In the realm of memories, “where” holds special importance. Where did I leave my keys? Where did I eat dinner last night? Where did I first meet that friend? Recalling locations is necessary for daily life, yet spatial memory — which keeps track of “where” — is one of the first cognitive abilities to fade in old age. And deficits earlier in life can be a telltale sign of dementia. Now, researchers at Stanford Medicine and their colleagues are uncovering what goes awry in older brains when spatial memory falters and whether these changes can be prevented. In a new study comparing young, ...

A research team at Lund University in Sweden has discovered a mechanism that helps acute myeloid leukemia cells to evade the body’s immune system. By developing an antibody that blocks the mechanism, the researchers could restore the immune system’s ability to kill the cancer cells in laboratory trials and in mice. The discovery is published in Nature Cancer. In brief: Facts about the study: peer-reviewed // basic research // translational research // in vivo // in vitro // The study shows how a newly discovered mechanism helps leukemia cells to evade the immune system. By generating ...

A new study, published today in Nature Genetics, created the largest genetic map of human metabolism, revealing new insights on the role of metabolites in health and disease and creating a blueprint for further research. Humans vary from person to person, and so does our metabolism. Yet, it is difficult to quantify precisely how much your genetic code contributes to this variability. Using data from half a million individuals through the UK Biobank, the authors examined the consequences of variation in our genetic code on blood levels of 250 small molecules including lipid levels, which are important for a healthy heart, or amino acids. The study is the result of a collaborative ...

The first picture taken of a person nowadays is usually an ultrasound scan in the womb. But the technology is capable of much more than that. Physiotherapists have long used ultrasound to heat bodily tissues, and oncological surgeons use high-intensity ultrasound – and the heat it generates inside the body – to destroy tumours.  Over the last decade, scientists have also been researching how low-intensity ultrasound can be used to influence neural activity in the brain in a targeted manner. Initial clinical trials ...

Trawling restrictions not only benefits fish and shellfish; anemones and corals are also becoming more common, according to a new study from the University of Gothenburg. Twenty-six years of underwater videos from the depths of the Koster Sea also show long-term changes in the ecosystem as the water becomes warmer. The marine wildlife in Kosterhavet National Park has changed rapidly in recent years. The introduction of trawling restrictions in the area for the national park during the last 25 years, brought about a change in the living conditions for the animals that live on the seabed. “Animals ...

Pertussis, or whooping cough, is on the rise and incidence now exceeds pre-pandemic numbers. While in adults and older children the cough can be bothersome and last for months, pertussis in young infants can be life-threatening. Most children under 2 months of age with pertussis in the United States are hospitalized. In a special article published in Pediatrics, experts strongly encourage vaccination, especially during pregnancy. “Pertussis symptoms are different in infants,” said leading author Caitlin Li, MD, infectious diseases specialist at Ann & Robert H. Lurie Children’s Hospital of Chicago and Assistant Professor of Pediatrics at Northwestern ...

Singapore, 3 October 2025 – Singapore General Hospital (SGH) has announced the launch of a Centre of Excellence (CoE) for robotic-assisted surgery, ensuring orthopaedic surgeons are equipped with knowledge of emerging technologies as the population ages and surgical needs evolve.    The Centre is established as part of a two-year strategic collaboration, formalised through a Memorandum of Understanding (MoU), with Johnson & Johnson MedTechwith an initial focus on training and research in total knee replacement.   Regional ...

Building on the landmark 2019 report, the 2025 EAT-Lancet Commission presents the most comprehensive scientific analysis of global food systems to date. It establishes a clear, science-based approach to provide 9.6 billion people with access to healthy diets within planetary boundaries while recognising that healthy and sustainable diets are the foundation of human rights. The report reveals that the global food system contributes to 30% of greenhouse gas emissions and is the largest driver of planetary boundary transgressions through its impacts on climate, biodiversity, freshwater consumption, and land use change.  Although there ...

Countries with the highest reported levels of hearing loss also have the lowest reported use of hearing aids, finds international research published in the open access journal BMJ Global Health. And men are generally more likely than women to report difficulties with their hearing, although this gender divide narrows with age, the findings show. An estimated 1.57 billion people—equivalent to 1 in 5 of the world’s population—had hearing loss in 2019. And it’s predicted that it will affect 2.45 billion people by 2050, say the researchers. Hearing loss is associated with an array of problems ...

Early medical abortion at home up to 12 weeks of pregnancy is safe, effective, and comparable to hospital care, finds a 5 year review of cases in Scotland, where this timeframe is legally permitted, and published online in the journal BMJ Sexual & Reproductive Health. It’s time to extend the current legal limit of 10 weeks to 12 weeks to enable women in the rest of the UK and Europe to choose this option, conclude the researchers. During the COVID-19 pandemic, legislation was introduced throughout Scotland, England, and Wales to allow women to ...

Scientists have unveiled a new approach to detecting gravitational waves in the milli-Hertz frequency range, providing access to astrophysical and cosmological phenomena that are not detectable with current instruments.   Gravitational waves—ripples in spacetime predicted by Einstein—have been observed at high frequencies by ground-based interferometers such as LIGO and Virgo, and at ultra-low frequencies by pulsar timing arrays. However, the mid-band range has remained a scientific blind spot.   Developed by researchers at the Universities of Birmingham and Sussex, the new detector concept uses cutting-edge optical cavity and atomic clock technologies ...

HOUSTON – (Oct. 2, 2025) – A team of researchers at Rice University has developed a new membrane that selectively filters out lithium from brines, offering a faster, cleaner way to produce the element at the heart of nearly every rechargeable battery. According to a study published in Nature Communications, the new membrane achieved one of the highest selectivities for lithium among similar membranes while using considerably less energy. The membrane design can be adapted to target the recovery of other valuable minerals, such as cobalt and nickel, and plugs ...

Don't love the gym? Neither does exercise scientist Ryan Montalvo. But he goes anyway. While any workout can seem daunting, the physical stress of exercise often affords long-term benefits. One advantage is that it triggers a physiological response that allows our cells to adjust to meet future energy demand in what’s known as a hormetic response. With an early career research grant from the American College of Sports Medicine Research Endowment, Montalvo will explore how this response to exercise-induced stress might help overcome noncommunicable diseases. Working ...

A study comparing evacuation patterns in response to two 2024 hurricanes, Milton and Helene, found that people in coastal areas with frequent hurricane exposure were much more likely to travel out of harm’s way compared to people in inland areas who were more likely to stay put. Researchers at Columbia University Mailman School of Public Health led the study. Their findings appear in the journal Environmental Research Letters.   These geographic differences are likely due to a combination of factors, including access to transportation infrastructure, social norms, and risk perception, ...

Expanding the depth and breadth of scientific expertise that defines Stem Cell Reports, the official journal of the International Society for Stem Cell Research, 13 distinguished researchers have joined the Editorial Board. Their appointment broadens representation across the diverse and international landscape of stem cell science and reinforces the Board’s commitment to championing the journal, raising its global visibility, and ensuring rigorous, high-quality peer review. “I am delighted to welcome our new editorial board members to Stem Cell Reports, said Janet Rossant, editor-in-chief. “Their breadth of expertise ...

A team of scientists from the University of Chicago, the University of California Berkeley, Argonne National Laboratory, and Lawrence Berkeley National Laboratory has developed molecular qubits that bridge the gap between light and magnetism—and operate at the same frequencies as telecommunications technology. The advance, published today in Science, establishes a promising new building block for scalable quantum technologies that can integrate seamlessly with existing fiber-optic networks. Because the new molecular qubits can interact at telecom-band frequencies, the work points toward future quantum networks—sometimes called the “quantum internet.” ...

ROCHESTER, Minn. — Mayo Clinic has been selected to lead a groundbreaking research project focused on improving indoor air quality and safety in healthcare settings by the Advanced Research Project Agency for Health (ARPA-H). The project, part of the ARPA-H BREATHE program, aims to develop new ways to monitor and improve air in real time, helping protect public health in buildings nationwide. Mayo Clinic will lead the Hospital Air QUality (HAIQU): Breathing Life into Patient Care project, focusing on improving indoor air quality in hospitals to enhance health. "Maintaining high indoor ...

Down syndrome is associated with accelerated aging. It is estimated that up to 90% of individuals with the condition develop Alzheimer’s disease before the age of 70. A study by researchers at the University of São Paulo (USP) in Brazil identified high levels of neuroinflammation in young individuals with Down syndrome, an additional factor explaining the high prevalence of Alzheimer’s disease in older people with the condition. The discovery paves the way for strategies to prevent and monitor the disease. The study, which was published in the journal Alzheimer’s & Dementia and ...

The human repairome, REPAIRome, will allow researchers around the world to rapidly check out how each of the 20,000 human genes affects DNA repair. Created by researchers at the Spanish National Cancer Research Centre (CNIO), it is published today in the journal Science. The human repairome is ‘a powerful resource for the scientific community’, the authors write in Science. It has ‘implications for human health, including cancer treatment’. It also allows progress ‘towards full control of CRISPR-Cas gene-editing technologies’, they add. The repairome ...

Advances in artificial intelligence-assisted protein engineering are enabling breakthroughs in protein design, but they also introduce biosecurity challenges related to potential production of harmful proteins. Though screening software to detect harmful proteins exists, a new multi-month analysis of such software reports that this software has vulnerabilities; some proteins of concern could evade detection. Critically, the study also offers a way to improve detection rates of proteins of concern going forward. AI-assisted protein design (AIPD) enables powerful advances in medicine and biology, enabling researchers to modify existing proteins or design wholly new ones ...

Wildfire disasters worldwide are growing notably in frequency and cost, according to a new study, with nearly half of the most damaging events over the last 44 years occurring in just the past decade, driven largely by increasingly extreme fire weather in vulnerable, densely populated regions. The findings, informed by an analysis of global reinsurance data and international disaster reports, reveal a concerning trend and highlight the need to adapt for a more fire-prone world. Humans have coexisted with wildfires for millennia, but climate change, land mismanagement, and expansion into flammable landscapes ...

Catastrophic wildfires – those causing massive damage and soaring suppression costs – are increasing in frequency and intensity worldwide, a trend expected to worsen with climate change. In a Policy Forum, Robert Gray and colleagues use British Columbia (BC), Canada, as a case study of a government at a crossroads: continue reactive spending on suppression and recovery or invest in strategies to reduce future wildfire risk. “Although we focus on BC, this same tough question, along with lessons learned and our main recommendations, apply to regional ...

Astronomers using the James Webb Space Telescope have detected the molecule phosphine beyond our Solar System, according to a new study, finding it in the atmosphere of the cold brown dwarf Wolf 1130C. The presence of the phosphorus-containing molecule phosphine (PH3) is well established in the atmospheres of Jupiter and Saturn, as well as in some giant stars. Although models predict that PH3 should be similarly common in gas giant exoplanets and brown dwarfs, searches for the molecule in the atmospheres of those objects have shown it to be in very low abundance, if not totally absent. Using the JWST NIRSpec instrument, Adam Burgasser ...

Directed evolution is a laboratory technique that mimics natural selection and allows scientists to evolve genes and the proteins they encode. Traditionally, this technique has been used in microbes, mammalian cells, or in test tubes. Now, researchers led by Prof. GAO Caixia from the Institute of Genetics and Developmental Biology (IGDB) of the Chinese Academy of Sciences (CAS) and Prof. QIU Jinlong from the Institute of Microbiology of CAS have developed a new system that enables rapid and scalable directed evolution of diverse genes directly ...

The fossil of a tiny fish found in southwestern Alberta provides new insight into the origin and evolution of otophysans, the supergroup of fish that includes catfish, carp and tetras, which today account for two-thirds of all freshwater species. The specimen, studied by researchers at Western University, the Royal Tyrrell Museum of Palaeontology and international collaborators, is a skeleton of a fish about 4 cm long from the Late Cretaceous period (the age of the iconic Tyrannosaurus Rex, about 100.5 million to 66 million years ago.) A new kind of fish entirely, it ...