A simple screening test of musculo-skeletal fitness has proved remarkably predictive of all-cause mortality in a study of more than 2000 middle-aged and older men and women. The study, performed in Brazil by Dr Claudio Gil Araújo and colleagues at the Clinimex - Exercise Medicine Clinic in Rio de Janeiro, is reported today in the European Journal of Cardiovascular Prevention.(1,2) The test was a simple assessment of the subjects' ability to sit and then rise unaided from the floor. The assessment was performed in 2002 adults of both sexes and with ages ranging from 51 ...

PHILADELPHIA — A novel approach to identifying potential anticancer drug combinations revealed that pairing cholesterol-reducing drugs called statins with cyclin-dependent kinase inhibitors might provide an effective approach to treating intractable melanomas driven by mutations in the NRAS and KRAS gene. David F. Stern, Ph.D., professor of pathology at Yale University School of Medicine in New Haven, Conn., and colleagues reported these data in Cancer Discovery, a journal of the American Association for Cancer Research. "The identification of gene mutations that ...

Scientists have isolated cancer stem cells that lead to the growth of Wilms' tumours, a type of cancer typically found in the kidneys of young children. The researchers have used these cancer stem cells to test a new therapeutic approach that one day might be used to treat some of the more aggressive types of this disease. The results are published online in EMBO Molecular Medicine. "In earlier studies, cancer stem cells were isolated from adult cancers of the breast, pancreas and brain but so far much less is known about stem cells in paediatric cancers," remarked Professor ...

A type of immune cell found in the small intestine plays a previously unsuspected role in monitoring antigens circulating in the bloodstream. The findings from a team of Massachusetts General Hospital (MGH) researchers clarify how dendritic cells in the intestinal lining collect antigens from both intestinal contents and the circulation, leading to the generation of T cells that suppress inflammation. Disruption of that regulatory system may lead to the development of autoimmune disorders, inflammatory bowel disease or food allergies. "In the circuitry we uncovered, ...

Thursday, December 13, 2012, Cleveland: Cleveland Clinic researchers from the Lerner Research Institute have uncovered two new genes associated with Cowden syndrome (CS) according to a new study, published today in the online version of the American Journal of Human Genetics. Cowden syndrome is a difficult-to-recognize, under-diagnosed condition that carries high risks of breast, thyroid, and other cancers. The discovery of the two new genes – led by Charis Eng, MD, Ph.D., Chair and Founding Director of the Cleveland Clinic's Lerner Research Institute's Genomic Medicine ...

LONDON – Globally, health advances present most people with a devastating irony: avoid premature death but live longer and sicker. That's one of the main findings from the Global Burden of Disease Study 2010 (GBD 2010), a collaborative project led by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. The findings are being announced at the Royal Society in London on Dec. 14 and published in The Lancet, the first time the journal has dedicated an entire triple issue to one study. The seven scientific papers and accompanying commentaries ...

Over 9 million people died as a consequence of high blood pressure in 2010, making it the health risk factor with the greatest toll worldwide, say experts. Smoking and alcohol use have also overtaken child hunger in the last two decades to become the second and third leading risks globally, according to a study estimating the disease burden attributable to 43 risk factors in 1990 and 2010. The analysis was undertaken by an international consortium of scientists as part of the Global Burden of Disease Study 2010, which is published in The Lancet today. "Overall we're ...

Boston, MA — No matter where they live, how much education they have, or what their incomes are, people have very similar perceptions on the impact of diseases and injuries. This finding – counter to the prevailing belief that people throughout the world view different health conditions in very different ways depending on their culture or individual circumstances – is part of a collaborative project, the Global Burden of Disease Study 2010 (GBD 2010). GBD 2010, launched by Harvard School of Public Health (HSPH), the Institute for Health Metrics and Evaluation (IHME) ...

Scientists have discovered new evidence about the evolution of viruses, in work that will change our understanding about the control of infectious diseases such as winter flu. Researchers at the University of Exeter's conducted experiments to manipulate a virus to see if it could evolve the ability to switch its behaviour according to how many other viruses infect a host. Previous research has focussed on trying to force harmful microbes to become less threatening to human health as they evolve. But the new research, which was carried out in collaboration with the ...

New York, NY, December 13, 2012— Despite important progress in research and development (R&D) for global health over the past decade, only a small fraction of new medicines developed between 2000 and 2011 were for the treatment of neglected diseases, highlighting the 'fatal imbalance' between global disease burden and drug development for some of the world most devastating illnesses, said Doctors Without Borders/Médecins Sans Frontières (MSF) and the Drugs for Neglected Diseases initiative (DNDi), in an analysis to be presented today at an international conference aimed ...

Mountain View, Calif. – December 13, 2012 -- 23andMe, the leading personal genetics company, today announced the availability of Ancestry Composition, a new feature that provides state-of-the-art geographic illustration of an individual's ancestral origins. Using 22 reference populations, the feature indicates what percent of a person's ancestry comes from various regions around the world. The analysis includes DNA inherited from all ancestors on both sides of the family. The results reflect where an individual's ancestors lived going back approximately 500 years. Ancestry ...

Scientists have identified a new mutation in the gene that causes the inherited disease known as Alpha-1 Antitrypsin Deficiency (Alpha-1), which affects roughly one in 2,500 people of European descent. Alpha-1 can lead to serious lung disease in adults, or liver disease at any age. The finding extends understanding of Alpha-1 at the molecular level, potentially leading to new drug development and better diagnostic tools. Dr Darren Saunders from Sydney's Garvan Institute of Medical Research and Professor Vanessa Hayes, from the J. Craig Venter Institute in San Diego, ...

Primary sources publisher, Adam Matthew, has announced the release of the fourth section of its highly renowned Victorian Popular Culture Portal. "Moving Pictures, Optical Entertainments and the Advent of Cinema" explores the cultural history of optical entertainments from the late 18th century to the early 20th century, bringing to life the rich cultural and scientific history from which cinema was born. From shadow puppets to dioramas, and from zoetropes to Hollywood, the long and varied evolution of visual entertainments is represented through objects, ephemera and ...

MAMMALS could be at a greater risk of extinction due to predicted increases in extreme weather conditions, states a paper published today by the Zoological Society of London (ZSL). Scientists have mapped out land mammal populations, and overlapped this with information of where droughts and cyclones are most likely to occur. This allowed them to identify species at high risk of exposure to extreme weather. The paper, published this week in the journal Conservation Letters, describes the results of assessing almost six thousand species of land mammals in this way. Lead ...

A hearing system component thought to be unique in toothed whales like dolphins has been discovered in insects, following research involving the University of Strathclyde. The research is challenging ideas about how a large group of insects including crickets and katydids hear, revealing the unexpected similarity to toothed whale hearing. Scientists from the School of Biological Sciences at The University of Auckland, with colleagues from Plant & Food Research in New Zealand, led the research with engineers from the University of Strathclyde working on the biomechanical ...

An anesthetic regimen typically used during surgery on pregnant mothers appears to have a negative effect on the development of the fetus, according to a new study on mice conducted by neurobiologists from the National Center for Toxicological Research, in Arizona. In the article 'Inhalation Anesthesia-Induced Neuronal Damage and Gene Expression Changes in Developing Rat Brain' published earlier this month in Systems Pharmacology, an open access journal by Versita – Dr. Fang Liu and Dr. Cheng Wang describe the effect of major, commonly used anesthetic compounds – Nitrous ...

Scientists have developed a new method for studying parasite numbers in the stomachs of individual seabirds in the wild. The technique enables the recording of video footage of worms inside seabird stomachs and is an important step forward in understanding the impact of parasites on seabird populations. The research is published today (13 December 2012) in the scientific journal Methods in Ecology and Evolution. The research team trialled the use of endoscopy, often used in human and veterinary medicine but rarely in field situations, to measure natural parasite loads, ...

Labour conditions, the amount of hours and working during the morning are the factors that most negatively affect the academic development of children who work. Using data from the 'Edúcame primero Colombia' Project ('Educate me first Colombia' in Spanish), a group of researchers in which the University of Seville participates has confirmed the incompatibility between studying and child labour. The International Labour Organisation states that, in 2010, approximately 215 million children across the world were working. This figure has been progressively decreasing in ...

More than two hundred gene locations have now been identified for the chronic bowel condition Crohn's Disease, in a study that analysed the entire human genome. Published today in The American Journal of Human Genetics, scientists at UCL have devised a new method for identifying and mapping gene locations for complex inherited diseases. Using this method, they have been able to identify a large number of additional genes for Crohn's Disease, making a total of more than 200, which is more than have been found for any other disease. For example, there are just 66 known ...

Philadelphia, Pa. (December 13, 2012) – Analysis of media portrayals of nursing homes finds that negative stories outnumber positive stories by five to one, reports a study in the December issue of Medical Care. The journal is published by Lippincott Williams & Wilkins, a part ofWolters Kluwer Health. Negative news coverage of nursing homes may shape public perceptions and consumer care choices, suggest Edward Alan Miller, PhD, MPA, of University of Massachusetts Boston and Denise A. Tyler, PhD, of Brown University. They write, "Our findings suggest that negative reporting ...

Randomly distributed sticky spots which are integral to the development of stem cells by maximising adhesion and acting as internal scaffolding have been artificially recreated by experts from the University of Sheffield for the first time. Using synthetic foam type materials to mimic the natural process – known as the extracellular matrix or ECM – scientists, from the University of Sheffield and University of California San Diego, created the random stickiness required for stem cells to properly adhere. The findings will better inform researchers across the world of ...

WASHINGTON, DC, December 13, 2012 — Three University of Kentucky (UK) sociologists have co-authored a study that helps to fill a gap in our understanding of suicide risk among African-American women. Appearing in the December issue of Social Psychology Quarterly (SPQ), the study, "Too Much of a Good Thing? Psychosocial Resources, Gendered Racism, and Suicidal Ideation among Low Socioeconomic Status African American Women," examines the relationship between racial and gender discrimination and suicidal ideation, or thinking about and desiring to commit suicide. The co-authors ...

PITTSBURGH—What is everyone looking at? It's a common question in social settings because the answer identifies something of interest, or helps delineate social groupings. Those insights someday will be essential for robots designed to interact with humans, so researchers at Carnegie Mellon University's Robotics Institute have developed a method for detecting where people's gazes intersect. The researchers tested the method using groups of people with head-mounted video cameras. By noting where their gazes converged in three-dimensional space, the researchers could determine ...

Their review is published online in the Springer publication, Psychonomic Bulletin and Review. A certain amount of mental deterioration is expected with advancing age. However, this may not necessarily have to be the case as particular aspects of cognitive function such as task switching, selective attention and working memory among others, all appear to benefit from aerobic exercise. Studies in older adults reviewed by the authors consistently found that fitter individuals scored better in mental tests than their unfit peers. In addition, intervention studies found scores ...

Wrinkles, dryness, and a translucent and fragile appearance are hallmarks of old skin, caused by the natural aging of skin cells. But while most of us can recognize the signs of lost youth when we peer into the mirror each morning, scientists do not have a standardized way to measure the extent of age damage in skin. Now a group of Taiwanese researchers has used a specialized microscope to peer harmlessly beneath the skin surface to measure natural age-related changes in the sizes of skin cells. The results, which are published in the Optical Society's (OSA) open-access ...