PHILADELPHIA — Treatment with denosumab resulted in a greater reduction in skeletal-related events in patients with breast cancer that spread to the bones compared with zoledronic acid, while also maintaining health-related quality of life, according to the results of a phase III study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "Our data indicate that denosumab should be the treatment of choice for the prevention of skeletal-related events and hypercalcemia in patients with breast cancer that has metastasized to the ...

How the intricate network of blood vessels forms within the brain has long fascinated biologists. Though the human brain comprises only 2 percent of body weight it receives up to 15 percent of the cardiac output through this network, or vessel vasculature. The vasculature in the human brain consists of a complex branching network of blood vessels, in total some several hundred miles in length. The network is formed so as to distribute blood efficiently to all brain regions, and abnormalities can lead to various neurological disorders, including strokes, learning difficulties ...

Among pregnant women who did not develop gestational diabetes, overweight women were 65 percent more likely, and obese women 163 percent more likely, to have overly large babies than their healthy weight counterparts. In this study, an overly large infant was identified based on having a birth weight over the 90th percentile for their gestational age at delivery and gender. Gaining excess weight during pregnancy also contributed to having a large for gestational age baby, regardless of maternal weight or whether she developed gestational diabetes. This Kaiser Permanente ...

The small fragments of tropical forests left behind after deforestation are suffering extensive species extinction, according to new research led by the University of East Anglia (UEA). Publishing today in the journal PLoS ONE, the researchers carried out a comprehensive assessment to estimate the long-term impact of forest fragmentation and hunting on tropical biodiversity in Brazil. They studied the Atlantic Forest of eastern Brazil, including the region's largest and least disturbed old-growth forest remnants, and found that remaining habitat fragments had been virtually ...

CHICAGO – Among couples in which one partner was diagnosed as having posttraumatic stress disorder (PTSD), participation in disorder-specific couple therapy resulted in decreased PTSD symptom severity and increased patient relationship satisfaction, compared with couples who were placed on a wait list for the therapy, according to a study in the August 15 issue of JAMA, a theme issue on violence and human rights. "There are well-documented associations between PTSD and intimate relationship problems, including relationship distress and aggression, and studies demonstrate ...

CHICAGO – The results of two studies in the August 15 issue of JAMA report on the psychological status of workers at the Fukushima nuclear power plants in Japan several months after the earthquake and tsunami in March 2011, and the amount of internal radiation exposure among residents of a city north of the power plant that experienced a meltdown. As reported in a Research Letter, Jun Shigemura, M.D., Ph.D., of the National Defense Medical College, Saitama, Japan, and colleagues examined the psychological status of Fukushima workers 2 to 3 months after the disaster for ...

CHICAGO – In a study that included more than 2,700 women receiving care in primary care clinics, those who were screened for partner violence and received a partner violence resource list did not experience significant differences for several outcomes, including overall quality of life, general health, and recurrence of partner violence, compared to women who just received a partner violence resource list, according to a study in the August 15 issue of JAMA, a theme issue on violence and human rights. "Recognition of partner violence as a health and public health problem ...

People with blood type A, B, or AB had a higher risk for coronary heart disease when compared to those with blood type O, according to new research published in Arteriosclerosis, Thrombosis and Vascular Biology, an American Heart Association journal. People in this study with the rarest blood type — AB, found in about 7 percent of the U.S. population — had the highest increased heart disease risk at 23 percent. Those with type B had an 11 percent increased risk, and those with type A had a 5 percent increased risk. About 43 percent of Americans have type O blood. "While ...

Computer and web-based weight management programmes may provide a cost effective way of addressing the growing problem of obesity, according to a team of seven researchers who undertook a Cochrane systematic review. The researchers, from Maryland, Massachusetts, New York, Pennsylvania and Rhode Island, USA, found that delivering weight loss or weight maintenance programmes online or by computer helped overweight and obese patients lose and/or maintain weight. Being overweight or obese can increase a person's risk of diabetes, heart disease, high blood pressure, stroke ...

Compounds in cocoa may help to reduce blood pressure, according to a new systematic review in The Cochrane Library. The researchers reviewed evidence from short-term trials in which participants were given dark chocolate or cocoa powder daily and found that their blood pressure dropped slightly compared to a control group. Cocoa contains compounds called flavanols, thought to be responsible for the formation of nitric oxide in the body. Nitric oxide causes blood vessel walls to relax and open wider, thereby reducing blood pressure. The link between cocoa and blood pressure ...

Exercise may improve quality of life for people with cancer, according to Cochrane researchers. In two separate Cochrane systematic reviews, the authors gathered together evidence showing that activities such as walking and cycling can benefit those who are undergoing or have completed treatment for cancer. People with cancer suffer from many different physical, psychological and social effects related to cancer, as well as treatment-related symptoms. There has been much interest in the effects of exercise on physical and psychological well-being in people with cancer. ...

Cold Spring Harbor, NY – A team led by scientists at Cold Spring Harbor Laboratory (CSHL) has developed a new way of making animal models for a broad class of human genetic diseases – those with pathology caused by errors in the splicing of RNA messages copied from genes. To date, about 6,000 such RNA "editing" errors have been found in various human illnesses, ranging from neurodegenerative disorders to cancer. The new modeling approach can provide unique insights into how certain diseases progress and is likely to boost efforts to develop novel treatments. It was ...

Nurse-centred care of HIV patients can be just as safe and effective as care delivered by doctors and has a number of specific health benefits, according to a new study led by the University of East Anglia (UEA) and the University of Cape Town (UCT). Published today in The Lancet, the research shows that neither survival rates nor virus suppression reduced when nurses administered antiretroviral drugs to patients in South Africa. Health benefits included: significantly improved detection of tuberculosis; increased white blood cell count; increased weight; and improved ...

Financial incentives (pay for performance) schemes for health professionals "can undermine motivation and worsen performance" warn US experts in an editorial published on bmj.com today. They also say that gaming of the system is rife. Their views are published alongside an analysis of the positive and negative effects of financial incentives led by Professor Paul Glasziou of Bond University in Australia. Glasziou and colleagues describe the current evidence on the effectiveness of financial incentives as "modest and inconsistent" and say that, although reward schemes ...

Certain medical students may be more likely to stay in their own countries or work in rural areas of their own countries when they qualify as doctors, suggests a study published on bmj.com today. Given that many low income countries have insufficient doctors to meet their needs, particularly in rural areas, the authors suggest that policy makers could use this evidence to adjust entrance criteria for medical schools that favour subsequent practice in less well served areas of their country. Previous studies have shown that, in high income countries, doctors with rural ...

A paper published on bmj.com today suggests that over 1000 people have committed suicide due to the 2008-2010 economic recession in the UK (846 men and 155 women). Suicides began to rise in the UK in 2008 following 20 years of decline - suicides rose 8% among men and 9% among women in 2008, compared to 2007. And even though suicides did begin to fall in 2010 figures were still above the 2007 averages. Previous studies have concluded that unemployment does increase the risk of suicide and non-fatal self-harm but while suicides tend to increase during economic downturns, ...

In a cautionary editorial alongside a related article in today's issue of the British medical journal BMJ, leading experts in health policy and behavioral economics argue that pay-for-performance (P4P) schemes – which financially reward doctors and hospitals for hitting specific, numerical targets in such matters as preventing hospital readmissions or prescribing certain drugs – are likely to do more harm than good. Such schemes are being adopted as a key component of the Accountable Care Organization strategy mandated by the 2010 health reform and are now part of the ...

In a major breakthrough, an international team of scientists has proven that addiction to morphine and heroin can be blocked, while at the same time increasing pain relief. The team from the University of Adelaide and University of Colorado has discovered the key mechanism in the body's immune system that amplifies addiction to opioid drugs. Laboratory studies have shown that the drug (+)-naloxone (pronounced: PLUS nal-OX-own) will selectively block the immune-addiction response. The results – which could eventually lead to new co-formulated drugs that assist patients ...

When a carnivore becomes extinct, other predatory species could soon follow, according to new research. Scientists have previously put forward this theory, but a University of Exeter team has now carried out the first experiment to prove it. Published today (15 August 2012) in the Royal Society journal Biology Letters, the study shows how the demise of one carnivore species can indirectly cause another to become extinct. The University of Exeter team believes any extinction can create a ripple effect across a food web, with far-reaching consequences for many other animals. ...

CAMBRIDGE, MA -- From an engineer's perspective, plants such as palm trees, bamboo, maples and even potatoes are examples of precise engineering on a microscopic scale. Like wooden beams reinforcing a house, cell walls make up the structural supports of all plants. Depending on how the cell walls are arranged, and what they are made of, a plant can be as flimsy as a reed, or as sturdy as an oak. An MIT researcher has compiled data on the microstructures of a number of different plants, from apples and potatoes to willow and spruce trees, and has found that plants exhibit ...

It's become a sport of sorts, predicting the low point of Arctic sea ice each year. Expert scientists with decades of experience do it but so do enthusiasts, whose guesses are gamely included in a monthly predictions roundup collected by Sea Ice Outlook, an effort supported by the U.S. government. When averaged, the predictions have come in remarkably close to the mark in the past two years. But the low and high predictions are off by hundreds of thousands of square kilometers. Researchers are working hard to improve their ability to more accurately predict how much ...

Girls with Attention Deficit Hyperactivity Disorder (ADHD) – and their families – often look forward to the likely decline in visible symptoms such as fidgety or disruptive behavior as they mature into young women. However, new findings from UC Berkeley caution that, as they enter adulthood, girls with histories of ADHD are more prone to internalize their struggles and feelings of failure – a development that can manifest itself in self-injury and even attempted suicide. "Like boys with ADHD, girls continue to have problems with academic achievement and relationships, ...

An intensifying Tropical storm called Kai-Tak (locally known as Helen) is causing more rain in the Philippines as it passes over northern Luzon. The Philippines have had a very wet month with the capital of Manila experiencing massive flooding earlier this month. NASA's TRMM satellite identified where the heavy rain was falling. Kai-tak has caused another day of warnings in the Philippines. On August 14, Public storm warning signal #1 is in effect for these provinces in Luzon: La Union, Nueva Ecija, Pangasinan, Rest of Aurora, and Tarlac. In addition, Public storm warning ...

Tropical Storm Hector is battling wind shear over the open waters of the Eastern Pacific Ocean, and NASA satellite data shows that has been affecting its organization and rainfall rates. The Tropical Rainfall Measuring Mission satellite known as TRMM is managed by both NASA and the Japanese Space Agency. From its orbit in space, TRMM's instruments can estimate rainfall from tropical cyclones. The TRMM satellite captured rainfall rates from Tropical Storm Hector on August 14, 2012 1:28 a.m. EDT. TRMM data showed that Hector had a small area of moderate to heavy rainfall ...

VIDEO: Filmed at 10,000 frames per second by Japan's NHK television, movies like this of electromagnetic bursts called "sprites " will help scientists better understand how weather high in the atmosphere relates... Click here for more information. High above the clouds during thunderstorms, some 50 miles above Earth a different kind of lightning dances. Bursts of red and blue light, known as "sprites," flash for a scant one thousandth of a second. They are often ...