Researchers from Ludwig-Maximilians-Universitaet (LMU) in Munich identify a novel signal transduction pathway, which activates the parkin gene and prevents stress-induced neuronal cell death. Parkinson's disease is the most common movement disorder and the second most common neurodegenerative disease after Alzheimer's disease. It is characterized by the loss of dopamin-producing neurons in the substantia nigra, a region in the midbrain, which is implicated in motor control. The typical clinical signs include resting tremor, muscle rigidity, slowness of movements, and ...

March 1, 2013 - Even in the face of a disaster, we remain optimistic about our chances of injury compared to others, according to a new study. Residents of a town struck by a tornado thought their risk of injury from a future tornado was lower than that of peers, both a month and a year after the destructive twister. Such optimism could undermine efforts toward emergency preparedness. After an F-2 tornado struck his town in Iowa, Jerry Suls, a psychologist at the University of Iowa who studies social comparison, turned his attention to risk perception. "I had dinner as ...

This press release is available in German. The computer is increasingly used to help in complex situations. The latest innovations in this area will be presented by Karlsruhe Institute of Technology (KIT) and the FZI Research Center for Information Technology at the CeBIT in early March (hall 9, stand G33). User-friendly systems display all facts to surgeons during operation and simultaneously translate university lectures for foreign students. In addition, smart living environments that support comfort, safety, and care services and software for the relocation of ...

The term "big data" is defined as a huge amount of digital information, so big and so complex that normal database technology cannot process it. It is not only scientific institutes like the nuclear research center CERN that often store huge amounts of data ("Big Data"). Companies like Google and Facebook do this as well, and analyze it to make better strategic decisions for their business. How successful such an attempt can be was shown in a New York Times article published last year. It reported on the US-based company "Target" which, by analyzing the buying patterns ...

A team led by the University of Colorado Boulder looking for clues about why Earth did not warm as much as scientists expected between 2000 and 2010 now thinks the culprits are hiding in plain sight -- dozens of volcanoes spewing sulfur dioxide. The study results essentially exonerate Asia, including India and China, two countries that are estimated to have increased their industrial sulfur dioxide emissions by about 60 percent from 2000 to 2010 through coal burning, said lead study author Ryan Neely, who led the research as part of his CU-Boulder doctoral thesis. Small ...

Changes made by humans to the natural landscapes can often compromise ecosystems, which paradoxically are vital for human survival. Pollination of crops by wild insects is one such vulnerable ecosystem service, as wild insects are declining in many agricultural landscapes. The study, recently published in Science, focused on understanding whether the ongoing loss of wild insects impacts crop harvest. For this purpose, the researchers compared fields with abundant and diverse wild insects to those with degraded assemblages of wild insects across 600 fields at 41 crop systems ...

A new University of Iowa study confirms what many women have long suspected – that pregnancy permanently changes the size and shape of a woman's feet. Flat feet are a common problem for pregnant women. The arch of the foot flattens out, possibly due to the extra weight and increased looseness (laxity) of the joints associated with pregnancy. The new study, published in the March issue of the American Journal of Physical Medicine & Rehabilitation, suggests that this loss of arch height is permanent. "I had heard women reporting changes in their shoe size with pregnancy, ...

The interplay between an infection during pregnancy and stress in puberty plays a key role in the development of schizophrenia, as behaviourists from ETH Zurich demonstrate in a mouse model. However, there is no need to panic. Around one per cent of the population suffers from schizophrenia, a serious mental disorder that usually does not develop until adulthood and is incurable. Psychiatrists and neuroscientsist have long suspected that adverse enviromental factors may play an important role in the development of schizophrenia. Prenatal infections such as toxoplasmosis ...

New Rochelle, NY, March 1, 2013—Most adults and children with type 1 diabetes are not in optimal glycemic control, despite advances in insulin formulations and delivery systems and glucose monitoring approaches. Critical barriers to optimal glycemic control remain. A panel of experts in diabetes management and research met to explore these challenges, and their conclusions and recommendations for how to improve care and optimize clinical decision-making are presented in a white paper in Diabetes Technology & Therapeutics (DTT), a peer-reviewed journal from Mary Ann Liebert, ...

(Boston) – A study led by researchers at Boston University School of Medicine (BUSM) has identified epigenetic mechanisms that connect a variety of diseases associated with inflammation. Utilizing molecular analyses of gene expression in macrophages, which are cells largely responsible for inflammation, researchers have shown that inhibiting a defined group of proteins could help decrease the inflammatory response associated with diseases such as obesity, type 2 diabetes, cancer and sepsis. The study, which is published online in the Journal of Immunology, was led by ...

SEATTLE – A study of older patients with advanced head and neck cancers has found that where they were treated significantly influenced their survival. The study, led by researchers at Fred Hutchinson Cancer Research Center and published in the March 1 online edition of Cancer, found that patients who were treated at hospitals that saw a high number of head and neck cancers were 15 percent less likely to die of their disease as compared to patients who were treated at hospitals that saw a relatively low number of such cancers. The study also found that such patients ...

CHAMPAIGN, Ill. — A study published in the journal Science reveals a decline in bee species since the late 1800s in West Central Illinois. The study could not have been conducted without the work of a 19th-century naturalist, says a co-author of the new research. Charles Robertson, a self-taught entomologist who studied zoology and botany at Harvard University and the University of Illinois, was one of the first scientists to make detailed records of the interactions of wild bees and the plants they pollinate, says John Marlin, a co-author of the new analysis in Science. ...

CHAPEL HILL, N.C. – In an article published as the cover story of the March 2013 issue of Nature Chemical Biology, Lindsey James, PhD, research assistant professor in the lab of Stephen Frye, Fred Eshelman Distinguished Professor in the UNC School of Pharmacy and member of the UNC Lineberger Comprehensive Cancer Center, announced the discovery of a chemical probe that can be used to investigate the L3MBTL3 methyl-lysine reader domain. The probe, named UNC1215, will provide researchers with a powerful tool to investigate the function of malignant brain tumor (MBT) domain ...

Colon cancer develops slowly. Precancerous lesions usually need many years to turn into a dangerous carcinoma. They are well detectable in an endoscopic examination of the colon called colonoscopy and can be removed during the same examination. Therefore, regular screening can prevent colon cancer much better than other types of cancer. Since 2002, colonoscopy is part of the national statutory cancer screening program in Germany for all insured persons aged 55 or older. However, only one fifth of those eligible actually make use of the screening program. The reasons ...

This press release is available in French. Montreal, March 1, 2013 – Construction in Montreal is under a microscope. Now more than ever, municipal builders need to comply with long-term urban planning goals. The difficulties surrounding massive projects like the Turcot interchange lead Montrealers to wonder if construction in this city is headed in the right direction. New research from Concordia University gives us hope that this could soon be the case if sufficient effort is made. A team of graduate students from Concordia's Department of Geography, Planning and Environment ...

A new study has exam­ined how bac­te­ria clog med­ical devices, and the result isn't pretty. The microbes join to cre­ate slimy rib­bons that tan­gle and trap other pass­ing bac­te­ria, cre­at­ing a full block­age in a star­tlingly short period of time. The find­ing could help shape strate­gies for pre­vent­ing clog­ging of devices such as stents — which are implanted in the body to keep open blood ves­sels and pas­sages — as well as water fil­ters and other items that are sus­cep­ti­ble to con­t­a­m­i­na­tion. The research was pub­lished in Pro­ceed­ings of the National ...

The bacteria that cause acne live on everyone's skin, yet one in five people is lucky enough to develop only an occasional pimple over a lifetime. In a boon for teenagers everywhere, a UCLA study conducted with researchers at Washington University in St. Louis and the Los Angeles Biomedical Research Institute has discovered that acne bacteria contain "bad" strains associated with pimples and "good" strains that may protect the skin. The findings, published in the Feb. 28 edition of the Journal of Investigative Dermatology, could lead to a myriad of new therapies to ...

Ecologists have evidence that some endangered primates and large cats faced with relentless human encroachment will seek sanctuary in the sultry thickets of mangrove and peat swamp forests. These harsh coastal biomes are characterized by thick vegetation — particularly clusters of salt-loving mangrove trees — and poor soil in the form of highly acidic peat, which is the waterlogged remains of partially decomposed leaves and wood. As such, swamp forests are among the few areas in many African and Asian countries that humans are relatively less interested in exploiting (though ...

Thyroid hormone treatment administered to rats at the time of a heart attack (myocardial infarction) led to significant reduction in the loss of heart muscle cells and improvement in heart function, according to a study published by a team of researchers led by A. Martin Gerdes and Yue-Feng Chen from New York Institute of Technology College of Osteopathic Medicine. The findings, published in the Journal of Translational Medicine, have bolstered the researchers' contention that thyroid hormones may help reduce heart damage in humans with cardiac diseases. "I am extremely ...

LEXINGTON, Ky. (Feb. 28, 2013) – A groundbreaking new study led by the University of Kentucky Markey Cancer Center's Dr. Peter Zhou found that triple-negative breast cancer cells are missing a key enzyme that other cancer cells contain — providing insight into potential therapeutic targets to treat the aggressive cancer. Zhou's study is unique in that his lab is the only one in the country to specifically study the metabolic process of triple-negative breast cancer cells. Normally, all cells — including cancerous cells — use glucose to initiate the process of making Adenosine-5'-triphosphate ...

In the nation's most diverse state, some of the sickest Californians often have the hardest time communicating with their doctors. So say the authors of a new study from the UCLA Center for Health Policy Research that found that residents with limited English skills who reported the poorest health and were enrolled in commercial HMO plans were more likely to have difficulty understanding their doctors, placing this already vulnerable population at even greater risk. The findings are significant given that, in 2009, nearly one in eight HMO enrollees in California was ...

LEXINGTON, Ky. (Feb. 26, 2013) — A new study authored by University of Kentucky researcher Elaine Wittenberg-Lyles shows that more empathic communication is needed between caregivers and hospice team members. The study, published in Patient Education and Counseling, was done in collaboration with Debra Parker Oliver, professor in the University of Missouri Department of Family and Community Medicine. The team enrolled hospice family caregivers and interdisciplinary team members at two hospice agencies in the Midwestern United States. Researchers analyzed the bi-weekly ...

Researchers at the Johns Hopkins Malaria Research Institute have developed a new method for studying the complex molecular workings of Anopheles albimanus, an important but less studied spreader of human malaria. An. albimanus carries Plasmodium vivax, the primary cause of malaria in humans in South America and regions outside of Africa. Unlike Anopheles gambiae, the genome of the An. albimanus mosquito has not been sequenced and since these two species are evolutionarily divergent, the genome sequence of An. gambiae cannot serve as an appropriate reference. The researcher's ...

A study by researchers at the Herbert Irving Comprehensive Cancer Center (HICCC) at NewYork-Presbyterian/Columbia University Medical Center, has found that nearly one in four women (23 percent) newly diagnosed with breast cancer reported symptoms consistent with post-traumatic stress disorder (PTSD) shortly after diagnosis, with increased risk among black and Asian women. The research has been e-published ahead of print in the Journal of the National Cancer Institute. "This study is one of the first to evaluate the course of PTSD after a diagnosis of breast cancer," said ...

A study by a Simon Fraser University researcher shows British Columbia has much higher traffic death rates than most northern European countries. Comparisons to the safest country, the Netherlands, suggest B.C. could reduce the number of traffic deaths by more than 200 per year. It also found that fatality and injury risks varied by travel mode. "Many studies have shown that overall, considering both potential physical activity benefits and injury risks, cycling and walking are on the whole very healthy travel activities," says SFU health sciences assistant professor ...