A gut feeling about neural stem cells Proper function of the digestive system requires coordinated contraction of the muscle in the wall of the intestinal tract, regulated by the enteric nervous system. Damage or loss of these neurons can result in intestinal motility disorders, such as Hirschsprung's disease, for which there is a dearth of effective treatments. In principle, disorders of the enteric nervous system could be treated by cell therapy, but it was previously unknown whether transplanted stem cells could migrate to the appropriate location in the gut and then ...

On April 14, 2003 a map of the human genome was completed, ushering in a new era of genetics in medicine with applications that include genetic testing; newborn screening; susceptibility to diseases such as cancer, cardiovascular disease, or psychiatric conditions; screening, diagnosis and monitoring of disease; and treatment planning. A special Genomics Issue, including an evidence review by researchers from the National Institutes of Health (NIH), published by Wiley in the Journal of Nursing Scholarship on behalf of the Honor Society of Nursing, Sigma Theta Tau International, ...

(SACRAMENTO, Calif.) ― A study of more than 12,000 children from emergency departments throughout the country in the Pediatric Emergency Care Applied Research Network (PECARN) has identified seven factors that can help physicians determine the need for a computed tomography (CT) scan following blunt trauma to the abdomen. Because CT scans pose radiation hazards for youngsters, the findings may enable doctors to determine which children do not need to be exposed to such tests after a traumatic injury. The study, titled "Identifying children at very low risk of clinically ...

Alexandria, VA — Cartilage tympanoplasty can be performed successfully in 95 percent of young children when appropriate conditions exist, according to a study in the February 2013 issue of Otolaryngology–Head and Neck Surgery. "Pediatric tympanoplasty is a frequently performed procedure with varying reported success rates ranging between 35 percent and 94 percent. In general, tympanic membrane repair success in children is often perceived as lagging behind what is typically achieved in adults having similar underlying risk factors," the authors write. The study was ...

Bethesda, MD—Smoking tobacco might be bad for your health, but a genetically altered version of the plant might provide a relatively inexpensive cure for the deadly rabies virus. In a new research report appearing in The FASEB Journal, scientists produced a monoclonal antibody in transgenic tobacco plants that was shown to neutralize the rabies virus. This new antibody works by preventing the virus from attaching to nerve endings around the bite site and keeps the virus from traveling to the brain. "Rabies continues to kill many thousands of people throughout the developing ...

(Boston) – In a study of communities in Massachusetts with high numbers of opioid overdose deaths, the implementation of overdose education and naloxone distribution (OEND) was associated with a significant reduction in opioid overdose death rates. Led by researchers at Boston Medical Center (BMC), Boston University Schools of Medicine (BUSM) and Public Health (BUSPH) in collaboration with the Massachusetts Department of Public Health (MDPH) and published in the British Medical Journal (BMJ), this study provides observational evidence that OEND is an effective public health ...

According to a study in the January issue of the Journal of the American College of Radiology, the use of volume-modulated arc therapy (VMAT) to deliver intensity-modulated radiation therapy (IMRT) to prostate cancer patients results in an overall reduction in treatment time of approximately 14 percent. The study was performed at Winship Cancer Institute of Emory University in Atlanta. Treatment with IMRT is increasingly standard for prostate cancer. However, although the benefits of IMRT in the treatment of prostate cancer are ample, it remains a complex and time-consuming ...

A worldwide review of global rainfall data led by the University of Adelaide has found that the intensity of the most extreme rainfall events is increasing across the globe as temperatures rise. In the most comprehensive review of changes to extreme rainfall ever undertaken, researchers evaluated the association between extreme rainfall and atmospheric temperatures at more than 8000 weather gauging stations around the world. Lead author Dr Seth Westra said, "The results are that rainfall extremes are increasing on average globally. They show that there is a 7% increase ...

URBANA – Increased levels of greenhouse gases, particularly carbon dioxide (CO2), have been associated with the burning of fossil fuels, deforestation, cultivation of grasslands, drainage of the land, and land use changes. Concerns about long-term shifts in climate patterns have led scientists to measure soil organic carbon (SOC) in agricultural landscapes and to develop methods to evaluate how changes in tillage practices affect atmospheric carbon sequestration. University of Illinois professor of soil science Kenneth Olson has used data collected over a 20-year period ...

Theoretical physicist Moumita Maiti and colleagues at the Jawaharlal Nehru Centre for Advanced Scientific Research in Bangalore, India, have now implemented an algorithm for analysing void space in sphere packing, where the spheres need not all be the same size. This method, about to be published in EPJ E, could be applied to analyse the geometry of liquids present between multi-sized spheres that are akin to a model for porous material. This provides a tool for studying the flow of such fluids through porous material. More importantly, it can also be used to study the ...

Coral reefs are predicted to decline under the pressure of global warming. However, a number of coral species can survive at seawater temperatures even higher than predicted for the tropics during the next century. How they survive, while most species cannot, is being investigated by researchers at the National Oceanography Centre, Southampton (NOCS) and New York University Abu Dhabi (NYUAD). We tend to associate coral reefs with tropical seas of around 28 degrees, where even slight warming can have devastating effects on corals. But in the Arabian/Persian Gulf, corals ...

January 31, 2013 - At the HiPEAC 2013 conference in Berlin, KALRAY demonstrated MPPA256, the world's first supercomputer-on-a-chip, consisting of 256 computing cores. This innovative processor combines the ultimate in several processor types and will enable a whole new class of embedded and industrial applications in the fields of image processing, signal processing, control, communications and data security. The MPPA256 is completely designed in Europe and is only one of the success stories resulting from the 170 million Euro investment in carefully selected European funded ...

A new way of growing graphene without the defects that weaken it and prevent electrons from flowing freely within it could open the way to large-scale manufacturing of graphene-based devices with applications in fields such as electronics, energy, and healthcare. A team led by Oxford University scientists has overcome a key problem of growing graphene – a one atom-thick layer of carbon – when using an established technique called chemical vapour deposition, that the tiny flakes of graphene form with random orientations, leaving defects or 'seams' between flakes that ...

Washington, DC, February 1, 2013 – There is general agreement among hospital infection preventionists (IPs) with respect to which practices have weak or strong evidence supporting their use to prevent healthcare-associated infection, according to a new study published in the February issue of the American Journal of Infection Control, the official publication of the Association for Professionals in Infection Control and Epidemiology (APIC). Furthermore, IPs with certification in infection prevention and control (CIC®) are two to three times more likely to perceive the ...

Boston - A study by researchers at the Institute for Aging Research (IFAR) at Hebrew SeniorLife, an affiliate of Harvard Medical School (HMS), has found that dairy intake —specifically milk and yogurt —is associated with higher bone mineral density (BMD) in the hip, but not the spine. Cream, on the other hand, may be associated with lower BMD overall. Published today in the journal Archives of Osteoporosis, these findings suggest that not all dairy products are equally beneficial in promoting bone strength. "Dairy foods provide several important nutrients that are beneficial ...

Philadelphia, PA, February 1, 2013 – Poor impulse control contributes to one's inability to control the consumption of rewarding substances, like food, alcohol, and other drugs. This can lead to the development of addiction. FDA-approved medications for alcoholism, like naltrexone (Revia) and disulfiram (Antabuse), are thought to reduce alcohol consumption by curbing cravings and creating unpleasant reactions to alcohol, effects which reduce the desire to drink alcohol. New medications, however, might target the uncontrollable urges to consume drugs of abuse. The idea ...

In a project that began with the retinal cells of nocturnal animals and has led to fundamental insights into the organization of genomic DNA, researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich show how the nuclear envelope affects nuclear architecture - and gene regulation. The double-stranded DNA molecules that make up the genetic material are wrapped around protein complexes to form compacted "chromatin". The active portion of the genome is less densely packed, and thus more easily accessible, than the inactive fraction, and is referred to as euchromatin. ...

We've all heard examples of animal altruism: Dogs caring for orphaned kittens, chimps sharing food or dolphins nudging injured mates to the surface. Now, a study led by the University of Colorado Boulder suggests some plants are altruistic too. The researchers looked at corn, in which each fertilized seed contained two "siblings" -- an embryo and a corresponding bit of tissue known as endosperm that feeds the embryo as the seed grows, said CU-Boulder Professor Pamela Diggle. They compared the growth and behavior of the embryos and endosperm in seeds sharing the same mother ...

Highlights African Americans and individuals without private health insurance are less likely to receive a kidney transplant before needing dialysis. Geographic region is not a major factor in determining whether a patient receives a kidney transplant before starting dialysis. Nearly 90,000 people in the U.S. are waiting for a kidney transplant, and many will die before a suitable organ becomes available. Washington, DC (January 31, 2013) — African-Americans and individuals without private health insurance are less likely than others to receive a kidney transplant ...

People having an ischemic stroke should receive clot-dissolving therapy – if appropriate -- within 60 minutes of arriving at the hospital, according to new American Stroke Association guidelines published in the American Heart Association journal Stroke. Ischemic stroke, which accounts for nine in 10 strokes, is caused by a blood clot in the arteries leading to the brain. Calling 9-1-1 immediately after recognizing any of the warning signs of stroke -- and getting to a stroke center as fast as possible -- are still the most important steps for optimal stroke care. During ...

A relatively inexpensive program set up to combat river blindness, an infectious disease, has resulted in major health improvements in Africa, shows a study conducted by Erasmus University Medical Center researchers. The study, due to be published January 31 in PLOS Neglected Tropical Diseases, shows that US$250 million helped cure or prevent blindness, skin disease, severe itching, and other symptoms in millions of people. In collaboration with the Management of the African Programme for Onchocerciasis Control (APOC), the researchers calculated the health impact of APOC. Onchocerciasis, ...

DARIEN, IL – A new study found a high prevalence of sleep disorders and a startlingly high rate of short sleep duration among active duty military personnel. The study suggests the need for a cultural change toward appropriate sleep practices throughout the military. "While sleep deprivation is part of the military culture, the high prevalence of short sleep duration in military personnel with sleep disorders was surprising," said Vincent Mysliwiec, MD, the study's principal investigator, lead author and chief of Pulmonary, Critical Care and Sleep Medicine at Madigan ...

SALT LAKE CITY, Jan. 31, 2013 – University of Utah researchers decoded the genetic blueprint of the rock pigeon, unlocking secrets about pigeons' Middle East origins, feral pigeons' kinship with escaped racing birds, and how mutations give pigeons traits like a fancy feather hairdo known as a head crest. "Birds are a huge part of life on Earth, and we know surprisingly little about their genetics," especially compared with mammals and fish, says Michael D. Shapiro, one of the study's two principal authors and an assistant professor of biology at the University of ...

New York University physicists have developed a method for moving microscopic particles with the flick of a light switch. Their work, reported in the journal Science, relies on a blue light to prompt colloids to move and then assemble—much like birds flock and move together in flight. The method offers the potential to enhance the design of a range of industrial products, including the architecture of electronics. The study's authors were: Jeremie Palacci and Stefano Sacanna, post-doctoral fellows in NYU's Center for Soft Matter Research who devised the research; ...

Medical illustrators and neurological imaging experts at Johns Hopkins have figured out how night-hunting owls can almost fully rotate their heads - by as much as 270 degrees in either direction - without damaging the delicate blood vessels in their necks and heads, and without cutting off blood supply to their brains. In what may be the first use of angiography, CT scans and medical illustrations to examine the anatomy of a dozen of the big-eyed birds, the Johns Hopkins team, led by medical illustrator Fabian de Kok-Mercado, M.A., a recent graduate student in the Department ...