An international research team has discovered a new way to effectively treat cancer, by using nutrients to reactivate suppressed metabolic pathways in cancer cells. The researchers used a common amino acid, tyrosine, packaged as a nanomedicine, to change the metabolism of melanoma, a deadly skin cancer, and prevent cancer growth.  Australia has the highest rate of skin cancer in the world. This new approach could be combined with current therapies to better treat melanoma. The technique also has the potential to treat other types of cancer. The study, Nutrient-delivery and metabolism reactivation therapy for melanoma, was led by Professor Wenbo ...

Clustering is widely exploited in data mining. It has been proved that embedding weak label prior into clustering is effective to promote its performance. Previous researches mainly focus on only one type of prior. However, in many real scenarios, two kinds of weak label prior information, e.g., pairwise constraints and cluster ratio, are easily obtained or already available. How to incorporate them to improve clustering performance is important but rarely studied. To deal with this problem, a research team led by Chenping ...

Chronic wounds, which include diabetic ulcers, surgical wounds, pressure injuries, and other problems, are deadlier than many people realize. Patients with chronic wounds have a five-year survival rate around 70%, worse than that of breast cancer, prostate cancer and other serious diseases. Treating wounds is also expensive, costing an estimated $28 billion each year in the U.S. alone. A team of researchers from the Keck School of Medicine of USC and the California Institute of Technology (Caltech) is developing a series of cutting-edge technologies to revolutionize wound care, including smart bandages that would automatically sense and ...

A test that looks for genetic hallmarks of brain cancers in samples of cerebrospinal fluid can decrease the time to diagnosis and eliminate the need for invasive brain biopsies for some patients. Mass General Brigham experts in neurosurgery, cancer and pathology worked together to develop a rapid, genotyping test that can detect key mutations associated with brain cancers from samples taken during a lumbar puncture. The team evaluated the technique known as TetRS (Targeted Rapid Sequencing) among 70 patients admitted to Massachusetts General Hospital with new central nervous system ...

It’s one of the fastest growing industries globally, raking in millions for the best players and attracting a huge fanbase, but a new Australian study has revealed the dark side of professional video gaming: cyberbullying and sexual harassment. Even though the esports industry is a diverse community, cyberbullying is rampant in this virtual world, and cis-gendered and trans-gendered women players are disproportionately more likely to be sexually harassed than men. Despite women making up 46% of the world’s three billion video gamer players, according to a new paper published in Entertainment Computing, women who play professionally (16% of esports competitors ...

Scientists at the Schmid College of Science and Technology at Chapman University developed a novel way to observe the elusive burrowing behavior of hagfish. Dr. Douglas S Fudge and his team created a specialized tank of transparent gelatin in order to visualize how the hagfish behave and locomote within sediments.  Hagfishes are bottom-dwelling marine animals that are capable of producing startling amounts of defensive slime when they are provoked. Understanding the burrowing activities of hagfishes could lead to increased knowledge of sediment turnover in marine benthic habitats, new insights into the reproductive behavior of hagfishes or ...

Eye-contact has a significant impact on interpersonal evaluation, and online job interviews are no exception. In addition to the quality of a resume, the direction of the interviewee’s gaze might help (or hinder) their chances of securing the job. Researchers published their results in Scientific Reports on May 31.   The study simulated online job interviews. Twelve students who participated in the study as a role of interviewees presented themselves twice, once looking directly at a web camera, and the other looking towards the screen. ...

An NYU Tandon School of Engineering project led by Chinmay Hegde – Associate Professor in the Department of Computer Science and Engineering and the Department of Electrical and Computer Engineering – is one of the first 35 initiatives selected for the National Artificial Intelligence Research Resource (NAIRR) Pilot by the U.S. National Science Foundation (NSF) and Department of Energy, a result of President Biden's Executive Order on the Safe, Secure and Trustworthy Development and Use of AI. The NAIRR Pilot aims to connect U.S. researchers and educators with the computational power, data resources, ...

A team of scientists used NASA’s James Webb Space Telescope to parse the composition of the Crab Nebula, a supernova remnant located 6,500 light-years away in the constellation Taurus. With the telescope’s MIRI (Mid-Infrared Instrument) and NIRCam (Near-Infrared Camera), the team gathered data that is helping to clarify the Crab Nebula’s history. The Crab Nebula is the result of a core-collapse supernova from the death of a massive star. The supernova explosion itself was seen on Earth in 1054 CE and was bright enough to view during the daytime. The much fainter remnant observed today ...

https://www.scienceopen.com/hosted-document?doi=10.15212/AMM-2023-0049 Announcing a new publication for Acta Materia Medica journal. Portal vein tumor thrombosis (PVTT), a severe complication of hepatocellular carcinoma (HCC), markedly influences patient prognosis by fostering a hypercoagulable state. However, its molecular underpinnings remain largely unexplored. This study sheds light on the critical role of the KIT ligand (KITLG) in modulating expression of the collagen gene COL4A1 via the STAT3-SMAD2 signaling pathway, thereby influencing platelet activation and PVTT development. Extensive analysis of PVTT tissue samples, ...

ACM, the Association for Computing Machinery, today announced that Nivedita Arora, of Northwestern University is the recipient of the ACM Doctoral Dissertation Award for her dissertation “Sustainable Interactive Wireless Stickers: From Materials to Devices to Applications,” which demonstrated wireless and batteryless sensor nodes using novel materials and radio backscatter. Arora’s research envisions creating sustainable computational materials that operate by harvesting energy from the environment and, at the end ...

Forecasters can use images in social media to better communicate weather related hazards of hurricanes, according to a pair of new studies.  Scientists at the U.S. National Science Foundation National Center for Atmospheric Research (NSF NCAR) analyzed 2017 Twitter (now X) data related to two hurricanes – Harvey and Irma. The researchers found that forecast information communicated in the early stages of storm development, when the threat posed by a hurricane is uncertain, sets the stage for how people react to subsequent ...

The ketogenic diet has its fanatics and detractors among dieters, but either way, the diet has a scientifically documented impact on memory in mice. Whlie uncovering how the high fat, low carbohydrate diet boosts memory in older mice, Buck scientists and a team from the University of Chile identified a new molecular signaling pathway that improves synapse function and helps explain the diet’s benefit on brain health and aging. Published in the June 5, 2024 issue of Cell Reports Medicine, the findings provide new directions for targeting the memory effects on a molecular level, without requiring a ketogenic diet or even the byproducts of it. “Our ...

Brazilian researchers have developed functional bread with the potential to prevent asthma, a respiratory disorder responsible for some 350,000 hospitalizations per year in the SUS (Sistema Único de Saúde), the nation’s public healthcare network. The formulation, for which a patent application has been filed in Brazil (BR1020210266465), is described in an article published in the journal Current Developments in Nutrition. It contains Saccharomyces cerevisiae UFMG A-905, ...

Potential New Treatment Option for Diabetic Retinopathy OU researcher developing potential new treatment for diabetic retinopathy that could address the problem much earlier. OKLAHOMA CITY, OKLA. – Patients with diabetes face a host of potential health problems as they work to manage the chronic disease. Still, one concern that seems to weigh heavily is the risk of losing their sight through a condition known as diabetic retinopathy. Researchers at the University of Oklahoma Health Sciences and Memorial Sloan Kettering (MSK) Cancer Center are studying a new, revolutionary treatment for diabetic retinopathy that could change the prognosis ...

Embargoed for release until 5:00 p.m. ET on Monday 17 June 2024     Annals of Internal Medicine Tip Sheet      @Annalsofim     Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not ...

Poor diet continues to take a toll on American adults. It’s a major risk factor for obesity, type 2 diabetes, cardiovascular disease, and certain cancers, and more than one million Americans die every year from diet-related diseases, according to the Food and Drug Administration. Poor diet and food insecurity is also costly, attributing to an estimated $1.1 trillion in healthcare expenditures and lost productivity. These burdens also contribute to major health disparities by income, education, zip code, race, and ethnicity. In a study from the Food is Medicine Institute at the Friedman School of Nutrition Science and Policy at Tufts University published today in ...

A new aging atlas gives scientists an in-depth view of how individual cells and tissues in worms age and how different lifespan-extending strategies might stop the clock. Aging impacts all the tissues in our body – from our muscles to our skin. Figuring out how individual tissues and cells age could help researchers better understand the aging process and aid in the development of anti-aging treatments. Due to their short lifespans, simple body plans, and genetic similarity to humans, many researchers study aging in roundworms. To look at aging at the level of tissues and cells, a team of researchers from HHMI's Janelia ...

By Beth Miller Human brain diseases, such as Parkinson’s disease, involve damage in more than one region of the brain, requiring technology that could precisely and flexibly address all affected regions simultaneously. Researchers at Washington University in St. Louis have developed a noninvasive technology combining a holographic acoustic device with genetic engineering that allows them to precisely target affected neurons in the brain, creating the potential to precisely modulate selected cell ...

Each of us individually is the accumulated product of thousands of generations that have come before us in an unbroken line. Our culture and technology today are also the result of thousands of years of accumulated and remixed cultural knowledge. But when did our earliest ancestors begin to make connections and start to build on the knowledge of others, setting us apart from other primates? Cumulative culture — the accumulation of technological modifications and improvements over generations — allowed humans to adapt to a diversity of environments and challenges. But, it is unclear when cumulative culture first developed during hominin evolution. A study published ...

“[...] our current work has provided a novel strategy to enrich for a sub-population of cancer cells, with high basal levels of mitophagy.”   BUFFALO, NY- June 17, 2024 – A new research paper was published on the cover of Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 16, Issue 11, entitled, “Mitophagy and cancer: role of BNIP3/BNIP3L as energetic drivers of stemness features, ATP production, proliferation, and cell migration.” Mitophagy is a selective form of autophagy which permits ...

Brain-computer interfaces or BCIs hold immense potential for individuals with a wide range of neurological conditions, but the road to implementation is long and nuanced for both the invasive and noninvasive versions of the technology. Bin He of Carnegie Mellon University is highly driven to improve noninvasive BCIs, and his lab uses an innovative electroencephalogram (EEG) wearable to push the boundaries of what’s possible. For the first time on record, the group successfully integrated a novel focused ultrasound stimulation to realize bidirectional BCI that both encodes and decodes brain waves using machine learning in a study with 25 human subjects. This work opens ...

Times of crises often call for strong and rapid action, but in polarized societies, strong top-down policies can backfire.  In a paper published on June 17, 2024, in Environmental Research Letters, SFI Applied Complexity Fellow Saverio Perri, SFI Science Board Fellow Simon Levin (Princeton University), and colleagues present a conceptual model of how these dynamics could play out in efforts to decarbonize our energy supply. The model illustrates the complex interplay between strong policies, people’s perception of risk, and the amount of polarization in a society. They show that in situations where the perception of risk is low — where the ...

Researchers at the University of Bonn have developed software that can simulate the growth of field crops. To do this, they fed thousands of photos from field experiments into a learning algorithm. This enabled the algorithm to learn how to visualize the future development of cultivated plants based on a single initial image. Using the images created during this process, parameters such as leaf area or yield can be estimated accurately. The results have been published in the journal Plant Methods. Which plants should I combine ...

African research is receiving a major visibility boost with the indexing of 10 national funders in Dimensions, the world’s largest linked research database. This project is a collaboration with Digital Science, the Africa PID Alliance (APA), the Association of African Universities (AAU), the Training Centre in Communication (TCC Africa), and the Research Organization Registry (ROR). “This project connects the research outputs from leading African funding bodies to the global research ecosystem,” said Joy Owango, Executive Director of TCC Africa ...