinawa Institute of Science and Technology (OIST) have discovered that a protein called Dscamb acts as a "self-avoidance enforcer" for color-detecting cells in the retinas of zebrafish, ensuring they maintain perfect spacing for optimal vision. Their findings have been published in Nature Communications.  Solving a mystery in vision science  Vertebrate retinas contain photoreceptor cells that convert light into neural signals. These photoreceptors come in two main types: rods, which function ...

The standard model of particle physics is our best theory of the elementary particles and forces that make up our world: particles and antiparticles, such as electrons and positrons, are described as quantum fields. They interact through other force-fields, such as the electromagnetic force that binds charged particles. To understand the behaviour of these quantum fields and with that our universe, researchers perform complex computer simulations of quantum field theories. Unfortunately, many of these calculations are too complicated for even our best supercomputers and pose great challenges for quantum computers as well, leaving many pressing ...

Artificial intelligence can improve intravenous nutrition for premature babies, a Stanford Medicine study has shown. The study, which will publish March 25 in Nature Medicine, is among the first to demonstrate how an AI algorithm can enable doctors to make better clinical decisions for sick newborns. The algorithm uses information in preemies’ electronic medical records to predict which nutrients they need and in what quantities. The AI tool was trained on data from almost 80,000 past prescriptions for intravenous nutrition, which was linked to information about how the tiny patients fared. Using AI to help prescribe IV nutrition could reduce medical errors, ...