NEW YORK (August 1, 2013) -- Researchers have discovered how an experimental drug is capable of completely eradicating human lymphoma in mice after just five doses. The study, led by researchers at Weill Cornell Medical College, sets the stage for testing the drug in clinical trials of diffuse large B-cell lymphoma (DLBCL), the most common subtype of non-Hodgkin lymphoma, itself the seventh most frequently diagnosed cancer in the U.S. In the journal Cell Reports, published today online, the scientists describe how the powerful master regulatory transcription factor Bcl6 ...

A boost in the speed of brain scans is unveiling new insights into how brain regions work with each other in cooperative groups called networks. Scientists at Washington University School of Medicine in St. Louis and the Institute of Technology and Advanced Biomedical Imaging at the University of Chieti, Italy, used the quicker scans to track brain activity in volunteers at rest and while they watched a movie. "Brain activity occurs in waves that repeat as slowly as once every 10 seconds or as rapidly as once every 50 milliseconds," said senior researcher Maurizio Corbetta, ...

EAST LANSING, Mich. — If two women have the same genetic mutation that puts them at higher-than-average risk for a disease such as breast cancer, why does only one develop the disease? In the current issue of PLOS Genetics, Michigan State University genetic scientists have begun to understand how the rest of the genome interacts with such mutations to cause the differences we see among individuals. "It's been known for a while that genetic mutations can modify each other's effects," said Ian Dworkin, MSU associate professor of zoology and co-author of the paper. "And ...

A trace substance in caramelized sugar, when purified and given in appropriate doses, improves muscle regeneration in a mouse model of Duchenne muscular dystrophy. The findings are published today, Aug. 1, in the journal Skeletal Muscle. Morayma Reyes, professor of pathology and laboratory medicine, and Hannele Ruohola-Baker, professor of biochemistry and associate director of the Institute for Stem Cell and Regenerative Medicine, headed the University of Washington team that made the discovery. The first authors of the paper were Nicholas Ieronimakis,UW Department of ...

In women who use donor eggs to become pregnant through in vitro fertilization (IVF), those who are obese are just as likely to become pregnant as normal weight women, according to a new report. Studies have shown that obesity is associated with lower chances of pregnancy using IVF, but most of this work is limited to women using their own eggs. Research on outcomes for obese women using donor eggs has had mixed results. The new analysis by investigators at Washington University School of Medicine in St. Louis and the University of California-Los Angeles pooled and analyzed ...

Irvine, Calif., July 31, 2013 — Breath analysis may prove to be an accurate, noninvasive way to quickly determine the severity of bacterial and other infections, according to a UC Irvine study appearing online today in the open-access journal PLOS ONE. Employing a chemical analysis method developed for air pollution testing, UC Irvine microbiologists and chemists were able to correlate inflammation levels in laboratory mice to the amount of naturally produced carbon monoxide and other gases in breath samples. The findings point to human applications of this technology ...

DENVER - Researchers at National Jewish Health have identified an enzyme that is essential to the allergic reaction to peanuts. Blocking the enzyme's activity in sensitized mice prevented diarrhea and inflammation, and reduced levels of several proteins associated with allergies. The findings, published online in the Journal of Allergy and Clinical Immunology, identify the enzyme, known as Cyp11a1, as a potential target for treatment of increasingly common and potentially deadly food allergy. "Right now, we have no therapy for food allergy other than to avoid the allergenic ...

Heart failure occurs when the heart cannot pump enough blood to meet the body's needs. It's a very common condition, affecting about six million people in the United States, but current therapies are not adequately effective at improving health and preventing deaths. A study published by Cell Press August 1st in the journal Cell reveals the key role of a family of molecules known as bromodomain and extraterminal domain (BET) proteins in activating genes that contribute to heart failure. The study also demonstrates that a BET-inhibiting drug can protect against heart failure ...

If you have trouble going to sleep at night and waking up for work or school in the morning, a week of camping in the great outdoors might be just what you need. That's according to evidence reported on August 1 in Current Biology, a Cell Press publication, showing that humans' internal biological clocks will tightly synchronize to a natural, midsummer light-dark cycle, if only they are given the chance. A week of exposure to true dawn and dusk with nights lit only by a campfire's glow had the biggest effect on people who might otherwise describe themselves as night owls. ...

Prolactin reduces arthritis inflammation Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health. In this issue of the Journal of Clinical Investigation, Carmen Clapp and colleagues at the National University of Mexico identify prolactin as a potential treatment for inflammatory joint disease. Prolactin treatment prevented chondrocyte death and associated cartilage degradation. In a rat model of inflammatory ...

Inflammatory joint diseases such as rheumatoid arthritis are the result of cartilage damage and loss. Chondrocytes are the only cells that are found in cartilage and their death is linked to decreased cartilage health. In this issue of the Journal of Clinical Investigation, Carmen Clapp and colleagues at the National University of Mexico identify prolactin as a potential treatment for inflammatory joint disease. Prolactin treatment prevented chondrocyte death and associated cartilage degradation. In a rat model of inflammatory arthritis, prolactin treatment reduced inflammation, ...

Bone integrity requires skeletal remodeling, which involves both bone formation and resorption. It has been previously shown that the formation of new bone is triggered by degradation of older bone. However, it is unknown how these two processes coordinate for skeletal maintenance. In this issue of the Journal of Clinical Investigation, Sunao Takeshita and colleagues at the National Center for Geriatrics and Gerontology identify a protein, CTHRC1 that is secreted by bone adsorbing cells (osteoclasts) and helps initiate bone formation. The authors found that CTHRC1 secretion ...

Patients suffering from chronic granulomatous disease (CGD) are prone to recurrent and potentially life threatening bouts of infection due to the inability of phagocytic cells to kill invading microorganisms. Normal phagocytes release reactive oxygen compounds in response to infection, but this defense is lacking in phagocytes of people with CGD. In the current issue of the Journal of Clinical Investigation, Griffin Rodgers and colleagues at the National Institutes of Health identify a neutrophil granule protein, OLFM4 as a potential therapeutic target for CGD patients. ...

There are some smells we all find revolting. But toward a handful of odors, different people display different sensitivities—some can smell them, while some can't, or some find them appealing, while others don't. A pair of studies appearing online on August 1 in the journal Current Biology, a Cell Press publication, now identifies the genetic differences that underpin the differences in smell sensitivity and perception in different individuals. The researchers tested nearly 200 people for their sensitivity for ten different chemical compounds that are commonly found in ...

A team of neuroscientists has identified a protein in laboratory mice linked to impairments similar to those afflicted with Angelman syndrome (AS)—a condition associated with symptoms that include autism, intellectual disability, and motor abnormalities. The findings appear in the journal Cell Reports. "By isolating a protein that contributes to cognitive deficits in Angelman syndrome, these findings mark a step forward in not only addressing AS, but perhaps other developmental disorders as well," said Eric Klann, a professor in New York University's Center for Neural ...

Hamilton, ON (August 1, 2013) –McMaster University researchers have revealed the location of human blood stem cells that may improve bone marrow transplants. The best stem cells are at the ends of the bone. It is hoped this discovery will lead to lowering the amount of bone marrow needed for a donation while increasing regeneration and lessening rejection in the recipient patients, says principal investigator Mick Bhatia, professor and scientific director of the McMaster Stem Cell and Cancer Research Institute. In a paper published online today by the journal Cell ...

Scientists have found that bacteria have the potential to teach valuable investment lessons. The research, published in the journal Ecology Letters, takes advantage of the fact that bacteria, like humans, have limited resources and are constantly faced with investment decisions. Bacteria though are successful with their investments and have colonised every inch of the surface of our planet. The researchers, from the Universities of Exeter and Sydney, used mathematical models and lab-based synthetic biology, to predict bacterial investment crashes and boom-bust cycles. ...

Researchers at the University of California, San Diego School of Medicine report a simple, easily reproducible RNA-based method of generating human induced pluripotent stem cells (iPSCs) in the August 1 edition of Cell Stem Cell. Their approach has broad applicability for the successful production of iPSCs for use in human stem cell studies and eventual cell therapies. Partially funded by grants from the California Institute for Regenerative Medicine (CIRM) and the National Institutes of Health (NIH), the methods developed by the UC San Diego researchers dramatically ...

PROVIDENCE, R.I. [Brown University] — RNA editing gives organisms a way to adapt the instructions that their DNA provides for making proteins. Few people would have described RNA editing as a simple process, but a new paper in Nature Communications demonstrates the process as more complex and difficult to predict than previously assumed. The study, done in living fruit flies, discovered two new mechanisms that govern editing in a key neurodevelopmental gene. RNA editing is governed not only by sequences of RNA nucleotides (the letters A, C, G, and U) and corresponding ...

In a small clinical study, researchers administered a new method for treating chronic wounds using a novel ultrasound applicator that can be worn like a band-aid. The applicator delivers low-frequency, low-intensity ultrasound directly to wounds, and was found to significantly accelerate healing in five patients with venous ulcers. Venous ulcers are caused when valves in the veins malfunction, causing blood to pool in the leg instead of returning to the heart. This pooling, called venous stasis, can cause proteins and cells in the vein to leak into the surrounding tissue ...

Researchers from Case Western Reserve University School of Medicine and the Dana-Farber Cancer Institute have made a fundamental discovery relevant to the understanding and treatment of heart failure – a leading cause of death worldwide. The team discovered a new molecular pathway responsible for causing heart failure and showed that a first-in-class prototype drug, JQ1, blocks this pathway to protect the heart from damage. In contrast to standard therapies for heart failure, JQ1 works directly within the cell's command center, or nucleus, to prevent damaging stress responses. ...

Some galaxies hit a point in their lives when their star formation is snuffed out, and they become "quenched". Quenched galaxies in the distant past appear to be much smaller than the quenched galaxies in the Universe today. This has always puzzled astronomers -- how can these galaxies grow if they are no longer forming stars? A team of astronomers has now used a huge set of Hubble observations to give a surprisingly simple answer to this long-standing cosmic riddle. Until now, these small, snuffed-out galaxies were thought to grow into the larger quenched galaxies we ...

Leading physicists last year turned game theory on its head by giving selfish players a sure bet to beat cooperative players. Now two evolutionary biologists at Michigan State University offer new evidence that the selfish will die out in the long run. "We found evolution will punish you if you're selfish and mean," said lead author Christoph Adami, MSU professor of microbiology and molecular genetics. "For a short time and against a specific set of opponents, some selfish organisms may come out ahead. But selfishness isn't evolutionarily sustainable." The paper "Evolutionary ...

Researchers at the University of California, San Diego School of Medicine have identified the gene mutation responsible for a particularly severe form of pontocerebellar hypoplasia, a currently incurable neurodegenerative disease affecting children. Based on results in cultured cells, they are hopeful that a nutritional supplement may one day be able to prevent or reverse the condition. The study, from a team of international collaborators led by Joseph G. Gleeson, MD – Howard Hughes Medical Institute investigator and professor in the UCSD Departments of Neurosciences ...

Spending just one week exposed only to natural light while camping in the Rocky Mountains was enough to synch the circadian clocks of eight people participating in a University of Colorado Boulder study with the timing of sunrise and sunset. The study, published online today in the journal Current Biology, found that the synchronization happened in that short period of time for all participants, regardless of whether they were early birds or night owls during their normal lives. "What's remarkable is how, when we're exposed to natural sunlight, our clocks perfectly ...