A computerized checklist system designed to help physicians identify and use the best methods of preventing potentially deadly blood clots in hospitalized trauma patients dramatically reduced the number of these dangerous venous thromboembolisms (VTEs), new Johns Hopkins research suggests. When a doctor enters medical orders for such patients, the automated checklist recommends evidence-based best treatments for each patient's needs, usually the regular administration of low-dose blood thinners or the use of compression devices to keep blood flowing in the legs. The researchers ...

Neuroscientists from New York University and the University of California, Irvine have isolated the "when" and "where" of molecular activity that occurs in the formation of short-, intermediate-, and long-term memories. Their findings, which appear in the journal the Proceedings of the National Academy of Sciences, offer new insights into the molecular architecture of memory formation and, with it, a better roadmap for developing therapeutic interventions for related afflictions. "Our findings provide a deeper understanding of how memories are created," explained the ...

CHICAGO – Men who were diagnosed as children with attention-deficit/hyperactivity disorder (ADHD) appeared to have significantly worse educational, occupational, economic and social outcomes in a 33-year, follow-up study that compared them with men without childhood ADHD, according to a report published Online First by Archives of General Psychiatry, a JAMA Network publication. ADHD has an estimated worldwide prevalence of 5 percent, so the long-term outcome of children with ADHD is a major concern, according to the study background. Rachel G. Klein, Ph.D., of the ...

CHICAGO – Patients who undergo bariatric weight loss surgery may be at increased risk for substance use (drug use, alcohol use and cigarette smoking) following surgery, particularly among patients who undergo laparoscopic Roux-en-Y gastric bypass surgery who appear to be at increased risk for alcohol use following surgery, according to a report published Online First by Archives of Surgery, a JAMA Network publication. "Studies have shown that drugs, alcohol, and food trigger similar responses in the brain and that bariatric surgery candidates whose condition has been ...

CHICAGO – A telephone survey of 4,851 individuals in Germany suggests the overall prevalence of sunbed use was nearly 40 percent for participants who had ever used one and 14.6 percent had used a tanning bed within the last 12 months, according to a study published Online First by Archives of Dermatology, a JAMA Network publication. Exposure to UV radiation (UVR) is one of the main risk factors for developing skin cancer and tanning beds are a common source of UVR. There also is evidence that the use of sunbeds significantly increases the risk of skin cancer, according ...

The most common measure of intelligence in animals, brain size relative to body size, may not be as dependent on evolutionary selection on the brain as previously thought, according to a new analysis by scientists. Brain size relative to body size has been used by generations of scientists to predict an animal's intelligence. For example, although the human brain is not the largest in the animal kingdom in terms of volume or mass, it is exceptionally large considering our moderate body mass. Now, a study by a team of scientists at UCL, the University of Konstanz, ...

[Second hand smoke in cars: assessing children's potential exposure during typical journey conditions 2012; 578-83; doi 10.1136/tobaccocontrol-2011-050197] Smoking during car journeys pumps harmful particulate matter into the indoor air space at levels that far exceed World Health Organization guidance—even when the windows are open or air conditioning is switched on—finds the largest study of its kind, in Tobacco Control. Such levels of exposure are likely to affect the health of any child passengers, say the authors. Levels of fine particulate matter were measured ...

[Shame! Self-stigmatisation as an obstacle to sick doctors returning to work: a qualitative study doi 10.1136/bmjopen-2012-001776] Doctors who have been on long term sick leave find it hard to return to work because they are overwhelmed with feelings of shame and failure, and fear the disapproval of colleagues, finds research published in the online journal BMJ Open. The authors call for cultural change, starting in medical school, to allow doctors to recognise their own vulnerabilities and cope better with both their own and their colleagues' ill health. The authors ...

TORONTO– Worker bees have become a highly skilled and specialized work force because the genes that determine their behaviour are shuffled frequently, helping natural selection to build a better bee, research from York University suggests. The embargoed study, to be published October 15 at 3pm EST in PNAS (Proceedings of the National Academy of Sciences), sheds light on how worker bees – who are sterile – evolved charismatic and cooperative behaviours such as nursing young bees, collecting food for the colony, defending it against intruders, and dancing to communicate ...

A brain pathway that is stimulated by traumatic or fearful experiences can be disrupted by two compounds that show promise for preventing post-traumatic stress disorder, Indiana University researchers reported. In a presentation prepared for the Neuroscience 2012 scientific conference in New Orleans Oct. 13 to 17, Anantha Shekhar and colleagues from IU reported the results of experiments with rats using a standard methodology called a conditioned fear test. The neural signaling activated by fearful experiences -- a process that also is involved in learning and in ...

NEW ORLEANS — Mother rats respond much differently to cocaine than female rats that have never given birth, according to new University of Michigan research that looks at both behavior and brain chemistry. The findings may help lay the groundwork for more tailored human addiction treatment, based on scientific understanding of how gender, hormones and life experience impact drug use. In an oral presentation at the Society for Neuroscience meeting, U-M researcher Jennifer Cummings, Ph.D., summarized findings from experiments with rats at the Molecular and Behavioral ...

(SACRAMENTO, Calif.) -- An analysis of 27 studies linking psoriasis in 314,000 individuals with diabetes has found strong correlation between the scaly skin rash and the blood sugar disorder that predisposes patients to heart disease, say UC Davis researchers who led the review. The findings appear in an article titled "Psoriasis and the risk of diabetes: a systematic review and meta-analysis," which is now online in the Archives of Dermatology. "Our investigation found a clear association between psoriasis and diabetes," said April Armstrong, assistant professor ...

LA JOLLA, CA – A study of binge-drinking rodents suggests that knocking back a few drinks every few days may swiftly reduce one's capacity to control alcohol intake. Scientists at The Scripps Research Institute (TSRI) found signs of cognitive impairment in rats similar to that seen in established alcoholism after the animals had only a few months of intermittent access to alcohol. The researchers linked the rats' impairment to a small group of neurons that inhibit "executive control" functions in the prefrontal cortex of the brain. These neurons were unusually active ...

For 50 years, the world's soybean crop has depended on the use of cyst nematode resistant varieties of beans, but no one knew how these plants fought off the nematode pests. Now, the secrets of resistant soybean plants are finally coming to light. Surprisingly, one of the genes related to nematode resistance in soybeans also has been associated with human diseases including lymphocytic leukemia, spina bifida and cardiovascular disease, according to a team of University of Missouri researchers and their colleagues whose breakthrough was recently published in the journal ...

WASHINGTON – When learning a new language, we automatically organize words into sentences that will be both clearly understood and efficient (quick) to communicate. That's the finding of a new study reported today in the Proceedings of the National Academy of Sciences (PNAS) which challenges opposing theories on why and how languages come to be organized the way they are. With more than 5000 languages in the world, it would be easy to assume all vary endlessly, but, in fact, there is great commonality: languages follow only a few recurrent patterns. These commonalities ...

Early signs of lung cancer could be diagnosed using a simple blood test following a new discovery by scientists at the University of York. Early detection of lung cancer has been shown to save lives, but available methods for screening at-risk people are either too costly or involve invasive procedures. The latest findings, published today in the US journal Proceedings of the National Academy of Sciences, mean that a simple blood test could now be developed. Dr Dawn Coverley, who is based at the University's Department of Biology and is funded by Yorkshire Cancer Research, ...

A new Ebola virus study resulting from a widespread scientific collaboration has shown promising preliminary results, preventing disease in infected nonhuman primates using monoclonal antibodies. In this week's online edition of the Proceedings of the National Academy of Sciences (PNAS), the research team describes a proof-of-concept for using a "cocktail" of monoclonal antibodies, or mAbs, to prevent lethal disease in rhesus macaques. When administered one hour after infection, all animals survived. Two-thirds of the animals were protected even when the treatment, known ...

A new method of using adult stem cells as a model for the hereditary condition Gaucher disease could help accelerate the discovery of new, more effective therapies for this and other conditions such as Parkinson's, according to new research from the University of Maryland School of Medicine. Scientists at the University of Maryland School of Medicine reprogrammed stem cells to develop into cells that are genetically similar to and react to drugs in a similar way as cells from patients with Gaucher disease. The stem cells will allow the scientists to test potential new ...

MADISON -- Troy, the palatial city of prehistory, sacked by the Greeks through trickery and a fabled wooden horse, will be excavated anew beginning in 2013 by a cross-disciplinary team of archaeologists and other scientists, it was announced today (Monday, Oct. 15). The new expedition will be led by University of Wisconsin-Madison classics Professor William Aylward, an archaeologist with long experience digging in the ruins of classical antiquity, including Troy itself. The new international project at Troy, to be conducted under the auspices of and in cooperation with ...

PHILADELPHIA — Making uniform coatings is a common engineering challenge, and, when working at the nanoscale, even the tiniest cracks or defects can be a big problem. New research from University of Pennsylvania engineers has shown a new way of avoiding such cracks when depositing thin films of nanoparticles. The research was led by graduate student Jacob Prosser and assistant professor Daeyeon Lee, both of the Department of Chemical and Biomolecular Engineering in Penn's School of Engineering and Applied Science. Graduate student Teresa Brugarolas and undergraduate ...

Soybean cyst nematode (SCN) does hundreds of millions of dollars' worth of damage each year. Matt Hudson and Brian Diers, crop sciences researchers at the University of Illinois and Andrew Bent at the University of Wisconsin, think they may have found a way to strengthen plant resistance. The research has just been published in Science Express. Diers and Hudson, with researchers at Wisconsin and the University of Nebraska, have been studying an area on chromosome 18 called Rhg1 (Resistance to H. glycines) that is known to be the location of the main source of SCN resistance. ...

COLUMBUS, Ohio – Companionship has the potential to reduce pain linked to nerve damage, according to a new study. Mice that were paired with a cage-mate showed lower pain responses and fewer signs of inflammation in their nervous system after undergoing surgery that affected their nerves than did isolated mice, suggesting that the social contact had both behavioral and physiological influences. The social contact lowered the pain response and signs of inflammation even in animals that had experienced stress prior to the nerve injury. These mice experienced a specific ...

MOUNTAIN VIEW, CA – October 15, 2012 – In a new theoretical study, 23andMe, the leading personal genetics company, developed a mathematical model which shows that family history and genetic tests offer different strengths. The study results suggest that both family history and genetics are best used in combination to improve disease risk prediction. The full results of the study have now been published online in the journal PLOS Genetics. Family history is most useful in assessing risks for highly common, heritable conditions such as coronary artery disease. However, ...

Archaeologists from the University of Leicester who uncovered a grave thought to contain the skeleton of King Richard III have revealed that the remains came within inches of being destroyed by Victorian builders. The University of Leicester led the search for the Anointed King who died at the battle of Bosworth in association with Leicester City Council and the Richard III Society. The University team dug three trenches under a Leicester car park before their discovery was made. Now site director Mathew Morris has disclosed that the remains were found just inches below ...

Exercise and healthy eating reduce body fat and preserve muscle in adults better than diet alone, according to a study funded and conducted by National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK), part of the National Institutes of Health. The study was recently published online in Obesity and will be in a future print edition. NIDDK senior investigator Kevin Hall, Ph.D., analyzed the individual effects of daily strenuous exercise and a restricted diet by examining data from 11 participants from the reality television program "The Biggest Loser." ...