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Growing shorter: Adult health habits influence how much we shrink with age

2013-04-01
Even if you didn't eat your veggies or drink your milk as a child, your height is still in your hands, reveal new findings by economists from the University of Southern California, Harvard University and Peking University. Using unique data from a new massive longitudinal survey of 17,708 adults beginning at age 45, the researchers show for the first time that lifestyle choices we make in adulthood — and not just the hand we're dealt as children — influence how tall we stand as we age. "Had we only examined the correlations between measured height and health, we would ...

Researchers discover brain cancer treatment using genetic material from bone marrow cells

2013-04-01
DETROIT – In a first-of-its-kind experiment using microvesicles generated from mesenchymal bone marrow cells (MSCs) to treat cancer, neurological researchers at Henry Ford Hospital have discovered a novel approach for treatment of tumor. Specifically, the research team found that introducing genetic material produced by MSCs, significantly reduced a particularly resistant form of malignant brain tumor in living lab rats. "This is the first foray of its type in experimental cancer therapy, and it represents a highly novel and potentially effective treatment," says Michael ...

Drug for erectile disorder show promise in the treatment of obesity

2013-04-01
Although sildenafil is best known for promoting erections, it may also serve as a weight loss aid by coaxing our bodies to store more healthy "brown fat" relative to unhealthy "white fat" than it would otherwise do on its own. According to new research published online in The FASEB Journal, this is because sildenafil inhibits the breakdown of cyclic GMP, which has been well known as a messenger molecule used by the body to control blood pressure and flow, and has now been shown to play an important role determining which type of fat—white or brown—the body stores. "There ...

Our internal clocks can become ticking time bombs for diabetes and obesity

2013-04-01
If you're pulling and all-nighter to finish a term paper, a new parent up all night with a fussy baby, or simply can't sleep like you once could, then you may be snoozing on good health. That's because new research published in The FASEB Journal used mice to show that proper sleep patterns are critical for healthy metabolic function, and even mild impairment in our circadian rhythms can lead to serious health consequences, including diabetes and obesity. "We should acknowledge the unforeseen importance of our 24-hour rhythms for health," said Claudia Coomans, Ph.D., a ...

Nothing fishy about it: Fish oil can boost the immune system

2013-04-01
Fish oil rich in DHA and EPA is widely believed to help prevent disease by reducing inflammation, but until now, scientists were not entirely sure about its immune enhancing effects. A new report appearing in the April 2013 issue of the Journal of Leukocyte Biology, helps provide clarity on this by showing that DHA-rich fish oil enhances B cell activity, a white blood cell, challenging the notion that fish oil is only immunosuppressive. This discovery is important as it shows that fish oil does not necessarily reduce the overall immune response to lower inflammation, possibly ...

Unique group for single fathers due to cancer offers support

2013-04-01
CHAPEL HILL, N.C. - Men who have dependent children and whose spouses or partners died from cancer are an overlooked population. These fathers face unique challenges not addressed by traditional grief support groups that often attract an older, female population. Faculty in the UNC Department of Psychiatry report on a successful pilot peer support program called "Single Fathers Due to Cancer" they created to help these men. The program is the first of its kind in the United States. They describe the program's development so that other institutions may develop similar ...

Researchers find link between blood clotting, immune response

2013-04-01
Rice University researchers have found an unexpected link between a protein that triggers the formation of blood clots and other proteins that are essential for the body's immune system. The find could lead to new treatments for thousands of patients who suffer from inflammatory diseases and disorders that cause abnormal blood clotting. The research is available online in the journal PLOS ONE. "This link opens the door for studying severe, debilitating inflammatory disorders where the disease mechanism is still poorly understood, including lupus, rheumatoid arthritis, ...

Early COPD diagnosis possible with nuclear medicine

2013-04-01
Reston, Va. (April 1, 2013) – In vivo ventilation/perfusion (V/Q) imaging can detect early changes to the lung caused by cigarette smoke exposure and provides a noninvasive method for studying lung dysfunction in preclinical models, according to research published in the April issue of The Journal of Nuclear Medicine. These measures have the potential to be applied clinically to study and diagnose the early stages of chronic obstructive pulmonary disease (COPD). COPD is a slow-progressing, debilitating lung disease which is commonly caused by cigarette smoking. Defining ...

Hospitals measure up for Medicare reimbursement

2013-04-01
CHICAGO --- For-profit hospitals are out-performing other hospitals when treating stroke, heart attack and pneumonia patients in emergency departments and, thus, will be more likely to receive bonuses under Medicare's new payment rules, according to a new Northwestern Medicine® study. Though nonprofit and public hospitals are lagging behind in performance, many are making noticeable improvements and also many will be eligible for bonuses, too. The findings give an early look at how hospitals are measuring up under the new, mandatory Hospital Inpatient Value-Based Purchasing ...

Can meditation make you a more compassionate person?

2013-04-01
Scientists have mostly focused on the benefits of meditation for the brain and the body, but a recent study by Northeastern University's David DeSteno, published in Psychological Science, takes a look at what impacts meditation has on interpersonal harmony and compassion. Several religious traditions have suggested that mediation does just that, but there has been no scientific proof—until now. In this study, a team of researchers from Northeastern University and Harvard University examined the effects meditation would have on compassion and virtuous behavior, and ...

Shedding light on early Parkinson's disease pathology

2013-04-01
Amsterdam, NL, April 1, 2013 – In a mouse model of early Parkinson's disease (PD), animals displayed movement deficits, loss of tyrosine-hydroxylase (TH)-positive fibers in the striatum, and astro-gliosis and micro-gliosis in the substantia nigra (SN), without the loss of nigral dopaminergic neurons. These findings, which may cast light on the molecular processes involved in the initial stages of PD, are available in the current issue of Restorative Neurology and Neuroscience. "The most intriguing finding of our study was the lack of a significant decrease of TH levels ...

Over-diagnosis of reflux in infants leads to needless medication

2013-04-01
Ann Arbor, Mich. — Medications used to treat gastroesophageal reflux disease, or GERD, are some of the most widely used medications in children less than one year old. But in a new study, researchers from the University of Michigan and the University of Missouri concluded that physicians often label common symptoms in infants, such as crying and spitting up, as disease. Frequent use of the GERD label can lead to overuse of medication, according to study published today online ahead of print in the journal Pediatrics. The study found that doctors' use of the label GERD ...

Soils in newly forested areas store substantial carbon that could help offset climate change

2013-04-01
ANN ARBOR—Surface appearances can be so misleading: In most forests, the amount of carbon held in soils is substantially greater than the amount contained in the trees themselves. If you're a land manager trying to assess the potential of forests to offset carbon emissions and climate change by soaking up atmospheric carbon and storing it, what's going on beneath the surface is critical. But while scientists can precisely measure and predict the amount of above-ground carbon accumulating in a forest, the details of soil-carbon accounting have been a bit fuzzy. Two ...

Sorting out the structure of a Parkinson's protein

2013-04-01
CAMBRIDGE, MA -- Clumps of proteins that accumulate in brain cells are a hallmark of neurological diseases such as dementia, Parkinson's disease and Alzheimer's disease. Over the past several years, there has been much controversy over the structure of one of those proteins, known as alpha synuclein. MIT computational scientists have now modeled the structure of that protein, most commonly associated with Parkinson's, and found that it can take on either of two proposed states — floppy or rigid. The findings suggest that forcing the protein to switch to the rigid structure, ...

University of Tennessee professor links massive prehistoric bird extinction to human colonization

2013-04-01
Research by a University of Tennessee, Knoxville professor has found that about a thousand bird species became extinct following human colonization. Research by Alison Boyer, a research assistant professor in ecology and evolutionary biology, and an international team studied the extinction rates of nonperching land birds in the Pacific Islands from 700 to 3,500 years ago. Some of the birds studied included birds of prey and ducks. The team uncovered the magnitude of the extinctions and insight into how and why human impacts varied across the region. The findings are ...

African Americans experience longer delay between prostate cancer diagnosis and treatment

2013-04-01
African American men on average wait a week longer than their Caucasian counterparts between the initial diagnosis of prostate cancer and treatment, according to University of North Carolina researchers. The study was published online March 28 in Cancer, the journal of the American Cancer Society, by a team led by Ronald Chen, MD, MPH, assistant professor with the UNC Lineberger Comprehensive Cancer Center. The study is the first published population-based examination of racial disparities in prostate cancer treatment delay. Using data from Medicare patients, Dr. Chen ...

Personalized brain mapping technique preserves function following brain tumor surgery

2013-04-01
PHILADELPHIA - Neurosurgeons can visualize important pathways in the brain using an imaging technique called diffusion tensor imaging (DTI), to better adapt brain tumor surgeries and preserve language, visual and motor function while removing cancerous tissue. In the latest issue of Neurosurgical Focus, researchers from the Perelman School of Medicine at the University of Pennsylvania review research showing that this ability to visualize relevant white matter tracts during glioma resection surgeries can improve accuracy and, in some groups, significantly extend survival ...

Organic labels bias consumers perceptions through the 'health halo effect'

2013-04-01
The word "organic" can mean many things to consumers. Even so, the power of an organic label can be very strong: studies have shown that this simple label can lead us to think that a food is healthier, through what is known as the 'health halo effect'. But can this bias go further? A study by Cornell University's Food and Brand Lab researchers Lee, Shimizu, Kniffin and Wansink set out to answer this question. Their study shows that an organic label can influence much more than health views: perceptions of taste, calories and value can be significantly altered when a food ...

Feeding corn germ to pigs does not affect growth performance

2013-04-01
URBANA - Inclusion of corn germ in swine diets can reduce diet costs, depending on the local cost of corn germ and other ingredients. Recent research conducted at the University of Illinois indicates that corn germ can be included at up to 30 percent in diets fed to growing pigs. "In previous research, we had seen that pigs do very well on diets containing 10 percent corn germ, so we wanted to investigate if higher inclusion rates can be used," said Hans Stein, professor of animal sciences at Illinois. The corn germ used in this study came from the ethanol, or dry grind, ...

Watching fluid flow at nanometer scales

2013-04-01
CAMBRIDGE, MA -- Imagine if you could drink a glass of water just by inserting a solid wire into it and sucking on it as though it were a soda straw. It turns out that if you were tiny enough, that method would work just fine — and wouldn't even require the suction to start. New research carried out at MIT and elsewhere has demonstrated for the first time that when inserted into a pool of liquid, nanowires — wires that are only hundreds of nanometers (billionths of a meter) across — naturally draw the liquid upward in a thin film that coats the surface of the wire. The ...

Prostate cancer risk rises in men with inherited genetic condition

2013-04-01
ANN ARBOR, Mich. — Men with an inherited genetic condition called Lynch syndrome face a higher lifetime risk of developing prostate cancer and appear to develop the disease at an earlier age, according to a new study led by researchers at the University of Michigan Comprehensive Cancer Center. Lynch syndrome is an inherited condition linked to a higher risk of several types of cancer. People with Lynch syndrome have up to 80 percent lifetime risk of colorectal cancer and are also more likely to develop endometrial, gastric, ovarian, urinary tract, pancreatic and brain ...

Mechanism of mutant histone protein in childhood brain cancer revealed

2013-04-01
Most cancer treatments are blunt. In an attempt to eradicate tumors, oncologists often turn to radiation or chemotherapy, which can damage healthy tissue along with the cancerous growths. New research from C. David Allis' laboratory at Rockefeller University may bring scientists closer to designing cancer therapeutics that can target tumors with pinpoint accuracy. Their findings, published last week in Science Express, follow a recent series of discoveries by several international genome sequencing consortiums that directly links a mutated histone protein to a rare brain ...

Electroencephalography underused investigative tool in hospitals

2013-04-01
Rochester, MN, April 1, 2013 – A retrospective study of patients who had in-hospital electroencephalography (EEG) has established that EEG is a valuable tool that could be deployed more widely to identify treatable causes of impaired consciousness in the hospital setting. The study is published in the April issue of the Mayo Clinic Proceedings. Altered mental status (AMS) and paroxysmal spells of uncertain origin are common among hospitalized patients. Impaired consciousness can sometimes be linked to metabolic or cardiac causes, but some of these spells may represent ...

Mayo Clinic: New multiple myeloma treatment guidelines personalize therapy for patients

2013-04-01
ROCHESTER, Minn. -- Researchers at Mayo Clinic Cancer Center have developed new guidelines to treat recently diagnosed multiple myeloma patients who are not participating in clinical trials. The guidelines give physicians practical, easy to follow recommendations for providing initial therapy, stem cell transplant and maintenance therapy. The guidelines are published in the current issue of the journal Mayo Clinic Proceedings and represent a consensus opinion of hematologists at Mayo Clinic Cancer Center sites in Minnesota, Florida and Arizona. "Multiple myeloma is an ...

Research deciphers HIV attack plan

2013-04-01
LOS ALAMOS, N. M., March 29, 2013—A new study by Los Alamos National Laboratory and University of Pennsylvania scientists defines previously unknown properties of transmitted HIV-1, the virus that causes AIDS. The viruses that successfully pass from a chronically infected person to a new individual are both remarkably resistant to a powerful initial human immune-response mechanism, and they are blanketed in a greater amount of envelope protein that helps them access and enter host cells. These findings will help inform vaccine design and interpretation of vaccine trials, ...
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