In a new study a team of researchers lead from Uppsala University show how lactase persistence variants tell the story about the ancestry of the Khoe people in southern Africa. The team concludes that pastoralist practices were brought to southern Africa by a small group of migrants from eastern Africa. The study is published in Current Biology today. "This is really an exciting time for African genetics. Up until now, routes of human migration in Africa were inferred mostly based on linguistics and archaeology, now we can use genetics to test these hypotheses." says ...

Researchers at the University of California, San Diego School of Medicine have found that too little or too much of an enzyme called SRPK1 promotes cancer by disrupting a regulatory event critical for many fundamental cellular processes, including proliferation. The findings are published in the current online issue of Molecular Cell. The family of SRPK kinases was first discovered by Xiang-Dong Fu, PhD, professor in the Department of Cellular and Molecular Medicine at UC San Diego in 1994. In 2012, Fu and colleagues uncovered that SPRK1 was a key signal transducer ...

MADISON, Wis. — By studying nerve cells that originated in patients with a severe neurological disease, a University of Wisconsin-Madison researcher has pinpointed an error in protein formation that could be the root of amyotrophic lateral sclerosis. Also called Lou Gehrig's disease, ALS causes paralysis and death. According to the ALS Association, as many as 30,000 Americans are living with ALS. After a genetic mutation was discovered in a small group of ALS patients, scientists transferred that gene to animals and began to search for drugs that might treat those ...

Harvard stem cell scientists have discovered that a recently approved medication for epilepsy may possibly be a meaningful treatment for amyotrophic lateral sclerosis (ALS)—Lou Gehrig's disease, a uniformly fatal neurodegenerative disorder. The researchers are now collaborating with Massachusetts General Hospital to design an initial clinical trial testing the safety of the treatment in ALS patients. The investigators all caution that a great deal needs to be done to assure the safety and efficacy of the treatment in ALS patients, before physicians should start offering ...

(MEMPHIS, Tenn. – April 3, 2014) – The St. Jude Children's Research Hospital—Washington University Pediatric Cancer Genome Project found mutations in the tumor suppressor gene TP53 in 90 percent of osteosarcomas, suggesting the alteration plays a key role early in development of the bone cancer. The research was published today online ahead of print in the journal Cell Reports. The discovery that TP53 is altered in nearly every osteosarcoma also helps to explain a long-standing paradox in osteosarcoma treatment, which is why at standard doses radiation therapy is largely ...

Analyzing federal health care data, a team of researchers led by a Johns Hopkins specialist concluded that doctors overlook or discount the early signs of potentially disabling strokes in tens of thousands of American each year, a large number of them visitors to emergency rooms complaining of dizziness or headaches. The findings from the medical records review, reported online April 3 in the journal Diagnosis, show that women, minorities and people under the age of 45 who have these symptoms of stroke were significantly more likely to be misdiagnosed in the week prior ...

HOUSTON -- Under stress from chemotherapy or radiation, some cancer cells dodge death by consuming a bit of themselves, allowing them to essentially sleep through treatment and later awaken as tougher, resistant disease. Interfering with a single cancer-promoting protein and its receptor can turn this resistance mechanism into lethal, runaway self-cannibalization, researchers at The University of Texas MD Anderson Cancer Center report in the journal Cell Reports. "Prolactin is a potent growth factor for many types of cancers, including ovarian cancer," said senior author ...

Montreal, April 3, 2014 – Bruno Giros, PhD, a researcher at the Douglas Mental Health University Institute and a professor in the Department of Psychiatry at McGill University, has demonstrated, for the first time, the role that dopamine plays in a region of the brain called the hippocampus. Published in Biological Psychiatry, this discovery opens the door to a better understanding of psychiatric diseases, such as schizophrenia. Dopamine is a neurotransmitter that plays a central role in brain function, and many mental illnesses involve an imbalance in this chemical. ...

Boulder, Colo., USA - The April 2014 Lithosphere is now available in print. Locations covered include the Acatlán Complex, Mexico; east Yilgarn craton, Australia; the eastern Paganzo basin, Argentina; the hotspot-related Yellowstone crescent, USA; and the western Alps. Locations investigated in four new papers published online on 2 April include the Banks Island assemblage in Alaska and British Columbia; The Diligencia basin of the Orocopia Mountains in California; a U.S. post-Grenville large igneous province; and South Island, New Zealand. Abstracts are online at http://lithosphere.gsapubs.org/content/early/recent. ...

CORVALLIS, Ore. – In a recent advance in solar energy, researchers have discovered a way to tap the sun not only as a source of power, but also to directly produce the solar energy materials that make this possible. This breakthrough by chemical engineers at Oregon State University could soon reduce the cost of solar energy, speed production processes, use environmentally benign materials, and make the sun almost a "one-stop shop" that produces both the materials for solar devices and the eternal energy to power them. The findings were just published in RSC Advances, ...

ANN ARBOR—Someone's drilling an icicle into your temple, you're throwing up, and light and sound are unbearable. Yes, it's another migraine attack. But now in 140 characters on Twitter, you can share your agony with other sufferers. It indicates a trend toward the cathartic sharing of physical pain, as well as emotional pain on social media. "As technology and language evolve, so does the way we share our suffering," said principal investigator Alexandre DaSilva, assistant professor and director of the Headache and Orofacial Pain Effort at University of Michigan School ...

It was disastrous when Europeans first arrived in what would become Brazil -- 95 percent of its population, the majority of its tribes, and essentially all of its urban and agricultural infrastructure vanished. The experiences of Brazil's indigenous societies mirror those of other indigenous peoples following "first contact." A new study of Brazil's indigenous societies led by Santa Fe Institute researcher Marcus Hamilton paints a grim picture of their experiences, but also offers a glimmer of hope to those seeking ways to preserve indigenous societies. Even among ...

The fifth tropical depression of the northwestern Pacific Ocean tropical cyclone season formed far from land as NASA's Aqua satellite passed overhead and captured a visible image of the storm on April 4. NASA's Aqua satellite passed over newborn Tropical Depression 05W on April 3 at 03:10 UTC/April 2 at 11:10 p.m. EDT. The Moderate Resolution Imaging Spectroradiometer or MODIS instrument captured a visible picture of the storm, revealing good circulation and strong convection and thunderstorms around the center of circulation. The Joint Typhoon Warning Center or JTWC ...

LA JOLLA, Calif., April 3, 2014 — Sanford-Burnham Medical Research Institute will present a wide range of new research data at the annual American Association for Cancer Research Meeting in San Diego starting Saturday, April 5, at the San Diego Convention Center. The presentations will cover a variety of topics including breast, melanoma, and prostate cancer, as well as novel methods of delivering drugs to tumors. If you are interested in interviewing a Sanford-Burnham researcher, please contact Susan Gammon at sgammon@sanfordburnham.org. Highlights of Sanford-Burnham's ...

Does genetic manipulation causes unintended changes in food quality and composition? Are genetically modified (GM) foods less nutritious than their non-GM counterparts, or different in unknown ways? Despite extensive cultivation and testing of GM foods, those questions still linger in the minds of many consumers. A new study in the March issue of The Plant Genome demonstrates a potentially more powerful approach to answering them. In research led by Owen Hoekenga, a Cornell University adjunct assistant professor, scientists extracted roughly 1,000 biochemicals, or "metabolites," ...

Secure mobile communications underpin our society and through mobile phones, tablets and laptops we have become online consumers. The security of mobile transactions is obscure to most people but is absolutely essential if we are to stay protected from malicious online attacks, fraud and theft. Currently available quantum cryptography technology is bulky, expensive and limited to fixed physical locations – often server rooms in a bank. The team at Bristol has shown how it is possible to reduce these bulky and expensive resources so that a client requires only the ...

VIDEO: This animation zooms into an image of the Milky Way, shown in visible light, and superimposes a gamma-ray map of the galactic center from NASA's Fermi. Raw data transitions to... Click here for more information. A new study of gamma-ray light from the center of our galaxy makes the strongest case to date that some of this emission may arise from dark matter, an unknown substance making up most of the material universe. Using publicly available data from NASA's Fermi Gamma-ray ...

New Rochelle, NY, April 3, 2014—Nearly 7% of Americans married between 2005-2012 met on social networking sites. How those couples compare to couples who met through other types of online meetings or the "old-fashioned" way in terms of age, race, frequency of Internet use, and other factors is explored in an article in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available free on the Cyberpsychology, Behavior, and Social Networking website. In "First Comes Social Networking, Then Comes ...

As fires sweep more frequently across the American Great Basin, the US Bureau of Land Management (BLM) has been tasked with reseeding the burned landscapes to stabilize soils. BLM's interventions have not helped to restore habitat for the greater sage grouse (Centrocercus urophasianus) reported scientists from the US Geological Survey (USGS) and US Forest Service in the Ecological Society of America's journal Ecosphere last week, but outlier project sites with good grouse habitat may yield clues to successful management scenarios. Their report arrives in the shadow of ...

Researchers have identified a genetic association with facial asymmetry in an ancient cavefish, a natural trait that may solve mysteries surrounding facial asymmetries in humans – conditions such as cleft palate or hemifacial microsomia. This exciting discovery by Joshua Gross, a University of Cincinnati assistant professor for the Department of Biological Sciences; and doctoral students Amanda Krutzler and Brian Carlson, is published in the research journal, Genetics. The researchers are studying the craniofacial features of the eyeless, cave-dwelling fish, Astyanax ...

A study presented during the World Congress on Osteoporosis, Osteoarthritis and Musculoskeletal Diseases in Seville shows that high levels of protein intake (HProt) enhance the positive impact of high physical activity (HPA) on bone structure and strength in healthy pre-pubertal boys. Researchers from the University of Geneva in Switzerland and Eindhoven University in the Netherlands tracked 176 healthy pre-pubertal boys (average age 7.4 years) to mid-adolescence (average age 15.2 years). Compared to moderate protein intake, HProt in combination with HPA was associated ...

Twenty percent of adults who have tonsillectomies will have a complication, which is significantly higher than previously shown, according to a team of researchers. The team also found that these complications substantially increase health care expenditures. "Since 1973, John Wenneberg and his colleagues at Dartmouth have been examining variation in the rates of tonsillectomy performed across regions, trying to explain why such wide variation is observed," said Dennis Scanlon, professor of health policy and administration, Penn State. "In other words, why are some patients ...

San Francisco, CA, April 2, 2014 – Eyedrops administered to infants as part of routine outpatient retinopathy of prematurity (ROP) screening can have life-threatening consequences. A case report published in the current issue of the Journal of the American Association for Pediatric Ophthalmology and Strabismus (AAPOS) describes cardiopulmonary arrest in a 27-week-old infant following administration of three sets of cyclopentolate 0.2%/phenylephrine 1% (Cyclomydril) eyedrops. "Cardiopulmonary arrest can occur from just instillation of eyedrops in a premature infant seen ...

Is a picture worth only a thousand words? According to Dr. Carmit Katz of Tel Aviv University's Bob Shapell School of Social Work, illustrations by children can be a critical tool in forensic investigations of child abuse. Dr. Katz's study, published in Child Abuse and Neglect, compared the results when child abuse victims were offered the opportunity to draw during questioning with victims not offered this opportunity. Her findings saw a significant difference, suggesting a therapeutic value and indicating that children empowered to draw pictures about their abuse provided ...

Radium-223 dichloride (radium-223 for short, trade name: Xofigo) has been approved since November 2013 for men with advanced prostate cancer, in whom hormone blockade is no longer effective, and symptomatic bone metastases, but without visceral metastases. In an early benefit assessment pursuant to the Act on the Reform of the Market for Medicinal Products (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether this new drug offers an added benefit over the appropriate comparator therapy specified by the Federal Joint Committee (G-BA). No ...