A collaborative research team including a Medical College of Wisconsin (MCW) pediatric neuropathologist successfully mitigated some of the effects of a muscular disease by using a new targeted enzyme replacement therapy strategy from 4s3 Bioscience. The findings are published in the January edition of Human and Molecular Genetics http://hmg.oxfordjournals.org/content/early/2013/01/09/hmg.ddt003.full.pdf+html. X-linked myotubular myopathy (XLMTM) is a severe muscle disease caused by an absence of a protein called myotubularin. There is currently no treatment for this ...

Scientists at CSIRO and RMIT University have produced a new two-dimensional material that could revolutionise the electronics market, making "nano" more than just a marketing term. The material – made up of layers of crystal known as molybdenum oxides – has unique properties that encourage the free flow of electrons at ultra-high speeds. In a paper published in the January issue of materials science journal Advanced Materials, the researchers explain how they adapted a revolutionary material known as graphene to create a new conductive nano-material. Graphene was ...

Light-sensing cells in the eye rely on their outer segment to convert light into neural signals that allow us to see. But because of its unique cylindrical shape, the outer segment is prone to breakage, which can cause blindness in humans. A study published by Cell Press on January 22nd in the Biophysical Journal provides new insight into the mechanical properties that cause the outer segment to snap under pressure. The new experimental and theoretical findings help to explain the origin of severe eye diseases and could lead to new ways of preventing blindness. ...

Charlottesville, VA (January 22, 2013). Researchers from Memorial Sloan-Kettering Cancer Center (New York, NY) have found that tumor "separation surgery" followed by high-dose hypofractionated stereotactic radiosurgery (SRS) or high-dose single-fraction SRS is safe and effective in controlling spinal metastases regardless of the radiosensitivity of the particular tumor type that has invaded the spine. This finding is fleshed out in the article "Local disease control for spinal metastases following 'separation surgery' and adjuvant hypofractionated or high-dose single-fraction ...

Johns Hopkins researchers have identified a rare gene mutation in a single family with a high rate of schizophrenia, adding to evidence that abnormal genes play a role in the development of the disease. The researchers, in a report published in the journal Molecular Psychiatry, say that family members with the mutation in the gene Neuronal PAS domain protein 3 (NPAS3) appear at high risk of developing schizophrenia or another debilitating mental illnesses. Normally functioning NPAS3 regulates the development of healthy neurons, especially in a region of the brain known ...

KANSAS CITY, MO – Over the past several years, Rong Li, Ph.D., at the Stowers Institute for Medical Research has been making crucial discoveries about the development of cell polarity—the process by which one side of a cell becomes different from the other side. Such polarity is critical for the functioning of the vast majority of cells. The outside surface of skin cells is very different from the surface inside the body, for example, while nerve cells have delicately branching dendrites on one end and axons on the other. Li's lab studies yeast cells, which form a unique ...

In the fall of 2010, Hoi-Ying Holman of the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) was approached by an international team researching a mysterious microbial community discovered deep in cold sulfur springs in southern Germany. "They told me what they were doing and said, 'We know what you contributed to the oil-spill research,'" recalls Holman, who heads the Chemical Ecology group in Berkeley Lab's Earth Sciences Division. "They wondered if I could help them determine the biochemistry of their microbe samples." Holman had ...

STANFORD, Calif. — Researchers at the Stanford University School of Medicine have found a novel way to engineer key cells of the immune system so they remain resistant to infection with HIV, the virus that causes AIDS. A new study describes the use of a kind of molecular scissors to cut and paste a series of HIV-resistant genes into T cells, specialized immune cells targeted by the AIDS virus. The genome editing was made in a gene that the virus uses to gain entry into the cell. By inactivating a receptor gene and inserting additional anti-HIV genes, the virus was blocked ...

In a paper published in Nature Communications on January 22, 2013, a team of paleontologists including Dr. Luis Chiappe, Director of the Natural History Museum of Los Angeles County's (NHM) Dinosaur Institute, has discovered a way to determine the sex of an avian dinosaur species. Confuciusornis sanctus, a 125-million-year-old Mesozoic bird, had remarkable differences in plumage — some had long, almost body length ornamental tail feathers, others had none — features that have been interpreted as the earliest example of avian courtship. However, the idea that male Confuciusornis ...

These mechanisms, described in vivo in mice, engage molecule CD98hc, which is involved in epidermis renewal and could be an indicator of the skin's capacity for regeneration. The results were published in the Journal of Experimental Medicine review. The epidermis, the surface layer of the skin, is mainly composed of keratinocytes cells, which, in humans, are renewed continuously over a 21-day cycle. These cells are located on a membrane made up of components from the extracellular matrix that provides the junction with the dermis, the deep layer of the skin (see diagram). ...

Bisphenol A (BPA) is a chemical compound that is included in the composition of plastics and resins. It is used, for example, in the manufacture of food containers such as bottles and babies' feeding bottles. It is also found in the protective films used inside food and drink cans and on till receipts where it used as a discloser. Significant levels of BPA have also been found in human blood, urine, amniotic fluid and placentas. Recent studies have shown that this industrial component has harmful effects on reproductive ability, development and the metabolism of laboratory ...

DURHAM, N.C. -- Hydraulically fractured natural gas wells are producing less wastewater per unit of gas recovered than conventional wells would. But the scale of fracking operations in the Marcellus shale region is so vast that the wastewater it produces threatens to overwhelm the region's wastewater disposal capacity, according to new analysis by researchers at Duke and Kent State universities. Hydraulically fractured natural gas wells in the Marcellus shale region of Pennsylvania produce only about 35 percent as much wastewater per unit of gas recovered as conventional ...

Alexandria, VA – Throughout history, humanity has steadily increased its dependence upon technology. Although technology has vastly improved the quality of life for billions of people, it has also opened us up to new risks and vulnerabilities. Terrorism and natural disasters might be at the forefront of the minds of policymakers and the U.S. population, but a significant threat lurks over our heads: the sun. A massive solar storm, the size last seen a century and a half ago, could easily leave hundreds of millions of people in the dark for days, weeks or even months. The ...

Glaciers in the tropical Andes have been retreating at increasing rate since the 1970s, scientists write in the most comprehensive review to date of Andean glacier observations. The researchers blame the melting on rising temperatures as the region has warmed about 0.7°C over the past 50 years (1950-1994). This unprecedented retreat could affect water supply to Andean populations in the near future. These conclusions are published today in The Cryosphere, an Open Access journal of the European Geosciences Union (EGU). The international team of scientists – uniting researchers ...

Over 500 billion cells in our bodies will be replaced daily, yet natural selection has enabled us to develop defenses against the cellular mutations which could cause cancer. It is this relationship between evolution and the body's fight against cancer which is explored in a new special issue of the Open Access journal Evolutionary Applications. "Cancer is far from a single well-defined disease which we can identify and eradicate," said Dr Athena Aktipis, Director, Human and Social Evolution, Center for Evolution and Cancer at the University of California, San Francisco. ...

Ann Arbor, Mich. — Egg allergic children, including those with a history of anaphylaxis to egg, can safely receive a single dose of the seasonal influenza vaccine, according to a new study from the University of Michigan. Historically, the CDC recommended that the seasonal influenza vaccine not be administered to egg allergic children. Recent research conducted at the University of Michigan, and elsewhere, helped modify this recommendation in 2011 so that caution was warranted for only those with severe egg allergy. The new study, published in the Annals of Allergy, ...

Women with hypertensive disorders in pregnancy are at higher risk of chronic kidney disease and end-stage renal disease compared with women without the disorders, according to a study in CMAJ (Canadian Medical Association Journal). "We found that women with hypertensive disorders during pregnancy were at higher risk of end-stage renal disease than women without complicated pregnancies," writes Dr. I-Kuan Wang, Division of Nephrology, China Medical University Hospital, Taichung, Taiwan, with coauthors. Hypertensive disorders such as gestational hypertension and preeclampsia ...

When people wash their hands with antibacterial soap, most don't think about where the chemicals contained in that soap end up. University of Minnesota engineering researchers do. A new University of Minnesota study determined that the common antibacterial agent, called triclosan, used in soaps and many other products is found in increasing amounts in several Minnesota freshwater lakes. The findings are directly linked to increased triclosan use over the past few decades. In addition, the researchers found an increasing amount of other chemical compounds, called chlorinated ...

NEW YORK (January 22, 2012) —Wildlife Conservation Society scientists have documented a thriving population of lowland tapirs – the strange forest and grassland-dwelling herbivore with the trunk-like snout – living in a network of remote national parks spanning the Peru-Bolivia border. Using a combination of camera traps, along with interviews with park guards and subsistence hunters, WCS estimates at least 14,500 lowland tapirs in the region. The population bridges five connected national parks in northwest Bolivia and southeastern Peru. The WCS findings were described ...

This press release is available in German. Dendritic cells, or DCs for short, perform a vital role for the immune system: They engulf pathogens, break them down into their component parts, and then display the pieces on their surface. This in turn signals other immune cells capable of recognizing these pieces to help kick-start their own default program for fighting off the invaders. In order to do their job, the DCs are dependent upon the support from a class of immune system molecules, which have never before been associated with dendritic cells: antibodies, best ...

Philadelphia, Pa. (January 22, 2013) – Researchers are making new strides in understanding the health consequences and treatment and rehabilitation needs of combat veterans and other service members affected by traumatic brain injury (TBI). The January-February issue of The Journal of Head Trauma Rehabilitation, official journal of the Brain Injury Association of America, is a special issue devoted to new research in military TBI. The journal is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. "For the second consecutive year, we've expedited ...

The strong binding of gold on electronically modified calcium oxide can now be understood in detail. In a computational study, researchers Jenni Andersin, Janne Nevalaita, Karoliina Honkala and Hannu Häkkinen at the University of Jyväskylä Nanoscience Center have shown how redox chemistry entirely determines the adsorption strength of gold on the modified oxide where one metal atom is replaced with molybdenum. The study was funded by the Academy of Finland. The research team applied the so-called Born-Haber cycle to analyse how different terms contribute to adsorption ...

Philadelphia, Pa. (January 22, 2013) – The most comprehensive review of new legal and regulatory issues affecting advanced nursing practice across the United States is now available in the "25th Annual Legislative Update," presented exclusively by The Nurse Practitioner: The American Journal of Primary Healthcare. The Nurse Practitioner is published by Lippincott Williams & Wilkins, a part of Wolters Kluwer Health. Compiled by Susanne J. Phillips, MSN, FNP-BC, the annual supplement presents a comprehensive review of the legislative proceedings, bills, and laws pertaining ...

Researchers at Royal Holloway university have found that Brazilians and Chileans want the state to buy on social and environmental criteria, not just on price. Based on this pioneering research, researchers from Royal Holloway have been invited to be the first academics to join the UN Environmental Programme's global Sustainable Public Procurement Initiative and attend its meeting in Paris this week. The Choices Project is a collaboration between Royal Holloway, the Universidade Federal do Rio de Janeiro and Universidad Diego Portales. The project team also involves ...

ROCHESTER, Minn. -- Bathing a tiny newborn can be an exciting experience for parents, but it can also be intimidating. Newborns are small and vulnerable, slippery when wet, and the products marketed for their delicate skin can leave parents with abundant choices. As newborns are welcomed into the world, their skin needs to adapt to the new environmental changes around them. It's important for parents to understand proper bathing techniques and the appropriate skin care needed for their little one. Pediatric dermatologist Dawn Davis, M.D., of Mayo Clinic Children's Center ...