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In two separate clinical studies, combined immunotherapy approach enhances cancer patient response

2024-06-20
Because not all cancer patients respond to a leading type of cancer immunotherapy drug, known as an immune checkpoint inhibitor, scientists explored whether adding janus kinase (JAK) inhibitors – drugs that treat chronic inflammation – could help. In two separate clinical studies, researchers found that adding JAK inhibitors did improve patients’ responses to cancer checkpoint inhibitor immunotherapies. “Aside from the exciting findings of the early phase trials reported by [both groups], they provide a great deal of data with complex analyses of immune ...

Airborne mapping reveals roles for biogenic sources and temperature in air pollution emissions in Los Angeles

2024-06-20
Airborne observations over California have revealed that biogenic sources of volatile organic compounds (VOCs) – blooming trees and growing plants – dominate summertime air pollutant formation in Los Angeles, in a way that increases with temperature. Future air pollution regulations thus need to consider that only 40% of urban VOC emissions (those not tied to biogenic sources) can be mitigated through regulations, say the authors. Ambient air pollution – the fourth-leading global ...

Old bombs reveal new insights: Plants store more carbon, but for a shorter time frame, than we thought

2024-06-20
Analysis of radiocarbon produced during nuclear bomb testing in the 1960s suggests that current Earth system models underestimate carbon uptake into terrestrial vegetation and soils. But, say the study’s authors, this storage is more short-lived than previously thought. The findings suggest that anthropogenic carbon dioxide will not reside as long in the terrestrial biosphere as models currently predict. Accurate climate predictions, crucial for developing effective climate policies, require a robust representation of the global carbon cycle. It’s thought that vegetation and soils account for taking up approximately 30% of anthropogenic carbon dioxide (CO2) ...

The time it takes a person to decide can predict their preference

The time it takes a person to decide can predict their preference
2024-06-20
Researchers led by Sophie Bavard at the University of Hamburg, Germany, found that people can infer hidden social preferences by observing how fast others make social decisions. Publishing June 20th in the open-access journal PLOS Biology, the study shows that when someone knows the options being considered by another person, and they know how long it takes them to reach their decisions, they can use this information to predict the other person’s preference, even if they do not know what the actual choices were. How do we know what someone’s social preferences ...

Hurricane changed ‘rules of the game’ in monkey society

Hurricane changed ‘rules of the game’ in monkey society
2024-06-20
A devastating hurricane transformed a monkey society by changing the pros and cons of interacting with others, new research shows. Hurricane Maria hit Puerto Rico in 2017, killing more than 3,000 people. It also destroyed 63% of vegetation on Cayo Santiago (also known as Monkey Island), which is home to a population of rhesus macaques. Even now, tree cover remains far below pre-hurricane levels and – in this hot part of the world – that makes shade a scarce and precious resource for the macaques. The new study, led by the universities of Pennsylvania and Exeter and published in the journal Science, shows the storm ...

Researchers widely observe yet seldom publish about same-sex sexual behavior in primates and other mammals - often because it is perceived to be rare

Researchers widely observe yet seldom publish about same-sex sexual behavior in primates and other mammals - often because it is perceived to be rare
2024-06-20
Researchers widely observe yet seldom publish about same-sex sexual behavior in primates and other mammals - often because it is perceived to be rare ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0304885 Article Title: Same-sex sexual behaviour among mammals is widely observed, yet seldomly reported: Evidence from an online expert survey Author Countries: Canada, USA Funding: The authors received no specific funding for this work. END ...

Wild chimpanzees seek out medicinal plants to treat illness and injuries

Wild chimpanzees seek out medicinal plants to treat illness and injuries
2024-06-20
Chimpanzees appear to consume plants with medicinal properties to treat their ailments, according to a study publishing on June 20 in the open-access journal PLOS ONE by Elodie Freymann from the University of Oxford, UK, and colleagues. Many plants produce compounds that have medicinal effects on humans and other animals. Wild chimpanzees eat a variety of plant matter, including some that is nutritionally poor but may treat or lessen the symptoms of illness. However, it is hard to determine whether chimpanzees self-medicate, by intentionally seeking out plants with properties that help their specific ailments, or passively consume plants ...

New catalyst unveils the hidden power of water for green hydrogen generation

New catalyst unveils the hidden power of water for green hydrogen generation
2024-06-20
Hydrogen is a promising chemical and energy vector to decarbonize our society. Unlike conventional fuels, hydrogen utilization as a fuel does not generate carbon dioxide in return. Unfortunately, today, most of the hydrogen that is produced in our society comes from methane, a fossil fuel. It does so in a process (methane reforming) that leads to substantial carbon dioxide emissions. Therefore, the production of green hydrogen requires scalable alternatives to this process. Water electrolysis offers a path to generate green hydrogen which can be ...

Supermassive black hole appears to grow like a baby star

Supermassive black hole appears to grow like a baby star
2024-06-20
Supermassive black holes pose unanswered questions for astronomers around the world, not least “How do they grow so big?” Now, an international team of astronomers, including researchers from Chalmers University of Technology in Sweden, has discovered a powerful rotating, magnetic wind that they believe is helping a galaxy’s central supermassive black hole to grow. The swirling wind, revealed with the help of the ALMA telescope in nearby galaxy ESO320-G030, suggests that similar processes are involved both in black hole growth and the birth of stars.   Most galaxies, including our own Milky Way have a supermassive black hole at their centre. How ...

Early detection crucial in bile duct cancer for patients with rare liver disease

Early detection crucial in bile duct cancer for patients with rare liver disease
2024-06-20
Primary sclerosing cholangitis (PSC) is a rare progressive liver disease that damages bile ducts and significantly increases the risk of bile duct cancer, particularly a type called cholangiocarcinoma (CCA). This cancer is aggressive, and curative surgery is uncommon. Liver transplantation is a potential treatment option for some PSC-CCA patients, especially if the cancer is caught early. Early diagnosis is essential for successful treatment. PSC can affect people of all ages but primarily strikes men in their 30s and 40s. It is often accompanied by inflammatory bowel disease (IBD). The disease can progress to liver failure and increase the risk of colorectal cancer ...

BCMA-CD19 bispecific CAR-T therapy in refractory chronic inflammatory demyelinating polyneuropathy

BCMA-CD19 bispecific CAR-T therapy in refractory chronic inflammatory demyelinating polyneuropathy
2024-06-20
This study is led by Professor Junnian Zheng and Ming Shi from the Cancer Institute of Xuzhou Medical University, together with the team of Professor Guiyun Cui and Wei Zhang from the Affiliated Hospital of Xuzhou Medical University. The team reported for the first time using BCMA-CD19 bispecific CAR T cells for treating relapsed/refractory CIDP.   Chronic Inflammatory Demyelinating Polyneuropathy (CIDP) is an uncommon condition with sudden onset symptoms, including nerve damage affecting movement, sensation, speech, breathing, and heart rate. ...

Embryo and organoid models do not threaten the definition of personhood, bioethicist says

2024-06-20
Advances in organoids and embryonic models of human development have the potential to prompt social and existential questions—e.g., what defines human individuality? However, bioethicist Insoo Hyun of Harvard Medical School and the Museum of Science in Boston says that these models have the potential to strengthen rather than weaken the concept of human individuality when considered within the philosophical frameworks of “personhood” and sentience. In a commentary publishing June 20 in the journal Cell, Hyun argues that despite huge advances, we are a long way off from developing technologies that would ...

Great British Bake Off finalist Josh Smalley discusses the parallels between chemistry and baking

Great British Bake Off finalist Josh Smalley discusses the parallels between chemistry and baking
2024-06-20
Last year on a Friday evening, chemical biology researcher Josh Smalley was in the lab when he received a call inviting him to appear on the 14th and latest season of The Great British Bake Off. Starting as one of a group of 12 amateur bakers, Smalley made it all the way to the final round, where the top 3 contestants compete for the winning spot. In an essay published in the journal Cell Chemical Biology on June 20, Smalley describes the overlap between chemistry and baking and how his training in one ...

New genetic cause of obesity could help guide treatment

2024-06-20
Scientists have discovered a new cause of why people who lack a specific blood group are genetically predisposed to be overweight or obese. A team of international researchers, led by the University of Exeter, discovered that people with a genetic variant that disables the SMIM1 gene have higher body weight because they expend less energy when at rest. SMIM1 was only identified 10 years ago, whilst searching  for the gene encoding a specific blood group, known as Vel. One in 5,000 people  lack both copies of the gene, making them Vel-negative. The findings from the new research suggest that this group is also more likely to be overweight, a conclusion ...

Palaeontology: New, small, ancient crocodile-like reptile described in Brazil

2024-06-20
The discovery of a new, ancient, predatory reptile dubbed Parvosuchus aurelioi — part of a group of crocodile-like reptiles called pseudosuchians — in Brazil is described in a paper in Scientific Reports. The specimen, which dates to approximately 237 million years ago, during the Middle-Late Triassic, is the first small predatory reptile of its kind to be found in this country. Prior to the dominance of the dinosaurs, pseudosuchians were a common form of ancient quadruped reptile during the Triassic Period (252 – 201 million years ago), with some species amongst ...

Prenatal maternal psychological distress during the pandemic and newborn brain development

2024-06-20
About The Study: The findings of this study suggest that increased maternal mental health symptoms during the COVID-19 pandemic are associated with subsequent changes in regional brain growth in newborn offspring.  Corresponding Author: To contact the corresponding author, Nickie Andescavage, M.D., email nniforat@childrensnational.org. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.17924) Editor’s Note: Please see the article for additional information, including ...

Healthy lifestyle and the likelihood of becoming a centenarian

2024-06-20
About The Study: In this case-control study of Chinese older adults, adhering to a healthy lifestyle appears to be important even at late ages, suggesting that constructing strategic plans to improve lifestyle behaviors among all older adults may play a key role in promoting healthy aging and longevity.  Corresponding Authors: To contact the corresponding authors, email Xiang Gao, M.D., Ph.D. (xiang_gao@fudan.edu.cn) and Xiaoming Shi, M.D., Ph.D. (shixm@chinacdc.cn). To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2024.17931) Editor’s Note: Please see ...

New, simple test detects rare fatal genetic heart condition

2024-06-20
A team of international researchers has revealed a new, simple clinical test to detect Calcium Release Deficiency Syndrome (CRDS), a life-threatening genetic arrhythmia that causes dangerously fast heartbeats and can lead to severe complications such as sudden cardiac arrest and death. The new diagnostic method monitors for changes in electrocardiography (ECG) after a brief period of a fast heartbeat and a pause, which can occur naturally or be induced by artificially pacing the heart. This research was co-led by Jason Roberts, a scientist at the Population ...

YALE NEWS: Chemotherapy before surgery benefits some patients with pancreatic cancer

2024-06-20
New Haven, Conn. — Patients with pancreatic cancer who received chemotherapy both before and after surgery experienced longer survival rates than would be expected from surgery followed by chemotherapy, according to a new study from researchers at Yale Cancer Center (YCC) and Yale School of Medicine. The study, published June 20 in JAMA Oncology, included patients with pancreatic ductal adenocarcinoma (PDAC), which accounts for 90% of pancreatic cancers. An aggressive cancer with a high mortality rate, PDAC is predicted ...

First conclusive evidence that a terrestrial leech species can jump

First conclusive evidence that a terrestrial leech species can jump
2024-06-20
A new study presents video evidence that at least one species of terrestrial leech can jump, behavior that scientists have debated for more than a century. Researchers from the American Museum of Natural History, Fordham University, and City University of New York (CUNY)’s Medgar Evers College published the footage and corresponding analysis today in the journal Biotropica. “We believe this is the first convincing evidence that leeches can jump and do so with visible energy expenditure,” said lead author Mai Fahmy, a visiting scientist at the Museum and a postdoctoral researcher ...

Creation of a power-generating, gel electret-based device

Creation of a power-generating, gel electret-based device
2024-06-20
1. A team of researchers from NIMS, Hokkaido University and Meiji Pharmaceutical University has developed a gel electret capable of stably retaining a large electrostatic charge. The team then combined this gel with highly flexible electrodes to create a sensor capable of perceiving low-frequency vibrations (e.g., vibrations generated by human motion) and converting them into output voltage signals. This device may potentially be used as a wearable healthcare sensor. 2. Interest in the development of soft, lightweight, power-generating materials has been growing in recent years for use in soft electronics designed for various purposes, such as ...

How E. coli defends itself against antibiotics

How E. coli defends itself against antibiotics
2024-06-20
When E. coli detects damage to its genetic material, it sends out an SOS signal that alters activity inside the cells. “The bacteria go into full emergency mode,” says PhD candidate Olaug Elisabeth Torheim Bergum at the Norwegian University of Science and Technology (NTNU). Imagine that you have a very sore throat. You're sick, your throat hurts, and a visit to the doctor confirms that the pain is due to a bacterial infection. You get a prescription for antibiotics, which quickly sorts out your sore throat. You are pleased that the treatment ...

Mental health leaders to gather for international summit on suicide prevention

2024-06-20
DETROIT (June 20, 2024)— Mental health experts from across the globe will gather to share insights, best practices, and innovations for preventing suicide during the 5th Zero Suicide International Summit June 24-25 in Liverpool, England. Named for the innovative, evidence-based suicide intervention model developed at Henry Ford Health, the Zero Suicide International Summit is presented by the Detroit-based healthcare system in partnership with Zero Suicide Alliance (ZSA) and The Kevin and Margaret Hines Foundation. The Zero Suicide model was developed at Henry Ford Health in 2001.  Within a year of implementing the ...

Can AI learn like us?

Can AI learn like us?
2024-06-20
It reads. It talks. It collates mountains of data and recommends business decisions. Today’s artificial intelligence might seem more human than ever. However, AI still has several critical shortcomings.  “As impressive as ChatGPT and all these current AI technologies are, in terms of interacting with the physical world, they’re still very limited. Even in things they do, like solve math problems and write essays, they take billions and billions of training examples before they can do them well, " explains Cold Spring Harbor Laboratory (CSHL) NeuroAI Scholar Kyle Daruwalla.  Daruwalla ...

Changing climate will make home feel like somewhere else

Changing climate will make home feel like somewhere else
2024-06-20
Changing climate will make home feel like somewhere else Interactive app shows how climate change will make places around the world  feel like they are closer to the equator FROSTBURG, MD (June 20, 2024)—The impacts of climate change are being felt all over the world, but how will it impact how your hometown feels? An interactive web application from the University of Maryland Center for Environmental Science allows users to search 40,581 places and 5,323 metro areas around the globe to match the expected future climate in each city with the current climate of another location, ...
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