About The Study: This study of 491,000 participants followed up for up to 15 years found that loneliness was associated with risk of incident Parkinson disease across demographic groups and independent of depression and other prominent risk factors and genetic risk. The findings add to the evidence that loneliness is a substantial psychosocial determinant of health. Authors: Antonio Terracciano, Ph.D., of the Florida State University College of Medicine in Tallahassee, is the corresponding author. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamaneurol.2023.3382) Editor’s ...

About The Study: In this study of 6,866 individuals with COVID-19, nirmatrelvir and ritonavir (Paxlovid [Pfizer]) treatment was associated with reduced risk of COVID-19 hospitalization or death in clinically extremely vulnerable individuals, with the greatest benefit observed in severely immunocompromised individuals. No reduction in the primary outcome (death from any cause or emergency hospitalization with COVID-19 within 28 days) was observed in lower-risk individuals, including those age 70 or older without serious comorbidities.  Authors: Colin R. Dormuth, Sc.D., ...

People frequently exposed to racial or ethnic discrimination may be more susceptible to obesity and related health risks in part because of a stress response that changes biological processes and how we process food cues. These are findings from UCLA researchers conducting what is believed to be the first study directly examining effects of discrimination on responses to different types of food as influenced by the brain-gut-microbiome (BGM) system. The changes appear to increase activation in regions of the brain associated with reward and self-indulgence – like seeking “feel-good” ...

DURHAM, N.C. – Researchers at Duke University have demonstrated an app driven by AI that can run on a tablet to accurately screen for autism in children by measuring and weighing a variety of distinct behavioral indicators. Called SenseToKnow, the app delivers scores that evaluate the quality of the data analyzed, the confidence of its results and the probability that the child tested is on the autism spectrum. The results are fully interpretable, meaning that they spell out exactly which of the behavioral indicators led to its conclusions and why. This ability ...

New York, NY (October 2, 2023)—Mount Sinai investigators have developed a new approach for treating invasive bladder cancer without the need for surgical removal of the bladder, according to a study published in Nature Medicine in September. Removing the bladder is currently a standard approach when cancer has invaded the muscle layer of the bladder. In a phase 2 clinical trial that was the first of its kind, doctors found that some patients could be treated with a combination of chemotherapy and immunotherapy without the need to remove their bladder. ...

Researchers at the University of Cologne’s CECAD Cluster of Excellence for Aging Research and the CEPLAS Cluster of Excellence for Plant Sciences have found a promising synthetic plant biology approach for the development of a therapy to treat human neurodegenerative diseases, especially Huntington’s disease. In their publication “In-planta expression of human polyQ-expanded huntingtin fragment reveals mechanisms to prevent disease-related protein aggregation” in Nature Aging, they showed that a synthetic enzyme derived from plants – stromal processing peptidase (SPP) – reduces the clumping of proteins responsible for the pathological changes ...

CONTAGIOUS CANCERS IN COCKLES SEQUENCED, SHOWING UNEXPECTED INSTABILITY    Transmissible cancers in cockles — marine cancers that can spread through the water — have been sequenced for the first time, unearthing new insight into how these cancers have spread across animal populations for hundreds, possibly thousands, of years. The study, from researchers at the Wellcome Sanger Institute, the CiMUS research centre at the Universidade de Santiago de Compostela in Spain, and collaborators across multiple countries, found that these cockle tumours are highly genetically unstable. The cancer ...

Observations of the BlueWalker 3 prototype satellite show it is one of the brightest objects in the night sky, outshining all but the brightest stars. Astronomers have raised concerns that without mitigation, groups of large satellites could disrupt our ability to observe the stars from Earth and perform radio astronomy. Several companies are planning ‘constellations’ of satellites – groups of potentially hundreds of satellites that can deliver mobile or broadband services anywhere in the world. However, these satellites need to be in ‘low-Earth’ orbit and can be relatively large, ...

When two, three or four apples are placed in front of us, we are able to recognize the number of apples very quickly. However, we need significantly more time if there are five or more apples and we often also guess the wrong number. In fact, the brain does actually register smaller numbers of things differently than larger ones. This has been demonstrated in a recent study by the University of Tübingen, University of Bonn and the University Hospital Bonn. The results were published in the magazine Nature ...

In a groundbreaking study published in JAMA Pediatrics on October 2, 2023, researchers at Boston Children’s Hospital shed new light on the evolving nature of Autism Spectrum Disorder (ASD) diagnoses in early childhood. Diagnosing ASD at a young age is important for early intervention and treatment, but this new study suggests that not all kids continue to meet the criteria for ASD as they get older. The team found that 37% of children diagnosed with ASD as toddlers no longer meet the criteria for ASD around the age of six. Children with lower adaptive skills—essential everyday abilities encompassing communication, self-care, and decision-making—tend ...

Vulnerable coastlines  Unfortunately, precisely in these rural densely populated Asian regions, mangroves have in the past been cleared to free up land for other uses such as aquaculture. This has made these coasts vulnerable to rapid erosion. Restoring mangroves seems a logical solution to reverse this process and protect these densely populated coastlines. However, this requires understanding if mangroves can cope with extreme rates of relative sea level rises, as experienced in these subsiding areas. Since 2015 NIOZ researcher Celine van Bijsterveldt visited Indonesia regularly during her studies and her Phd. ...

Using a new analysis method for satellite images, an international research team, coordinated by the French Alternative Energies and Atomic Energy Commission (CEA) and INRAE, mapped for the first time annual changes in global forest biomass between 2010 and 2019. Researchers discovered that boreal and temperate forests have become the main global carbon sinks. Tropical forests, which are older and degraded by deforestation, fire and drought, are nearly carbon neutral. The findings, published in Nature Geoscience, highlight the importance of accounting for young forests and forest ...

Subarachnoid haemorrhage (SAH) is one of the most dangerous cerebrovascular disorders, with as many as 40% of patients dying within one month of the event. A study recently published in the esteemed Neurology journal investigated whether there are differences in the prognosis of SAH patients between the university hospital districts in Finland. The research dataset was composed of nearly 10,000 SAH cases from 1998 to 2017, including information on patients who died before receiving neurosurgical care. Prognoses ...

Mobile phones, smartwatches and earbuds are some gadgets that we carry around physically without much thought. The increasingly digitalised world sees a shrinking gap between human and technology, and many researchers and companies are interested in how technology can be further integrated into our lives.   What if, instead of incorporating technology into our physical world, we assimilate ourselves into a virtual environment? This is what Assistant Professor Xiong Zehui from the Singapore University of Technology ...

The research teams of Professor René Ketting at the Institute of Molecular Biology (IMB) in Mainz, Germany, and Dr. Sebastian Falk at the Max Perutz Labs in Vienna, Austria, have identified a new enzyme called PUCH, which plays a key role in preventing the spread of parasitic DNA in our genomes. These findings may reveal new insights into how our bodies detect and fight bacteria and viruses to prevent infections. Our cells are under constant attack from millions of foreign intruders, such as viruses and bacteria. To keep us from getting sick, ...

UVA Health researchers have developed a powerful new tool to understand how medications affect men and women differently, and that will help lead to safer, more effective drugs in the future. Women are known to suffer a disproportionate number of liver problems from medications. At the same time, they are typically underrepresented in drug testing. To address this, the UVA scientists have developed sophisticated computer simulations of male and female livers and used them to reveal sex-specific differences in how the tissues are affected by drugs. The new model has already provided ...

Using zebrafish as a model, investigators have determined a suitable combination of chemical compounds in which to store hearts, and potentially other organs, when frozen for extended periods of time before transplantation. The work, which is published in The FASEB Journal, involved a variety of methods, including assays at multiple developmental stages, techniques for loading and unloading agents, and the use of viability scores to quantify organ function. These methods allowed scientists to perform the largest and most comprehensive screen of cryoprotectant agents to determine their toxicity and efficiency at preserving ...

Osaka, Japan - Circadian rhythms, the internal biological clocks that regulate our daily activities, are essential for maintaining health and well-being. While the role of transcription in these rhythms is well-established, a new study sheds light on the critical importance of post-transcriptional processes. The research, titled “Circadian ribosome profiling reveals a role for the Period2 upstream open reading frame in sleep,” to be published in PNAS, redefines our understanding of how translation and post-transcriptional processes influence the body’s internal clock and its impact on sleep patterns. Timing Is Everything: ...

Osaka, Japan – Memory B cells depend on autophagy for their survival, but the protein Rubicon is thought to hinder this process. Researchers from Osaka University have discovered a shorter isoform of Rubicon called RUBCN100, which enhances autophagy in B cells. Mice that lacked the longer isoform, RUBCN130, produced more memory B cells in a way that relied on autophagy. These findings provide further insight into the role of Rubicon in autophagy. Autophagy is a mechanism that degrades and ...

Until recently, our understanding of Parkinson's disease has been quite limited, which has been apparent in the limited treatment options and management of this debilitating condition. Our recent understanding has primarily revolved around the genetic factors responsible for familial cases, while the causative factors in the vast majority of patients remained unknown. However, in a new study, researchers from the University of Copenhagen have unveiled new insights into the workings of the brain in Parkinson's patients. Leading the groundbreaking discovery is Professor Shohreh Issazadeh-Navikas. “For the first time, we can show that mitochondria, ...

Predation is a driving force in the evolution of anti-predator strategies, and death feigning, characterized by immobility in response to threats, is a common defensive mechanism across various animal species. While this behavior can enhance an individual's survival prospects by reducing a predator's interest, it also carries costs, such as limited opportunities for feeding and reproduction. Recently, researchers from Okayama University, Japan, investigated how pheromones, important chemical signals that affect foraging and reproduction, might influence death-feigning behavior in the red flour beetle, Tribolium castaneum.  “Male beetles release an aggregation pheromone called ...

Genetic quality or genetic compatibility? What do female fruit flies prioritize when mating? Researchers at the University of Zurich show that both factors are important at different stages of the reproductive process and that females use targeted strategies to optimize the fitness of their offspring. Breeding female fruit flies face a difficult decision: do they mate with the male that has the best genes, or with the one whose genes best match their own? Evolutionary biologists from the University of Zurich and Concordia University have now investigated ...

Identifying the underlying cause of extreme events such as floods, heavy downpours or tornados is immensely difficult and can take a concerted effort by scientists over several decades to arrive at feasible physical explanations. Extreme events cause significant deviation from expected behavior and can dictate the overall outcome for a number of scientific problems and practical situations. For example, practical scenarios where a fundamental understanding of extreme events can be of vital importance include rogue waves in the ocean that could endanger ships and offshore structures or increasingly ...

A breakthrough study, jointly led by Professor Jang Hyun Choi and Professor Sung Ho Park from the Department of Biological Sciences at UNIST has identified an important factor involved in the development of non-alcoholic fatty liver disease (NAFLD) caused by obesity. The research team discovered that Thrap3, a protein associated with thyroid hormone receptors, plays a significant role in exacerbating NAFLD by inhibiting the activity of adenosine monophosphate-activated protein kinase (AMPK), a key regulator of fat metabolism in the liver. NAFLD encompasses various metabolic diseases such as fatty hepatitis and cirrhosis resulting from excessive fat accumulation. ...

Lower income breast cancer patients often struggle to afford life’s necessities such as housing, transportation and utilities due to direct and incidental costs related to their treatment, according to a new analysis by Susan G. Komen®, the world’s leading breast cancer organization. These top needs were identified by Susan G. Komen’s Patient Care Center, which provided nearly $9.1 million in grants to more than 16,000 breast cancer patients from April 1, 2022 to March 31, 2023, as part of Komen’s direct-to-patient ...