Using skin cells from adult siblings with schizophrenia and a genetic mutation linked to major mental illnesses, Johns Hopkins researchers have created induced pluripotent stem cells (iPS cells) using a new and improved "clean" technique. Reporting online February 22 in Molecular Psychiatry, the team confirms the establishment of two new lines of iPS cells with mutations in the gene named Disrupted In Schizophrenia 1, or DISC1. They made the cells using a nonviral "epiosomal vector" that jumpstarts the reprogramming machinery of cells without modifying their original ...

Researchers at the University of Granada have proved that neuropsychological rehabilitation helps in significantly reducing cognitive, emotional and behavioural after-effects in patients with acquired brain injury, generaly due to traumatic brain injury and ictus. These patients should not wait to be treated later by the social services, since early intervention (within six months after the traumatism) reduces further after-effects. Despite the prevention campaigns launched for reducing traffic accidents and improving heart-friendly habits, traumatic brain injury and ...

A pilot study in healthy children and adolescents shows that it is feasible to screen for undiagnosed heart conditions that increase the risk of sudden cardiac arrest (SCA). Adding a 10-minute electrocardiogram (EKG or ECG) to a history and physical examination identified unsuspected cases of potentially serious heart conditions. Although more research is needed, the preliminary results suggest that a relatively low-cost screening might help identify children who are at risk for sudden cardiac arrest, possibly preventing childhood death. "In the United States, the ...

Halifax Savings research has shown that children in Wales have the highest ownership levels of games consoles and mobile phones across the nation and also spend the most amount of money on computer games and equipment. They also do extremely well when it comes to owning an iPod or MP3 player and only fall down slightly on music downloads and mobile phone expenditure. A full house for Welsh gamers 100% of the children surveyed in Wales owned a games console, well above the national average of 91%. Children in Wales also spent the highest amount of money on computer ...

Washington, D.C. (March 17, 2011) -- A team of researchers has integrated tiny detectors capable of counting individual photons on computer chips. These detectors, called "single-photon avalanche diodes (SPAD)," act like mini Geiger counters, producing a "tick" each time a photon is detected. The researchers present their findings in Applied Physics Letters, a journal published by the American Institute of Physics. "In the past, making these detectors required specialized processes, but recently there has been tremendous progress in making these devices in 'standard' ...

Researchers working in a research project within the Academy of Finland's Research Programme on Substance Use and Addictions have been developing a targeted drug that could aid in smoking reduction therapy. The new drug slows down the metabolism of nicotine, which would help smokers to cut down their smoking. Nicotine is absorbed rapidly through the lining of the mouth but most readily through the lungs, from where it quickly passes through the body and into the brain. Once the nicotine reaches the liver, it is metabolised by an enzyme called CYP2A6. Preliminary studies ...

Radioactive waste decaying down at the dump needs millions of years to stabilize. The element Neptunium, a waste product from uranium reactors, could pose an especially serious health risk should it ever seep its way into groundwater – even 5 million years after its deposition. Now, researchers at the University of Copenhagen have shown the hazardous waste can be captured and contained. The means? A particular kind of green goop that occurs naturally in oxygen-poor water. Bo C. Christiansen is a geochemist at the University of Copenhagen who specializes in "green rust". ...

With the cost savings of giving something up for Lent likely to reach GBP57.37 by Easter Sunday, Lloyds TSB Savings believes that people may consider prolonged or permanent periods of abstinence to enable them to meet long-term financial goals. Of the 66% making a lifestyle change, a third (30%) would like to sell unwanted possessions on eBay, rising to almost half (48%) of 18 to 24 year olds, but decreasing to as few as one in five (19%) in Scotland. One quarter (25%) would like to shop less, 22% to start cycling or walking to work and cutting back on going out for ...

TORONTO, Ont., March 17, 2011 — Major clinical studies that evaluate prevention strategies for heart disease and stroke fail to consider a participant's ethnicity, a factor that can more than double the rate of death in some groups, according to research led by St. Michael's Dr. Joel Ray. The study, published online in the Quarterly Journal of Medicine, reviewed 45 major clinical trials on prevention strategies. Researchers found that only 1 in 4 studies reported on the ethnicity of participants. None included information about whether a participant was an immigrant. ...

(Boston) – Researchers at Boston University School of Medicine (BUSM), in collaboration with Johns Hopkins University, have identified a potential new biomarker and therapeutic target for melanoma. The novel cell screening method used in the study also clarifies the process behind tumor metastasis and may allow the identification of biomarkers for other aggressive cancers. The findings now appear online in Cancer Research. According to the American Cancer Society melanoma is the most serious type of skin cancer and one in 55 people will be diagnosed with it during their ...

Grand Rapids, Mich. (March 17, 2011) – In a recently-published study mapping the structure and function of the so-called "orphan" nuclear receptor TR4, Van Andel Research Institute (VARI) investigators suggest that Vitamin A may play a more direct role than was previously known in certain physiological functions including sperm cell formation and the development of the central nervous system. Scientists had previously determined that Vitamin A derivatives such as retinal and the retinoic acids are involved in physiological functions in the human body. But there has ...

New Rochelle, NY, March 17, 2011—At-home, daily application of light therapy via light-emitting diodes (LEDs) placed on the forehead and scalp led to improvements in cognitive function and post-traumatic stress disorder in patients with a traumatic brain injury (TBI), according to a groundbreaking study published in Photomedicine and Laser Surgery, a peer-reviewed journal published by Mary Ann Liebert, Inc. The article is available free online at www.liebertpub.com/pho Margaret Naeser, PhD, LAc, VA Boston Healthcare System, Boston University School of Medicine, and colleagues ...

If you ask people how much they plan to exercise, they'll exercise more—but only if that's a personal goal, according to a new study in the Journal of Consumer Research. "When people have set for themselves targets about how much they should engage in a behavior (say, if the behavior is how much to exercise per week), asking them to predict whether they will exercise in the next week makes them think about what they think they should do," write authors Pierre Chandon (INSEAD), Ronn J. Smith (University of Arkansas), Vicki G. Morwitz (New York University), Eric R. Spangenberg, ...

People who make an effort to exert self-control are attracted to aggressive art and public policy appeals, according to a new study in the Journal of Consumer Research. They also don't appreciate messages that nag them to control their behavior. "We set out to examine whether exerting self-control can indeed lead to a wide range of angry behaviors and preferences subsequently, even in situations where such behaviors are quite subtle," write authors David Gal (Northwestern University) and Wendy Liu (University of California San Diego). "Research has shown that exerting ...

San Diego, Calif., USA – Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher Z. Zhang will hold an oral presentation on a study titled "Fuz is Essential for Craniofacial and Tooth Development." Fuz has been identified as a planar cell polarity effector gene and shown to be involved in ciliogenesis. The objective of this study was ...

New Rochelle, NY, March 17, 2011—Simulated interactions in which adults with autism converse with a virtual partner may help them develop better social interaction skills, according to a novel study presented in Cyberpsychology, Behavior, and Social Networking, a peer-reviewed journal published by Mary Ann Liebert, Inc. (www.liebertpub.com). The article is available free online at http://www.liebertpub.com/cyber More than half of individuals diagnosed with autism have normal intellectual capabilities yet struggle in social and work environments because of their severely ...

Even if you have a grasp on your own abilities, you might have trouble estimating the abilities of others, according to a new study in the Journal of Consumer Research. These false impressions affect people's product choices. "We've known that people overestimate their relative ability for seemingly easy tasks, like driving, and underestimate for difficult tasks," write authors Andrew D. Gershoff (University of Texas at Austin) and Katherine A. Burson (University of Michigan). The researchers found that people tend to think others are fairly evenly spread out in their ...

Colorectal cancer cells trigger a set of genes similar to those found in intestinal stem cells, scientists at the Institute for Research in Biomedicine (IRB Barcelona) have found. The team of researchers, led by ICREA researcher Eduard Batlle, propose that patients with colorectal cancer undergo genetic tests of their intestinal epithelium in order to predict a higher risk of relapse. The results of the study, published online this week in Cell Stem Cell, offer new possibilities for diagnosing and treating the disease. Colon cancer is the second cause of death by cancer ...

The American Thoracic Society has released new official clinical guidelines on the diagnosis and management of idiopathic pulmonary fibrosis (IPF). The statement replaces ATS guidelines published in 2000, and reviews current knowledge in the epidemiology, etiology, diagnosis and management of IPF, as well as available treatment options, including pharmacologic and non-pharmacologic therapies and palliative care. The statement appears in the March 15, 2011, American Journal of Respiratory and Critical Care Medicine. IPF is a chronic, progressive, fatal form of fibrotic ...

Signing your name on the dotted line heightens your sense of self and leads to purchase behavior that affirms your self-identity, according to a new study in the Journal of Consumer Research. But signing can reduce engagement in consumers who don't identify strongly with a product or category. "Although there are numerous ways in which people may present their identity to others, signing one's name has distinct legal, social, and economic implications," write authors Keri L. Kettle and Gerald Häubl (University of Alberta). The act of signing also has implications in the ...

San Diego, Calif., USA – Today, during the 89th General Session & Exhibition of the International Association for Dental Research, held in conjunction with the 40th Annual Meeting of the American Association for Dental Research and the 35th Annual Meeting of the Canadian Association for Dental Research, lead researcher V. Qvist will hold an oral presentation on a research study titled "Sealing Manifest Occlusal Caries in Permanent Teeth - 2½-year Results." This research was performed under the objective of investigating the possibility of non-operative sealing of manifest ...

A University of York scientist is proposing a radical programme of 'assisted colonisation' to save species endangered by climate change. Chris Thomas, Professor of Conservation Biology, says the strategy is applicable across the world, and he suggests Britain as a potential haven for species such as the Iberian lynx, the Spanish Imperial Eagle, the Pyrenean Desman and the Provence Chalkhill Blue butterfly. In an opinion paper in Trends in Ecology and Evolution, Professor Thomas, of the University's Department of Biology, says that moving endangered species is the only ...

If you're considering a purchase, you might want to avoid asking an expert's advice. According to a new study in the Journal of Consumer Research, experts have a hard time recalling product features—especially if they feel they need to explain their logic. "People tend to assume that knowledge is always a good thing, but our research suggests that in some cases this may not be true," write authors Ravi Mehta (University of Illinois, Urbana-Champaign), JoAndrea Hoegg (University of British Columbia), and Amitav Chakravarti (New York University). The researchers evaluated ...

COLUMBUS, Ohio – In a first-of-its-kind study, researchers found that mobile media technologies such as smart phones aren't taking people away from relying on traditional media sources such as newspapers or television. Instead, mobile media are filling the spaces in people's daily routine in which other media sources are either unavailable or inconvenient to use. That suggests mobile media use is taking a different path to popularity than did technologies like television, said John Dimmick, lead author of the study and professor of communication at Ohio State University. "Typically, ...

UCLA researchers have identified a new biomarker that could help them track how effectively the immune system is able to clear the brain of amyloid beta, which forms the plaques considered one of the hallmarks of Alzheimer's disease. The pilot study, currently published online in the Journal of Alzheimer's Disease, demonstrates how the immune gene MGAT3, which is essential in clearing amyloid beta, is expressed differently in different Alzheimer's patients. The finding may be useful in providing more highly individualized disease prognoses in the future. It may also ...