New Haven, Conn.—The risk of dying from a heat wave is highest when heat waves occur early in the summer and are hotter and longer than usual, according to a Yale study published in the journal Environmental Health Perspectives (EHP). During the first heat wave of a summer, the risk of mortality increases 5.04 percent, compared to 2.65 percent for heat waves that occur later in the summer. Michelle Bell, a co-author of the study and associate professor of environmental health at the Yale School of Forestry & Environmental Studies, said that people may be less accustomed ...

In a new UCSF study of more than 2 million mammogram screenings performed on nearly 700,000 women in the United States, scientists for the first time show a direct link between reduced hormone therapy and declines in ductal carcinoma in situ (DCIS) as well as invasive breast cancer. The researchers saw such a striking decrease, they believe they also have uncovered indirect evidence that hormones promote breast tumor growth. The declines occurred in the age groups that most widely embraced then abandoned hormone therapy. For nearly a decade, postmenopausal women have ...

La Jolla, CA – November 29, 2010 - For Immediate Release – A team of scientists from The Scripps Research Institute have uncovered a previously unknown regulatory mechanism in the body's response to eliminate pathogens, such as bacteria and viruses. The findings challenge a long-held dogma in the field of immunology and have potential implications for far-ranging topics from how vaccines should be administered to the origin of autoimmunity. The results of the study, led by Scripps Research Professor Michael McHeyzer-Williams, were published in the December issue of the ...

Vitamin D and calcium have been the focus of much research since the Institute of Medicine set nutritional reference values for them in 1997. Known as Dietary Reference Intakes, the values for these and other nutrients serve as a guide for good nutrition and provide the scientific basis for the development of food guidelines in both the United States and Canada. Updated DRIs for these two nutrients are presented in a new IOM report, Dietary Reference Intakes for Calcium and Vitamin D, which will be released on Tuesday, Nov. 30. INFORMATION: Details: Embargoed copies ...

CHICAGO – People with obstructive sleep apnea (OSA), a sleep disorder associated with obesity, have more non-calcified or "bad" plaque in their coronary arteries, according to a study presented today at the annual meeting of the Radiological Society of North America (RSNA). "Our study reveals that individuals with obstructive sleep apnea are prone to developing an aggressive form of atherosclerosis that puts them at risk for impaired blood flow and cardiovascular events," said U. Joseph Schoepf, M.D., professor of radiology and medicine and director of cardiovascular ...

CHICAGO – In a study being presented today at the annual meeting of the Radiological Society of North America (RSNA), researchers say they may have an explanation as to why African Americans, despite having lower amounts of coronary artery calcification, are at increased risk for heart attacks and other cardiovascular events compared with Caucasians. The answer, according to researchers at the Medical University of South Carolina (MUSC) in Charleston, S.C., may be increased levels of non-calcified plaque, which consists of buildups of soft deposits deep in the walls of ...

CHICAGO – Researchers in London say they have found an effective two-part treatment for microtears in the hamstring: injections of the patient's own blood and a steroid along with "dry-needling," in which repeated needle punctures cause controlled internal bleeding in the injured area. Results of the study were presented today at the annual meeting of the Radiological Society of North America (RSNA). "By injecting the patient's own blood where it is needed at the site of a damaged tendon, we help the patient heal themselves," said lead researcher Waseem A. Bashir, M.D., ...

CHICAGO – For years, it was believed that obese women were at lower risk for developing osteoporosis, and that excess body fat actually protected against bone loss. However, a study presented today at the annual meeting of the Radiological Society of North America (RSNA) found that having too much internal abdominal fat may, in fact, have a damaging effect on bone health. "We know that obesity is a major public health problem," said the study's lead author, Miriam A. Bredella, M.D., a radiologist at Massachusetts General Hospital and assistant professor of radiology at ...

CHICAGO – Using functional magnetic resonance imaging (fMRI), researchers have captured pictures of the brain while patients experienced a pain stimulus with and without acupuncture to determine acupuncture's effect on how the brain processes pain. Results of the study, which the researchers say suggest the effectiveness of acupuncture, were presented today at the annual meeting of the Radiological Society of North America (RSNA). "Until now, the role of acupuncture in the perception and processing of pain has been controversial," said lead researcher Nina Theysohn, M.D., ...

A new report in the December Cell Metabolism identifies a protein without which diets high in saturated fat lead to a massive inflammatory response that can prove fatal. The studies in mice suggest that deficiencies in this protective pathway could promote inflammation in those who regularly consume high levels of saturated fat. "In mice without this protein that ate a lot of saturated fat, the lymph nodes blew up to extreme levels," said Sander Kersten of the Nutrigenomics Consortium and Wageningen University in the Netherlands. "I'd never seen anything like it before." Kersten ...

Our brains are packed with cholesterol, almost all of which has to be produced within the brain itself, where it is critical for normal brain functions. Now, a new study in the December Cell Metabolism, a Cell Press publication, reveals how that critical cholesterol synthesis in the brain is derailed in mice with diabetes. The findings offer a new explanation for the neurologic and cerebral complications that come with diabetes, including cognitive dysfunction, depression, and an increased risk of Alzheimer's disease, according to the researchers. "People with diabetes ...

HOUSTON - (Dec. 1, 2010) – SRC-1 (steroid receptor coactivator) orchestrates glucose production in the liver, regulating the activity of a cascade of enzymes that turns sugar production on and off in the liver, said Baylor College of Medicine (www.bcm.edu) and Duke University Medical Center (www.dukehealth.org) researchers in a report that appears in the current issue of Cell Metabolism (http://www.cell.com/cell-metabolism/). "As we achieve a better understanding of gluconeogenesis (production of glucose) in the liver, we can look for new ways to treat metabolic diseases ...

Washington, D.C. (November 30, 2010) -- Nuclear magnetic resonance (NMR) is one of the best tools for gaining insight into the structure and dynamics of molecules because nuclei in atoms within molecules will behave differently in a variety of chemical environments. Nuclei can be thought of as tiny compasses that align when placed in the field of a strong magnet. Similar to magnetic resonance imaging (MRI), conventional NMR uses short pulses of radio waves to drive nuclei away from equilibrium and a 'signal' emerges as nuclei slowly realign with the field. Results reported ...

Washington, D.C. (November 30, 2010) -- One of the holy grails of nanotechnology in medicine is to control individual structures and processes inside a cell. Nanoparticles are well suited for this purpose because of their small size; they can also be engineered for specific intracellular tasks. When nanoparticles are excited by radio-frequency (RF) electromagnetic fields, interesting effects may occur. For example, the cell nucleus could get damaged inducing cell death; DNA might melt; or protein aggregates might get dispersed. Some of these effects may be due to the ...

Washington, D.C. (November 30, 2010) -- Quantum information processing is arguably one of the most fascinating facets of modern quantum physics. A quantum computer operates with quantum bits (qubits) as units of information. Obeying the laws of quantum mechanics, such a computer would be capable of addressing several of the most difficult computational tasks unsolvable with present technology. In the past few decades, scientists learned to perform room-sized experiments to optically control and read out a small number of qubits. Now, researchers in Germany have successfully ...

Washington, D.C. (November 30, 2010) -- A broad review of current research on nuclear power economics has been published in the Journal of Renewable and Sustainable Energy. The report concludes that nuclear power will continue to be a viable power source but that the current fuel cycle is not sustainable. Due to uncertainty about waste management, any projection of future costs must be built on basic assumptions that are not grounded in real data. "The goal of this study was to determine what assumptions are key to reaching conclusions about the relative costs of technologies," ...

SEATTLE – The worst global economic crisis in decades has not stopped public and private donors from giving record amounts of money to health assistance for developing countries, according to a new report by the Institute for Health Metrics and Evaluation (IHME) at the University of Washington. The research shows that development assistance for health has grown 375% from $5.66 billion in 1990 to $26.87 billion in 2010. However, IHME's preliminary estimates show that the growth rate is slowing. Between 2004 and 2008, the period of the most dramatic increases in health funding, ...

The fragile regions in mammalian genomes that are thought to play a key role in evolution go through a "birth and death" process, according to new bioinformatics research performed at the University of California, San Diego. The new work, published in the journal Genome Biology on November 30, could help researchers identify the current fragile regions in the human genome – information that may reveal how the human genome will evolve in the future. "The genomic architecture of every species on Earth changes on the evolutionary time scale and humans are not an exception. ...

VIDEO: Dr. Daniel Kelly describes how mice without the protein PGC-1 lose the ability to exercise. Click here for more information. ORLANDO, Fla., November 30, 2010 – Daniel Kelly, M.D., and his colleagues at Sanford-Burnham Medical Research Institute (Sanford-Burnham) at Lake Nona have unveiled a surprising new model for studying muscle function: the couch potato mouse. While these mice maintain normal activity and body weight, they do not have the energy to exercise. In the ...

BEER-SHEVA, ISRAEL, November 30, 2010 -- "Good looks" are only sometimes a positive factor in consideration for a job, according to new research from Ben-Gurion University of the Negev (BGU). In the new working paper, "Are Good-Looking People More Employable?" two economics researchers from BGU prove that a double standard exists between good looks as a positive factor in men and women. The research involved sending 5,312 CVs (resumes) in pairs to 2,656 advertised job openings in Israel. In each pair, one CV was without a picture while the second, otherwise almost identical ...

Geo-microbiologists from Arizona State University have solved a long-standing conundrum about how some photosynthetic microorganisms, endolithic cyanobacteria, bore their way into limestone, sand grains, mussel shells, coral skeletons and other substrates composed of carbonate. According to the lead investigator, ASU professor Ferran Garcia-Pichel, the answer to the mystery of what is "at the heart of an erosive force of global proportions" is a calcium-driven pump, similar to that which we use to power our muscles. The results of Garcia-Pichel's study "Microbial excavation ...

Jerusalem, November 30, 2010 – Researchers at the Hebrew University of Jerusalem who have been examining what happens in a "model earthquake" in their laboratory have discovered that basic assumptions about friction that have been accepted for hundreds of years are just wrong. Their findings provide a new means for replicating how earth ruptures develop and possibly enabling prediction of coming severe earthquakes. "The findings have a wide variety of implications for materials science and engineering and could help researchers understand how earthquakes occur and how ...

Coping with chronic pain can affect every aspect of a person's life and cause conflict between what their mind wants to achieve and what their body allows them to do, according to research in the December issue of the Journal of Nursing and Healthcare of Chronic Illness. Swedish researchers carried out in-depth interviews with ten people who had experienced chronic pain for between four and 32 years and were taking part in an outpatient rehabilitation programme. Nine of the patients, who ranged from 22 to 50 with an average age of 38, were unable to work because of their ...

Thanks to collaborative work between scientists in Donostia-San Sebastian and the University of Kiel (Germany) it has been shown that it is possible to determine and control the number of atoms in contact between a molecule and a metal electrode of copper, at the same time as the electric current passing through the union being recorded. These results were published in the Nature Nanotechnology journal. One of the key problems in nanotechnology is the formation of electrical contacts at an atomic scale. This demands the detailed characterisation of the current flowing ...

New research using a world leading motorcycle simulator to analyse rider behaviour has proved that safer doesn't necessarily mean slower and that formal advanced training for bikers can demonstrate improved safety on our roads. The study was carried out by researchers at The University of Nottingham's Centre for Motorcycle Ergonomics & Rider Human Factors. The preliminary results of the research are published today by the Institute of Advanced Motorists (IAM) which funded the research. Motorcyclists are badly over-represented in accident statistics. As of June 2010 ...