Patients who had surgery for periampullary cancer (a variety of types of cancer that are located in and near the head of the pancreas, including an area called the ampulla where the bile duct joins up with the pancreatic duct to empty their secretions into the upper small intestine) and received chemotherapy had a statistically significant survival benefit, compared to patients who did not receive chemotherapy, after adjusting for prognostic variables, according to a study in the July 11 issue of JAMA. Periampullary carcinomas arise from the head of the pancreas. "The ...

In this week's PLoS Medicine, Julia Hussein from the University of Aberdeen in Scotland and colleagues assess the evidence for the effectiveness of interventions that aim to help pregnant women reach health facilities during an emergency in developing country settings. In a systematic review of the literature they found that the level of evidence for emergency obstetric referral interventions was poor and that limitations in the design of individual studies made determining the effect of referral interventions on outcomes difficult. The authors note, "[d]espite the wealth ...

In a new article published this week that forms part of the PLoS Medicine series on Global Mental Health Practice, Shoba Raja and colleagues report their case study of implementing the "BasicNeeds" model of mental health and development in Nepal, which emphasizes user empowerment, community development, strengthening of health systems, and policy influencing. The authors say their model works in partnership with governments to provide the "great push" that is required to set up services where mental health and development have not yet been a priority. The authors report ...

Insecticide resistance is threatening the effectiveness of insecticide-treated bed nets and indoor insecticide sprays to control adult mosquito vectors, and so more sustainable integrated management strategies that use optimal suites of control tactics are needed. These are the arguments of Willem Takken from the Wageningen University and Research Centre in The Netherlands and colleagues in this week's PLoS Medicine. Experience in agriculture suggests that such integrated approaches can provide more effective and durable pest management, say the authors, which will require ...

DURHAM, N.C. – A drug designed to shield the heart from injury during bypass surgery failed to reduce deaths, strokes and other serious events among patients at high risk of complications, according to a large, prospective study lead by researchers at Duke University Medical Center. But the international study also produced a surprising silver lining. As reported in the July 11 issue of the Journal of the American Medical Association, the researchers discovered that complications among bypass surgery patients were far less frequent than previously reported. "We expected ...

People who are born deaf process the sense of touch differently than people who are born with normal hearing, according to research funded by the National Institutes of Health. The finding reveals how the early loss of a sense— in this case hearing—affects brain development. It adds to a growing list of discoveries that confirm the impact of experiences and outside influences in molding the developing brain. The study is published in the July 11 online issue of The Journal of Neuroscience. The researchers, Christina M. Karns, Ph.D., a postdoctoral research associate in ...

The cancer drug bevacizumab (Avastin®) offers only a modest benefit in delaying disease progression in patients with advanced stage breast cancer, according to a systematic review by Cochrane researchers. The researchers assessed the efficacy of bevacizumab in combination with chemotherapy, an established cancer treatment in this indication, and found no overall survival benefit when adding bevacizumab to chemotherapy. Breast cancer is the most common cause of cancer death among women. If it spreads to other parts of the body it is referred to as "metastatic" and the ...

Taking iron supplements one to three times a week instead of every day is just as effective at preventing anaemia in pregnant women, according to the findings of a new Cochrane systematic review. The authors of the review also showed that women experienced fewer side effects when taking iron supplements intermittently rather than daily. Lack of iron can cause anaemia in pregnant women, potentially increasing the risk of complications at delivery. It may also be harmful to their babies, through increased risk of low birth weight and even delayed growth and development ...

People at high risk of HIV infection can reduce their risk of acquiring the disease by taking antiretroviral drugs, according to Cochrane researchers. In an update of a systematic review first published in 2009, the researchers found that uninfected people in relationships with HIV-infected partners, men who have sex with men and those in other high risk groups are at a lower risk of becoming infected with the virus if they regularly take drugs that are normally prescribed to treat people with HIV. Antiretroviral therapy (ART) is the standard drug treatment for HIV in ...

COLUMBIA, Mo. -- Computer networks are the battlefields in cyberwarfare, as exemplified by the United States' recent use of computer viruses to attack Iran's nuclear program. A computer model developed at the University of Missouri could help military strategists devise the most damaging cyber attacks as well as guard America's critical infrastructure. The model also could benefit other projects involving interconnected groups, such as restoring ecosystems, halting disease epidemics and stopping smugglers. "Our model allows users to identify the best or worst possible ...

WASHINGTON — Researchers at Georgetown University Medical Center appear to have solved the mystery of why some patients infected with HIV, who are using antiretroviral therapy and show no signs of AIDS, develop serious depression as well as profound problems with memory, learning, and motor function. The finding might also provide a way to test people with HIV to determine their risk for developing dementia. They say the answer, published in the July 11 issue of the Journal of Neuroscience, may ultimately lead to a therapeutic solution that helps these patients as well ...

A multi-institutional team of researchers that included scientists with the U.S. Department of Energy's Lawrence Berkeley National Laboratory (Berkeley Lab) has created the first artificial molecules whose chirality can be rapidly switched from a right-handed to a left-handed orientation with a beam of light. This holds potentially huge possibilities for the application of terahertz technologies across a wide range of fields, including biomedical research, homeland security and ultrahigh-speed communications. Chirality is the distinct left/right orientation or "handedness" ...

King penguins tolerate some, but not all, human interference. Research published in BioMed Central's open access journal, BMC Ecology, investigates the adjustment of a king penguin colony on the protected Possession island in the subantarctic Crozet Archipelago to over 50 years of constant human disturbance. A team of researchers from the University of Strasbourg, the Centre National de la Recherche Scientifique (CNRS) and the University of Lausanne, compared 15 king penguins (Aptenodytes patagonicus) breeding in areas disturbed daily by humans and 18 penguins breeding ...

The ability for substances to pass through the blood-brain barrier is increased after adult stroke, but not after neonatal stroke, according to a new study the UCSF that will be published July 11 in the Journal of Neuroscience. The novel findings may have major implications for drug development and the treatment of neonatal stroke, the researchers said. The blood-brain barrier is selectively permeable and blocks unwanted molecules from entering into the brain. The selectivity is achieved through fine coordination in function of many transporting systems in endothelial ...

Research: Long term alcohol intake and risk of rheumatoid arthritis in women: a population based cohort study Moderate consumption of alcohol is associated with a reduced risk of developing rheumatoid arthritis, suggests a study published on bmj.com today. The results show that women who regularly consume more than three alcoholic drinks a week for at least 10 years have about half the risk of developing rheumatoid arthritis compared with non-drinkers. After adjusting for factors such as age, smoking and dietary habits, women who reported drinking more than three ...

Research: Weight gain in smokers after quitting cigarettes: meta-analysis Editorial: Quitting smoking and gaining weight: the odd couple Giving up smoking is associated with an average weight gain of 4-5 kg after 12 months, most of which occurs within the first three months of quitting, finds a study published on bmj.com today. Although this figure is higher than previously thought, an accompanying editorial argues that the health benefits of quitting far outweigh this modest gain in body weight and should not deter people from quitting. It is well known that ...

Toronto – Not all brand–consumer relationships are created equal. Marketers who realize this will be in a better position to retain customers and improve the perceptions of consumers who are unhappy with a brand's service or product, says a new paper from the University of Toronto. Consumers form connections with brands in ways that mirror social relationships. How consumers evaluate a brand depends heavily on whether the brand adheres to—or violates—the implicit relationship agreement. Pankaj Aggarwal, a marketing professor at the Rotman School of Management and ...

A new study published in the July 11 issue of the Journal of Neuroscience details the development of the first mouse model engineered to carry the most common mutation in Usher syndrome III causative gene (Clarin-1) in North America. Further, the research team from Case Western Reserve University School of Medicine used this new model to understand why mutation in Clarin-1 leads to hearing loss. Usher Syndrome is an incurable genetic disease and it is the most common cause of the dual sensory deficits of deafness and blindness. It affects an estimated 50,000 Americans ...

Ottawa, ON – July 10, 2012 — Monitoring the effectiveness of the HPV vaccine in Canada requires that data from multiple registries and other data sources be combined. Linking registries can be problematic, however, since they are often managed by unrelated organizations. Privacy legislation may also restrict the sharing of data for such linkages. To address these challenges, Dr. Khaled El-Emam and his team at the CHEO Research Institute have developed a secure protocol that allows the linking of individual patient records without revealing personal information, which has ...

People with lower incomes value the institution of marriage just as much as those with higher incomes and have similar romantic standards for marriage, according to a new study published in the Journal of Marriage and Family. The new research suggests that government initiatives to strengthen marriage among low-income populations should move beyond promoting the value of marriage and instead focus on the actual problems that low-income couples face. The study, which analysed results from a survey of 6,012 people, was carried out by Dr Thomas Trail and Dr Benjamin Karney ...

In his thesis, Gul Amin, who recently received his doctorate at the Physical Electronics and Nanotechnology group, Campus Norrköping, shows how it is possible to grow white LEDs directly on paper and also to print them on wallpaper for example - this method has a patent pending. The active components are nanorods of zinc oxide on a thin layer of polydiethylflourene (PFO), a conducting polymer. But the paper has first been coated with a thin, water-repellent, protective and levelling layer of cyclotene, a resin. "This is the first time anyone has been able to build ...

This press release is available in German. Black skin cancer, also known as melanoma, is particularly aggressive and becoming increasingly common in Switzerland. Despite intensive research, however, there is still no treatment. Researchers from the University of Zurich have now discovered a gene that plays a central role in black skin cancer. Suppressing this gene in mice inhibits the development of melanoma and its proliferation – a discovery that could pave the way for new forms of therapy. Until recently, it was assumed that a tumor was composed of many ...

Migratory birds and fish use the Earth's magnetic field to find their way. LMU researchers have now identified cells with internal compass needles for the perception of the field – and can explain why high-tension cables perturb the magnetic orientation. Although many animal species can sense the geomagnetic field and exploit it for spatial orientation, efforts to pinpoint the cells that detect the field and convert the information into nerve impulses have so far failed. "The field penetrates the whole organism, so such cells could be located almost anywhere, making them ...

A new species of monkey flower, created by the union of two foreign plant species, has been discovered on the bank of a stream in Scotland. Genetic changes in this attractive yellow-flowered hybrid have allowed it to overcome infertility and made it a rare example of a brand new species that has originated in the wild in the last 150 years. Thousands of wild species and some crops are thought to have originated in this way, yet only a handful of examples exist where this type of species formation has occurred in recent history. The ancestors of the new plant were brought ...

Scientists at the University Medical Center of Johannes Gutenberg University Mainz in Germany identified a novel strategy to target the oncologically relevant protein-cleaving enzyme Taspase1. Taspase1 levels are not only elevated in cancer cells of patients with head and neck tumors and other solid malignancies but the enzyme is also critical for the development of leukemias. Central to this concept is the approach to inhibit the enzyme's activity by 'gluing together' individual Taspase1 molecules. The results of a study undertaken by Professor Dr. Roland Stauber of the ...