KNOXVILLE—Despite overwhelming evidence about the benefits of physical activity for children, most American youngsters are not meeting the federal recommendation of 60 minutes a day. A new study by a team of University of Tennessee researchers has identified specific ways—and estimated minutes for each approach—that can help children achieve the recommended daily physical activity goal. The results of various approaches, ranging from mandatory physical education in school to changes in playground designs, were published recently in the American Journal of Preventive ...

KANSAS CITY, MO—A seemingly obscure gene in the female fruit fly that is only active in cells that will become eggs has led researchers at the Stowers Institute for Medical Research to the discovery of a atypical protein that lures, traps, and inactivates the powerful Polo kinase, widely considered the master regulator of cell division. Its human homolog, Polo-like kinase-1 (Plk1), is misregulated in many types of cancer. Stowers Investigator and senior author R. Scott Hawley, Ph.D., hopes that this highly selective kinase trap might give drug developers, who are working ...

Substantial regional variation in Medicare spending for patients with advanced cancer is not linked to differences in survival, according to a study published March 12 in the Journal of the National Cancer Institute. Cancer care accounts for approximately 10% of Medicare spending, and costs are highest for cancer patients with late-stage disease. Prior research studies have shown that there are large regional differences in spending within the Medicare program, however it is unknown if higher average regional spending for advanced cancer is linked to improved survival ...

SAN DIEGO – Brain imaging soon after mild traumatic brain injury (mTBI) or mild concussion can detect tiny lesions that may eventually provide a target for treating people with mTBI, according to a study released today and that will be presented at the American Academy of Neurology's 65th Annual Meeting in San Diego, March 16 to 23, 2013. Studies of brain tissue once a person has died have shown that different types of lesions are associated with more severe TBI. "Our study suggests that imaging may be used to detect and distinguish between these lesions in a living ...

An HIV prevention strategy in which people at risk of becoming exposed to HIV take antiretroviral drugs to reduce their chance of becoming infected (often referred to as pre-exposure prophylaxis or PrEP), may be a cost-effective method of preventing HIV in some settings, according to a study by international researchers published in this week's PLOS Medicine. In an analysis of 13 modelling studies led by Gabriela Gomez from the Department of Global Health, Academic Medical Centre, University of Amsterdam/AIGHD in The Netherlands, the authors evaluated the impact of pre-exposure ...

A study published this week in PLOS Medicine finds that while antipsychotic medications are associated with small-to-moderate improvements in depressive symptoms in adults, there is little evidence for improvement on measures of quality of life and these medications are linked to adverse events such as weight gain and sedation. The results of the study, conducted by Glen Spielmans of Metropolitan State University in St. Paul, Minnesota and colleagues, have potential implications for the treatment of depression by providing clinicians with a better understanding of the ...

Participant-led research, such as studies conducted via social networks, are increasingly common and have several advantages over more standard research but there are some concerns about their ethical oversight, according to experts writing in this week's PLOS Medicine. Effy Vayena from the University of Zurich in Switzerland and John Tasioulas from University College London argue that the distinctive nature of such participant-led research means that the standards of ethical oversight should be adapted to strike a balance between protecting the interests of research ...

In low-income countries a substantial challenge in planning and delivering healthcare is the accurate assessment of disease burden. In this week's PLOS Medicine, Miguel SanJoaquin from the University of Malawi College of Medicine and colleagues describe their experience of implementing an electronic patient record system in a large referral hospital in southern Malawi. The system, known as Surveillance Programme of IN-patients and Epidemiology (SPINE), is used to record patient details during consultations and this data can be used to monitor changing patterns of disease ...

In laboratory studies, Johns Hopkins researchers say they have found that stem cells from a patient's own fat may have the potential to deliver new treatments directly into the brain after the surgical removal of a glioblastoma, the most common and aggressive form of brain tumor. The investigators say so-called mesenchymal stem cells (MSCs) have an unexplained ability to seek out damaged cells, such as those involved in cancer, and may provide clinicians a new tool for accessing difficult-to-reach parts of the brain where cancer cells can hide and proliferate anew. The ...

Among adults without diabetes, quitting smoking, compared with continuing smoking, was associated with a lower risk of cardiovascular disease despite subsequent weight gain, according to a study appearing in the March 13 issue of JAMA. "Cigarette smoking is the leading cause of preventable mortality in the United States and a major risk factor for cardiovascular disease (CVD). Smoking cessation substantially reduces the risks of CVD; however, quitting smoking is associated with a small number of adverse health consequences, weight gain being one of smokers' major concerns," ...

In research that included nearly 14,000 healthy infants in Belarus, an intervention that succeeded in improving the duration and exclusivity of breastfeeding during infancy did not result in a lower risk of overweight or obesity among the children at age 11.5 years, according to a study appearing in the March 13 issue of JAMA. Observational studies suggest that greater duration and exclusivity of having been breastfed reduces child obesity risk. "However, breastfeeding and growth are socially patterned in many settings," and observed associations between these variables ...

Among patients who were identified as likely having moderate to severe obstructive sleep apnea, treatment based in primary care was not clinically inferior to treatment at a specialist sleep center for improvement in daytime sleepiness scores, according to a study appearing in the March 13 issue of JAMA. "Obstructive sleep apnea with accompanying daytime sleepiness was estimated during the early 1990s to affect between 2 percent and 4 percent of middle-aged adults. With growing awareness of the public health implications of untreated disease and rising obesity rates ...

In a study that included 3.3 million percutaneous coronary intervention (PCI; procedures such as balloon angioplasty or stent placement used to open narrowed coronary arteries) procedures, major bleeding after PCI was associated with significantly increased in-hospital mortality, with an estimated 12 percent of deaths after PCI related to bleeding complications, according to a study appearing in the March 13 issue of JAMA. "Bleeding represents the most common noncardiac complication of PCI. Postprocedural bleeding is associated with short- and long-term death, nonfatal ...

An analysis of data from the Framingham Offspring Study – a long-term study that follows children of participants in the original Framingham Heart Study – may have answered a question that has troubled individuals considering stopping smoking: do the health effects of any weight gained after quitting outweigh the known cardiovascular benefits of smoking cessation? The report in the March 13 issue of JAMA concludes that the benefits of stopping smoking far exceed any weight-gain associated risk. "Among people without diabetes, those who stopped smoking had a 50 percent ...

The first randomised trial to compare treatments for ectopic pregnancies has found no significant differences in subsequent fertility between medical treatment and conservative surgery on one hand, and conservative or radical surgery on the other. The study, which is published online today (Wednesday) in Europe's leading reproductive medicine journal Human Reproduction [1], compared three ways of treating an ectopic pregnancy: medically by methotrexate injection to interrupt pregnancy in the Fallopian tube; conservative surgery, which preserves the Fallopian tube (known ...

It is estimated that there are 10 million cases of traumatic brain injury globally every year with mild traumatic brain injuries being responsible for 70-90% of these. Incidence is highest among young males. Current literature suggests that mild traumatic brain injuries cause changes in brain tissues and have important long-term consequences on cognitive function. Deficits have been described in attention, memory, verbal learning and processing speed and may occur in 15-25% of those suffering one of these injuries. However, little is known about population-wide cognitive ...

When Gulf of Mexico algae don't get enough nutrients, they focus their remaining energy on becoming more and more poisonous to ensure their survival, according to a new study by scientists from North Carolina State University and the National Oceanic and Atmospheric Administration. The study shows that harmful and ubiquitous Karenia brevis algae, which cause red tide blooms across the Gulf of Mexico, become two to seven times more toxic when levels of phosphorus, a major algal nutrient found in fertilizers and human waste, are low. Like wearing a suit of armor, producing ...

Citizen science surveys compare well with traditional scientific methods when it comes to monitoring species biodiversity – according to new research from the University of East Anglia. Research published today in the journal Methods in Ecology and Evolution shows that methods to record marine diversity used by amateurs returned results consistent with techniques favoured by peer-reviewed science. The findings give weight to the growing phenomenon of citizen science, which sees data crowd-sourced from an army of avid twitchers, divers, walkers and other wildlife enthusiasts. ...

Children as young as 3 years old know when they are not sure about a decision, and can use that uncertainty to guide decision making, according to new research from the Center for Mind and Brain at the University of California, Davis. "There is behavioral evidence that they can do this, but the literature has assumed that until late preschool, children cannot introspect and make a decision based on that introspection," said Simona Ghetti, professor of psychology at UC Davis and co-author of the study with graduate student Kristen Lyons, now an assistant professor at Metropolitan ...

Mouse model studies show that administered genetically or topically, protein Smad7 protects against or heals mouth sores commonly associated with cancer treatment. In some cancer patients treated with radiation, the mouth sores known as oral mucositis become so severe that feeding tubes are required for nutrition and narcotics are needed for pain. In fact, 40-70 percent of patients treated with upper-body radiation develop the condition to some degree. Currently, there is no FDA approved treatment. A University of Colorado Cancer Center study published this week in the ...

PROVIDENCE, R.I. [Brown University] — As Kenyan citizens negotiated the tensions following the March 4 nationwide elections, memories of the violence that followed the December 2007 vote weighed heavily for many reasons. Among those in any nation with an HIV epidemic, argue authors of a new paper in AIDS Reviews, should be the long-term damage that political conflict can do to public health by disrupting treatment and thereby promoting resistance to antiretroviral drugs and treatment failure. "It's the long-term consequences that make this a bigger issue," said lead author ...

AUGUSTA, Ga. – A guidance cue that helps kidneys form may also be a red flag that they are in danger, researchers report. Acute kidney injury, a common and serious complication of hospitalization, is on the increase worldwide, affecting an estimated 6 percent of all hospitalized patients and 30-40 percent of adults and children having cardiopulmonary bypass surgery. About 10-15 percent of acute injuries translate to chronic kidney damage or failure that may require dialysis or a kidney transplant, said Dr. Ganesan Ramesh, kidney pathologist in the Vascular Biology ...

Dog-strangling vine (Vincetoxicum rossicum) is an exotic plant originating from the Ukraine and southeastern Russia that is becoming increasingly invasive in southern Ontario, Canada. It has been found growing successfully in both disturbed and undisturbed areas, in open fields, forest edges and understories, parks, road edges and railway embankments. The invasive plant effectively competes for light by forming large and dense stands that climb over other plants. A study published in the open access, peer-reviewed journal NeoBiota explores the effects of V. rossicum invasion ...

The Orinoco River flows from the Andes in Colombia to the Atlantic in Venezuela. The area of the basin includes landscapes of the Andes, plains of the Llanos and the Guiana shield. Orinoco's tributary rivers form a basin considered to be the 3rd most important river system on the planet, and one of the most biologically diverse areas of the world. Colombia has shown a strong commitment to the achievement of the Convention on Biological Diversity's 2010 biodiversity target, by promoting the conservation of at least 10% of its natural ecosystems. Protected Area categories ...

PASADENA, Calif.—Thanks to a new high-tech gadget, astronomers have observed four planets orbiting a star relatively close to the sun in unprecedented detail, revealing the roughly ten-Jupiter-mass planets to be among the most exotic ones known. The team, which includes several researchers from the California Institute of Technology (Caltech), describes its findings in a paper accepted for publication by the Astrophysical Journal. The findings were made possible by a first-of-its-kind telescope imaging system that allowed the astronomers to pick out the planets amidst ...