LA JOLLA, CA—Mutant presenilin is infamous for its role in the most aggressive form of Alzheimer's disease—early-onset familial Alzheimer's—which can strike people as early as their 30s. In their latest study, researchers at the Salk Institute uncovered presenilin's productive side: It helps embryonic motor neurons navigate the maze of chemical cues that pull, push and hem them in on their way to their proper targets. Without it, budding motor neurons misread their guidance signals and get stuck in the spinal cord. By putting genes associated with Alzheimer's disease ...

ANN ARBOR, Mich.---The decreases in Earth's snow and ice cover over the past 30 years have exacerbated global warming more than models predict they should have, on average, new research from the University of Michigan shows. To conduct this study, Mark Flanner, assistant professor in the Department of Atmospheric, Oceanic and Space Sciences, analyzed satellite data showing snow and ice during the past three decades in the Northern Hemisphere, which holds the majority of the planet's frozen surface area. The research is newly published online in Nature Geoscience. Snow ...

Convalescent plasma therapy—using plasma from patients who have recovered from an infection to treat those with the same infection—has been used to treat multiple diseases. However, the efficacy of this treatment in patients with severe 2009 H1N1 influenza is unknown. A study published in the February 15 issue of Clinical Infectious Diseases suggests that convalescent plasma may reduce the death rate in patients severely ill with this type of influenza. (Please see below for a link to the embargoed study online.) From September 2009 through June 2010, patients from ...

ZapitSMS, the worldwide PC to Mobile text messaging provider has introduced the Bulk messaging feature to their Online SMS services. The new feature allows corporate, educational institutions and individual clients to send Bulk SMS from any PC connected to internet. Race River Corporation, the developer of ZapitSMS has announced the new feature for sending Bulk SMS via ZapitSMS Web-Admin. The recently added feature is simple to use and now available through ZapitSMS Web Admin. The ZapitSMS system allows uploading list of contact details using CSV file and creating message ...

MyBinding,com, a division of Information Management Services, LCC, recently announced the promotion of Jeff McRitchie from Director to Vice-President of Marketing MyBinding.com, one of the country's leading online retailers of document finishing equipment and supplies, recently announced that Jeff McRitchie, the company's Director of Marketing, has been promoted. McRitchie is now serving as the Vice-President of Marketing. "We are proud of Jeff and all that he's done for the company," said Cory Ware, co-owner of the company. "He's been a real asset to us and it seemed ...

The Managing Director Steve Fitzpatrick this week has revealed a history of building tender prices on the latest building projects managed by Your Building Broker with astonishing results. Home Buyers are expected to save huge amounts of money on their home building project by working with Your Building Broker instead of the old fashioned methods of going directly to a home builder or Architect designer. Your Building Broker was formed in 2010 as the building industry in Perth Western Australia was becoming insular with land sales agents doing deals with large building ...

Luigi's Tahoe Pizzeria is now open and serving up the finest ( http://www.pizzalaketahoe.com/ ) pizza in South Lake Tahoe, Nevada. Luigi's one-of-a-kind staff is committed and dedicated to making your dining experience one with variety while being cost affordable in an inviting environment. In addition to ( http://www.pizzalaketahoe.com/ ) pizza, Luigi's serves up your favorite salads, sandwiches, desserts and wide selection of amazing beers. If beer is not of your tasting, their selection of California and Italian wines is sure to satisfy your lunch or dinner craving. ...

Join Jennifer Longmore, North America's Soul Purpose Expert, as she hosts 11 Global Spiritual Leaders where they will each share their wisdom and expertise to help you fully step into your greatness and make YOUR mark on the world. From February 7th to February 21st, you will get access to these world-class leaders: • Star Ladin • Marsh Engle • Joanna Garzilli • Heather Dominick • Jacqueline Joy • Madeleine Marentette • Amanda Moxley • Laura Hollick • Amethyst Wyldfyre • Jessica Eaves Mathews • Linda P. Jones • Jennifer Longmore These powerful guides are ...

TonerGreen, the online printer supply store that offers eco-friendly, U.S.-made and non-patent infringing ink and toner cartridges, has been given the Green America Business Seal of Approval to certify its commitment in providing not just eco-friendly printing solutions but also in social and environmental responsibility. Green America's Green Business Network is the first and one of the most reliable networks for all businesses that are both active in giving socially and in offering nature-friendly services. As a non-profit organization that aims to bring together green ...

UniversalAutoTransport.com, a site that provides auto shipping quotes and transportation advice as well as information on individual state driving laws, was founded 11 years ago and has served customers through several incarnations. On 1/11/2011, UAT affirms its commitment to providing timely shipping and transportation news roundups, as well. The website's aim is to become a clearinghouse for the automobile transportation industry, which has experienced impressive growth in the past several years, and today includes many thousands of small and medium operators and entrepreneurs. ...

The New Year often brings the desire to make changes for the better, and VisionBedding makes that much easier this year with a unique line of bedding and accessories suitable for even the most creative individual. Dubbed "funky bedding ( http://www.visionbedding.com/Bedding/funky.php ) & decor," the new line was unveiled late last year at the overwhelming suggestion of customers. "We routinely turn to our customers to develop new styles," said Justin Poile, Founder and CEO of VisionBedding. "The funky decor took us by surprise, but once we looked at the idea, we decided ...

It's no secret that the mobile industry is surging at an astronomical rate. According to a report by GetJar, the industry will be worth $17.5 billion by 2012. Make no mistake, this is an industry being driven by apps that sell for between $0.99 and $2.99 on average. The industry as such has attracted capital investment as well as growing exposure in popular culture. GetJar estimates that mobile phone users will download approximately 50 billion applications in 2012 (majority of them being free apps of course) which is a 92% yer over year growth rate from the 7 billion ...

Good Feet , a custom fit arch support retailer launches its third round of their Feel Good Sweepstakes. For the month of January, the sweepstakes offers weekly giveaways for a pair of Good Feet Custom Fit Arch Supports. With over a 2,000 entries thus far, the sweepstakes has already reached great popularity. Sweepstakes entries can be submitted on the Good Feet website or Facebook page now through the end of January. Contestants are also encouraged to "Like" the Good Feet Facebook page or "Follow" Good Feet on Twitter (@MrGoodFeet) to stay updated on contest news and winners. According ...

The CIO Canada Summit team announced today that Canadian CIOs and senior technology executives are invited to qualify as speakers for the upcoming event to be held February 27 - March 2, 2011 at the Fairmont The Queen Elizabeth in Montreal, QC. The CIO Canada Summit will bring together CIOs, technology analysts and solution providers to discuss the latest IT topics and trends. The event's agenda features think tanks, analysts Q&A sessions, roundtables and open forums, and is designed to encourage in-depth conversation and idea sharing among the event's attendees. Current ...

NAAFA is pleased to announce that we will be returning to the Washington, DC area for our 2011 annual fund raising convention. Make plans now to join us at The Westin Washington Dulles Airport. Room rates are a super low $79 per night and can be booked for Thursday, Aug 4, 2011 - Monday, August 8, 2011! The Westin is prepared to receive your NAAFA convention reservations today at: http://www.starwoodmeeting.com/StarGroupsWeb/booking/reservation?id=1101116740&key=4FB52 We have worked hard to keep the cost of this convention down and to get the lowest hotel prices we ...

The Advanced Google AdWords training course in Perth is a half day course that is designed as an advanced course for those businesses that have some experience with setting up or running a Google AdWords campaign, but want to get better results from their spend. It will cover such areas as advanced campaign settings and structure, keyword targeting, writing effective adverts, bid management techniques, the use of landing pages and conversion tracking. There is also a full day training course taking place on the previous day, Thursday 10th March, which is designed for ...

Hound Comics CEO William 'Brimstone' Kucmierowski is looking to make Brimstone and The Borderhounds: The Animated Series into a family affair. Rather than auditioning a slew of actors and actresses, Hound Comics and Floating Pear Productions have chosen to cherry pick what they feel is the perfect cast for the eclectic grouping of Borderhound characters. The well-known names create an ensemble that represents the wide spectrum of entertainment including pro wrestlers, models, reality stars and other personalities. "When working in entertainment, you can go for months at ...

Outpost24, the Technology Leader in Vulnerability Management and assessment, today announced that it has opened a new office in Athens, Greece. The new office is part of Outpost24's continued expansion into the Southeast European area in an effort to meet the growing demand for easy-to-use vulnerability assessment and management solutions while keeping a low total cost of ownership (TCO) for businesses in both Greece and Cyprus. "During this period in time we are finding digital crime is one of the more severe issues that all businesses regardless of size or industry ...

The Professional Image - publisher for the culinary profession, announces that Michael Bennett, the executive chef of Bimini Boatyard in Fort Lauderdale will be demonstrating at the uber-affluent Ocean Reef club, Key Largo, Fl. on January 27th, 2011. In conjunction with the Ocean Reef club's "Reef Cup" fishing tournament, chef Michael Bennett says "lecturing at the Ocean Reef club's cooking school is akin to being invited to cook at New York City's James Beard House." Ocean Reef Club is an exclusive resort at the northernmost apex of Key Largo, Florida. It has become ...

Herzanek is the founder of Changing Lives Foundation and author of the book, "Why Don't They Just QUIT?", now in its second printing. Herzanek also spends time counseling inmates and advising their family members and others in the community on effective ways to negotiate the often complex "world of addiction and recovery." "I have been impressed with Joe's honesty and openness since our very first "Recovery Now" conversation, but that pales in comparison to my respect for his knowledge and compassion in reaching out and helping people in a deeply personal way," said ...

Local personal trainer and fitness boot camp instructor Luka Hocevar has run the most successful fitness transformation contests around. Hocevar and his Results Boot Camp team are at it again with an 8-week transformation contest starting January 22nd, to get his clients beach body ready for spring break. The top prize for the contest is valued at over $2,000. "It can sometimes be difficult to find the motivation to both get into shape and to stay in shape," Hocevar says. "It's critical to implement some friendly competition and include some powerful incentives to push ...

Every year at tax time, peoples' mental gears begin turning in an effort to find ways in which to invest their hard-earned returns. _b_Unfortunately_/b_, those gears normally end up clogged with so much information that, the person ends up simply spending their money on something that will never make them any money back. As the leader in the Vending Machines industry, Gumball Machine Warehouse is offering sales on all types of vending machines; for the beginning part of the year! (2010's terrible economical conditions had plenty of people finding their way to us, as ...

Justopenthebook.com is an online Christian ministry whose mission is to encourage others to develop a closer relationship with God by opening and studying His word. Recently, two close friends of the owners of justopenthebook.com were diagnosed with breast cancer, and the ministry decided to help breast cancer research. To help support the battle against breast cancer, 10 percent of all donations received by justopenthebook.com in the month of January will be given to the Susan G. Komen 3-Day for the Cure. Donations are accepted at http://www.justopenthebook.com Komen ...

Online investment resource IndependentInvestor.co.uk has suggested that one of the keys to successful trading is the implementation of a disciplined approach to making trading decisions, both in terms of cutting from losing positions and engaging in the proper way with research into individual CFD markets. With the high profile of the risks associated with CFD trading, the urge towards an emphasis on discipline in trading is designed to shore up trading profitability, by both eliminating a portion of risk while minimising losses when they inevitably arise, and is designed ...

Businesses of every size have a new time clock software tool that eliminates undesirable employee overtime costs with today's release of Virtual TimeClock '11 from Redcort Software. Employers can now prevent or restrict clock in and out times based on employee shifts, instantly track late arrivals, and view shift reports and summaries to reduce overtime costs and more easily manage employee time and attendance. "Our customers tell us a top concern is to eliminate the high cost of unnecessary and unauthorized employee overtime," said Keith DeLong, CEO of Redcort Software. ...