TAAD causes thousands of deaths in the United States each year. Although timely surgical repair of aneurysms can prevent death, thoracic aneurysms are often asymptomatic until dissection (tearing of the vessel wall), and there are few recognized risk factors that can be used for screening. "Prospective identification of patients at risk for TAAD using a genetic strategy will be critical to prevent sudden deaths from this treatable disease," explains senior study author Dr. John W. Belmont from Baylor College of Medicine. To begin to unravel the genetic origins of TAAD, ...

DURHAM, N.C. -- The review process being used by the Food and Drug Administration to assess the safety of a faster-growing transgenic salmon fails to weigh the full effects of the fish's widespread production, according to analysis by a Duke University-led team in this week's Science. The salmon, whose genome contains inserted genes from two other fish species, could become the first genetically modified animal approved for human consumption in the United States. The FDA held two days of hearings in September to assess the fish's human and environmental health risks. ...

The pathogen Shigella flexneri invades the cells that line the gut and causes Shigellosis, a disorder characterized by diarrhea and sometimes even death in humans. S. flexneri subverts the normal immune response of the host by interfering with the ability of the infected cell to secrete chemicals called chemokines that stimulate inflammation. Inflammation is a complex response to pathogens that attracts white blood cells to destroy the bacteria. Despite the documented ability of S. flexneri to suppress inflammation in infected cells, intestinal cells do secrete large amounts ...

Researchers have uncovered a fundamental link between the two defining properties of quantum physics. Stephanie Wehner of Singapore's Centre for Quantum Technologies and the National University of Singapore and Jonathan Oppenheim of the United Kingdom's University of Cambridge published their work today in the latest edition of the journal Science. The result is being heralded as a dramatic breakthrough in our basic understanding of quantum mechanics and provides new clues to researchers seeking to understand the foundations of quantum theory. The result addresses the ...

Panama Canal, PanNew data suggest that the Limon and Pedro Miguel faults in Central Panama have ruptured both independently and in unison over the past 1400 years, indicating a significant seismic risk for Panama City and the Panama Canal, according to research published today by the Bulletin of the Seismological Society of America (BSSA). The Panama Canal is undergoing expansion to allow for greater traffic of larger ships, scheduled for completion by 2014. As part of a seismic hazard characterization for the Panama Canal Authority (ACP) expansion project, Rockwell, ...

Over the last 15 years, astronomers have detected nearly 500 planets orbiting stars in our cosmic neighbourhood, but none outside our Milky Way has been confirmed [1]. Now, however, a planet with a minimum mass 1.25 times that of Jupiter [2] has been discovered orbiting a star of extragalactic origin, even though the star now finds itself within our own galaxy. It is part of the so-called Helmi stream — a group of stars that originally belonged to a dwarf galaxy that was devoured by our galaxy, the Milky Way, in an act of galactic cannibalism about six to nine billion years ...

Understanding the evolution of life-threatening viruses like influenza, Ebola and dengue fever, could help us to minimize their impact. New research points the way to a fossil record of viruses that have insinuated themselves into the genomes of insects and other animals, providing clues about their evolutionary history. The findings, published online on November 18 in the open-access journal PLoS Genetics, could enable scientists to elucidate general principles in virus evolution from their genetic "fossils", which in turn could inform approaches for controlling disease. Robert ...

LA JOLLA, CA – November 16, 2010 – A team led by scientists at The Scripps Research Institute has solved the structure of one of the receptors that responds to the neurotransmitter dopamine. Although dopamine transmission is essential to normal brain functioning, the biological assembly of the molecules involved in this crucial neuronal interplay had not been known—until now. The work was reported in the November 19, 2010, issue of the journal Science. In the new study, whose authors included collaborators from Weill Cornell Medical College, Receptos, the National Institute ...

As experts gather in St Petersburg, Russia for next week's Tiger Summit, fewer than 3,200 tigers survive in the wild worldwide. More than half live in India, where they are spread over a vast area (100,000 sq km) of forest. According to Dr Yadvendradev Jhala of the Wildlife Institute of India, lead author of the new study: "Tigers are cryptic, nocturnal and occur at low densities so they are extremely difficult to monitor. Unless we know how many tigers are left in the wild, and whether their numbers are increasing or decreasing, we will not be able to conserve them." Until ...

Cough medicine could be used as way of predicting how well individual patients metabolise tamoxifen used in the treatment of their breast cancer, according to new research presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Friday). The findings suggest that it could be possible to use cough suppressant syrup as a probe, which would enable doctors to identify patients with altered metabolism and use this information to improve individual treatment, making it more effective and reducing the chances of side-effects. ...

Researchers have found that a newly developed drug, which is aimed at a particular receptor involved in the development of blood vessels that sustain tumour growth, is active in patients with advanced cancers and, in some cases, has halted the progress of the disease. The drug, ACE-041, targets a different molecular pathway to other anti-angiogenesis drugs and may provide a new option to treat cancer. Results from a phase I clinical study of ACE-041 were presented at the 22nd EORTC-NCI-AACR [1] Symposium on Molecular Targets and Cancer Therapeutics in Berlin today (Friday). ...

UCLA researchers have pinpointed the culprit behind chronic rejection of heart, lung and kidney transplants. Published in the Nov. 23 edition of Science Signaling, their findings suggest new therapeutic approaches for preventing transplant rejection and sabotaging cancer growth. The team focused on the mechanism behind narrowing of the donor's grafted blood vessels, which blocks blood from reaching the transplanted organ. Starved of oxygen and other nutrients, the organ eventually fails, forcing the patient back on the transplant waiting list. "Chronic rejection ...

It may have been 1 billion years since plants and animals branched apart on the evolutionary tree but down through the ages they have developed strikingly similar mechanisms for detecting microbial invasions and resisting diseases. This revelation was arrived at over a period of 15 years by teams of researchers from seemingly disparate fields who have used classical genetic studies to unravel the mysteries of disease resistance in plants and animals, according to a historical overview that will appear in the Nov. 19 issue of the journal Science. The report, written ...

STANFORD, Calif. — Universal access to lifesaving AIDS drugs — a United Nations' Millennium Development Goal that officials hoped to accomplish by 2010 — would require a staggering $15 billion annual investment from the international community at a time when the economic downturn is challenging continued funding for relief efforts, according to a new analysis by researchers at the Stanford University School of Medicine. The study underscores the need for groups combating AIDS to rethink how they allocate scarce resources, as what was once the centerpiece of the movement ...

GALVESTON, Texas — In a comprehensive global survey, researchers in Texas and England have concluded that improving the mental and physical health of inmates will improve public health. In their article, "The health of prisoners," Seena Fazel of the University of Oxford and Jacques Baillargeon of the University of Texas Medical Branch at Galveston, write that caring for the mental and physical health of prisoners has a direct and important impact on public health that should be recognized. Their findings, to be published Online First in the British medical journal The ...

A clearer understanding of the Universe, its origins and maybe even its destiny is a significant step closer, thanks to new research. As part of a major international experiment called ALPHA*, based at CERN in Switzerland, researchers have helped to achieve trapping and holding atoms of 'anti-hydrogen', which has not previously been possible. The project involves physicists at Swansea University led by Professor Mike Charlton, Dr Niels Madsen and Dr Dirk Peter van der Werf and the University of Liverpool under Professor Paul Nolan, all supported by the Engineering ...

Like gangsters running a protection racket, drongos in the Kalahari Desert act as lookouts for other birds in order to steal a cut of their food catch. The behaviour, revealed in research funded by the Biotechnology and Biological Sciences Research Council (BBSRC) published in Evolution and reported in Nature's Research Highlights today (18 November), may represent a rare example of two species evolving from a parasitic to a mutualistic relationship. The team from the Universities of Bristol, Cambridge and Cape Town showed that victimised pied babblers gained a mitigating ...

Different techniques should be used to remove single stones that have become lodged in the distal ureter after being expelled by the kidney, depending on whether they are under or above one centimetre, according to the December issue of BJUI. Surgeons from the Department of Urology at University Federico II, Naples, Italy, believe that extracorporeal shockwave lithotripsy (ESWL) - which uses a non-invasive acoustic pulse to break down ureteric stones - should be the treatment of first choice in patients with a stone of up to 1cm. Patients with a stone over 1cm should ...

The video games industry is leading the overall trend of transformation of digital products into e-services, according to the report "Born digital/ Grown digital – Assessing the future competitiveness of the EU video games software industry" published today by the European Commission's Joint Research Centre. Online games, for example, play a major role in the digital content convergence process based on digital distribution of different types of content and the diffusion of interactive capabilities for consumers. This phenomenon is having an effect on the movie, video, ...

Scientists and engineers at the internationally acclaimed Space Research Centre at the University of Leicester are developing a conceptual motor design for a Mars 'hopping' vehicle which should lead to a greater understanding of the 'Red Planet'. Their research findings have been published this month by the Proceedings of the Royal Society A (http://rspa.royalsocietypublishing.org/content/early/2010/11/11/rspa.2010.0438.short?rss=1 ) Robots exploring Mars can carry scientific instruments that measure the physical and chemical characteristics of the Martian surface ...

Researchers funded by the BBSRC Crop Science Initiative have made a discovery that could instigate a paradigm shift in breeding resistance to late blight – a devastating disease of potatoes and tomatoes costing the industry £5-6 billion a year worldwide. They will share this research with industry at an event in London later today (18 November). Professor Paul Birch of the University of Dundee and his team at the Scottish Crop Research Institute (SCRI), the University of Dundee, and the University of Aberdeen have developed a new approach to breeding resistance to the ...

Researchers have uncovered the genetic basis of remarkable broad-spectrum resistance to a viral infection that, in some parts of the world, is the most important pathogen affecting leafy and arable brassica crops including broccoli, cauliflower, cabbage, kale, swede and oilseed rape. They have tested resistant plants against a range of different strains of the virus taken from all over the world and so far, no strain has been able to overcome the resistance. The research on the so-called Turnip mosaic virus (TuMV), led by Dr John Walsh of the University of Warwick and ...

The transplant community was largely unaware of sub-standard transportation practices for donor organs until a number of fatal air crashes took the lives of transplant personnel, calling attention to procurement aviation safety. A new report highlighting the need for improved safety measures in organ procurement travel appears in the December issue of Liver Transplantation, a peer-reviewed journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases (AASLD). In the U.S., the Organ Procurement and Transplantation Network (OPTN) ...

OAKLAND, Calif. – Compared to women never on hormone therapy, those taking hormone therapy only at midlife had a 26 percent decreased risk of dementia; while women taking HT only in late life had a 48 percent increased risk of dementia, according to Kaiser Permanente researchers. Women taking HT at both midlife (mean age 48.7 years) and late life had a similar risk of dementia as women not on HT, according to the study which appears in the Annals of Neurology. The study was funded in part by the National Institutes of Health. Although previous research has shown that ...

A protein known to exist in the brain for more than 30 years, called 5-lipoxygenase, has been found to play a regulatory role in the formation of the amyloid beta in the brain, the major component of plaques implicated in the development of Alzheimer's disease, according to researchers at Temple University's School of Medicine. The researchers also found that inhibitors of this protein currently used to control asthma could possibly be used to prevent or treat Alzheimer's disease. The researchers published their findings, "5-Lipoxygenase as Endogenous Modulator of Amyloid ...