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Casa de Madrid is located on the 4th floor of a 18th-century building in the middle of the old town called Madrid de los Austrias, built during the Habsburg dynasty in the 16th century. From the many balconies of the luxurious guesthouse, the guests have perfect views of the Royal Palace and the Opera. "It's very interesting to my guests because they adore to be right in the centre." owner Marta explains. Each of the seven rooms is individually styled: "The decoration of each room is very different yet on the whole, when you walk the house, you can feel ...

The event will see thousands of wine appreciators from all over Europe heading into the city to take part and sample some of the latest vintages to come out of the region. With so many wine fans from all over the continent expected in Stuttgart, leading hotel room comparison website DirectRooms.com is advising people to book their accommodation in the city well before arriving to avoid disappointment. The Stuttgart Wine Festival takes place in the Stuttgart Wine Village venue, a picturesque location for a fun event. Last year's festival saw over a million attendees ...

The event has grown in popularity year on year and thanks to the race taking place in Vanuatu, cheap Port Vila hotels are expected to be at a premium - so says online hotel comparator DirectRooms.com. The Vanuatu Adventure Race 2011 is a competition which tests the fitness of participants in events covering mountain biking, hiking, snorkelling over the local reefs and more - a true test of fitness on challenging terrains. This year's Vanuatu Adventure Race 2011 will be held between the 13th and 15th of August and the Vanuatu capital of Port Vila is the perfect place ...

The 10K Turibana to Santa Cruz run will stretch from Noord's Panaderia del Campo and along open roads to the finish at the sports centre Compleho Deportivo Betico Croes. To be able to take part entries are being accepted on 1st August until race day which falls on 4th September 2011. The race is open to male and female runners and competitors don't have to be in peak physical condition as the event is seen as a way to get into long distance running. The race will start at 05:30 to avoid the midday heat and runners are free to raise sponsorship money in aid of local non-profit ...

Long Island orthodontist Leon Klempner today announces the launch of The Smile Rescue Fund for Kids, an organization he founded to provide funding to children born with severe facial and craniofacial deformities. These children have such significant challenges that they cannot be helped by their families, governmental agencies and currently established charitable organizations. Facial deformities result in many challenging medical issues, including feeding problems, hearing loss, unintelligible speech, and recurrent ear infections. But the social and psychological consequences ...

Scholastic Administr@tor magazine has named RealCareer Business Education Simulations from Realityworks, Inc. a 2011 "Best in Tech" award winner. The national awards were presented at the 2011 International Society for Technology Education (ISTE) conference in Philadelphia on June 28. Scholastic Administr@tor selected the "Best in Tech" winners based on information from educators who have used the new technology, as well as editorial interviews. Ruthie Bass of North Shore Senior High School in Houston, TX provided information on the RealCareer Business ...

Submittal Exchange announces the full integration of Greengrade LEED Management Software with its core Integrated Project Collaboration Software, Submittal Exchange for Construction. The timing of the announcement coincides with Greengrade's successful direct integration with USGBC's LEED Online for submitting LEED certification applications. Greengrade is a collaborative online management software tool that allows LEED project teams to communicate, track and manage LEED project information from planning to submission. The new integration between LEED Online and Greengrade ...

General Motors recently announced that it would be teaming up with coverage provider MetLife to offer car insurance with no down payment and no payments for the entire first year following the purchase of certain GM models in Oregon and Washington. What's surprising about the financial protection provided for free through the offer is that it far exceeds the requirements set by law in the two states. Washington currently requires drivers to only carry $25,000 in bodily injury liability protection per person and $50,000 total per accident, along with $10,000 in property ...

The ever-expanding number of technology applications, combined with meaningful use and other initiatives, results in the increasing demand for application interoperability in healthcare organizations. This in turn places greater pressure and incentive on those organizations to find better and easier ways to facilitate interfacing. Providers want all the horsepower of a robust, scalable, and flexible interface engine (IE) wrapped up in an easy-to-use package. KLAS' new report entitled "Interface Engines: Beyond Interoperability" scrutinizes vendor performance, ...

The team of researchers from the Universities of Bristol, Queensland (Australia), Oxford, Texas and Toronto, used a technique called genome-wide association where millions of genetic markers are measured in thousands of people that have the disease and thousands of healthy individuals. Markers which are more frequent in individuals with the disease are more likely to be involved in the condition. Using this approach the investigators found an additional seven genes likely to be involved in the condition, bringing the total number of genes known to predispose to AS ...

A study involving over 5,000 people living with the joint disorder ankylosing spondylitis has identified a series of genetic variants associated with increased susceptibility to the condition as well as providing new clues to how the condition may be treated in the future. The study, a collaboration between the Australo-Anglo-American Spondyloarthritis Consortium and the Wellcome Trust Case Control Consortium, also provides one of the first confirmed examples of gene-gene interaction seen in humans. Ankylosing spondylitis is an autoimmune disease that affects as many ...

New York, NY — July 10, 2011 — Researchers at Columbia Engineering School have built optical nanostructures that enable them to engineer the index of refraction and fully control light dispersion. They have shown that it is possible for light (electromagnetic waves) to propagate from point A to point B without accumulating any phase, spreading through the artificial medium as if the medium is completely missing in space. This is the first time simultaneous phase and zero-index observations have been made on the chip-scale and at the infrared wavelength. The study, to ...

TORONTO, ON – University of Toronto researchers have derived inspiration from the photosynthetic apparatus in plants to engineer a new generation of nanomaterials that control and direct the energy absorbed from light. Their findings are reported in a forthcoming issue of Nature Nanotechnology, which will be released on July 10, 2011. The U of T researchers, led by Professors Shana Kelley and Ted Sargent, report the construction of what they term "artificial molecules." "Nanotechnologists have for many years been captivated by quantum dots – particles of semiconductor ...

Researchers at the Emory Vaccine Center have developed a method for predicting whether someone will produce high levels of antibodies against a flu shot a few days after vaccination. After scanning the extent to which carefully selected genes are turned on in white blood cells, the researchers can predict on day three, with up to 90 percent accuracy, who will make high levels of antibodies against a standard flu shot four weeks later. The results were published online July 10 in the journal Nature Immunology. "It often takes several weeks after vaccination for an ...

VIDEO: This is a video of a violent interaction between the mother and the perpetrator recorded on the first day of infanticide recorded on April 28, 2010. Click here for more information. Finding their young dead in the nest is not uncommon for bird mothers. In many bird species some of the nestlings die before they leave the nest. This is known as "brood reduction", a common form of infanticide that the parents are to blame. On the other hand, witnessing a perpetrator killing ...

Olympia, site of the famous Temple of Zeus and original venue of the Olympic Games in ancient Greece, was presumably destroyed by repeated tsunamis that travelled considerable distances inland, and not by earthquake and river floods as has been assumed to date. Evidence in support of this new theory on the virtual disappearance of the ancient cult site on the Peloponnesian peninsula comes from Professor Dr Andreas Vött of the Institute of Geography of Johannes Gutenberg University Mainz, Germany. Vött investigated the site as part of a project in which he and his team are ...

They attack other colonies, plunder and rob, kill other colonies' inhabitants or keep them as slaves: Ants are usually regarded as prototypes of social beings that are prepared to sacrifice their lives for their community, but they can also display extremely aggressive behavior towards other nests. The evolution and behavior of ants, in particular the relationship between socially parasitic ants and their hosts, is the research topic of a work group headed by Professor Dr Susanne Foitzik at the Institute of Zoology at Johannes Gutenberg University Mainz, Germany. Evolutionary ...

ST. PAUL, Minn. – Osteoporosis and low bone density are common in people in the early stages of multiple sclerosis (MS), according to a new study published in the July 12, 2011, print issue of Neurology®, the medical journal of the American Academy of Neurology. "We've known that people who have had MS for a long time are at a greater risk of low bone density and broken bones, but we didn't know whether this was happening soon after the onset of MS and if it was caused by factors such as their lack of exercise due to lack of mobility, or their medications or reduced ...

There is no difference between brand-name and generic drug formulations of amiodarone — taken to control arrhythmia – in the incidence of thyroid dysfunction, according to a study in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/site/embargo/cmaj101800.pdf. Amiodarone, prescribed to control irregular heartbeats, is known for causing hypo- and hyper-thyroidism. Amiodarone is available in Canada in brand-name formulations as well as less costly generic versions. Generic formulations may be substituted if considered bioequivalent ...

Current alcohol consumption guidelines are inadequate for the prevention of cancer and new international guidelines are needed, states an analysis in CMAJ (Canadian Medical Association Journal) (pre-embargo link only) http://www.cmaj.ca/site/embargo/cmaj110363.pdf. Guidelines in some countries are not currently based on evidence for long-term harm. Most guidelines are based on studies that assessed the short-term effects of alcohol, such as social and psychological issues and hospital admissions, and were not designed to prevent chronic diseases. As well, in some countries, ...

Power and Potential of Mobile Sensing Devices to Improve Health Care Researchers from Dartmouth offer a provocative glimpse into the possibilities of wireless mobile technology to measure elderly patients' physical activity and social interactions and improve detection of changes in their health. Sensors on a waist-mounted wireless mobile device worn by eight patients aged 65 and older continuously measured patients' time spent walking level, up or down an elevation, and stationary (sitting or standing), and time spent speaking with one or more other people. Researchers ...

A new study has found that almost all patients with high-grade noninvasive bladder cancer do not receive complete care as recommended by current guidelines. Published early online in CANCER, a peer-reviewed journal of the American Cancer Society, the study indicates that efforts are needed to identify and overcome barriers to providing optimal care to patients with bladder cancer. High-grade noninvasive bladder cancer has up to a 70 percent chance of recurring after treatment and up to a 50 percent chance of progressing to a more invasive tumor. Effective treatment for ...

Genetic instructions for developing limbs and digits were present in primitive fish millions of years before their descendants first crawled on to land, researchers have discovered. Genetic switches control the timing and location of gene activity. When a particular switch taken from fish DNA is placed into mouse embryos, the segment can activate genes in the developing limb region of embryos, University of Chicago researchers report in Proceedings of the National Academy of Sciences. The successful swap suggests that the recipe for limb development is conserved in species ...

Durham, N.C., U.S. and Melbourne, Australia -- A team of Duke University Medical Center and Australian scientists has found that addictive drugs may have hijacked the same nerve cells and connections in the brain that serve a powerful, ancient instinct: the appetite for salt. Their rodent research shows how certain genes are regulated in a part of the brain that controls the equilibrium of salt, water, energy, reproduction and other rhythms – the hypothalamus. The scientists found that the gene patterns activated by stimulating an instinctive behavior, salt appetite, ...