Team describes molecular detail of HIV's inner coat, pointing the way to new therapies

CHAMPAIGN, Ill. — Researchers report that they have determined the precise chemical structure of the HIV capsid, a protein shell that protects the virus's genetic material and is a key to its virulence. The capsid has become an attractive target for the development of new antiretroviral drugs. The report appears as the cover article in the journal Nature. Scientists have long sought to understand how the HIV capsid is constructed, and many studies have chipped away at its mystery. Researchers have used a variety of laboratory techniques – cryo-electron microscopy, cryo-EM ...

Chevy Chase, MD—Practicing a form of meditation and stretching can help relieve symptoms of post-traumatic stress disorder and normalize stress hormone levels, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). More than 7 million adults nationwide are diagnosed with post-traumatic stress disorder (PTSD) in a typical year. The mental health condition, triggered by a traumatic event, can cause flashbacks, anxiety and other symptoms. PTSD patients have high levels of corticotrophin-releasing ...

Chevy Chase, MD—Levels of a biomarker in a pregnant woman's blood can help physicians gauge her risk of developing gestational diabetes during the first trimester, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). Gestational diabetes is a form of diabetes that can develop during pregnancy, often during the second trimester. The condition causes glucose levels in the bloodstream to be higher than normal. Early diagnosis and treatment can help the woman manage the condition. If left untreated, ...

Chevy Chase, MD—Pregnant women who have thyroid disorders face greater risk of preterm birth and other complications that have short- and long-term consequences for the health of mother and child, according to a recent study accepted for publication in The Endocrine Society's Journal of Clinical Endocrinology & Metabolism (JCEM). The risk of complications is heightened for both women who have underactive thyroid glands – a condition known as hypothyroidism – and those with overactive thyroid glands, or hyperthyroidism. Up to four percent of all pregnancies involve mothers ...

The way in which stars evolve and end their lives was for many years considered to be well understood. Detailed computer models predicted that stars of a similar mass to the Sun would have a period towards the ends of their lives -- called the asymptotic giant branch, or AGB [1] -- when they undergo a final burst of nuclear burning and puff off a lot of their mass in the form of gas and dust. This expelled material [2] goes on to form the next generations of stars and this cycle of mass loss and rebirth is vital to explain the evolving chemistry of the Universe. This ...

The physics behind some of the most extraordinary stellar objects in the Universe just became even more puzzling. A group of astronomers led by McGill researchers using NASA's Swift satellite have discovered a new kind of glitch in the cosmos, specifically in the rotation of a neutron star. Neutron stars are among the densest objects in the observable universe; higher densities are found only in their close cousins, black holes. A typical neutron star packs as much mass as half-a-million Earths within a diameter of only about 20 kilometers. A teaspoonful of neutron ...

Astrophysicists have found that contrary to decades of orthodoxy, stars with a high sodium content die before reaching the final, spectacular stages of life. In a study published today in Nature, an international group of researchers led by Dr Simon Campbell of the Monash Centre for Astrophysics (MoCA), used the European Southern Observatory's 'Very Large Telescope' (VLT) to observe NGC 6752, a globular cluster of stars in our galaxy, 13,000 light years from Earth. They found that 70 per cent of stars in the tightly bound group fail to reach the final red giant phase. ...

Researchers have identified a sub-group of cells that could contribute to prostate cancer recurrence, opening up new ways to treat the disease, which claims more than 3000 lives a year in Australia. Published today in Science Translational Medicine, a study led by Monash University researchers has found prostate cancer cells that survive androgen withdrawal treatment. Previously unidentified, these cells are potential targets for future treatments. As they are present early in disease development, there is the possibility of therapy before the cancer reaches the aggressive, ...

A study at the University of California, San Diego School of Medicine identified a protein that is responsible for regulating blood vessel growth by mediating the efficient removal of cholesterol from the cells. Unregulated development of blood vessels can feed the growth of tumors. The work, led by Yury Miller, MD, PhD, associate professor of medicine at UC San Diego, will be published in the advance online edition of the journal Nature on May 29. Cholesterol is a structural component of the cell and is indispensable for normal cellular function, although its excess ...

University Park, PA -- One of the densest objects in the universe, a neutron star about 10,000 light years from Earth, has been discovered suddenly putting the brakes on its spinning speed. The event is a mystery that holds important clues for understanding how matter reacts when it is squeezed more tightly than the density of an atomic nucleus -- a state that no laboratory on Earth has achieved. The discovery, by an international team of scientists that includes a Penn State University astronomer, will be published in the journal Nature on 30 May 2013. The scientists ...