Tiny particles filled with a drug could be a new tool for treating cancer in the future. A new study published by Swedish scientists in Particle & Particle Systems Characterization shows how such nanoparticles can be combined to secure the effective delivery of cancer drugs to tumour cells – and how they can be given properties to make them visible in MR scanners and thus rendered trackable. The team, which consisted of scientists from Karolinska Institutet (KI) and the Royal Institute of Technology (KTH) in Stockholm, and from Chalmers University of Technology in Gothenburg, ...

PASADENA, Calif., Feb. 27, 2013 – Patients with diabetes who undergo total knee replacement surgery do not have increased risk of surgical complications compared to those patients without diabetes, according to a Kaiser Permanente study published today in The Journal of Bone and Joint Surgery. Researchers studied the electronic health records of more than 40,000 patients who had a first-time knee replacement from January 1, 2001 through December 31, 2009. Of the patients studied, 12.5 percent had controlled diabetes, 6.2 percent had uncontrolled diabetes and 81.3 percent ...

Researchers at IDIBELL and CIBERER Virginia Nunes and Miguel López de Heredia have collected data from 400 patients with Wolfram syndrome published worldwide in the last fifteen years to better understand the natural history of disease. The findings lead them to propose a revision of the diagnostic criteria of the disease because 15% of paediatric patients escape from diagnosis. The results of this review have been published this week in the online edition of the journal Genetics in Medicine to coincide with the World Day of rare diseases, on February 28th. These rare ...

CSIC researcher Maxi San Miguel, director of the Institute for Cross-Disciplinary Physics and Complex Systems (IFISC), a joint research Institute of CSIC and the University of the Balearic Islands, explains: "We say there is a conflict when there is an unusual high number of editing and corrections in articles related to some topic or personage on which there are very divergent or polarised opinions. Our model identifies the different types of behaviours according to two main parameters: the reposition rate of editors as time goes by; and the level of tolerance, that is, ...

A new model suggests that inhospitable hydrodgen-sulphide rich waters could have delayed the spread of complex life forms in ancient oceans. The research, published online this week in the journal Nature Communications, considers the composition of the oceans 550-700 million years ago and shows that oxygen-poor toxic conditions, which may have delayed the establishment of complex life, were controlled by the biological availability of nitrogen. In contrast to modern oceans, data from ancient rocks indicates that the deep oceans of the early Earth contained little oxygen, ...

Tel Aviv — In addition to struggling in school, many learning disabled children are known to face social and emotional challenges including depression, anxiety, and isolation. Often beginning early in childhood, they become more pronounced during adolescence, an emotionally turbulent time. For these youngsters, more positive relationships with the significant adults in their lives — including parents and teachers — can improve learning and "socioemotional" experiences, says Dr. Michal Al-Yagon of Tel Aviv University's Jaime and Joan Constantiner School of Education. In ...

The study(*) has enabled scientists to develop a new model that will allow agricultural landholders to determine and improve their climate balance. As part of the study, scientists investigated 40 organic and 40 conventional agricultural holdings across Germany's four agricultural regions. They focused exclusively on crop and dairy farms. The scientists recorded all relevant climate gas streams during the entire production process, including methane, nitrous oxide and carbon dioxide. In the case of dairy farms, they also factored in the purchase of soybean meal from ...

About St. Michael's Hospital St. Michael's Hospital provides compassionate care to all who enter its doors. The hospital also provides outstanding medical education to future health care professionals in more than 23 academic disciplines. Critical care and trauma, heart disease, neurosurgery, diabetes, cancer care, and care of the homeless are among the hospital's recognized areas of expertise. Through the Keenan Research Centre and the Li Ka Shing International Healthcare Education Center, which make up the Li Ka Shing Knowledge Institute, research and education at ...

New Rochelle, NY, February 28, 2013—Sexting, the use of technology to send or receive sexually explicit messages, photos, or videos, is a relatively new trend and, in many cases, has legal implications. As many as 25-50% of young people may participate in sexting. A close-up look at the sexting practices of a group of urban ethnic minority youths is presented in an article in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal from Mary Ann Liebert, Inc., publishers. The article is available online on the Cyberpsychology, Behavior, and Social Networking ...

Previous studies have shown that carnivores can have indirect positive effects on each other, which means that when one species is lost, others could soon follow. A team from the University of Exeter and the University of Bern has now found that reducing the numbers of one species of carnivore can lead to the extinction of others. Published online today (28 February 2013) in the journal Ecology Letters, the study shows that simply reducing the population size of one carnivore can indirectly cause another similar species to become extinct. The research shows that changes ...

During embryo development, genes are dynamically, and very precisely, switched on and off to confer different properties to different cells and build a well-proportioned and healthy animal. Fgf8 is one of the key genes in this process, controlling in particular the growth of the limbs and the formation of the different regions of the brain. Researchers at EMBL have elucidated how Fgf8 in mammal embryos is, itself, controlled by a series of multiple, interdependent regulatory elements. Their findings, published today in Developmental Cell, shed new light on the importance ...

Athens, Ga. – New research from the University of Georgia has identified the neural pathways in an insect brain tied to eating for pleasure, a discovery that sheds light on mirror impulsive eating pathways in the human brain. "We know when insects are hungry, they eat more, become aggressive and are willing to do more work to get the food," said Ping Shen, a UGA associate professor of cellular biology in the Franklin College of Arts and Sciences. "Little is known about the other half—the reward-driven feeding behavior—when the animal is not so hungry but they still get ...

Ottawa, ON (February 28, 2013) – New insight into grape seed extract as a therapeutic and preventative measure to fight obesity-induced kidney damage is presented in a new study. Grape seed and skin extract (GSSE) is known to contain powerful antioxidants. This study, published in the journal Applied Physiology, Nutrition, and Metabolism, is the first to make a link between GSSEs and high-fat-diet-induced renal disease. The authors examined the effect of GSSE processed from a grape cultivar ('Carignan') of Vitis vinifera from northern Tunisia on rats. Rats were fed ...

It is rather difficult to imagine, but approximately 635 million years ago, ice may have covered a vast portion of our planet in an event called "Snowball Earth." According to the Snowball Earth hypothesis, the massive ice age that occurred before animal life appeared, when Earth's landmasses were most likely clustered near the equator, precipitated relatively rapid changes in atmospheric conditions and a subsequent greenhouse heat wave. This particular period of extensive glaciation and subsequent climate changes might have supplied the cataclysmic event that gave rise ...

Does advertising influence society, or is it merely a reflection of society's pre-existing norms? Where male attitudes are concerned, a new study implicates magazine advertisements specifically aimed at men as helping to reinforce a certain set of views on masculinity termed "hyper-masculinity." The article by Megan Vokey, a Ph.D. candidate from the University of Manitoba, and colleagues is published in Springer's journal Sex Roles. Hyper-masculinity is an extreme form of masculine gender ideology comprised of four main components: toughness, violence, dangerousness and ...

Setting up home in the stinging tentacles of a sea anemone might seem like a risky option, but anemonefish – also known as clownfish and popularised in the movie Finding Nemo – are perfectly content in their unlikely abode. Fending off peckish anemone predators in return for refuge, plucky clownfish have achieved a satisfactory arrangement with their deadly partners. Yet Joe Szczebak from Auburn University, USA, wondered whether there might be more to the unconventional collaboration than met the eye. According to Szczebak, coral reefs are awash with oxygen during the day, ...

ROCHESTER, Minn. — Researchers have identified a possible treatment window of several years for plaques in the brain that are thought to cause memory loss in diseases such as Alzheimer's. The Mayo Clinic study is published in the Feb. 27 online issue of Neurology, the medical journal of the American Academy of Neurology. "Our study suggests that plaques in the brain that are linked to a decline in memory and thinking abilities, called beta amyloid, take about 15 years to build up and then plateau," says lead author Clifford Jack, Jr., M.D., a Mayo Clinic radiologist, ...

STANFORD, Calif. — Does eating too much sugar cause diabetes? For years, scientists have said "not exactly." Eating too much of any food, including sugar, can cause you to gain weight; it's the resulting obesity that predisposes people to diabetes, according to the prevailing theory. But now the results of a large epidemiological study suggest sugar may also have a direct, independent link to diabetes. Researchers from the Stanford University School of Medicine, the University of California-Berkeley and the University of California-San Francisco examined data on sugar ...

A new genetic analysis of human lice from across the world sheds light on the global spread of these parasites, their potential for disease transmission and insecticide resistance. The results are published February 27 in the open access journal PLOS ONE by Marina S. Ascunce and colleagues from the Florida Museum of Natural History, University of Florida. Lice have been constant travel companions for humans ever since they left Africa and began colonizing other parts of the world. Since they have evolved along with humans, the geographic distribution of lice can reveal ...

Higher humidity levels indoors can significantly reduce the infectivity of influenza virus particles released by coughing, according to research published February 27 in the open access journal PLOS ONE by John Noti and colleagues from the National Institute for Occupational Safety and Health, Centers for Disease Control and Prevention. The researchers tested the effect of relative humidity on the capacity of flu virus released in a simulated 'cough' to re-infect cells. They found that an hour after being released in a room at a relative humidity of 23% or less, 70-77% ...

Sports-related head injuries are a growing concern, and new research suggests that even less forceful actions like 'heading' a soccer ball may cause changes in performance on certain cognitive tasks, according to a paper published February 27 in the open access journal PLOS ONE by Anne Sereno and colleagues from the University of Texas Health Science Center at Houston. The researchers tested the effects of non-injurious head-to-ball impacts on cognitive function using a tablet-based app. They found that high school female soccer players were significantly slower than ...

Laparoscopic surgeons may improve certain aspects of surgical performance by regularly playing on a Nintendo® Wii, according to research published February 27 in the open access journal PLOS ONE by Gregorio Patrizi and colleagues from the University of Rome, Italy. Considering the technical skills required to perform laparascopic procedures, several studies aim to evaluate and improve training for surgeons outside the operating room. Previous studies have assessed the effect of playing video games on hand-eye coordination and spatial attention. In the current research, ...

The presence of an animal can significantly increase positive social behaviors in children with autism spectrum disorders (ASD), according to research published February 20 in the open access journal PLOS ONE by Marguerite E O'Haire and colleagues from the University of Queensland, Australia. The authors compared how 5-13 year old children with ASD interacted with adults and typically-developing peers in the presence of two guinea pigs compared to toys. They found that in the presence of animals, children with ASD demonstrated more social behaviors like talking, looking ...

VIDEO: This video shows two episodes in which a bearded capuchin monkey places and strikes a nut with the Stop meridian marked with a black line or a black-hatched line, and... Click here for more information. Bearded capuchin monkeys deliberately place palm nuts in a stable position on a surface before trying to crack them open, revealing their capacity to use tactile information to improve tool use. The results are published February 27 in the open access journal PLOS ...

MEDFORD/SOMERVILLE, Mass. (February 27, 2013) – For the first time, scientists have shown that transplanted eyes located far outside the head in a vertebrate animal model can confer vision without a direct neural connection to the brain. Biologists at Tufts University School of Arts and Sciences used a frog model to shed new light – literally – on one of the major questions in regenerative medicine, bioengineering, and sensory augmentation research. "One of the big challenges is to understand how the brain and body adapt to large changes in organization," says Douglas ...