A new report in the December Cell Metabolism identifies a protein without which diets high in saturated fat lead to a massive inflammatory response that can prove fatal. The studies in mice suggest that deficiencies in this protective pathway could promote inflammation in those who regularly consume high levels of saturated fat. "In mice without this protein that ate a lot of saturated fat, the lymph nodes blew up to extreme levels," said Sander Kersten of the Nutrigenomics Consortium and Wageningen University in the Netherlands. "I'd never seen anything like it before." Kersten ...

Our brains are packed with cholesterol, almost all of which has to be produced within the brain itself, where it is critical for normal brain functions. Now, a new study in the December Cell Metabolism, a Cell Press publication, reveals how that critical cholesterol synthesis in the brain is derailed in mice with diabetes. The findings offer a new explanation for the neurologic and cerebral complications that come with diabetes, including cognitive dysfunction, depression, and an increased risk of Alzheimer's disease, according to the researchers. "People with diabetes ...

HOUSTON - (Dec. 1, 2010) – SRC-1 (steroid receptor coactivator) orchestrates glucose production in the liver, regulating the activity of a cascade of enzymes that turns sugar production on and off in the liver, said Baylor College of Medicine (www.bcm.edu) and Duke University Medical Center (www.dukehealth.org) researchers in a report that appears in the current issue of Cell Metabolism (http://www.cell.com/cell-metabolism/). "As we achieve a better understanding of gluconeogenesis (production of glucose) in the liver, we can look for new ways to treat metabolic diseases ...

Washington, D.C. (November 30, 2010) -- Nuclear magnetic resonance (NMR) is one of the best tools for gaining insight into the structure and dynamics of molecules because nuclei in atoms within molecules will behave differently in a variety of chemical environments. Nuclei can be thought of as tiny compasses that align when placed in the field of a strong magnet. Similar to magnetic resonance imaging (MRI), conventional NMR uses short pulses of radio waves to drive nuclei away from equilibrium and a 'signal' emerges as nuclei slowly realign with the field. Results reported ...

Washington, D.C. (November 30, 2010) -- One of the holy grails of nanotechnology in medicine is to control individual structures and processes inside a cell. Nanoparticles are well suited for this purpose because of their small size; they can also be engineered for specific intracellular tasks. When nanoparticles are excited by radio-frequency (RF) electromagnetic fields, interesting effects may occur. For example, the cell nucleus could get damaged inducing cell death; DNA might melt; or protein aggregates might get dispersed. Some of these effects may be due to the ...

Washington, D.C. (November 30, 2010) -- Quantum information processing is arguably one of the most fascinating facets of modern quantum physics. A quantum computer operates with quantum bits (qubits) as units of information. Obeying the laws of quantum mechanics, such a computer would be capable of addressing several of the most difficult computational tasks unsolvable with present technology. In the past few decades, scientists learned to perform room-sized experiments to optically control and read out a small number of qubits. Now, researchers in Germany have successfully ...

Washington, D.C. (November 30, 2010) -- A broad review of current research on nuclear power economics has been published in the Journal of Renewable and Sustainable Energy. The report concludes that nuclear power will continue to be a viable power source but that the current fuel cycle is not sustainable. Due to uncertainty about waste management, any projection of future costs must be built on basic assumptions that are not grounded in real data. "The goal of this study was to determine what assumptions are key to reaching conclusions about the relative costs of technologies," ...

SEATTLE – The worst global economic crisis in decades has not stopped public and private donors from giving record amounts of money to health assistance for developing countries, according to a new report by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. The research shows that development assistance for health has grown 375% from $5.66 billion in 1990 to $26.87 billion in 2010. However, IHME's preliminary estimates show that the growth rate is slowing. Between 2004 and 2008, the period of the most dramatic increases in health funding, ...

The fragile regions in mammalian genomes that are thought to play a key role in evolution go through a "birth and death" process, according to new bioinformatics research performed at the University of California, San Diego. The new work, published in the journal Genome Biology on November 30, could help researchers identify the current fragile regions in the human genome – information that may reveal how the human genome will evolve in the future. "The genomic architecture of every species on Earth changes on the evolutionary time scale and humans are not an exception. ...

VIDEO: Dr. Daniel Kelly describes how mice without the protein PGC-1 lose the ability to exercise. Click here for more information. ORLANDO, Fla., November 30, 2010 – Daniel Kelly, M.D., and his colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) at Lake Nona have unveiled a surprising new model for studying muscle function: the couch potato mouse. While these mice maintain normal activity and body weight, they do not have the energy to exercise. In the ...

BEER-SHEVA, ISRAEL, November 30, 2010 -- "Good looks" are only sometimes a positive factor in consideration for a job, according to new research from Ben-Gurion University of the Negev (BGU). In the new working paper, "Are Good-Looking People More Employable?" two economics researchers from BGU prove that a double standard exists between good looks as a positive factor in men and women. The research involved sending 5,312 CVs (resumes) in pairs to 2,656 advertised job openings in Israel. In each pair, one CV was without a picture while the second, otherwise almost identical ...

Geo-microbiologists from Arizona State University have solved a long-standing conundrum about how some photosynthetic microorganisms, endolithic cyanobacteria, bore their way into limestone, sand grains, mussel shells, coral skeletons and other substrates composed of carbonate. According to the lead investigator, ASU professor Ferran Garcia-Pichel, the answer to the mystery of what is "at the heart of an erosive force of global proportions" is a calcium-driven pump, similar to that which we use to power our muscles. The results of Garcia-Pichel's study "Microbial excavation ...

Jerusalem, November 30, 2010 – Researchers at the Hebrew University of Jerusalem who have been examining what happens in a "model earthquake" in their laboratory have discovered that basic assumptions about friction that have been accepted for hundreds of years are just wrong. Their findings provide a new means for replicating how earth ruptures develop and possibly enabling prediction of coming severe earthquakes. "The findings have a wide variety of implications for materials science and engineering and could help researchers understand how earthquakes occur and how ...

Coping with chronic pain can affect every aspect of a person's life and cause conflict between what their mind wants to achieve and what their body allows them to do, according to research in the December issue of the Journal of Nursing and Healthcare of Chronic Illness. Swedish researchers carried out in-depth interviews with ten people who had experienced chronic pain for between four and 32 years and were taking part in an outpatient rehabilitation programme. Nine of the patients, who ranged from 22 to 50 with an average age of 38, were unable to work because of their ...

Thanks to collaborative work between scientists in Donostia-San Sebastian and the University of Kiel (Germany) it has been shown that it is possible to determine and control the number of atoms in contact between a molecule and a metal electrode of copper, at the same time as the electric current passing through the union being recorded. These results were published in the Nature Nanotechnology journal. One of the key problems in nanotechnology is the formation of electrical contacts at an atomic scale. This demands the detailed characterisation of the current flowing ...

New research using a world leading motorcycle simulator to analyse rider behaviour has proved that safer doesn't necessarily mean slower and that formal advanced training for bikers can demonstrate improved safety on our roads. The study was carried out by researchers at The University of Nottingham's Centre for Motorcycle Ergonomics & Rider Human Factors. The preliminary results of the research are published today by the Institute of Advanced Motorists (IAM) which funded the research. Motorcyclists are badly over-represented in accident statistics. As of June 2010 ...

If you should find yourself running from the police, watch your step. If you fall and break an ankle, chances are you'll receive less pain medication when they take you to the ER for treatment. That's one of the findings from a study by Case Western Reserve University sociologist Susan Hinze, and Joshua Tamayo-Sarver, who collected the data and is an emergency department doctor in California. The researchers examined the prescription patterns of 398 randomly selected emergency department doctors from the American College of Emergency Physicians who responded to a ...

Scientists are calling for radical new approaches to conservation following the first biodiversity audit of its kind. Led by the University of East Anglia (UEA), with partners Natural England, the Forestry Commission, Norfolk and Suffolk Biodiversity Partnerships and County Councils, the Brecks Partnership, and Plantlife, the painstaking study pooled information on every plant and animal species recorded in Breckland – a special landscape of heathland, forest and farmland stretching across the Norfolk and Suffolk border. In an unprecedented effort, the UEA team collated ...

In a unique study involving young boa constrictors, University of Cincinnati researchers put snakes to work on varying diameters and flexibility of vertical rope to examine how they might move around on branches and vines to gather food and escape enemies in their natural habitat. The findings by Greg Byrnes, a University of Cincinnati postdoctoral fellow in the department of biological sciences, and Bruce C. Jayne, a UC professor of biology, are published in the December issue of The Journal of Experimental Biology. For many Americans, it was the most dreaded moment ...

CHICAGO (November 30, 2010) – Surgeons married to physicians face more challenges in balancing their personal and professional lives than do surgeons whose partners work in a non-physician field or stay at home, according to new research findings focused on surgeon marriages published in the November issue of the Journal of the American College of Surgeons. As part of the significant influx of women into the workforce over the last 50 years, more women are now surgeons and physicians than ever before. This trend has produced many more dual- career marriages, including ...

A European consortium comprising the National Physical Laboratory, ST Microelectronics, the University of Edinburgh, and TU Delft has been involved in the development and application of the Megaframe Imager - an ultrafast camera capable of recording images at the incredible rate of one million frames Since the introduction of solid-state optical sensors, like those found in digital cameras, the main trend has been towards increasing the resolution (i.e. number of pixels) while miniaturising the chip. However, the other factor is the number of frames the chip is capable ...

Society appreciates powerful individuals' efforts, regardless of them having success or failing. Conversely, when someone without such power fails, their failure is attributed to their "unability to carry out their tasks", and their efforts are not appreciated. In other words: individuals' personal power clearly affects how others perceive their success or failures. That is the conclusion drawn from a research conducted by professors Rocío Martínez Gutiérrez, Rosa Rodríguez Bailón and Miguel Moya, of the Department of Social Psychology of the University of Granada, recently ...

For companies carrying out R+D activities, having researchers leave for competitor companies poses an important challenge. Even if a company's innovations are patented, their employees leaving can lead to information and knowledge leaks to their rivals. Which researchers in an R+D firm are most likely to leave to work for the competition? This research, carried out by by Neus Palomeras and Eduardo Melero from the UC3M Department of Business Economics, attempts to answer this question. The most noteworthy conclusion of this study, published in the journal, Management ...

New research by University of Minnesota psychologists shows how social support benefits are maximized when provided "invisibly"—that is without the support recipient being aware that they are receiving it. The study, "Getting in Under the Radar: A Dyadic View of Invisible Support," is published in the December issue of the journal Psychological Science. In the study, graduate student Maryhope Howland and professor Jeffry Simpson suggest there may be something unique about the emotional support behaviors that result in recipients being less aware of receiving support. ...

BOSTON – November 30, 2010 – The brain contains more cholesterol than any other organ in the body, has to produce its own cholesterol and won't function normally if it doesn't churn out enough. Defects in cholesterol metabolism have been linked with Alzheimer's disease and other neurodegenerative conditions. Now researchers at Joslin Diabetes Center have discovered that diabetes can affect how much cholesterol the brain can make. Scientists in the laboratory of C. Ronald Kahn, M.D., head of Joslin's Integrative Physiology and Metabolism research section, found that brain ...