HOUSTON (Oct. 6, 2025) – Researchers at Texas Children’s Neurological Research Institute (NRI) and Baylor College of Medicine have developed a powerful new tool within the Genome Aggregation Database (gnomAD) to sharpen the accuracy of genetic testing – a breakthrough with direct implications for patient diagnoses and care worldwide. The work, published in Nature Communications, applies a method called local ancestry inference (LAI), which breaks the genome into ancestry-specific segments to provide more accurate insights into genetic differences. “This research updates our genomic resources to better reflect the ...

October 6, 2025 (Washington, DC)—The Milken Institute Science Philanthropy Accelerator for Research and Collaboration (SPARC), in partnership with the Ann Theodore Foundation (ATF), today announced that the Ann Theodore Foundation Breakthrough Sarcoidosis Initiative (ATF-BSI) has awarded five grants totaling more than $2.5 million to interdisciplinary research teams. Concurrently, the two partners have launched ATF-BSI’s fifth round of philanthropic funding via a new request for proposals (RFP) related to sarcoidosis ...

Embargoed until 7 a.m. CT/8 a.m. ET, Monday, Oct. 6, 2025 DALLAS, Oct. 6, 2025 — Emelia J. Benjamin, M.D., FAHA, professor of medicine at Boston University (BU), will receive the 2025 Eugene Braunwald Academic Mentorship Award at the American Heart Association’s Scientific Sessions 2025. The meeting, to be held Nov. 7-10, 2025, in New Orleans, is a premier global exchange of the latest scientific advancements, research and evidence-based clinical practice updates in cardiovascular science. Dr. Benjamin will be recognized with the award during the Presidential Session on Sunday, Nov. 9, 2025. Named for legendary cardiologist Eugene ...

Soil contamination is a global environmental concern, with toxic metals and metalloids from industrial activities persisting as long-term pollutants. Arsenic (As), although naturally occurring, becomes widespread when mobilized by mining. Abandoned gold mines are major sources, releasing arsenic-rich minerals into surrounding environments through erosion and leaching. Forest soils, essential for ecosystem health and biodiversity, are particularly vulnerable. Despite arsenic’s mobility under specific soil conditions and known toxicity, its behavior in forest soils and impacts on soil organisms remain poorly understood. In ...

Taste is one of our most vital senses, shaping appetite, nutrition, and quality of life. Yet taste buds are fragile, relying heavily on the nerves that connect them to the brain. When those nerves are cut or damaged, taste buds usually deteriorate — but later regenerate as nerves regrow. How this recovery occurs has remained unclear.  Now, a study led by Dr. Dong-Hoon Kim and Professor Yong Taek Jeong at Korea University College of Medicine, published in the International Journal of Oral Science ...

Alexandria, Va. — October 6, 2025 — HealthFORCE, a national alliance of leaders dedicated to addressing the root causes of America’s healthcare workforce crisis, along with the American Academy of Physician Associates (AAPA) and West Health, today released “Aging Well with AI: Empowering Care through Innovation,” the first in a two-part white paper series exploring how artificial intelligence (AI) can strengthen the U.S. healthcare workforce and improve access to care. The paper was commissioned by the three ...

Sir Ernest Shackleton’s ship, Endurance, was crushed by Antarctic sea ice and sank in November 1915. Emblematic of the heroic age of Antarctic exploration, it is widely considered the strongest polar ship of its time, albeit with a fatal flaw — a weakness in the rudder that caused the ship to sink.  Now, a world-first study incorporating both technical analysis and research into diaries and correspondence sheds new light on the expedition and the man himself. Not only did the ship have structural weaknesses that made it notably less robust than other early polar vessels ...

New research shows that marine heatwaves can reshape ocean food webs, which in turn can slow the transport of carbon to the deep sea and hamper the ocean’s ability to buffer against climate change. The study, published in the scientific journal Nature Communications today, was conducted by an interdisciplinary team of researchers from MBARI, the University of Miami Rosenstiel School of Marine, Atmospheric, and Earth Science, the Hakai Institute, Xiamen University, the University of British Columbia, the University of Southern Denmark, and Fisheries and Oceans Canada. To explore the impacts of marine heatwaves on ocean food webs and carbon flows, the research team combined multiple ...

Key Takeaways Researchers at Harvard and Northwestern have developed a machine learning method that can design intrinsically disordered proteins with custom properties, addressing nearly 30% of all human proteins that are currently out of reach of AI tools like AlphaFold. The new approach uses automatic differentiation, traditionally a deep learning tool, to optimize protein sequences for desired properties. The method opens new possibilities for engineering proteins, directly from physics-based models, that do not fold into a specific shape. In synthetic and structural biology, advances in artificial intelligence have led to an explosion of designing new proteins with ...

A world-first study has proven microbes essential for human health can survive the extreme forces of space launch. Space agencies are planning to send crews to Mars within decades but sustaining life on the red planet would be more difficult if important bacteria die during the flight. Now an Australian-led study has found the spores of Bacilus subtilis, a bacterium essential for human health, can survive rapid acceleration, short-duration microgravity and rapid deceleration. The spores of bacteria were launched high into ...

Wheat has a very large and complex genome. Researchers have found that different varieties can use their genes in different ways. By studying RNA—the molecules that carry out instructions from DNA—researchers can see which genes are active and when. By mapping this gene activity for the first time, researchers are able accelerate international wheat breeding programmes, developing new varieties of wheat which can adapt to the rapidly escalating climate emergency. Wheat is the most widely cultivated crop in the world, with over 215 million hectares grown annually. To meet the demands of a growing global population, plant breeders face ...

New research reveals that inflammatory responses may play a role in different types of fatigue experienced by many people with cancer. The findings are published by Wiley online in CANCER, a peer-reviewed journal of the American Cancer Society. Cancer-related fatigue can be a distressing and persistent burden that causes patients to feel physical, emotional, and/or cognitive tiredness or exhaustion. Activation of inflammatory responses by the tumor itself and/or by cancer treatment is thought to be a key biological driver of this symptom, but inflammatory activity across the cancer continuum has not been thoroughly ...

Traumatic brain injuries (TBI) in older adults are associated with new cases of dementia, use of home care services, and admission to long-term care, according to new research published in CMAJ (Canadian Medical Association Journal) https://www.cmaj.ca/lookup/doi/10.1503/cmaj.250361. “One of the most common reasons for TBI in older adulthood is sustaining a fall, which is often preventable,” write Dr. Yu Qing Huang, ICES PhD student, and Dr. Jennifer Watt, associate professor and ICES scientist, both geriatricians at St. Michael’s ...

Results from a randomized clinical trial published in Pediatrics show that pediatricians who received targeted educational and clinical decision-support tools were significantly more likely to advise parents to introduce peanut-containing foods early – an approach recommended by national prevention guidelines but often underused in practice. About 8% of U.S. children have food allergies. Peanut allergy, the most common pediatric food allergy, affects more than 2% of children nationwide. “We found ...

UNDER EMBARGO UNTIL OCT 6 at 12:01 a.m. ET Media Contact: media@pptaglobal.org New Survey: Most Americans Believe Plasma Donation Saves Lives, Yet Few Have Donated October 6 – Washington, D.C. – International Plasma Awareness Week (IPAW) takes place globally from October 6-10. The week encourages communities around the world to recognize the vital role of plasma in creating lifesaving medicines and honors those who donate. A new survey has found that 72% of respondents agree that plasma-derived medicines can save lives, yet most have not donated plasma. The survey asked over 1,000 American adults questions about their understanding of plasma donation and lifesaving plasma-derived ...

Doctors were nearly 15 times more likely to follow allergy-prevention guidelines with new tools Tools included a training video and health record prompts for doctors and handouts for families Randomized trial included 30 pediatric practices and 18,480 infant visits CHICAGO --- A few easy-to-implement tools — a training video, electronic health record prompts and handouts for families — greatly increased how often pediatricians recommended early peanut introduction to infants, reports a new clinical study led by Northwestern University and Ann & Robert H. Lurie Children's Hospital of Chicago. Since 2017, national guidelines have encouraged ...

UNDER EMBARGO UNTIL 00:01AM UK TIME ON MONDAY 6 OCTOBER 2025 Research unearths origins of Ancient Egypt’s Karnak Temple   Most complete study of the temple complex and its landscape establishes earliest occupation and hints at link to creation myth Researchers have carried out the most comprehensive geoarchaeological survey of Egypt’s Karnak Temple near Luxor – one of the ancient world’s largest temple complexes and a UNESCO World Heritage site welcoming millions of tourists every year. The study, published in Antiquity today [6 October] reveals new evidence on the ...

About The Study: In contrast to earlier studies, this meta-analysis found significantly higher treatment failure and major complication rates within a year with nonoperative management among children and adolescents. The meta-analysis provides pediatricians and pediatric surgeons with up-to-date data to inform shared decision-making with families and encourage individualized, patient-centered treatment.  Corresponding Author: To contact the corresponding author, Isabella Faria, MD, email imdefrei@utmb.edu. To access the embargoed ...

(Barcelona, Spain, Sunday 5 October 2025) High metabolic activity of visceral fat may be associated with more aggressive endometrial cancer, new research presented today at the 38th Annual Congress of the European Association of Nuclear Medicine (EANM'25) has shown.1 While obesity is a recognised risk factor for endometrial cancer,2-3 the findings indicate that disease aggressiveness may be driven not only by the amount of visceral fat but also by its metabolic activity. Visceral fat is the fat that surrounds the internal organs, and to a larger degree than subcutaneous ...

Tokyo, Japan – Researchers from Tokyo Metropolitan University have developed a new structure determination method using Nuclear Magnetic Resonance (NMR) spectroscopy which shows how different parts of complex molecular machinery like enzymes move while they help catalyze reactions. Focusing on an enzyme in yeast, they demonstrated how contrasts in atomic scale motions impact their function. The method promises unprecedented access to the mechanisms by which biomolecules work, and how they relate to illnesses.   Enzymes are indispensable to the function of all biological organisms, ...

RIVERSIDE, Calif. -- The COVID-19 pandemic did not affect everyone equally. Communities of color, especially Latino (including undocumented persons), Black, and Native American groups, as well as people with low incomes, experienced much higher rates of infection, hospitalization, and death.  Research has shown that several key factors worsened health inequalities during the COVID-19 pandemic. Crowded housing, dense neighborhoods, and location played a major role in how the virus spread. Systemic racism, discrimination, and unstable jobs made some communities even more at risk. A new report, published in Health Expectations, highlights how ...

NORMAN, Okla. – Researchers at the University of Oklahoma’s Advanced Radar Research Center (ARRC) continue to lead the way in radar innovation. A $19.9 million award from the U.S. National Science Foundation’s Mid-scale Research Infrastructure-1 program will fund the development of two groundbreaking KaRVIR systems (Dual-Doppler 3D Mobile Ka-band Rapid-Scanning Volume Imaging Radars for Earth System Science). These state-of-the-art radars will provide unique capabilities to close critical observational gaps in the atmospheric ...

Triple negative breast cancer (TNBC) is one of the most aggressive and hardest forms of breast cancer to treat, but a new study led by Weill Cornell Medicine suggests a surprising way to stop it from spreading. Researchers have discovered that an enzyme called EZH2 drives TNBC cells to divide abnormally, which enables them to relocate to distant organs. The preclinical study also found drugs that block EZH2 could restore order to dividing cells and thwart the spread of TNBC cells. “Metastasis is the main reason patients with triple negative breast cancer face poor survival odds,” said senior author Dr. Vivek Mittal, Ford-Isom Research Professor of Cardiothoracic Surgery and ...

Pancreatic neuroendocrine neoplasms (PNENs) are a rare form of cancer that affects hormone-producing cells in the pancreas. Although uncommon, their incidence has been rising steadily over the past few decades. Treatment options include chemotherapy and targeted therapies, but surgery remains the only chance for a cure. However, surgical decisions often depend on pathology results that can take hours or even days, delaying treatment and increasing the risk of incomplete tumor removal. Researchers at the University of Arizona have developed a new imaging method that could help surgeons identify cancerous tissue more quickly and accurately. The technique, called multiphoton microscopy ...

DETROIT — A Wayne State University study published in the Oct. 3, 2025, issue of Nature Communications revealed that Zika virus exposure during pregnancy causes long-term, sex-specific changes to a baby’s immune system, particularly affecting the frontline immune cells that fight infection. The study, “Prenatal exposure to Zika virus shapes offspring neutrophil function in a sex-specific manner,” was led by Dr. Jiahui Ding, assistant professor of obstetrics and gynecology in Wayne State’s School of Medicine. “We discovered that when a pregnant mother is infected with Zika virus, the resulting inflammatory ...