(Press-News.org) Munich, 1 July 2014: With an ever-ageing female patient population, egg donation is an increasingly common treatment in infertility. ESHRE's own annual reports on fertility treatments in Europe show a rise in egg donation cycles from 15,028 in 2007 to 24,517 in 2010 (to 4.05% of all treatments). This proportion is still some way behind the USA, where egg donation now accounts for around 12% of all treatments.
As women age their store of viable eggs reduces such that their "ovarian reserve" (and likelihood of pregnancy) declines. Once the eggs have gone, they cannot be replaced, and egg donation is the only possible treatment. In addition, studies consistently show that eggs produced by women in older age groups form embryos with a higher prevalence of chromosome defects than those from younger women: these embryos are less likely to implant and more likely to result in miscarriage if they do implant. As a result, fertility treatment with donor eggs is much more common among older women than among younger.
Studies also show that egg donation is an increasingly successful treatment, with live birth rates of around 55% per transfer recorded in the latest US data; success largely depends on the age of the donor, not on the age of the recipient.
Egg donation, like IVF and ICSI, is considered a safe treatment, despite the older age of patients, but a new study from France has found that the pregnancies of egg donation patients are at a higher risk of disorders - particularly relating to high blood pressure - than the pregnancies of routine IVF patients using their own eggs.
Details of this study are presented today by Dr Hélène Letur from the Institut Mutualiste Montsouris in Paris at the 30th Annual Meeting of ESHRE held in Munich.
"A few other studies have shown results suggesting an increased risk of pregnancy-induced hypertension in egg donation patients," said Dr Letur. "However, most of them have small samples and do not adequately control for several important confounders, such women's age, multiple pregnancy, and infertility history. Our aim was to find out whether pregnancies from egg donation are genuinely associated with a higher risk of hypertension and pre-eclampsia than those from treatments using the patient's own eggs. This has growing importance because of the increasing number of egg donations."(1)
This was a case-control study from seven IVF centres in France in which each singleton egg donation pregnancy recorded at 7-8 weeks between 2005 and 2011 was matched with two control routine IVF pregnancies; 580 pregnancies were included in the study (217 egg donation, 363 controls).
Results showed that the egg donation patients had a more than three-fold higher risk of pregnancy-induced hypertension than the routine IVF patients, with prevalence rising from 5.3% to 17.8% (odds ratio 3.84, 95% CI 1.89-7.77) and an even higher risk of pre-eclampsia, from 2.8% to 11.2% (OR 4.60, 95% CI 1.81-11.67) - although the latter finding was based on very few numbers. Further analysis showed a modest effect of patient age (OR 1.08) and no significant effect of previous pregnancy, previous IVF cycles or frozen embryo transfer.(2)
"This study confirms several other reports in the literature," said Dr Letur, "with a large sample and matched control group. We would have to conclude from the results that egg donation itself is a risk factor for pregnancy-induced hypertension and pre-eclampsia."
Dr Letur added that the high prevalence of pregnancy induced hypertension in the egg donation group (almost 18% were affected) means that patients and obstetricians must be aware of the risk. "Preventive measures and care are necessary," she said. These include screening for risk factors for hypertension (such as obesity and diabetes) and early treatment if gestational hypertension is detected. "For the future," she added, "might we match donors and recipients based on genetic factors, or consider fertility preservation for women with a high risk of premature ovarian failure?"
Possible biological explanations for the findings include changes in the immune tolerance of the embryo, whose full genome is not concordant with the recipient's. Blood pressure may rise, says Dr Letur, "to imrpove materno-fetal exchanges".
Abstract O-163, Tuesday 1 July 15.45 CET
Pregnancies issued from egg donation are associated to a higher risk of hypertensive pathologies than control ART pregnancies. Results of a large comparative cohort study
1. Pregnancy-induced hypertension (or gestational hypertension) is usually defined by a blood pressure reading of 140/90 mmHg measured on at least two occasions after 20 weeks' gestation. Pre-eclampsia is a rarer condition defined by a similar blood pressure reading plus an elevated measure of protein in a urine sample ("proteinuria"). Age (over 40, adolescence), multiple pregnancy, hypertension and family history have been identified as risk factors. Around 3-5% of all pregnancies are affected. Most cases of pre-eclampsia are mild and cause no trouble, but deteriorating cases can be serious for both mother and baby. In this study gestational hyptertension was defined as a BP reading of 140/90 mmHg without proteinuria on at least two occasions after 20 weeks' gestation; pre-eclampsia as 140/90 mmHg with proteinuria on repeated readings after 20 weeks; and eclampsia as 160/140 with proteinuria on repeated readings after 20 weeks.
2. While egg donation is generally a treatment for women of an older maternal age (58% in ESHRE's latest monitoring figures were aged over 40), the picture in France is slightly different. There, says Dr Letur, egg donation in the social security system is restricted to women under 43, and in this study the average patient age was 34.5 years. The most frequent indication was premature ovarian failure (premature menopause), suggesting that the results in this study are a genuine effect of egg donation, and not of older age.
When obtaining outside comment, journalists are requested to ensure that their contacts are aware of the embargo on this release.
For further information on the details of this press release, contact:
Christine Bauquis at ESHRE
Mobile: +32 (0)499 25 80 46
Pregnancies following egg donation associated with more than 3-fold higher risk of hypertension
Results from a large case-control study
ELSE PRESS RELEASES FROM THIS DATE:
Most women are aware of oocyte freezing for social reasons
Munich, 1 July 2014: While the majority of younger women are aware of egg freezing as a technique of fertility preservation and consider it an acceptable means of reproductive planning, only one in five would consider it appropriate for them, according to the results of an internet survey performed in the UK and Denmark. The questionnaire, which was accessible online, was completed anonymously by 973 women with a median age of 31 years between September 2012 and September 2013. Results are reported today at the ESHRE Annual Meeting in Munich by Dr Camille Lallemant of ...
Short sleep, aging brain
Researchers at Duke-NUS Graduate Medical School Singapore (Duke-NUS) have found evidence that the less older adults sleep, the faster their brains age. These findings, relevant in the context of Singapore's rapidly ageing society, pave the way for future work on sleep loss and its contribution to cognitive decline, including dementia. Past research has examined the impact of sleep duration on cognitive functions in older adults. Though faster brain ventricle enlargement is a marker for cognitive decline and the development of neurodegenerative diseases such as Alzheimer's, ...
New approach identifies cancer mutations as targets of effective melanoma immunotherapy
PHILADELPHIA —A new approach demonstrated that the recognition of unique cancer mutations appeared to be responsible for complete cancer regressions in two metastatic melanoma patients treated with a type of immunotherapy called adoptive T-cell therapy. This new approach may help develop more effective cancer immunotherapies, according to a study published in Clinical Cancer Research, a journal of the American Association for Cancer Research. "This study provides the technical solution to identify mutated tumor targets that can stimulate immune responses, which is one ...
Deployment-related respiratory symptoms in returning veterans
In a new study of the causes underlying respiratory symptoms in military personnel returning from duty in Iraq and Afghanistan, a large percentage of veterans had non-specific symptoms that did not lead to a specific clinical diagnosis. Most patients who did receive a diagnosis had evidence of asthma or nonspecific airway hyperreactivity, which may have been due in some cases to aggravation of pre-existing disease by deployment exposures. "Earlier studies of military personnel deployed in Southwest Asia have shown increases in non-specific respiratory symptoms related ...
Foodborne bacteria can cause disease in some breeds of chickens after all
Contrary to popular belief, the foodborne pathogen Campylobacter jejuni is not a harmless commensal in chickens but can cause disease in some breeds of poultry according to research published in mBio®, the online open-access journal of the American Society for Microbiology. "The main implication is that Campylobacter is not always harmless to chickens. This rather changes our view of the biology of this nasty little bug," says Paul Wigley of Institute for Infection and Global Health at the University of Liverpool, an author on the study. Campylobacter jejuni is the ...
The inhibition of a protein opens the door to the treatment of pancreatic cancer
Researchers from IMIM (Hospital del Mar Medical Research Institute) have identified a new protein, galectin-1, as a possible therapeutic target for pancreatic cancer. For the first time they have demonstrated the effects of the inhibition of this protein in mice suffering this type of cancer and the results showed an increase in survival of 20%. The work further suggests that it could be a therapeutic target with no adverse effects. Until now, the strategies for treating this tumour were aimed at attacking the tumour cells and had little success. The latest studies indicate ...
Scientists chart a baby boom -- in southwestern Native-Americans from 500 to 1300 A.D.
Scientists have sketched out one of the greatest baby booms in North American history, a centuries-long "growth blip" among southwestern Native Americans between 500 and 1300 A.D. It was a time when the early features of civilization--including farming and food storage--had matured to a level where birth rates likely "exceeded the highest in the world today," the researchers report in this week's issue of the journal Proceedings of the National Academy of Sciences. Then a crash followed, says Tim Kohler, an anthropologist at Washington State University (WSU), offering ...
Lead in kids' blood linked with behavioral and emotional problems
Emotional and behavioral problems show up even with low exposure to lead, and as blood lead levels increase in children, so do the problems, according to research funded by the National Institute of Environmental Health Sciences (NIEHS), part of the National Institutes of Health. The results were published online June 30 in the journal JAMA Pediatrics. "This research focused on lower blood lead levels than most other studies and adds more evidence that there is no safe lead level," explained NIEHS Health Scientist Administrator Kimberly Gray, Ph.D. "It is important to ...
Malaria parasite manipulates host's scent
UNIVERSITY PARK, Pa. -- Malaria parasites alter the chemical odor signal of their hosts to attract mosquitos and better spread their offspring, according to researchers, who believe this scent change could be used as a diagnostic tool. "Malaria-infected mice are more attractive to mosquitos than uninfected mice," said Mark Mescher, associate professor of entomology, Penn State. "They are the most attractive to these mosquito vectors when the disease is most transmissible." Malaria in humans and animals is caused by parasites and can be spread only by an insect vector, ...
Adults can undo heart disease risk
CHICAGO --- The heart is more forgiving than you may think -- especially to adults who try to take charge of their health, a new Northwestern Medicine® study has found. When adults in their 30s and 40s decide to drop unhealthy habits that are harmful to their heart and embrace healthy lifestyle changes, they can control and potentially even reverse the natural progression of coronary artery disease, scientists found. The study was published June 30 in the journal Circulation. "It's not too late," said Bonnie Spring lead investigator of the study and a professor of ...
LAST 30 PRESS RELEASES:
Scientists model 'true prevalence' of COVID-19 throughout pandemic
New breakthrough to help immune systems in the fight against cancer
Through the thin-film glass, researchers spot a new liquid phase
Administering opioids to pregnant mice alters behavior and gene expression in offspring
Brain's 'memory center' needed to recognize image sequences but not single sights
Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions
Changes in disparities in access to care, health after Medicare eligibility
Use of high-risk medications among lonely older adults
65+ and lonely? Don't talk to your doctor about another prescription
Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy
Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose
Plant root-associated bacteria preferentially colonize their native host-plant roots
Rare inherited variants in previously unsuspected genes may confer significant risk for autism
International experts call for a unified public health response to NAFLD and NASH epidemic
International collaboration of scientists rewrite the rulebook of flowering plant genetics
Improving air quality reduces dementia risk, multiple studies suggest
Misplaced trust: When trust in science fosters pseudoscience
Two types of blood pressure meds prevent heart events equally, but side effects differ
New statement provides path to include ethnicity, ancestry, race in genomic research
Among effective antihypertensive drugs, less popular choice is slightly safer
Juicy past of favorite Okinawan fruit revealed
Anticipate a resurgence of respiratory viruses in young children
Anxiety, depression, burnout rising as college students prepare to return to campus
Goal-setting and positive parent-child relationships reduce risk of youth vaping
New research identifies cancer types with little survival improvements in adolescents and young adul
Oncotarget: Replication-stress sensitivity in breast cancer cells
Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas
Development of a novel technology to check body temperature with smartphone camera
The mechanics of puncture finally explained
Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests[Press-News.org] Pregnancies following egg donation associated with more than 3-fold higher risk of hypertension
Results from a large case-control study