The finding involves the cancer gene RhoC, which has previously been shown to promote metastasis of many types of cancer. RhoC levels increase as breast cancer progresses and high levels of RhoC are associated with worse patient survival. Cancer stem cells are the small number of cells within a tumor that are believed to fuel the tumor's growth and spread. Researchers believe traditional chemotherapy and radiation treatments often become ineffective because they do not kill the cancer stem cells, and that the key to future treatments is to develop drugs that target and ...

New Rochelle, NY, July 24, 2012—A naturally occurring line of immunodeficient pigs can support the growth of human tumors injected under their skin, offering a promising new large animal model for studying human cancers and testing new drugs and treatment strategies. The ability of human melanoma cells and pancreatic carcinoma cells to grow in these pig models is described in an article in BioResearch Open Access, a new bimonthly peer-reviewed open access journal from Mary Ann Liebert, Inc. (http://www.liebertpub.com). The article is available free online at the BioResearch ...

ROCHESTER, Minn. -- Participation in competitive sports by people with long QT syndrome -- a genetic abnormality in the heart's electrical system -- has been a matter of debate among physicians. Current guidelines disqualify most LQTS patients from almost every sport. In a first-of-its-kind study, Mayo Clinic's LQTS Clinic recently examined its own experience, determining the outcome of LQTS patients who chose to remain athletes against guideline recommendations. The study is published online in the Journal of the American Medical Association. In the study, the records ...

The scientific community has always wanted to know why people who eat high-salt diets are prone to developing medical problems such as kidney stones and osteoporosis. Medical researchers at the University of Alberta may have solved this puzzle through their work with animal lab models and cells. Principal investigator Todd Alexander and his team recently discovered an important link between sodium and calcium. These both appear to be regulated by the same molecule in the body. When sodium intake becomes too high, the body gets rid of sodium via the urine, taking calcium ...

Human defensins, aptly named antimicrobial peptides, are made in immune system cells and epithelial cells (such as skin cells and cells that line the gut). One of these peptides, human neutrophil peptide 1, under certain circumstances hinders HIV infection, but exactly how it works remains unclear. HIV entry into mature T-helper cells (cells essential to the immune system) proceeds by attachment of the virus to specific targets on T-helper cells, uptake of the virus, fusion of its envelope with the cell membranes, and release of the virus into the cells. In a forthcoming ...

In addition to the well-known risk factor of smoking, chronic obstructive pulmonary disease (COPD) increases lung cancer risk. A University of Colorado Cancer Center study published in the journal Cancer Prevention Research details one novel mechanism of this risk: long-term oxygen depletion stimulates signals that promote tumor growth. In addition, this early study – performed in animal models – shows that tumors fueled by these COPD-induced signals may be especially susceptible to prevention or perhaps even treatment with drugs that turn off these same signals, namely ...

CORVALLIS, Ore. – The northern spotted owl, a threatened species in the Pacific Northwest, would actually benefit in the long run from active management of the forest lands that form its primary habitat and are increasingly vulnerable to stand-replacing fire, researchers conclude in a recent study. Whatever short-term drawbacks there may be from logging, thinning, or other fuel reduction activities in areas with high fire risk would be more than offset by improved forest health and fire-resistance characteristics, the scientists said, which allow more spotted owl habitat ...

Scientists have long speculated that high diabetes rates among Native Americans may have roots in the evolutionary past. "Thrifty" genes that helped ancient hunter-gatherers store fat for survival during famine may contribute to diabetes in modern times of plenty. But a new analysis of fossil feces from an Arizona cave suggests that the evolution of thrifty genes had little to do with famine and much more to do with the nature of the ancient feast. The research, reported in the August issue of Current Anthropology, shows that prehistoric hunter-gatherers in the Southwest ...

Emerging techniques to pull carbon dioxide from the air and store it away to stabilize the climate may become increasingly important as the planet tips into a state of potentially dangerous warming, researchers from Columbia University's Earth Institute argue in a paper out this week. The upfront costs of directly taking carbon out of the air will likely be expensive, but such technology may well become cheaper as it develops and becomes more widely used, and cost should not be a deterrent to developing such a potentially valuable tool, the authors said. The techniques ...

The famous biologist Stephen J. Gould once asked: If we rerun the tape of life, would the outcome of evolution be the same? For years, scientists have questioned whether evolution is predictable, or whether chance events make such predictability unlikely. A study published online July 23 in the Proceedings of the National Academy of Sciences finds that in the case of insects that developed resistance to a powerful plant toxin, the same adaptations have occurred independently, in separate species in different places and times. The paper examines 18 insect species across ...

A new probe developed collaboratively at Norris Cotton Cancer Center and Dartmouth College's Thayer School of Engineering uses an innovative fluorescence-reading technology to help brain surgeons distinguish cancerous tissue from normal tissue. The probe tool, now already in use at the Cancer Center for brain surgery, may one day be used for surgeries for a variety of cancers. Performing surgery to remove a brain tumor requires surgeons to walk a very fine line. If they leave tumor tissue behind, the tumor is likely to regrow; if they cut out too much normal tissue, they ...

Six months ago, researchers at UCLA published a study that showed using a specific type of yoga to engage in a brief, simple daily meditation reduced the stress levels of people who care for those stricken by Alzheimer's and dementia. Now they know why. As previously reported, practicing a certain form of chanting yogic meditation for just 12 minutes daily for eight weeks led to a reduction in the biological mechanisms responsible for an increase in the immune system's inflammation response. Inflammation, if constantly activated, can contribute to a multitude of chronic ...

Vaccines against human papillomavirus (HPV) are now recommended by the Centers for Disease Control and Prevention for both teenage boys and girls. The vaccine protects against the two most common types of the virus that cause cervical cancer: HPV 16 and 18. Is there a chance that the increased number of people vaccinated might result in an increase of other types of HPV that cause cancer? A UNC-led international team of scientists studied this question in a group of 2228 Kenyan men as a "nested" trial in a larger trial. Their first paper in the Journal of Infectious ...

BETHESDA, Md. (July 24, 2012)—Childhood obesity has nearly tripled in the past three decades, and by 2009, 17 percent of those 2-19 years of age were classified as obese. If actions against childhood obesity do not take place it is likely that today's children could be the first generation in over a century to experience a decline in life expectancy due to the epidemic of childhood obesity which leads to complications in later life. While little is known about how inactivity and obesity lead to undesirable side effects such as diabetes, cardiovascular disease and some cancers, ...

BOSTON—The opportunistic fungal pathogen Candida albicans inconspicuously lives in our bodies until it senses that we are weak, when it quickly adapts to go on the offensive. The fungus, known for causing yeast and other minor infections, also causes a sometimes-fatal infection known as candidemia in immunocompromised patients. An in vivo study, published in mBio, demonstrates how C. albicans can distinguish between a healthy and an unhealthy host and alter its physiology to attack. "The ability of the fungus to sense the immune status of its host may be key to its ability ...

A Cleveland Clinic research team is developing virtual models of human knee joints to better understand how tissues and their individual cells react to heavy loads – virtual models that someday can be used to understand damage mechanisms caused by the aging process or by debilitating diseases, such as osteoarthritis. Led by Ahmet Erdemir, Ph.D., the team is leveraging the powerful computing systems of the Ohio Supercomputer Center to develop state-of-the-art computational representations of the human body to understand how movement patterns and loads on the joints deform ...

Could a low-cost screening device connected to a cell phone save thousands of women and children from anemia-related deaths and disabilities? That's the goal of Johns Hopkins biomedical engineering undergraduates who've developed a noninvasive way to identify women with this dangerous blood disorder in developing nations. The device, HemoGlobe, is designed to convert the existing cell phones of health workers into a "prick-free" system for detecting and reporting anemia at the community level. The device's sensor, placed on a patient's fingertip, shines different wavelengths ...

Once you pop the top of a tube of potato chips, it can be hard to stop munching its contents. But Cornell University researchers may have found a novel way to help: edible serving-size markers that act as subconscious stop signs. As part of an experiment carried out on two groups of college students (98 students total) while they were watching video clips in class, researchers from Cornell's Food and Brand Lab served tubes potato chips, some of which contained chips dyed red. Researchers found that the red chips served as subconscious "stop signs" that curtailed the amount ...

Do you have what it takes to be an ethical hacker? Can you step into the shoes of a professional paid to outsmart supposedly locked-down systems? Now you can at least try, no matter what your background, with a new card game developed by University of Washington computer scientists. "Control-Alt-Hack" gives teenage and young-adult players a taste of what it means to be a computer-security professional defending against an ever-expanding range of digital threats. The game's creators will present it this week in Las Vegas at Black Hat 2012, an annual information-security ...

White blood cells called neutrophils, which are the first line of defense against infection, play an unexpected role by boosting antibody production, according to research led by Mount Sinai School of Medicine. The findings suggest neutrophils have multiple roles within the immune system and function at levels previously unknown to the scientific community. The research, published in Nature Immunology, provides groundbreaking insight into possible new approaches in vaccine development for blood-borne infections and HIV. Neutrophils are part of the so-called innate immune ...

Researchers from Mount Sinai School of Medicine have developed a new computational method that will make it easier for scientists to identify and prioritize genes, drug targets, and strategies for repositioning drugs that are already on the market. By mining large datasets more simply and efficiently, researchers will be able to better understand gene-gene, protein-protein, and drug/side-effect interactions. The new algorithm will also help scientists identify fellow researchers with whom they can collaborate. Led by Avi Ma'ayan, PhD, Assistant Professor of Pharmacology ...

VIDEO: Parasitic vines like dodder are major pests. UC Davis plant biologist Neelima Sinha talks about her work which helps plants fight off these parasites by attacking the connections where they... Click here for more information. Dodder vines are parasitic plants that suck water, nutrients and information from other plants as they spread over them. Plant biologists at the University of California, Davis, have now shown that they can make plants resistant to dodder by attacking ...

For the first time, scientists have identified tropical and subtropical species of marine protozoa living in the Arctic Ocean. Apparently, they traveled thousands of miles on Atlantic currents and ended up above Norway with an unusual—but naturally cyclic—pulse of warm water, not as a direct result of overall warming climate, say the researchers. On the other hand: arctic waters are warming rapidly, and such pulses are predicted to grow as global climate change causes shifts in long-distance currents. Thus, colleagues wonder if the exotic creatures offers a preview of climate-induced ...

People who grew up in the worst years of 'The Troubles ' are more prone to suicide in Northern Ireland, according to new research carried out at Queen's University Belfast. The research, which examined death registration data over the last 40 years, found that the highest suicide rate is for men aged 35-44 (41 per 100,000 by 2010) followed closely by the 25-34 and 45-54 age groups. The findings showed that children who grew up in the worst years of violence between 1969 and 1977-78 are the cohort which now has the highest suicide rates and the most rapidly increasing rates ...

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