The fate of mature T lymphocytes might be a lot more flexible than previously thought. New research from the RIKEN Center for Allergy and Immunology (RCAI) in Japan and La Jolla Institute for Allergy and Immunology (LIAI) in the USA shows for the first time that mature CD4+ helper T lymphocytes can be re-programed to become killer-like CD8+ T lymphocytes and gain killing functions. The findings are reported today in the journal Nature Immunology, by a team of researchers led by Ichiro Taniuchi from RIKEN and Hilde Cheroutre from La Jolla. The team show using transgenic ...

DURHAM, N.H. -- Warmer temperatures due to climate change could cause soils to release additional carbon into the atmosphere, thereby enhancing climate change – but that effect diminishes over the long term, finds a new study in the journal Nature Climate Change. The study, from University of New Hampshire professor Serita Frey and co-authors from the University of California-Davis and the Marine Biological Laboratory, sheds new light on how soil microorganisms respond to temperature and could improve predictions of how climate warming will affect the carbon dioxide flux ...

A new finding by Harvard stem cell biologists turns one of the basics of neurobiology on its head – demonstrating that it is possible to turn one type of already differentiated neuron into another within the brain. The discovery by Paola Arlotta and Caroline Rouaux "tells you that maybe the brain is not as immutable as we always thought, because at least during an early window of time one can reprogram the identity of one neuronal class into another," said Arlotta, an Associate Professor in Harvard's Department of Stem Cell and Regenerative Biology (SCRB). The principle ...

In 1953, Cambridge researchers Watson and Crick published a paper describing the interweaving 'double helix' DNA structure - the chemical code for all life. Now, in the year of that scientific landmark's 60th Anniversary, Cambridge researchers have published a paper proving that four-stranded 'quadruple helix' DNA structures - known as G-quadruplexes - also exist within the human genome. They form in regions of DNA that are rich in the building block guanine, usually abbreviated to 'G'. The findings mark the culmination of over 10 years investigation by scientists ...

An extensive genomic study of the childhood cancer neuroblastoma reinforces the challenges in treating the most aggressive forms of this disease. Contrary to expectations, the scientists found relatively few recurrent gene mutations—mutations that would suggest new targets for neuroblastoma treatment. Instead, say the researchers, they have now refocused on how neuroblastoma tumors evolve in response to medicine and other factors. "This research underscores the fact that tumor cells often change rapidly over time, so more effective treatments for this aggressive cancer ...

Biotechnologists have been working hard to address the climate change and limited fossil resource issues through the development of sustainable processes for the production of chemicals, fuels and materials from renewable non-food biomass. One promising sustainable technology is the use of microbial cell factories for the efficient production of desired chemicals and materials. When microorganisms are isolated from nature, the performance in producing our desired product is rather poor. Metabolic engineering is performed to improve the metabolic and cellular characteristics ...

(MEMPHIS, Tenn. – January 20, 2013) Research led by St. Jude Children's Research Hospital scientists has identified a possible lead in treatment of two childhood leukemia subtypes known for their dramatic loss of chromosomes and poor treatment outcomes. The findings also provide the first evidence of the genetic basis for this high-risk leukemia, which is known as hypodiploid acute lymphoblastic leukemia (ALL). Normal human cells have 46 chromosomes, half from each parent, but hypodiploid ALL is characterized by fewer than 44 chromosomes. Chromosomes are highly condensed ...

SAN DIEGO – (January 20th, 2013) A research team led by the La Jolla Institute for Allergy & Immunology has discovered the mechanism that enables CD4 helper T cells to assume the more aggressive role of killer T cells in mounting an immune attack against viruses, cancerous tumors and other damaged or infected cells. The finding, made in collaboration with researchers from the RIKEN Institute in Japan, could enable the development of more potent drugs for AIDS, cancer and many other diseases based on using this mechanism to trigger larger armies of killer T cells against ...

Tucson Therapist, Dr. Shannon Sticken, announces that she is offering therapy and counseling for individuals and couples who are working to overcome problems with sex addiction. Dr. Sticken is a Licensed Psychologist and Certified Sex Addiction Therapist who has extensive work experience and training to help clients rebuild their lives after sex addiction. "When many of my clients come into treatment, they are trying to figure out how to not only control their behavior, but also to build or rebuild trust and intimacy," says Sticken. This is what creates the ...

A picture is worth a thousand words and a stylish picture frame only adds to that value. Luminous Life Frames launches their exquisite photo frames giving families,businesses and friends a alternative to the typical picture frame. Luminous Life is creation of a line of stunning backlit photo frames designed to celebrate the great moments of life. Luminous Life Frames utilizes your treasured photos to create heirloom "memory frames" for celebrations including weddings, Bar/Bat Mitzvah's, birthdays, graduations, family reunions, and anniversaries. Luminous Life ...

The Eagle Claw, a revolutionary swing support golf grip aid exhibiting at the 2013 PGA Show this month in Florida, will proudly display their most recent achievement: USGA approval under the section "Equipment Permitted Conditionally for Medical Reasons" which was granted earlier this month. The Eagle Claw was conceived over 10 years ago when inventor Gerald Basden strained his thumb during a golf round. The usually debilitating ailment led to Gerald building a prototype that would enable him to continue to play golf whilst the injury healed without loss to ...

Streaming live on the Co-Creator Radio Network (www.co-creatornetwork.com) on Tuesday, January 22, at 11 a.m. Pacific time/2 p.m. Eastern time, on her show "Why Shamanism Now?: A Practical Path to Authenticity," shaman and founder of the Last Mask Center for Shamanic Healing Christina Pratt tells listeners that if the New World is to be different than the one before, then we must learn to ally our minds with paradox. We must see the deeper truth that the nature of our world—and our selves included—is the living expression of complementary dualism in which two ...

The Michael Lord Gallery is pleased to announce the exhibition: Betty Gold: New Maquettes and Paintings. The public is invited to attend the opening artist reception on Friday, February 1, from 6 to 8 pm. The exhibition continues through February 28. Betty Gold was born in 1935 in Austin, Texas. After completing her studies at the University of Texas, she entered the tutelage and apprenticeship of sculptor Octavio Medillan in Dallas, Texas. As art writer Steven Biller notes, "Gold is a former beauty pageant winner with jet black hair and a native Texas twang. She ...

One Thirteen Luxury Home Decor has improved the online, home decor market through its website http://www.onethirteen.com. This simple and accessible online store has made it easier to purchase transitional and other styles of furniture than previously imagined. The site allows registered users to make their selections through timed offers, giving the customer access to a regular selection of new products. By so doing they eliminate the time often associated with gaining access to a new stock of transitional furniture. This ease of access is also seen in the customer account ...

The U.S. Food and Drug Administration has announced it is requiring users of the insomnia drug Ambien and its generic counterparts (all drugs containing the active ingredient zolpidem), to take a lower recommended dose of these medications. They are particularly aiming this toward women, as the drug stays in their system much longer than with men. Women at the time of menopause frequently have sleep problems and insomnia, and some may turn to sleep medications. Ellis Unger, M.D., director of the Office of Drug Evaluation in the FDA's Center for Drug Evaluation and Research ...

Brian Giordano, President of Integrated Audio Video at Southpoint, has announced that David Steffens has joined the team as a Senior Project Manager, and Garrett Seybert has been hired as a Level 1 Project Manager. Originally from Troy, Michigan, David Steffens has over 20 years of experience in electronics working for companies including: Tweeter in North Carolina, NOW Audio Video in North Carolina and Tennessee, Media Systems in Boston and Palm Beach, and Rising Sounds in Florida. As Senior Project Manager at Integrated Audio Video, Steffens will be responsible for ...

Hennessey Capital, a division of Hitachi Capital America Corp., announced today their support of The Salvation Army's Annual Red Wings alumni hockey game benefitting the Bed & Bread Program. On Saturday, January 26, members of the Detroit Red Wings Alumni Association will face off against the Oakland Jr. Grizzlies and Troy Sting, as well as the Troy Youth Hockey Association, at 7 p.m. at the Troy Sports Center located at 1819 E. Beaver Rd. in Troy. The voice of the Detroit Red Wings, Karen Newman, will kick-off the festivities with a performance of the national ...

Lock is extremely excited to announce the new addition to their LockPRO Family, Michael "The Grinder" Mizrachi. "The Grinder" as he is affectionately known, began his career when he left college to pursue a life as a professional poker player. He exploded on the scene when he won two World Poker Tour titles and Card Player's 2006 Player of the Year award. The Grinder is also a 2-time WSOP Players Champion, 3-time WSOP bracelet winner and is ranked 8th on the all-time money list with over $14,000,000 in lifetime earnings. His career and popularity ...

The business climate has dramatically changed over the past few years, and sales targets are deemed to be more difficult to hit than the same time last year. However, by implementing new business practices that identify and reach the best prospects, it is possible to rise above the sluggish economy reports Harvey Wayne Communications. Harvey Wayne Communications suggest due to the way most companies negatively view and respond to an economic crisis, it creates an opportunity for proactive businesses to build exposure, win new business and expand in the market. The key ...

While many environmentalists have lauded recycling and reducing waste for years, the concept of turning "one man's trash into another man's treasure," has begun to take a whole new turn in the world of consumerism and style. While repurposing used objects is a practice commonly found throughout the arts and crafts community, many consumers are finding that the quality of these items--especially furniture--is exceptional enough to buy. A recent article from Core 77 highlights one Pennsylvania-based company that has repurposed wood from 18th century barns to create ...

The latter half of 2012 has proven to be a busy season for ITERA International Group of Companies, but also a highly rewarding one. Still celebrating its 20-year anniversary, the company has been awarded with a prestigious national honor; ITERA has been selected as 2012's "Company of the Year" in the "Fuel and Energy" category, a national award that marks the highest honor bestowed upon Russian enterprises. "That ITERA International Group of Companies would win such a distinct honor, right on the heels of our two-decade anniversary, is wonderfully ...

The online marketplace and social sphere has remained an incredibly valuable spot for companies to market, as many continue to explore new ways to reach out to target consumers through social media efforts. While these efforts may seem lifeless and impersonal to many, a recent article from Entrepreneur suggests that consumers are looking for a human connection from new companies, even if that connection is coming from the Internet. Jason Proch, a leading marketing professional, explains that while it is important to connect the consumer to the story and the brand of a start-up ...

The Tour Odeon, due to be completed in 2014, is a 170 meter, 49-floor double skyscraper billed to be the tallest and most lavish development in Monaco since Le Millefiori and L'Annonciade, residential towers built in 1969. The project is being overseen by architect Alexandre Girald and interior designer Alberto Pinto. Girald, who is currently collaborating with Lord Norman Foster on the new yacht club in Monte Carlo, is regarded as the most important and influential architect working in Monaco today. Pinto is lauded as a master of modern European architecture and ...

Dr. Kenneth Siegel is proud to announce that Dental Excellence of Blue Bell has added Tekscan technology to help guide occlusal adjustments and ensure more effective treatments for their patients. For years, Siegel's office has served patients in the Philadelphia area by providing high quality general and cosmetic treatments; however, the addition of Tekscan's T-Scan III will promote greater occlusal analysis results, thanks to increased accuracy and efficiency. "The T-Scan is an amazing, handheld diagnostic device that provides computerized occlusal analysis," ...

CheapTrafficAttorneys.com is offering a discount on legal representation for traffic violation tickets at the Metropolitan Traffic Ticket Court on South Hill Street in Los Angeles. For a limited time, an experienced traffic ticket attorney from CheapTrafficAttorneys.com will represent clients in court who wish to contest tickets for qualifying traffic violations for the low price of only $169. Many people who receive a ticket for a traffic violation in the Los Angeles area wish to fight their ticket, but they hesitate to do so because they do not have the time or the ...