Biologists at UC San Diego have discovered a chemical that offers a completely new and promising direction for the development of drugs to treat metabolic disorders such as type 2 diabetes—a major public health concern in the United States due to the current obesity epidemic. Their discovery, detailed in a paper published July 13 in an advance online issue of the journal Science, initially came as a surprise because the chemical they isolated does not directly control glucose production in the liver, but instead affects the activity of a key protein that regulates the ...

Obesity is not to blame for poor educational performance, according to early findings from research funded by the Economic and Social Research Council (ESRC). In a study that combines statistical methods with genetic information, researchers dispel the false idea that being overweight has damaging educational consequences. Previous studies have shown that children who are heavier are less likely to do well at school. However, Dr Stephanie von Hinke Kessler Scholder from University of York argues it's vital to understand what drives this association. "We sought to test ...

Adverse childhood experiences (ACEs) can stay with us for life. New research published in BioMed Central's open access journal Substance Abuse Treatment, Prevention, and Policy explains how these events can be tied up with adult smoking patterns, especially for women, and suggests that treatment and strategies to stop smoking need to take into account the psychological effects of childhood trauma. ACEs can range from emotional, physical, and sexual abuse to neglect and household dysfunction and affect a large range of people. In one of the largest studies of ACEs survey ...

Receptor The protein in question is the adenosine A2A receptor, the main receptor for caffeine in the human body. This receptor is also linked to Parkinson's disease. The class of around 800 proteins to which the adenosine A2A receptor belongs forms the target for roughly half of all medicines. 'No wonder that researchers across the globe have been trying for decades to find out more about these proteins,' comments IJzerman. Crystallizing the protein To find out whether medicines are effective, you need to understand how the receptors in the cell wall work. An important ...

Research: Reoperation rates after breast conserving surgery for breast cancer among women in England: retrospective study of hospital episode statistics One in five women with breast cancer who opt for breast conserving surgery rather than a mastectomy have a reoperation, according to a national study published on bmj.com today. This information on the risk of reoperation should help women in making the decision about whether to undergo breast conserving surgery or mastectomy. 45,000 women are diagnosed with breast cancer each year in England and in 2008, 58% chose ...

Research: Impact of age and sex on primary preventative treatment for cardiovascular disease in the West Midlands, UK: cross sectional study. More patients aged 75 and over should be prescribed drugs to help lower their risk of cardiovascular disease, a study published today on bmj.com suggests. The researchers argue that older people are being "largely ignored" by current guidance, yet as the population ages, greater use of these drugs could reduce disability and prolong healthy life expectancy. Cardiovascular diseases such as stroke, heart attack and heart failure ...

Diagnosis is key to the control and prevention of endemic livestock diseases in developing regions. New research has found the use of a low-cost diagnostic decision support tool could lead to the improvement in clinical practice by veterinary and animal health officers in sub-Saharan Africa. An international team, led by Professor Mark Eisler, Chair in Global Farm Animal Health in the School of Veterinary Sciences at the University of Bristol, evaluated the effectiveness of a low-cost decision support tool as a diagnostic aid by observing whether its introduction to ...

Who were the first humans to enter the North American continent? Were they humans who founded what is known as the Clovis culture over 13,000 years ago? Or did other, totally unrelated peoples precede the Clovis immigrants? This issue has been intensely, if not bitterly debated for decades. The Clovis culture has been seen as the cradle of North American indigenous culture. Now new international research shows that people of another culture and technology were present concurrently or even previous to those of Clovis. Scientists have added a new and dramatic chapter to the ...

VANCOUVER, B.C. – July 11, 2012 – For centuries, people made wine by stomping grapes with their bare feet. But now, the art of winemaking is going high-tech at The University of British Columbia's Wine Research Centre. Have you ever gotten a headache or a rash from a single glass of wine? Has one glass of Merlot or Shiraz resulted in a painful hangover? If yes, you may be one of the 30 percent of people who are allergic to compounds that are in some of the world's most popular wines. A team of researchers at UBC's Wine Research Centre – which has received funding from ...

As thousands of Americans await a life-saving kidney or liver transplant, medical teams are paying close attention to another organ: their hearts. This month the American Heart Association attempts to bring harmony to the varied cardiac evaluation policies created at U.S. hospitals that assess a patient's overall health before transplant surgery. Approximately 85,000 people are on the waiting list for a kidney transplant and 16,000 are waiting for a liver. It's not unusual for these transplant candidates to be well over age 50 and at increased risk for heart disease. The ...

PASADENA, Calif.—Each century, about two massive stars in our own galaxy explode, producing magnificent supernovae. These stellar explosions send fundamental, uncharged particles called neutrinos streaming our way and generate ripples called gravitational waves in the fabric of space-time. Scientists are waiting for the neutrinos and gravitational waves from about 1000 supernovae that have already exploded at distant locations in the Milky Way to reach us. Here on Earth, large, sensitive neutrino and gravitational-wave detectors have the ability to detect these respective ...

Coral reefs in the Indo-Pacific region, including the Great Barrier Reef, recover faster from major stresses than their Caribbean counterparts, leading marine scientists said today. Dr George Roff and Professor Peter Mumby from the ARC Centre of Excellence for Coral Reef Studies and The University of Queensland told the 12th International Coral Reef Symposium in Cairns that coral reefs in the Indo-Pacific Ocean are naturally tougher than the Caribbean reefs. "The main reason that Indo-Pacific reefs are more resilient is they have less seaweed than the Caribbean Sea," ...

Collagenase extracted from Clostridium histolyticum (trade name: Xiapex®) was approved in the beginning of 2011 for the treatment of people with Dupuytren's contracture. In an early benefit assessment pursuant to the "Act on the Reform of the Market for Medicinal Products" (AMNOG), the German Institute for Quality and Efficiency in Health Care (IQWiG) examined whether collagenase offers an added benefit in comparison with conventional regimens. However, such an added benefit cannot be inferred from the dossier, as the drug manufacturer presented either no data or unsuitable ...

For the first time, scientists in Germany's multiple sclerosis competence network have been able to identify an antibody that bonds with the potassium channel KIR4.1. "We found this autoantibody in almost half of the MS patients in our study," explains Bernhard Hemmer, Professor of Neurology at the Klinikum rechts der Isar hospital at Technische Universitaet Muenchen (TUM). The biomarker was not present in healthy patients. The findings could therefore indicate that KIR4.1 is one of the targets of the autoimmune response in MS. Humans and animals without the KIR4.1 channel ...

Millions of people suffering from Multiple Sclerosis, Parkinson's, muscular dystrophy, spinal cord injuries or amputees could soon interact with their computers and surroundings using just their eyes, thanks to a new device that costs less than £40. Composed from off-the-shelf materials, the new device can work out exactly where a person is looking by tracking their eye movements, allowing them to control a cursor on a screen just like a normal computer mouse. The technology comprises an eye-tracking device and "smart" software that have been presented today, Friday ...

Transplant recipients who smoke or have smoked increase their risk of viral hepatitis reinfection following liver transplantation according to new research available in the July issue of Liver Transplantation, a journal published by Wiley on behalf of American Association for the Study of Liver Diseases. Findings suggest that tobacco in cigarettes may adversely affect immune system response in patients transplanted for viral hepatitis. According to the Centers for Disease Control and Prevention (CDC), tobacco use causes more than five million deaths per year worldwide, ...

Before her death in December 2010, Nieves López Martínez, palaeontologist of the Complutense University of Madrid, was working on the research of dinosaur eggs with a very peculiar characteristic: an ovoid, asymmetrical shape. Together with Enric Vicens, palaeontologist of the Universitat Autònoma de Barcelona, the two scientists conducted an exhaustive analysis of their discovery, recently published in the journal Palaeontology. The new type of dinosaur egg has been given the scientific name of Sankofa pyrenaica. The eggs were discovered in the Montsec area of Lleida, ...

Negative suggestion can induce symptoms of illness. Nocebo effects are the adverse events that occur during sham treatment and/or as a result of negative expectations. While the positive counterpart—the placebo effect—has been intensively studied in recent years, the scientific literature contains few studies on nocebo phenomena. In the latest issue of Deutsches Ärzteblatt International, Winfried Häuser of the Technical University of Munich and his co-authors present the underlying neurobiological mechanisms and highlight the relevance of the nocebo effect in everyday ...

Fuel cells are inefficient because the catalyst most commonly used to convert chemical energy to electricity is made of the wrong material, a researcher at Case Western Reserve University argues. Rather than continue the futile effort to tweak that material - platinum - to make it work better, Chemistry Professor Alfred Anderson urges his colleagues to start anew. "Using platinum is like putting a resistor in the system," he said. Anderson freely acknowledges he doesn't know what the right material is, but he's confident that researchers' energy would be better spent ...

WASHINGTON, July 11, 2012 — The latest episode in the American Chemical Society's (ACS') award-winning Global Challenges/Chemistry Solutions podcast series describes a new, inexpensive paper-based device designed for diabetes testing in rural areas of developing countries. Based on a report by Jan Lankelma, Ph.D., and colleagues in ACS' journal Analytical Chemistry, the podcast is available without charge at iTunes and from www.acs.org/globalchallenges. It explains the need for less-expensive methods to help people with diabetes monitor their blood sugar levels. ...

The constant hunger to break new records has turned boat building into a high-tech business. The racing yachts that compete at international regattas today are sporting machines designed to reach top speeds. The process of optimizing the boats has been ongoing for decades. However, just a short while ago it looked as if a limit had been reached. On the fifth leg of the Volvo Ocean Race in spring 2012, from New Zealand to Brazil, only one of the six teams reached its destination without technical problems – all the others were forced to either take a break from the race ...

Research from the University of Melbourne has shown that two different vaccine viruses- used simultaneously to control the same condition in chickens- have combined to produce new infectious viruses, prompting early response from Australia's veterinary medicines regulator. The vaccines were used to control infectious laryngotracheitis (ILT), an acute respiratory disease occurring in chickens worldwide. ILT can have up to 20% mortality rate in some flocks and has a significant economic and welfare impact in the poultry industry. The research found that when two different ...

Thursday, July 12, 2012 Athens, Ga. – Hypertension frequently coexists in patients with diabetes. A new University of Georgia study shows why the co-morbid conditions can result in impaired vision. "Results showed early signals of cell death in eyes from diabetic animals within the first six weeks of elevated blood pressure. Later, the tiny blood vessels around the optic nerve that nourish the retina and affect visual processing showed signs of decay as early as 10 weeks after diabetic animals develop hypertension," said Azza El-Remessy, assistant professor in the ...

Researchers at the IRCM, led by geneticist Dr. Jacques Drouin, recently defined the interaction between two essential proteins that control inflammation. This important breakthrough will be published in tomorrow's print edition of the scientific journal Molecular Cell. IRCM scientists study glucocorticoids, a class of steroid hormones that suppress the immune system and reduce inflammation. They are used in medicine to treat diseases such as allergies, asthma, and autoimmune diseases. "In molecular biology and genetics, proteins known as transcription factors bind ...

Researchers from North Carolina State University have developed highly conductive and elastic conductors made from silver nanoscale wires (nanowires). These elastic conductors could be used to develop stretchable electronic devices. Stretchable circuitry would be able to do many things that its rigid counterpart cannot. For example, an electronic "skin" could help robots pick up delicate objects without breaking them, and stretchable displays and antennas could make cell phones and other electronic devices stretch and compress without affecting their performance. However, ...