Matt Johnson fell in love with San Diego in 1998, and has resided here ever since. He is familiar with the local neighborhoods inside and out, and has the ability to assist you in selecting the best one for your family's needs. Matt got his start in real estate at the age of 9, helping his Dad turn dilapidated old houses into the gem of the neighborhood. He later continued on that tradition, becoming a professional home renovator with operations in two states. Several years later, he realized his passion was in the sales and marketing side, so he obtained his license ...

NEW YORK (March 3, 2013) -- The powerful master regulatory transcription factor called Bcl6 is key to the survival of a majority of aggressive lymphomas, which arise from the B-cells of the immune system. The protein has long been considered too complex to target with a drug since it is also crucial to the healthy functioning of many immune cells in the body, not just B cells gone bad. But now, in the journal Nature Immunology, researchers at Weill Cornell Medical College report that it is possible to shut down Bcl6 in the cancer, known as diffuse large B-cell lymphoma ...

An international group of researchers has discovered seven new regions of the human genome—called loci—that are associated with increased risk of age-related macular degeneration (AMD), a leading cause of blindness. The AMD Gene Consortium, a network of international investigators representing 18 research groups, also confirmed 12 loci identified in previous studies. The findings are reported online today in the journal Nature Genetics. Supported by the National Eye Institute (NEI), a part of the National Institutes of Health, the study represents the most comprehensive ...

March 3, 2013— (Bronx, NY) — Researchers at Albert Einstein College of Medicine of Yeshiva University have discovered how the most common genetic mutations in familial Parkinson's disease damage brain cells. The study, which published online today in the journal Nature Neuroscience, could also open up treatment possibilities for both familial Parkinson's and the more common form of Parkinson's that is not inherited. Parkinson's disease is a gradually progressing disorder of the nervous system that causes stiffness or slowing of movement. According to the Parkinson's ...

PHILADELPHIA – A multi-institution group of researchers has found new candidate disease proteins for neurodegenerative disorders. James Shorter, Ph.D., assistant professor of Biochemistry and Biophysics at the Perelman School of Medicine, University of Pennsylvania, Paul Taylor, M.D., PhD, St. Jude Children's Research Hospital, and colleagues describe in an advanced online publication of Nature that mutations in prion-like segments of two RNA-binding proteins are associated with a rare inherited degeneration disorder affecting muscle, brain, motor neurons and bone (called ...

Researchers at the University of Rochester and the University of Ottawa have applied a recently developed technique to directly measure for the first time the polarization states of light. Their work both overcomes some important challenges of Heisenberg's famous Uncertainty Principle and also is applicable to qubits, the building blocks of quantum information theory. They report their results in a paper published this week in Nature Photonics. The direct measurement technique was first developed in 2011 by scientists at the National Research Council, Canada, to measure ...

HOUSTON – Cancer vaccines that attempt to stimulate an immune system assault fail because the killer T cells aimed at tumors instead find the vaccination site a more inviting target, scientists at The University of Texas MD Anderson Cancer Center report in Nature Medicine. A common substance used in many cancer vaccines to boost immune attack betrays the cause by facilitating a buildup of T cells at the vaccination site, which then summon more T cells to help with the perceived threat. "Vaccines stimulate production of T cells primed to attack the target cancer, and ...

A study led by St. Jude Children's Research Hospital has discovered mutations in two genes that lead to the death of nerve cells in amyotrophic lateral sclerosis (ALS), also known as Lou Gehrig's disease, and related degenerative diseases. The same mutation occurred in both genes and led to the abnormal build-up of the proteins inside cells. These proteins play an essential role in normal RNA functioning and have also been linked to cancer, including the Ewing sarcoma, the second most common type of bone cancer in children and adolescents. The finding is the latest in ...

Scientists have produced an instruction manual for the human genome that provides a framework to better understand the relationship between an individual's genetic make-up and their lifestyle. The international team of researchers say their study – published in Nature Biotechnology – provides the best model yet to explain why individuals react differently to environmental factors such as diet or medication. "This research is the second important stage of our understanding of the human genome," said study author Professor Pedro Mendes, from The University of Manchester's ...

A team of researchers from Johns Hopkins Children's Center, the University of Mississippi Medical Center and the University of Massachusetts Medical School describe the first case of a so-called "functional cure" in an HIV-infected infant. The finding, the investigators say, may help pave the way to eliminating HIV infection in children. A report on the case is scheduled for presentation at a press conference on Sunday, March 3, at the 20th Conference on Retroviruses and Opportunistic Infections (CROI) in Atlanta. Johns Hopkins Children's Center virologist Deborah Persaud, ...

Building on earlier pioneering work by researchers at the University of California, San Diego, an international consortium of university researchers has produced the most comprehensive virtual reconstruction of human metabolism to date. Scientists could use the model, known as Recon 2, to identify causes of and new treatments for diseases like cancer, diabetes and even psychiatric and neurodegenerative disorders. Each person's metabolism, which represents the conversion of food sources into energy and the assembly of molecules, is determined by genetics, environment and ...

MADISON — A multi-university team of researchers has artificially engineered a unique multilayer material that could lead to breakthroughs in both superconductivity research and in real-world applications. The researchers can tailor the material, which seamlessly alternates between metal and oxide layers, to achieve extraordinary superconducting properties — in particular, the ability to transport much more electrical current than non-engineered materials. The team includes experts from the University of Wisconsin-Madison, Florida State University and the University ...

(Boston) – An international group of researchers has discovered seven new regions of the human genome—called loci—that are associated with increased risk of age-related macular degeneration (AMD), a leading cause of blindness. The AMD Gene Consortium, a network of international investigators representing 18 research groups, also confirmed 12 loci identified in previous studies. The study, which is published online in Nature Genetics and represents the most comprehensive genome-wide analysis of genetic variations associated with AMD, was supported by the National Eye Institute ...

An international group of investigators has identified seven new genetic regions associated with age-related macular degeneration (AMD), a common cause of blindness in older individuals. The findings, reported online March 3 in Nature Genetics, could point to new biological pathways and therapeutic targets for AMD. The AMD Gene Consortium, a network of 18 research groups supported by the National Eye Institute, also confirmed 12 genetic loci identified in previous studies. The study represents the most comprehensive genome-wide analysis of genetic variations associated ...

BOSTON, Mass, March 4, 2013—The first large, population-based study to follow children with attention-deficit hyperactivity disorder (ADHD) into adulthood shows that ADHD often doesn't "go away," and that children with ADHD are more likely to have other psychiatric disorders as adults. Although numbers were small, they also appear more likely to commit suicide and are often incarcerated as adults. "Only 37.5 percent of the children we contacted as adults were free of these really worrisome outcomes," says William Barbaresi, MD, of Boston Children's Hospital, lead investigator ...

ARLINGTON HEIGHTS, ILL. (March 4, 2013) – Two million Americans are allergic to insect stings, an allergy which sends more than 500,000 people to the emergency room annually. Yet, according to a study published today in the March issue of Annals of Allergy, Asthma & Immunology, the scientific journal of the American College of Allergy, Asthma and Immunology (ACAA), while fire ant allergy sufferers know allergy shots can save their life, more than 60 percent do not adhere to treatment guidelines. For optimal protection against fire ant stings, allergists recommend allergy ...

A small study from Johns Hopkins adds to the growing body of evidence that red blood cells stored longer than three weeks begin to lose the capacity to deliver oxygen-rich cells where they may be most needed. In a report published online in the journal Anesthesia & Analgesia, the Johns Hopkins investigators say red cells in blood stored that long gradually lose the flexibility required to squeeze through the body's smallest capillaries to deliver oxygen to tissue. Moreover, they say, that capacity is not regained after transfusion into patients during or after surgery. ...

Yacht Crew Direct has launched its online sailing crew finder service yachtcrewdirect.com, bringing budding crew together with global sailing adventurers, super yachts and everything in between. The yachtcrewdirect.com site lists professional paid crew jobs, round the world travel opportunities and mile building trips for new crew, all posted by the yacht owners/operators themselves. Yacht Crew Direct allows crew to search anywhere in the world for a working passage or professional job to apply for. Perfect for backpackers looking for creative ways to travel cheaply ...

Fundraising company Dibbee recently added young entrepreneur and Collegiate Entrepreneurs' Organization's National Growth & Programs Manager Michael Luchies as their Director of Marketing. CEO Jay Ponnada was matched with Luchies through CoFoundersLab; a matchmaking site for entrepreneurs. One day after Luchies had contacted Jay through the site they met at a local coffee shop. Just a week later they had agreed in principal to add Luchies to the team as the new Director of Marketing. "It seemed like fate, as corny as it sounds," said Luchies during ...

The Rate Speeches second generation Public Speaking Topic Generator now has database of more than 7,000 topics, compared to the Rate Speeches first generation, which was launched with about 2,000 topics. The topic generator is free to use and does not require users to register, log in, or disclose any information. In addition, most topics include a variety of subtopics. In this second generation topic generator, Rate Speeches has more than 230,000 subtopics for the 7,000 topics. Subtopics expand the topics and provide ideas on how to analyze or explore topics. Subtopics ...

Passion 4 Life Liquid Vitamins & Minerals ( http://www.passion4lifevitamins.com ) has been chosen as a semi-finalist, competing for a coveted slot in the TV show "So You Think You Can Sell". In an effort to help the Southern California small business and startup community, the show So You think You Can Sell conducted a Pitchfest, which was a rare opportunity for seven businesses to pitch their product to the judges on episode 2. Passion 4 Life Liquid Vitamins and Minerals will be selected by the judges, the company's fans as well as the website and television ...

Miami is known for its paradise like weather, sexy people, and its rambunctious lifestyle, making it the perfect setting for Eenie Minnie Miney Moe- an Indie Crime Thriller. The film is based on Raul, a tow truck driver in Miami Beach, who wants to make money and make it fast. He has the perfect tool to open the doors to any car in Miami. Each car holds a prize; he soon learns that every reward has its consequences. The film is brought to life by Miami Locals: Andres Dominguez, who plays the main character, tow truck driver Raul, he also starred in Magic City Memoirs. ...

Soterix Medical Inc. is pleased to report positive results of a double-blind, sham-controlled, crossover trial of 18 patients with Fibromyalgia conducted at Harvard Medical School. Fibromyalgia is a prevalent chronic pain syndrome characterized by altered pain and sensory processing in the central nervous system, which is often refractory to multiple therapeutic approaches. The Harvard clinical trial examined the effects of the Soterix Medical's exclusive 4x1 High Definition - Transcranial Direct Current Stimulation (HD-tDCS) on overall perceived pain in patients. HD-tDCS ...

Alan Blakely, the Salt Lake City-based architectural photographer, today announced three unique photography packages designed to transform the brand image of companies in the architecture, design and construction industries. Blakely's photography packages are offered at fixed prices and available anywhere in the United States. "After years of shooting for clients throughout the U.S. and Canada it occurred to me that it often takes only a small investment in photography for a company to completely change its brand image and market position," Mr. Blakely explains. ...

Intemation, a BIM technology provider, announces the release of the AEC/O Industry's first and only asset data commissioning solution for Lifecycle BIM. From Feasibility to O&M, Intemation's new platform enables facility owners and their stakeholders to easily create and manage ANY parametric data type throughout the entire facility lifecycle. "The launch of Intemation and the release of the bimCx platform is a culmination of the best talent in the Industry, many years of research and development, as well as lots of hard work. An early prototype of the solution ...