PHILADELPHIA — A variant site linked to poor outcome in advanced colorectal cancer has now been found to predict improved prognosis in early stages of cancer, according to research presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010. Researchers said they don't know why this variant site, a microRNA binding site that should allow appropriate regulation of the KRAS gene, exhibited a Dr. Jekyll and Mr. Hyde duality. Further study could show that patients with this miRNA variant might ...

PHILADELPHIA — Researchers have identified two small-molecule inhibitors that effectively targeted the focal adhesion kinase (FAK), an enzyme present in certain cancers that helps tumors thrive and survive. If the drugs are developed into oral therapeutic agents in the future, they could open up the potential for more effective and less toxic cancer therapies, according to research presented at The American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010. "It is well known that FAK is overexpressed ...

PHILADELPHIA — University of Pittsburgh researchers have devised a three-dimensional system in laboratory culture that mimics the growth patterns of colon cancer stem cells in patients. Their findings were presented at the American Association for Cancer Research special conference on Colorectal Cancer: Biology to Therapy, held Oct. 27-30, 2010. The assay, which uses green fluorescent "reporter" proteins to watch the process of stem cell differentiation, is designed to understand how these cancer stem cells behave, and to identify and test therapies that could halt production ...

A highly skillful and delicate method of sharpening and retouching stone artifacts by prehistoric people appears to have been developed at least 75,000 years ago, more than 50,000 years earlier than previously thought, according to a new study led by the University of Colorado at Boulder. The new findings show that the technique, known as pressure flaking, took place at Blombos Cave in South Africa during the Middle Stone Age by anatomically modern humans and involved the heating of silcrete -- quartz grains cemented by silica -- used to make tools. Pressure flaking ...

Nearly one in four stars like the sun could have Earth-size planets, according to a University of California, Berkeley, study of nearby solar-mass stars. UC Berkeley astronomers Andrew Howard and Geoffrey Marcy chose 166 G and K stars within 80 light years of Earth and observed them with the powerful Keck telescope for five years in order to determine the number, mass and orbital distance of any of the stars' planets. The sun is the best known of the G stars, which are yellow, while K-type dwarfs are slightly smaller, orange-red stars. The researchers found increasing ...

PROVIDENCE, R.I. [Brown University] — Mad Cow disease and its human variant Creutzfeldt—Jakob disease, which are incurable and fatal, have been on a welcome hiatus from the news for years, but because mammals remain as vulnerable as ever to infectious diseases caused by enigmatic proteins called prions, scientists have taken no respite of their own. In the Oct. 29 edition of the journal Science, researchers at Brown University report a key new insight into how prion proteins — the infectious agents — become transmissible: In yeast at least, it is the size of prion complexes, ...

Elderly patients with kidney failure get kidney transplants more often than they did a decade ago, according to a study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). The results suggest that the chances of receiving a kidney transplant are better than ever for an older patient who needs one. Kidney failure afflicts nearly half a million individuals in the United States, and 48% of sufferers are 60 years of age or older. Kidney disease patients who obtain a transplant live longer than those that remain on dialysis. ...

CAMBRIDGE, Mass. -- In a study of mice with lymphoma, MIT biologists have discovered that a small number of cancer cells escape chemotherapy by hiding out in the thymus, an organ where immune cells mature. Within the thymus, the cancer cells are bathed in growth factors that protect them from the drugs' effects. Those cells are likely the source of relapsed tumors, said Michael Hemann, MIT assistant professor of biology, who led the study. The researchers plan to soon begin tests, in mice, of drugs that interfere with one of those protective factors. Those drugs were ...

Many times, cancer patients respond very well to chemotherapy initially only to have their disease return, sometimes years later. Now researchers reporting in the October 29th issue of the journal Cell, a Cell Press publication, have new insight into the factors that allow some lingering tumor cells to resist treatment and to seed that kind of resurgence. Contrary to expectations, it appears that the answer doesn't necessarily lie in the cancerous cells themselves. The evidence based on studies of mice with lymphoma shows that cues coming from healthy cells in response ...

The lower the birth weight, the greater the chance of poor growth rate in children with chronic kidney disease (CKD), according to a new study appearing in an upcoming issue of the Clinical Journal of the American Society of Nephrology (CJASN). In the general population, low birth weight is not an important cause of poor growth and short stature. To determine whether low birth weight is a risk factor for poor growth in children with CKD, Larry Greenbaum, MD, PhD (Emory University and Children's Healthcare of Atlanta, Atlanta, GA) and his colleagues analyzed results from ...

PASADENA, Calif.—A team of scientists led by researchers from the California Institute of Technology (Caltech) and NASA's Jet Propulsion Laboratory (JPL) have fully characterized a key chemical reaction that affects the formation of pollutants in smoggy air. The findings suggest that in the most polluted parts of Los Angeles—and on the most polluted days in those areas—current models are underestimating ozone levels, by between 5 to 10 percent. The results—published in this week's issue of the journal Science—are likely to have "a small but significant impact on the predictions ...

NEW YORK, October 28, 2010 – An international study led by researchers at Memorial Sloan-Kettering Cancer Center has identified genetic variants in women with BRCA2 mutations that may increase or decrease their risk of developing breast cancer. The study was published today online in the open-access journal PLoS Genetics. The findings of the study suggest that genetic variants on chromosomes 10 and 20 may modify risk for breast cancer among women with a BRCA2 mutation. Researchers analyzed DNA samples from 6,272 women with BRCA2 mutations in a two-stage genome-wide ...

White blood cells called neutrophils are part of the body's first line of defense against bacterial infection. Neutrophils are recruited from the bloodstream to infected tissues where they release powerful chemicals that kill bacteria and amplify the immune response. These cells function as first responders at the scene of infection and often have a short life span. As a result, new neutrophils are produced continuously from stem cells in the bone marrow. Previous research has suggested that regulation of neutrophil production is a complex and carefully controlled process. "We ...

SEATTLE – An international team of researchers led by an investigator from Fred Hutchinson Cancer Research Center has made a second critical advance in determining the cause of a common form of muscular dystrophy known as facioscapulohumeral dystrophy, or FSHD. In August 2010 the group published a landmark study that established a new and unifying model for the cause of FSHD. The current work, published Oct. 28 in PLoS Genetics, shows that the disease is caused by the inefficient suppression of a gene that is normally expressed only in early development. The work will ...

The ability to keep CO2 out of the atmosphere to help prevent climate change is a global issue. The challenge is to use materials that can capture the CO2 and easily release it for permanent storage. Researchers at the University of Calgary and University of Ottawa have provided deeper insights to CO2 capture by "seeing" the exact sites where CO2 is held in a capture material. Their discovery, published in prestigious journal Science, will allow scientists to design better materials to capture more CO2. The findings can be likened to learning about a better fit between ...

Extra-virgin olive oil can protect the liver from oxidative stress. Researchers writing in BioMed Central's open access journal Nutrition and Metabolism exposed rats to a moderately toxic herbicide known to deplete antioxidants and cause oxidative stress, finding that those rats fed on a diet containing the olive oil were partially protected from the resulting liver damage. Mohamed Hammami from the University of Monastir, Tunisia and King Saud University, Riyadh, Saudi Arabia, worked with a team of researchers to carry out the experiments in a group of 80 rats. He said, ...

Mayer Hillman, Senior Fellow Emeritus at the Policy Studies Institute, argues that the effect of doing so would be to increase the number of 'accessible' daylight hours and thus encourage more outdoor activity throughout the year. A major public health problem contributing to the incidence of chronic illnesses in the UK is caused by lack of exercise, writes Hillman. Adults are recommended to engage in at least 30 minutes of moderate or vigorous activity daily and children at least one hour. However, surveys have revealed a trend towards declining fitness and it has been ...

DETROIT – Developing a molecular fingerprint for head and neck cancer tumors could help improve diagnosis and treatment for this deadly and often-times disfiguring form of cancer, according to researchers at Henry Ford Hospital in Detroit. Their new study has taken the first step toward doing that by identifying five risk factors for late-stage head and neck cancer – two genes, tumor grade, and vascular invasion and location of the tumor. Race, however, was not an independent predictor for late-stage disease, contrary to other research findings. In fact, 88 percent ...

Expert typists are able to zoom across the keyboard without ever thinking about which fingers are pressing the keys. New research from Vanderbilt University reveals that this skill is managed by an autopilot, one that is able to catch errors that can fool our conscious brain. The research was published in the Oct. 29 issue of Science. "We all know we do some things on autopilot, from walking to doing familiar tasks like making coffee and, in this study, typing. What we don't know as scientists is how people are able to control their autopilots," Gordon Logan, Centennial ...

GRAND RAPIDS, MICH., October 28, 2010 –The majority of Americans report getting a cold or flu in the past year, and more than a third say they'll make lifestyle changes to prevent getting sick again this year. However, 40 percent of Americans don't plan to take what is arguably the easiest and tastiest step to help potentially prevent illness this cold and flu season – eat more fruits and vegetables daily. (1) According to a newly released report, America's Phytonutrient Report: Immune Health by Color, American adults who fall short in meeting their recommended daily ...

The complexity of the immune system and nervous system turn Neuroimmunology into one of the most exciting fields of modern biomedicine. Between October 26th and 30th takes place in Sitges (Barcelona, Spain) the X International Congress of Neuroimmunology of the International Society of Neuroimmunology. This event highlights the advances that have been made in recent years thanks to new technologies, but also highlights the long road ahead. New biomarkers, potential immunotherapies, stem cell strategies and new discoveries about the natural history of neuroimmunological ...

Pittsburgh, PA— During the winter months the days grow colder and the nights longer causing households to use more electricity, often resulting in higher bills. Most households have no way of monitoring how much electricity is being consumed; however, researchers in Pittsburgh believe a new monitoring system may soon be available for residential use. The research is published in a special issue of Yale's Journal of Industrial Ecology on environmental applications of information and communication technology sponsored by CSC's Leading Edge Forum. "There are many opportunities ...

Two people can learn to cooperate with each other intuitively – without communication or any conscious intention to cooperate. But this process breaks down in groups of three or more. A study by members of the University of Leicester's School of Psychology and Department of Economics set out to explain how two people learn to cooperate without even knowing that they are interacting with each other. In larger groups, explicit communication is needed to coordinate actions. Professor Andrew Colman, Dr Briony Pulford, Dr David Omtzigt, and Dr Ali al-Nowaihi carried out ...

Is there a relation between the structure of specific regions of the brain and nicotine dependence? This is the question researchers of the Charité – Universitätsmedizin Berlin and of the Physikalisch-Technische Bundesanstalt (PTB) Berlin have been investigating lately. The results of these investigations extend and specify those of preceding studies: A specific region of the cerebral cortex of smokers is thinner than that of people who have never smoked in their lives. This region is decisive for reward, impulse control, and the making of decisions. The questions of whether ...

A new Danish study from LIFE - Faculty of Life Sciences at the University of Copenhagen shows that the parasitic disease, commonly known as snail fever, or schistosomiasis, almost eats its way into women's reproductive organs. Today researchers from all over the world are gathering in Copenhagen to find out what can be done to halt the disease which is affecting millions of women in Africa. Six hundred million people in, for example, Africa live with the daily risk of being infected with the parasitic disease schistosomiasis, otherwise known as snail fever. It happens ...