PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

A discovery could prevent the development of brain tumours in children

Researchers at the IRCM show that a protein called Sonic Hedgehog causes DNA damage

2014-10-02
(Press-News.org) Montréal, October 2, 2014 – Scientists at the IRCM discovered a mechanism that promotes the progression of medulloblastoma, the most common brain tumour found in children. The team, led by Frédéric Charron, PhD, found that a protein known as Sonic Hedgehog induces DNA damage, which causes the cancer to develop. This important breakthrough will be published in the October 13 issue of the prestigious scientific journal Developmental Cell. The editors also selected the article to be featured on the journal's cover.

Sonic Hedgehog belongs to a family of proteins that gives cells the information needed for the embryo to develop properly. It also plays a significant role in tumorigenesis, the process that transforms normal cells into cancer cells.

"Our team studied a protein called Boc, which is a receptor located on the cell surface that detects Sonic Hedgehog," explains Lukas Tamayo-Orrego, PhD student in Dr. Charron's laboratory and co-first author of the study. "We had previously shown that Boc is important for the development of the cerebellum, the part of the brain where medulloblastoma arises, so we decided to further investigate its role."

"With this study, we found that the presence of Boc is required for Sonic Hedgehog to induce DNA damage," adds Dr. Charron, Director of the Molecular Biology of Neural Development research unit at the IRCM. "In fact, Boc causes DNA mutations in tumour cells, which promotes the progression of precancerous lesions into advanced medulloblastoma."

"Our study shows that when Boc is inactivated, the number of tumours is reduced by 66 per cent," says Frederic Mille, PhD, co-first author of the article and former postdoctoral fellow in Dr. Charron's research unit. "The inactivation of Boc therefore reduces the development of early medulloblastoma into advanced tumours."

Medulloblastoma ranks among the leading causes of cancer-related mortality in children. Current treatments include surgery, as well as radiation therapy and chemotherapy. Although the majority of children survive the treatment, radiation therapy damages normal brain cells in infants and toddlers and causes long-term harm.

"As a result, many children who undergo these treatments suffer serious side effects including cognitive impairment and disorders," states Dr. Charron. "Our results indicate that Boc could potentially be targeted to develop a new therapeutic approach that would stop the growth and progression of medulloblastoma and could reduce the adverse side effects of current treatments."

INFORMATION:

About the research project This research project was supported by grants from the Canadian Institutes of Health Research, the Canadian Cancer Society and the Cancer Research Society. Other authors from the IRCM include Martin Lévesque (co-first author), Julie Cardin, Nicolas Bouchard, and Luisa Izzi. The project was also conducted in collaboration with the laboratories of Stefan Pfister in Heidelberg, Germany, and Michael Taylor in Toronto. For more information, please refer to the article summary published online by Developmental Cell: http://www.cell.com/developmental-cell/abstract/S1534-5807(14)00520-6.

About Frédéric Charron Frédéric Charron obtained his PhD in experimental medicine from McGill University. He is an Associate IRCM Research Professor and Director of the Molecular Biology of Neural Development research unit. Dr. Charron is Associate Research Professor in the Department of Medicine (accreditation in molecular biology) and Adjunct Member in the Department of Neuroscience at the Université de Montréal. He is also Adjunct Professor in the Department of Medicine (Division of Experimental Medicine), the Department of Biology, and the Department of Anatomy and Cell Biology at McGill University. In addition, he is a member of the McGill Integrated Program in Neuroscience, the Montreal Regional Brain Tumor Research Group at the Montreal Neurological Institute, and the Centre of Excellence in Neurosciences (CENUM) at the Université de Montréal. Dr. Charron is a Senior Research Scholar from the Fonds de recherche du Québec – Santé (FRQS). For more information, visit http://www.ircm.qc.ca/charronlab.

About the IRCM The IRCM is a renowned biomedical research institute located in the heart of Montréal's university district. Founded in 1967, it is currently comprised of 35 research units and four specialized research clinics (cholesterol, cystic fibrosis, diabetes and obesity, hypertension). The IRCM is affiliated with the Université de Montréal, and the IRCM Clinic is associated to the Centre hospitalier de l'Université de Montréal (CHUM). It also maintains a long-standing association with McGill University. The IRCM is funded by the Quebec ministry of Economy, Innovation and Export Trade (Ministère de l'Économie, de l'Innovation et des Exportations).



ELSE PRESS RELEASES FROM THIS DATE:

Study: Big-headed ants grow bigger when faced with fierce competitors

Study: Big-headed ants grow bigger when faced with fierce competitors
2014-10-02
CHAMPAIGN, Ill. — The big-headed ant (Pheidole megacephala) is considered one of the world's worst invasive ant species. As the name implies, its colonies include soldier ants with disproportionately large heads. Their giant, muscle-bound noggins power their biting parts, the mandibles, which they use to attack other ants and cut up prey. In a new study, researchers report that big-headed ant colonies produce larger soldiers when they encounter other ants that know how to fight back. The new findings appear in the Biological Journal of the Linnean Society. Big-headed ...

Blackflies may be responsible for spreading nodding syndrome

2014-10-02
London, United Kingdom, October 2, 2014 – Despite decades of research, scientists have yet to pinpoint the exact cause of nodding syndrome (NS), a disabling disease affecting African children. A new report suggests that blackflies infected with the parasite Onchocerca volvulus may be capable of passing on a secondary pathogen that is to blame for the spread of the disease. New research is presented in the International Journal of Infectious Diseases. Concentrated in South Sudan, Northern Uganda, and Tanzania, NS is a debilitating and deadly disease that affects young ...

Unexpectedly speedy expansion of human, ape cerebellum

2014-10-02
A new study published in the Cell Press journal Current Biology on October 2 could rewrite the story of ape and human brain evolution. While the neocortex of the brain has been called "the crowning achievement of evolution and the biological substrate of human mental prowess," newly reported evolutionary rate comparisons show that the cerebellum expanded up to six times faster than anticipated throughout the evolution of apes, including humans. The findings suggest that technical intelligence was likely at least as important as social intelligence in human cognitive ...

How curiosity changes the brain to enhance learning

2014-10-02
The more curious we are about a topic, the easier it is to learn information about that topic. New research publishing online October 2 in the Cell Press journal Neuron provides insights into what happens in our brains when curiosity is piqued. The findings could help scientists find ways to enhance overall learning and memory in both healthy individuals and those with neurological conditions. "Our findings potentially have far-reaching implications for the public because they reveal insights into how a form of intrinsic motivation—curiosity—affects memory. These findings ...

Stopping liver cancer in its tracks

Stopping liver cancer in its tracks
2014-10-02
This release is available in Japanese. A University of Tokyo research group has discovered that AIM (Apoptosis Inhibitor of Macrophage), a protein that plays a preventive role in obesity progression, can also prevent tumor development in mice liver cells. This discovery may lead to a therapy for hepatocellular carcinoma (HCC), the most common type of liver cancer and the third most common cause of cancer deaths. Professor Toru Miyazaki's group at the Laboratory of Molecular Biomedicine from Pathogenesis, in the Faculty of Medicine has shown that AIM (also known ...

Ancient protein-making enzyme moonlights as DNA protector

Ancient protein-making enzyme moonlights as DNA protector
2014-10-02
LA JOLLA, CA—October 2, 2014—Scientists at The Scripps Research Institute (TSRI) have found that an enzyme best known for its fundamental role in building proteins has a second major function: to protect DNA during times of cellular stress. The finding is remarkable on a basic science level but also points the way to possible therapeutic applications. Strategies that enhance the DNA-protection function of the enzyme, TyrRS, could help protect people from radiation injuries as well as from hereditary defects in DNA repair systems. "We overexpressed TyrRS in zebrafish ...

52-million-year-old amber preserves 'ant-loving' beetle

52-million-year-old amber preserves ant-loving beetle
2014-10-02
Scientists have uncovered the fossil of a 52-million-year old beetle that likely was able to live alongside ants—preying on their eggs and usurping resources—within the comfort of their nest. The fossil, encased in a piece of amber from India, is the oldest-known example of this kind of social parasitism, known as "myrmecophily." Published today in the journal Current Biology, the research also shows that the diversification of these stealth beetles, which infiltrate ant nests around the world today, correlates with the ecological rise of modern ants. "Although ants ...

Counting the seconds for immunological tolerance

Counting the seconds for immunological tolerance
2014-10-02
Our immune system must distinguish between self and foreign and in order to fight infections without damaging the body's own cells at the same time. The immune system is loyal to cells in the body, but how this works is not fully understood. Researchers in the Departments of Biomedicine and Nephrology at the University Hospital and the University of Basel have discovered that the immune system uses a molecular biological clock to target intolerant T cells during their maturation process. These recent findings have been reported in the scientific journal Cell. A functioning ...

DNA 'bias' may keep some diseases in circulation, Penn biologists show

2014-10-02
It's an early lesson in genetics: we get half our DNA from Mom, half from Dad. But that straightforward explanation does not account for a process that sometimes occurs when cells divide. Called gene conversion, the copy of a gene from Mom can replace the one from Dad, or vice versa, making the two copies identical. In a new study published in the American Journal of Human Genetics, University of Pennsylvania researchers Joseph Lachance and Sarah A. Tishkoff investigated this process in the context of the evolution of human populations. They found that a bias toward ...

Study indicates possible new way to treat endometrial, colon cancers

Study indicates possible new way to treat endometrial, colon cancers
2014-10-02
Scientists love acronyms. In the quest to solve cancer's mysteries, they come in handy when describing tongue-twisting processes and pathways that somehow allow tumors to form and thrive. Two examples are ERK (extracellular-signal-related kinase) and JNK (c-June N-Terminal Kinase), enzymes that may offer unexpected solutions for treating some endometrial and colon cancers. A study led by Gordon Mills, M.D., Ph.D., professor and chair of Systems Biology at The University of Texas MD Anderson Cancer Center with Lydia Cheung, Ph.D. as the first author, points to cellular ...

LAST 30 PRESS RELEASES:

Study unexpectedly finds living in rural, rather than urban environments in first five years of life could be a risk factor for developing type 1 diabetes

Editorial urges deeper focus on heart-lung interactions in pulmonary vascular disease

Five University of Tennessee faculty receive Fulbright Awards

5 advances to protect water sources, availability

OU Scholar awarded Fulbright for Soviet cinema research

Brain might become target of new type 1 diabetes treatments

‘Shore Wars:’ New research aims to resolve coastal conflict between oysters and mangroves, aiding restoration efforts

Why do symptoms linger in some people after an infection? A conversation on post-acute infection syndromes

Study reveals hidden drivers of asthma flare-ups in children

Physicists decode mysterious membrane behavior

New insights about brain receptor may pave way for next-gen mental health drugs

Melanoma ‘sat-nav’ discovery could help curb metastasis

When immune commanders misfire: new insights into rheumatoid arthritis inflammation

SFU researchers develop a new tool that brings blender-like lighting control to any photograph

Pups in tow, Yellowstone-area wolves trek long distances to stay near prey

AI breakthrough unlocks 'new' materials to replace lithium-ion batteries

Making molecules make sense: A regional explanation method reveals structure–property relationships

Partisan hostility, not just policy, drives U.S. protests

The Journal of Nuclear Medicine Ahead-of-Print Tip Sheet: August 1, 2025

Young human blood serum factors show potential to rejuvenate skin through bone marrow

Large language models reshape the future of task planning

Narrower coverage of MS drugs tied to higher relapse risk

Researchers harness AI-powered protein design to enhance T-cell based immunotherapies

Smartphone engagement during school hours among US youths

Online reviews of health care facilities

MS may begin far earlier than previously thought

New AI tool learns to read medical images with far less data

Announcing XPRIZE Healthspan as Tier 5 Sponsor of ARDD 2025

Announcing Immortal Dragons as Tier 4 Sponsor of ARDD 2025

Reporting guideline for chatbot health advice studies

[Press-News.org] A discovery could prevent the development of brain tumours in children
Researchers at the IRCM show that a protein called Sonic Hedgehog causes DNA damage