In a new study with implications for state and federal efforts to reform payments to doctors and hospitals to encourage greater coordination of care, Harvard Medical School researchers found that a global payment system underway in Massachusetts lowered medical spending while improving the quality of patient care relative to the traditional fee-for-service system. The study, published today in the New England Journal of Medicine, examined the Alternative Quality Contract (AQC), which was first introduced by Blue Cross Blue Shield of Massachusetts (BCBSMA) in 2009 and ...

Fairbanks, Alaska—Until now, scientists were uncertain about how much and where in the world terrestrial carbon is being stored. In the July 14 issue of Science Express, scientists report that, between 1990 and 2007, the world's forests stored about 2.4 gigatons of carbon per year. Their results suggest that forests account for nearly all of the world's land-based carbon uptake. Boreal forests are estimated to be responsible for 22 percent of the carbon stored in the forests. A warming climate has the potential to increase fires and insect damage in the boreal forest ...

Fairbanks, Alaska—A scientist at the University of Alaska Fairbanks and colleague at Emory University are seeking to persuade the National Science Foundation to reevaluate its decision to cancel a program that has placed 10,000 science graduate students in more than 6,000 K-12 public schools across the country. In an editorial in the July 15 issue of the journal Science, UAF biology professor Richard Boone and Emory University professor Pat Marsteller advocate for developing an enhanced version of NSF's Graduate Science, Technology, Engineering and Mathematics Fellows ...

Mosquitoes die soon after a blood meal if certain protein components are experimentally disrupted, a team of biochemists at the University of Arizona has discovered. The approach could be used as an additional strategy in the worldwide effort to curb mosquito-borne diseases like dengue fever, yellow fever and malaria. When the researchers blocked a cellular process known as vesicle transport, on which the mosquitoes rely to release digestive enzymes into the gut among other functions, it caused the affected animals to die within two days of blood feeding. "The idea ...

Thermal expansion of seawater contributed only slightly to rising sea levels compared to melting ice sheets during the Last Interglacial Period, a University of Arizona-led team of researchers has found. The study combined paleoclimate records with computer simulations of atmosphere-ocean interactions and the team's co-authored paper is accepted for publication in Geophysical Research Letters. As the world's climate becomes warmer due to increased greenhouse gases in the atmosphere, sea levels are expected to rise by up to three feet by the end of this century. But ...

NEW YORK, July 16, 2011 – Experts from the Center of Excellence on Brain Aging at NYU Langone Medical Center will present new research at the 2011 Alzheimer's Association International Conference on Alzheimer's disease to be held in Paris, France from July 16 – 21. Of particular interest is the presentation about mild cognitive impairment in retired football players, with Stella Karantzoulis, PhD, and the selected "Hot Topics" presentation about a new experimental approach to targeting amyloid plaques, with Fernando Goni, PhD. Each presentation is embargoed as noted below. The ...

Coronary computed tomography angiography (CTA) has excellent image quality and diagnostic confidence for the entire spectrum of pediatric patients, with significant reduction of risk with recent technological advancements, according to a study to be presented at the Sixth Annual Scientific Meeting of the Society of Cardiovascular Computed Tomography (SCCT) in Denver, July 14-17. "Traditionally, pediatric patients who require coronary artery imaging have undergone a cardiac catheterization, which is an invasive procedure with a significant radiation dose, requiring sedation ...

Researchers at New York University's Department of Chemistry and NYU Langone Medical Center have developed a compound that blocks signaling from a protein implicated in many types of cancer. The compound is described in the latest issue of the journal Nature Chemical Biology. The researchers examined signaling by receptor tyrosine kinase (RTK). Abnormal RTK signaling is a major underlying cause of various developmental disorders and diseases, including many forms of cancer. RTK signaling pathway employs interactions between proteins Sos and Ras, and accounts for a broad ...

Boston, MA – Using nanotechnology to engineer sensors onto the surface of cells, researchers at Brigham and Women's Hospital (BWH) have developed a platform technology for monitoring single-cell interactions in real-time. This innovation addresses needs in both science and medicine by providing the ability to further understand complex cell biology, track transplanted cells, and develop effective therapeutics. These findings are published in the July 17 issue of Nature Nanotechnology. "We can now monitor how individual cells talk to one another in real-time with unprecedented ...

What spreads the sea floors and moves the continents? What melts iron in the outer core and enables the Earth's magnetic field? Heat. Geologists have used temperature measurements from more than 20,000 boreholes around the world to estimate that some 44 terawatts (44 trillion watts) of heat continually flow from Earth's interior into space. Where does it come from? Radioactive decay of uranium, thorium, and potassium in Earth's crust and mantle is a principal source, and in 2005 scientists in the KamLAND collaboration, based in Japan, first showed that there was a way ...

Almost a quarter of men and women in England and over a third of adults in America are obese. Obesity increases the risk of diabetes and heart disease and can significantly shorten a person's life expectancy. New research published by BioMed Central's open access journal International Journal of Behavioral Nutrition and Physical Activity shows that improving body image can enhance the effectiveness of weight loss programs based on diet and exercise. Researchers from the Technical University of Lisbon and Bangor University enrolled overweight and obese women on a year-long ...

Some of the human X chromosome originates from Neanderthals and is found exclusively in people outside Africa, according to an international team of researchers led by Damian Labuda of the Department of Pediatrics at the University of Montreal and the CHU Sainte-Justine Research Center. The research was published in the July issue of Molecular Biology and Evolution. "This confirms recent findings suggesting that the two populations interbred," says Dr. Labuda. His team places the timing of such intimate contacts and/or family ties early on, probably at the crossroads ...

July 17, 2011 – (BRONX, NY) – Researchers at Albert Einstein College of Medicine of Yeshiva University have developed the first fluorescent protein that enables scientists to clearly "see" the internal organs of living animals without the need for a scalpel or imaging techniques that can have side effects or increase radiation exposure. The new probe could prove to be a breakthrough in whole-body imaging – allowing doctors, for example, to noninvasively monitor the growth of tumors in order to assess the effectiveness of anti-cancer therapies. In contrast to other body-scanning ...

Using a technique known as thermochemical nanolithography (TCNL), researchers have developed a new way to fabricate nanometer-scale ferroelectric structures directly on flexible plastic substrates that would be unable to withstand the processing temperatures normally required to create such nanostructures. The technique, which uses a heated atomic force microscope (AFM) tip to produce patterns, could facilitate high-density, low-cost production of complex ferroelectric structures for energy harvesting arrays, sensors and actuators in nano-electromechanical systems (NEMS) ...

Japan's March 11 Tohoku Earthquake is among the strongest ever recorded, and because it struck one of the world's most heavily instrumented seismic zones, this natural disaster is providing scientists with a treasure trove of data on rare magnitude 9 earthquakes. Among the new information is what is believed to be the first study of how a shock this powerful affects the rock and soil beneath the surface. Analyzing data from multiple measurement stations, scientists at the Georgia Institute of Technology found that the quake weakened subsurface materials by as much as ...

MAYWOOD, Ill. -- Retired NFL football players are at higher risk for mild cognitive impairment, which can be a precursor to Alzheimer's disease, a Loyola University Health System study has found. A screening survey of 513 retired players and their wives found that 35 percent of the players had scores suggesting possible mild cognitive impairment (MCI). Their average age was 61. "It appears there may be a very high rate of cognitive impairment in these retired football players, compared to the general population in that age range," said neuropsychologist Christopher Randolph, ...

PHILADELPHIA — The use of trastuzumab, chemotherapy and surgery among women with HER2-positive metastatic breast cancer significantly improved survival from the time central nervous system metastases were diagnosed. Based on these study results, lead researcher Adam Brufsky, M.D., Ph.D., said, "We clearly now know that these women should get trastuzumab and potentially chemotherapy, even if cancer spreads to the brain." "Women with HER2-positive breast cancer have a reasonable chance of living a long time with their disease, and they should be given aggressive therapy ...

1. Testing for the Lynch Syndrome in All Colorectal Cancer Patients Cost-effective Relatives of Those Who Test Positive Are at Increased Risk and Should Also be Tested The Lynch syndrome is the most common genetic cause of colorectal cancer and is also associated with endometrial and other types of cancer. While only three percent of colorectal cancer patients carry the gene, it has been suggested that testing for the Lynch syndrome in all patients newly diagnosed with colorectal cancer could help identify families at risk. Researchers used a computer model to estimate ...

A landmark study by the BC Centre for Excellence in HIV/AIDS (BC-CfE) and the University of British Columbia (UBC) shows that patients in Africa receiving combination antiretroviral therapy (cART) for HIV can expect to live a near normal lifespan. The study, published today in the prestigious Annals of Internal Medicine, is the first large-scale analysis of life expectancy outcomes in Africa for HIV patients on cART and shows significant variance between patient subgroups. Females have a significantly higher life expectancy than men, and in all participants, early initiation ...

For the first time, scientists gathered oil and gas directly as it escaped from a deep ocean wellhead — that of the damaged Deepwater Horizon oil rig. What they found allows a better understanding of how pollution is partitioned and transported in the depths of the Gulf of Mexico and permits superior estimation of the environmental impact of escaping oil, allowing for a more precise evaluation of previously estimated repercussions on seafloor life in the future. The explosion of the Deepwater Horizon rig in April 2010 was both a human and an environmental catastrophe. ...

A medicine designed to improve levels of "good" cholesterol may also help control blood sugar in people with diabetes who are taking cholesterol-lowering drugs, according to a new analysis in Circulation: Journal of the American Heart Association. Researchers made the finding while analyzing data from a clinical trial on the drug torcetrapib that was halted five years ago. Torcetrapib is a cholesterol ester transfer protein (CETP) inhibitor, a type of drug that increases levels of high-density lipoproteins (HDLs, or "good" cholesterol). The study found that 6,661 people ...

Milk and soy protein supplements were associated with lower systolic blood pressure compared to refined carbohydrate dietary supplements, in a study reported in Circulation: Journal of the American Heart Association. The study's results suggest that partly replacing refined carbohydrates with foods or drinks high in soy or milk protein may help prevent and treat high blood pressure, said Jiang He, M.D., Ph.D., lead researcher of the study. The randomized, controlled clinical trial is the first to document that milk protein lowers blood pressure for people with pre-hypertension ...

STANFORD, Calif. — Screening every new colon cancer patient for a particular familial disorder extends lives at a reasonable cost, say Stanford University School of Medicine researchers. The team hopes the results will encourage more medical centers to adopt widespread screening policies. Approximately 3 to 5 percent of colorectal tumors are caused by a heritable condition called Lynch syndrome, which greatly increases the odds of colon and other cancers in a person's lifetime. Siblings and children of someone with Lynch syndrome each have a 50 percent chance of carrying ...

SANTA CLARA, Calif., July 18, 2011 — A new study by researchers at Santa Clara University's Center for Science, Technology, and Society sheds light on the current investment methods and profit expectations of 45 "impact investors," who invest in social-entrepreneur ventures around the world. The study aims to be a first step toward creating a more coordinated, venture-capital-style system for such social-venture startups. The study, Coordinating Impact Capital, A New Approach to Investing in Small and Growing Businesses, will be unveiled at an event July 26 from 4 to ...

High levels of 'bad' cholesterol (LDL cholesterol) are a risk factor for developing atherosclerotic cardiovascular disease (ASCVD) — a disease of the major arterial blood vessels that is one of the major causes of heart attack and stroke. Although the use of statins and the adoption of lifestyle changes to reduce LDL cholesterol levels have decreased the incidence of and mortality from ASCVD, many individuals fail to reach target levels of LDL cholesterol. Researchers are therefore seeking new targets for LDL cholesterol–lowering therapeutics. Human genetic and mechanistic ...