A new-generation lung cancer drug has shown an impressive ability to prevent disease progression when administered as a first-line treatment in patients with advanced disease, investigators reported at the 35th Congress of the European Society for Medical Oncology (ESMO). Preliminary results from an ongoing Phase-II trial of the drug PF299804 (PF-299) showed that close to 85% of patients whose cancers harbor mutated forms of the EGFR gene have remained progression-free for at least nine months, reported Dr Tony Mok from the Chinese University of Hong Kong. While some ...

An ongoing Phase-II trial investigating a new, targeted therapy for metastatic urothelial cancer has generated promising early results, Italian researchers reported at the 35th Congress of the European Society for Medical Oncology (ESMO) in Milan, Italy. Urothelial cancers affect the tissue lining the inner surfaces of the bladder and other parts of the urinary system. In cases of metastatic disease, median survival is approximately 12-15 months and there is a 10-15% chance of prolonging it by the use of standard chemotherapy regimens, particularly in otherwise healthy ...

The results of a large Phase-III clinical trial have shown that the drug everolimus delays tumor progression in patients with a hard-to-treat group of rare cancers that affect particular hormone-producing cells. At the 35th Congress of the European Society for Medical Oncology (ESMO), Dr Marianne Pavel from Charité University in Berlin, Germany reported that everolimus improved progression-free survival by 5.1 months in patients with advanced neuroendocrine tumors. Neuroendocrine tumors are slow-growing malignancies that originate from cells of the body's neuroendocrine ...

A new class of compounds identified by researchers at Emory University School of Medicine could be developed into drugs for the treatment of schizophrenia. The compounds enhance signaling by molecules in the brain called NMDA receptors, which scientists believe are functioning at low levels in people with schizophrenia. Led by Stephen Traynelis, PhD, professor of pharmacology, a team of Emory researchers sifted through thousands of chemicals and found one, called CIQ, which could selectively enhance the function of certain NMDA receptors without affecting others. The ...

Iowa City, IA—October 11, 2010— A new study published in Applied Cognitive Psychology finds that college-aged men are very likely to remember a woman's initial sexual interest (attraction or rejection), especially when the woman in question is thought to be attractive, is dressed more provocatively, and expresses positive sexual interest. In the study the men were shown full-body photographs of college-aged women who expressed cues of sexual interest or rejection. The participating males represented mixed sexual histories, and a capacity for varying degrees of sexually ...

GAINESVILLE, Fla. --- University of Florida researchers presenting new fossil evidence of an exceptionally well-preserved 55-million-year-old North American mammal have found it shares a common ancestor with rodents and primates, including humans.The study published today in the online edition of the Zoological Journal of the Linnean Society, describes the cranial anatomy of the extinct mammal, Labidolemur kayi. High resolution CT scans of the specimens allowed researchers to study minute details in the skull, including bone structures smaller than one-tenth of a millimeter. ...

The genetic inherited material DNA was long viewed as the sole bearer of hereditary information. The function of its packaging proteins, the histones, was believed to be exclusively structural. Additional genetic information can be stored, however, and passed on to subsequent generations through chemical changes in the DNA or histones. Scientists from the Max Planck Institute for Biophysical Chemistry in Göttingen have succeeded in creating an experimental system for testing the function of such chemical histone modifications and their influence on the organism. Chemical ...

More brilliant X-rays, more cost-effective methods for developing new energy sources and advanced manufacturing processes are just some of the benefits which may come from a novel technology, proven at the theoretical level by a consortium of British and European laser scientists. The research, led by scientists at the Science and Technology Facilities Council's Central Laser Facility is published in this week's edition of Nature Physics (October 10 2010). A team of scientists from the Instituto Superior Tecnico in Lisbon, Imperial College London, and the Universities ...

A University of Colorado at Boulder space dust counter designed, tested and operated by students that is flying aboard NASA's New Horizons mission to Pluto now holds the record for the most distant working dust detector ever to travel through space. The instrument on the New Horizons mission -- officially named the Venetia Burney Student Dust Counter, or SDC, after an 11-year-old English girl who named Pluto more than 75 years ago -- reached a distance of 1.67 billion miles from Earth on Oct. 10. Designed by a student team from CU-Boulder's Laboratory for Atmospheric ...

Providence, RI---It was a mathematician, Joseph Fourier (1768-1830), who coined the term "greenhouse effect". That this term, so commonly used today to describe human effects on the global climate, originated with a mathematician points to the insights that mathematics can offer into environmental problems. Three articles in the November 2010 issue of the Notices of the American Mathematical Society examine ways in which mathematics can contribute to understanding environmental and ecological issues. "Earthquakes and Weatherquakes: Mathematics and Climate Change", ...

Prenatal treatment of congenital toxoplasmosis with antibiotics might substantially reduce the proportion of infected fetuses that develop serious neurological sequelae (brain damage, epilepsy, deafness, blindness, or developmental problems) or die, and could be particularly effective in fetuses whose mothers acquired Toxoplasma gondii, the parasite that causes toxoplasmosis, during the first third of pregnancy. These are the findings of an observational study by Ruth Gilbert from the UCL Institute of Child Health, London, UK, and colleagues and published in this week's ...

Wayne Hall, Rebecca Mathews and Katherine Morley discuss the limitations of genomic risk prediction for population-level preventive health care. Whilst genome-wide association studies and genomic sequencing have the potential to reveal susceptibilities to disease, they sound a note of caution about widescale implementation of such tests. In particular they point out that before genomic information is used in public health screening, it must first be shown that it predicts disease risk better than phenotypic information. They go on to point out that before genomic information ...

In research published this week in PLoS Medicine, Stephen Freedman (University of Toronto) and colleagues performed a cost analysis of the emergency department administration of oral ondansetron to children with dehydration and vomiting secondary to gastroenteritis and found that this treatment could provide substantial economic, as well as clinical, benefit. The researchers analyzed the costs of the administration of oral ondansetron in both the US and Canada, if routinely given to children with gastroenteritis-induced vomiting and dehydration in the emergency department ...

CHAMPAIGN, Ill. — A study of peptide hormones in the brain of a seemingly primitive flatworm reveals the surprising complexity of its nervous system and opens up a new approach for combating a major parasitic disease, researchers report. The study appears in the open-access journal PLoS Biology. The planarian flatworm, Schmidtea mediterranea, is perhaps best known for its prodigious powers of regeneration. Cut it in half (lengthwise or crosswise) and each fragment will regrow its missing parts, including its brain. The planarian is of interest to those studying reproduction ...

Helping to address the issue of medication adherence, persons with opioid dependence who had the medication buprenorphine implanted had less opioid use over 16 weeks, according to a study in the October 13 issue of JAMA. Dependence on opioids, in the form of heroin or prescription pain medications, is a significant health concern. A treatment that has been increasing in usage is the medication buprenorphine, with numerous studies supporting the efficacy of sublingually (beneath the tongue) administered buprenorphine. However, poor treatment adherence, resulting in craving ...

Use of stricter guidelines for the use of red blood cell transfusions for patients undergoing cardiac surgery was associated similar rates of death and severe illness compared to patients who received more transfusions, according to a study in the October 13 issue of JAMA. Another study in this issue of JAMA examines the variation in the use of blood transfusions for patients undergoing cardiac surgery. Cardiac surgery is associated with a high rate of blood transfusion. The rationale for red blood cell (RBC) transfusion is based on the observation that anemia is an independent ...

A study that includes data on more than 100,000 patients who underwent coronary artery bypass graft surgery finds that there is wide variability among hospitals in the U.S. on the use of blood transfusions, without a large difference in the rate of death, suggesting that many transfusions may be unnecessary, according to a study in the October 13 issue of JAMA. Another study in this issue of JAMA examines the effect of a restrictive transfusion strategy on outcomes after cardiac surgery. "Patients who undergo cardiac surgery receive a significant proportion of the 14 ...

A sizeable proportion of patients with advanced cancer and a life expectancy of only a few years continue to undergo common cancer screening tests that are unlikely to provide meaningful benefit, according to a study in the October 13 issue of JAMA. Cancer screening programs, such as mammography, Papanicolaou test, prostate-specific antigen (PSA) and colonoscopy, evaluate asymptomatic patients for the detection of early forms of cancer and have contributed substantially to the decline in deaths from cancer. "Although the benefits of cancer screening are compelling for ...

DURHAM, NC – Transfusion rates for blood products used in a common heart surgery range from no patients to nearly all patients, and vary by hospital, according to findings from a group of researchers from Duke University Medical Center. The study, which looked at data from 102,470 patients in 798 hospitals, examined the variation in transfusion rates for red blood cells (RBCs), plasma and platelets, but the team didn't reach conclusions about how well patients fared if they did or didn't get a transfusion. "We don't know whether the variability is potentially harming ...

At a press conference held in Brussels today, the International Osteoporosis Foundation (IOF), the Belgian Bone Club and the European Parliament Osteoporosis Interest Group called on health care professionals and health policy officials in Europe to take action to prevent spinal fractures. The call to action was made at the launch of a unique photographic essay, 'snap! the breaking spine', leading up to World Osteoporosis Day on October 20, 2010. Taking viewers across the globe to Brazil, Canada, India, Jordan and Switzerland, the photographic essay captures a typical ...

A mobile outreach program staffed by current and former sex workers is associated with increased entry to detoxification and residential drug treatment among women in street-based sex work, according to an evaluation led by the BC Centre for Excellence in HIV/AIDS (BC-CfE) and the University of British Columbia (UBC). The study, recently published in the peer-reviewed medical journal Drug and Alcohol Dependence, examined the link between accessing Vancouver's Mobile Access Project, or "the MAP van," and uptake of addiction treatment services by women engaged in street-based ...

Even after initial procedures to clear blockages in leg arteries, hospitalizations and associated costs in patients with peripheral artery disease increase as the condition progresses, according to research reported in Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal. "We are dealing with clinically and economically severe consequences of PAD, a disease which is truly preventable," said Elizabeth Mahoney, Sc.D., the study's lead author. "Our prior research estimated that vascular-related hospitalizations for PAD patients cost the ...

South San Francisco, CA – October 12, 2010 – Titan Pharmaceuticals, Inc. (TTNP.OB) today announced that data from its previously completed and announced Phase 3 randomized, placebo-controlled clinical trial of Probuphine were published in the Journal of the American Medical Association (JAMA). The article highlights data from the 163-patient trial, which showed that patients receiving Titan's Probuphine implant had significantly less illicit opioid use, experienced fewer symptoms of withdrawal and craving, stayed in treatment longer and had greater overall improvement ...

Researchers at the University of California, San Diego School of Medicine, led by Larry R. Squire, PhD, professor of psychiatry, psychology and neurosciences at UC San Diego and a scientist at the VA San Diego Healthcare System, report that working memory of relational information – where an object is located, for example – remains intact even if key brain structures like the hippocampus are damaged. The findings, published in the October 13, 2010 issue of The Journal of Neuroscience, run contrary to previous research that suggested spatial information, especially if ...

SALT LAKE CITY—University of Utah (U of U) medical researchers have made an important step in diagnosing autism through using MRI, an advance that eventually could help health care providers indentify the problem much earlier in children and lead to improved treatment and outcomes for those with the disorder. In a study published on October 15, 2010 in Cerebral Cortex online, researchers led by neuroradiologist Jeffery S. Anderson, M.D., Ph.D., U of U assistant professor of radiology, used MRI to identify areas where the left and right hemispheres of the brains of people ...