Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies
DNA repeats on the Y chromosome become more active and toxic as male flies age
2021-04-22
(Press-News.org) Males may have shorter lifespans than females due to repetitive sections of the Y chromosome that create toxic effects as males get older. These new findings appear in a study by Doris Bachtrog of the University of California, Berkeley published April 22 in PLOS Genetics.
In humans and other species with XY sex chromosomes, females often live longer than males. One possible explanation for this disparity may be repetitive sequences within the genome. While both males and females carry these repeat sequences, scientists have suspected that the large number of repeats on the Y chromosome may create a "toxic y effect" that shortens males' lives. To test this idea, Bachtrog studied male fruit flies from the species Drosophila miranda, which have about twice as much repetitive DNA as females and a shorter lifespan. They showed that when the DNA is in its tightly packed form inside the cells of young male flies, the repeat sections are turned off. But as the flies age, the DNA assumes a looser form that can activate the repeat sections, resulting in toxic side effects.
The new study demonstrates that Y chromosomes that are rich in repeats are a genomic liability for males. The findings also support a more general link between repeat DNA and aging, which currently, is poorly understood. Previous studies in fruit flies have shown that when repeat sections become active, they impair memory, shorten the lifespan and cause DNA damage. This damage likely contributes to aging's physiological effects, but more research will be needed to uncover the mechanisms underlying repeat DNA's toxic effects.
INFORMATION:
Peer-reviewed Observational study Cells
In your coverage please use this URL to provide access to the freely available article in PLOS Genetics:
http://journals.plos.org/plosgenetics/article?id=10.1371/journal.pgen.1009438
Citation: Nguyen AH, Bachtrog D (2021) Toxic Y chromosome: Increased repeat expression and age-associated heterochromatin loss in male Drosophila with a young Y chromosome. PLoS Genet 17(4): e1009438. https://doi.org/10.1371/journal.pgen.1009438
Funding: This work was supported by NIH grants (nos. R01GM076007, R01GM101255 and R01AG057029) to DB. The funders had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript.
Competing interests: The authors have declared that no competing interests exist.
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[Press-News.org] Toxic masculinity: Y chromosome contributes to a shorter lifespan in male flies
DNA repeats on the Y chromosome become more active and toxic as male flies age
