“Given the potential challenges of directly inhibiting UGDH, therapeutic strategies may extend to targeting downstream pathways and upstream substrates.”  A new review paper was published in Oncotarget's Volume 14 on September 28, 2023, entitled, “UDP-glucose dehydrogenase (UGDH) in clinical oncology and cancer biology.” UDP-glucose-6-dehydrogenase (UGDH) is a cytosolic, hexameric enzyme that converts UDP-glucose to UDP-glucuronic acid (UDP-GlcUA), a key reaction in hormone and xenobiotic metabolism and in the production of extracellular matrix precursors.  In this review, researchers Meghan J. Price, Annee D. Nguyen, Jovita K. Byemerwa, ...

Paleolithic human populations survived even in the coldest and driest upland parts of Spain, according to a study published October 4, 2023 in the open-access journal PLOS ONE by Manuel Alcaraz-Castaño of the University of Alcalá, Spain, Javier Aragoncillo-del Rió of the Molina-Alto Tajo UNESCO Global Geopark, Spain and colleagues. Research into ancient hunter-gatherer populations of the Iberian Peninsula has mainly focused on coastal regions, with relatively little investigation into the inland. A classic hypothesis has been that the cold and dry conditions of inland Iberia ...

Antimicrobials don't appear to help pet dogs with uncomplicated diarrhea - so should likely be prescribed less often by vets - according to new causal inference study ### Article URL:  https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0291057 Article Title: Target trial emulation: Do antimicrobials or gastrointestinal nutraceuticals prescribed at first presentation for acute diarrhoea cause a better clinical outcome in dogs under primary veterinary care in the UK? Author Countries: UK Funding: CP is supported at the RVC ...

A new analysis estimates a variety of potential benefits for environmental sustainability—for instance, reduced freshwater consumption and greenhouse gas emissions—that could result from switching all pet dogs and cats in the US or around the world to nutritionally sound, vegan diets. Andrew Knight of Griffith University, Australia, presents these calculations in the open-access journal PLOS ONE on October 4, 2023. The livestock industry has environmental impacts, such as land and freshwater ...

First fully peer-reviewed, indexed study to look at link between strict vegetarianism and genetics More people would like to be vegetarian than actually are. ‘We think it’s because there is something hard-wired here that people may be missing’ Findings open the door to further studies that could have important implications regarding dietary recommendations and the production of meat substitutes CHICAGO --- From Impossible Burger to “Meatless Mondays,” going meat-free is certainly in vogue. But a person’s genetic makeup plays ...

What if a vaccine, given to patients just before or after arriving at the hospital, could protect them against lethal superbugs that lurk in healthcare settings? That’s the premise behind an experimental vaccine invented by a USC-led team and patented by the university. Researchers designed the formula to prevent serious infections from drug-resistant pathogens. A new study shows that a single dose, administered in mouse models, put immune cells into "Incredible Hulk" mode, providing rapid protection against eight different bacteria and fungi species. “It’s an early warning system. ...

WINSTON-SALEM, NC – October 4, 2023  - A research paper published today in Science Translational Medicine presents a significant breakthrough in the area of skin regeneration and wound healing by researchers at the Wake Forest Institute for Regenerative Medicine (WFIRM). The study, titled "Bioprinted Skin with Multiple Cell Types Promotes Skin Regeneration, Vascularization, and Epidermal Rete Ridge Formation in Full-Thickness Wounds," shows the successful development of bioprinted skin that ...

In recent years, studies have revealed that the now-arid region of northern Arabia was once much wetter and greener, providing Neolithic human populations with access to both water and game. The present aridity of the region, however, preserves little organic matter, making a reconstruction of the Neolithic lifestyle difficult. Now, in a new study published in the journal PLOS ONE, researchers from the Max Planck Institute of Geoanthropology, the National Research Council of Italy, Institute of Heritage Science (CNR ISPC), and University College London present use-wear ...

An international team of scientists has found early human migrants left Africa for Eurasia, across the Sinai peninsula and on through Jordan, over 80-thousand years ago. Researchers from the University of Southampton (UK) and Shantou University (China), together with colleagues in Jordan, Australia and the Czech Republic(1), have proved there was a “well-watered corridor” which funnelled hunter-gatherers through The Levant towards western Asia and northern Arabia via Jordan. Their findings, published in the journal Science Advances, support previous research conducted ...

EMBARGOED FOR USE UNTIL: 2 p.m. (ET) on Oct. 4, 2023 -- A UCLA-led team of researchers has found nerve pathways that supply brown adipose tissue (BAT), a type of tissue that releases chemical energy from fat metabolism as heat – a finding that could pave the way toward using it to treat obesity and related metabolic conditions. The researchers have for the first time detailed this nerve supply and provided examples of how manipulating it can change BAT activity, marking a first step toward understanding how to use it therapeutically, said ...

To date it has been unclear exactly how the sex of a bee is determined. A research team from Heinrich Heine University Düsseldorf (HHU) comprising biologists and chemists has now identified a key gene and the molecular mechanism linked with it. In the current issue of the scientific journal Science Advances, they describe how this process is similar to a game involving two dice. The sex of a living creature has significant consequences for its form, function and behaviour. The biological sex of an organism is usually determined at the start of its life. In humans, for example, the presence of the sex-determining “Y chromosome” ...

WASHINGTON, DC – The Department of Energy’s (DOE’s) Office of Science has selected 60 graduate students representing 26 states for the Office of Science Graduate Student Research (SCGSR) program’s 2023 Solicitation 1 cycle. Through world-class training and access to state-of-the-art facilities and resources at DOE National Laboratories, SCGSR prepares graduate students to enter jobs of critical importance to the DOE mission and secures our national position at the forefront of discovery and innovation. “This ...

NEW YORK (October 4, 2023) -- The Brain & Behavior Research Foundation today announced that Special Olympics International is the recipient of the 2023 Pardes Humanitarian Prize in Mental Health. It is recognized for its lasting humanitarian impact around the world through sports training and athletic competition for adults and children with intellectual disabilities. An Honorary Pardes Prize Recipient was also announced for 2023 – Henry Jarecki, M.D – for his important contributions to the field of psychiatry and his unique work to preserve academic and scientific freedom. “Special Olympics International is being honored as a beacon of light ...

ROCHESTER, Minn. — Mayo Clinic researchers have developed a calculation that can help identify moderate aortic stenosis patients at higher risk of dying from the condition. According to new research published in Mayo Clinic Proceedings, calculating the patient's mean arterial pressure (AugMAP) is a simple and effective way to identify those patients who may benefit from more aggressive treatment strategies. "Physiologically, AugMAP can be considered a marker of global left ventricular contractile function," says Chieh-Ju Chao, M.D., senior associate consultant in the Mayo Clinic Department ...

Applying machine learning to find the properties of atomic pieces of geometry shows how AI has the power to accelerate discoveries in maths. Mathematicians from Imperial College London and the University of Nottingham have, for the first time, used machine learning to expand and accelerate work identifying ‘atomic shapes’ that form the basic pieces of geometry in higher dimensions. Their findings have been published in Nature Communications. The way they used artificial intelligence, in the form of machine learning, could transform how maths is done, say the authors. Dr Alexander Kasprzyk from ...

Rivers across England have seen a significant improvement in river invertebrate biodiversity since 1989, shows a study led by UK Centre for Ecology & Hydrology (UKCEH) researchers. The study, which involved one of the largest and most wide-ranging analyses of long-term monitoring data in the world – spanning over 30 years, found improvements in invertebrate biodiversity across all regions and river types in England. This improvement is all the more surprising given English rivers are amongst the most highly exposed to wastewater and other pressures in Europe. The recent State of Nature report shows that the overall abundance of species in Great ...

New Orleans – The National League for Nursing (NLN) presented Demetrius Porche, DNS, PhD, ANEF, FACHE, FAANP, FAAN, Professor and Dean of LSU Health New Orleans School of Nursing, with its Mary Adelaide Nutting Award for Outstanding Teaching or Leadership in Nursing Education during the 2023 NLN Education Summit. The Annual NLN Awards recognize and honor individuals of stature and distinction for their outstanding contributions to nursing education and the broader space of health care. The NLN Mary Adelaide ...

The Translational Plant Sciences Center has awarded funding to four new research projects to help them grow and cultivate external funding. The center provided the projects up to $10,000 a year for up to two years to support the development of innovative research leading to extramural support through the Translational Plant Sciences Center (TPSC) Seed Grant program. “This program aims to provide faculty with funds to explore new research by establishing teams composed of labs and partners both inside and outside of TPSC and Virginia Tech ...

ITHACA, N.Y. -- Volcanic ash is no ordinary dust: It gets injected into the atmosphere, climbs to the stratosphere, impacts climate, powders roadways and clogs jet engines. To bridge the knowledge gap between volcanologists and atmospheric scientists working on climate change and observing global systems, Cornell researchers have characterized volcanic ash samples from many explosive eruptions of a broad compositional range. The work is helping scientists uncover how this tiny material – measured in microns and nanometers – plays a big role in the atmosphere. Volcanic ash is formed from minerals trapped in ...

AURORA, Colo. (Oct. 4, 2023) – A pilot program that successfully reduced burnout among female medical residents has shown even greater results on a national level, according to researchers at the University of Colorado Anschutz Medical Campus. The study was published today in the journal JAMA Network Open. “We did a pilot program in 2021to see if it would work and it did,” said study co-author Tyra Fainstad, MD, associate professor at the University of Colorado School of Medicine. “Then we expanded it to 26 graduate medical institutions in 19 states. There were 1,017 participants. We saw significant improvement in every wellbeing outcome we assessed including all ...

HOUSTON ― The University of Texas MD Anderson Cancer Center’s Research Highlights showcases the latest breakthroughs in cancer care, research and prevention. These advances are made possible through seamless collaboration between MD Anderson’s world-leading clinicians and scientists, bringing discoveries from the lab to the clinic and back. Recent developments at MD Anderson include a computer game that helps breast cancer survivors improve symptoms of peripheral neuropathy, a publicly available single-cell atlas of CD19 chimeric antigen receptor (CAR) T cells, new targets for TP53-mutant acute myeloid leukemia (AML), a preclinical target ...

Cancer immunotherapy drugs called PD-1 inhibitors are widely used to stimulate the immune system to fight cancer, but many patients either don’t respond or develop resistance to them. A new small-molecule drug candidate being tested in an early-stage clinical trial aims to improve patient responses to immunotherapy.  Now scientists have shown, in a study published today in Nature, that the small molecule works through two different mechanisms to slow tumor growth and increase survival in lab animals.  Researchers from the Tumor ...

In a study on the prevalence of attention-deficit/hyperactivity disorder (ADHD) and its association with crash risk among older adult drivers, researchers at Columbia University Mailman School of Public Health found that older adult drivers with ADHD are at a significantly elevated crash risk compared with their counterparts without ADHD. Outcomes included hard- braking events, and self-reported traffic ticket events, and vehicular crashes. Until now research on ADHD and driving safety was largely limited to ...

About The Study: This study found that the burden of respiratory syncytial virus (RSV)-associated hospitalizations in Canadian pediatric hospitals was substantial, particularly among infants less than six months of age, and RSV hospitalizations increased in 2021-2022 compared with the pre-pandemic period, while severity of illness remained similar. These findings suggest that RSV preventive strategies for infants less than six months of age would be associated with decreased RSV disease burden in children.  Authors: Jesse Papenburg, ...

About The Study: Based on U.S. national representative data, the estimated attention-deficit hyperactivity disorder (ADHD) prevalence was 10.08% to 10.47% among children and adolescents ages 4 to 17 from 2017 to 2022, which was similar to the prevalence from the National Health Interview Survey in 2015 to 2016 (10.20%). No significant annual change in the prevalence of ADHD was found from 2017 to 2022. Notably, the estimated prevalence of ADHD among individuals in the U.S. in this study was higher than worldwide estimates (5.3%) in earlier years (1978-2005). Authors: Wenhan Yang, M.D., Ph.D., of Guangdong ...