PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Increased use of minimally invasive non-endoscopic tests for Barrett's esophagus screening

Embargoed news from Annals of Internal Medicine

2021-05-04
(Press-News.org) Below please find summaries of new articles that will be published in the next issue of Annals of Internal Medicine. The summaries are not intended to substitute for the full articles as a source of information. This information is under strict embargo and by taking it into possession, media representatives are committing to the terms of the embargo not only on their own behalf, but also on behalf of the organization they represent. 1. Increased use of minimally invasive non-endoscopic tests for Barrett's esophagus screening could impact detection and prevention of esophageal cancer Abstract: https://www.acpjournals.org/doi/10.7326/M20-7164 URL goes live when the embargo lifts The authors of a new commentary from Mayo Clinic suggest that more extensive use of minimally invasive non-endoscopic tests for Barrett's esophagus (BE) screening could impact early detection and prevention of esophageal adenocarcinoma (EAC), a particularly deadly form of cancer. This is important because BE, the only known precursor to esophageal cancer, is often asymptomatic. Their commentary is published in Annals of Internal Medicine.

BE may progress to EAC through the development of low- and high-grade dysplasia. Endoscopic treatment for dysplasia can reduce the risk for progression to cancer and endoscopic treatment of early-stage esophageal cancer significantly increase chances of long-term survival. Endoscopic screening for BE in patients with chronic reflux and other risk factors followed by endoscopic surveillance is recommended by professional societies, but it is invasive and costly and asymptomatic patients are missed by screening. As such, the authors suggest that a paradigm shift in strategies for BE screening and early detection of dysplasia or EAC is needed.

Minimally invasive non-endoscopic esophageal sampling devices currently in development are showing promise for early detection and could help to overcome the challenges associated with endoscopy. Among these, the best-studied include string-attached, capsule enclosed, compressed spherical pieces of polyurethane foam that deploy in the stomach 5 minutes after swallowing and a balloon that is inflated after swallowing and is inverted and withdrawn via an attached cord. These devices provide esophageal cytology samples, which are analyzed for biomarkers associated with BE and EAC such as methylated DNA markers. These swallowable esophageal cell collection devices can be administered by a nurse in an office setting (with procedure times ?10 minutes) and do not require sedation.

According to the authors, encouraging progress in the nonendoscopic detection of BE will potentially lead to a more complete identification of those at risk for EAC and, when paired with improved dysplasia detection and risk prognostication, could lead to meaningful advances in EAC outcomes.

Media contacts: For an embargoed PDF, please contact Angela Collom at acollom@acponline.org. The corresponding author, Prasad G. Iyer MD MS can be reached through Nicole Ferrara at ferrara.Nicole@mayo.edu. 2. Essay provides context to debate over use of mechanical ventilation for COVID-19 Abstract: https://www.acpjournals.org/doi/10.7326/M21-0270 An essay from Harvard University provides context to the debate over mechanical ventilation for COVID-19 patients. The author argues that the good-faith debate that broke out over acute respiratory distress syndrome, or ARDS, and Covid-19 at the beginning of the pandemic was the product of increasing dependence on high technologies in the hospital. By learning the history of these technologies, clinicians can understand how diagnoses and treatments came to be, and what unhelpful, questionable, or obsolete assumptions those technologies carry with them. The essay is published in Annals of Internal Medicine.

The value of manual positive-pressure ventilation was first noted during the polio epidemic of 1952. This treatment dramatically improved mortality rates and paved the way for widespread use of mechanical ventilators and the expansion of intensive care units over the next decade and beyond. While ventilators aided healing in patients with some conditions, they also contributed to the emergence of ARDS as it is recognized and treated today.

By the 1980s, several researchers began to argue for the existence of a phenomenon known as ventilator-induced lung injury (VILI), which seemed to be an inevitable consequence of the treatment. If the ventilator had brought ARDS into existence, it had done the same for ventilator-induced lung injury. In the early 1990s, the formal definition of ARDS was revised to begin clinical trials of ventilatory strategies to avoid VILI. Of note, the new definition - which emphasized O2 levels - may have encouraged early intubation of COVID-19 patients, despite still having compliant, flexible lungs, likely making ventilation a poor treatment choice.

While historical knowledge does not settle the debate, it may provide valuable clinical context. The author suggests that this awareness might help scientists take a fresh look at this perplexing syndrome and encourage a more open-minded and less defensive discussion.

Media contacts: For an embargoed PDF, please contact Angela Collom at acollom@acponline.org. The corresponding author, Yvan Prkachin, PhD, can be reached directly at yvanprkachin@fas.harvard.edu. Also new in this issue: The problem of conflicting guidelines
Centor
Annals On Call
Abstract: https://www.acpjournals.org/doi/10.7326/A20-0012

Social Impacts of the COVID-19 Pandemic through Visual Art
Manohar
Graphic Medicine
Abstract: https://www.acpjournals.org/doi/10.7326/G21-0022

INFORMATION:



ELSE PRESS RELEASES FROM THIS DATE:

Solar development: super bloom or super bust for desert species?

Solar development: super bloom or super bust for desert species?
2021-05-04
Throughout the history of the West, human actions have often rushed the desert -- and their actions backfired. In the 1920s, the Colorado River Compact notoriously overallocated water still used today by several western states because water measurements were taken during a wet period. More currently, operators of the massive Ivanpah Solar Electric Generating System in the Mojave Desert are spending around $45 million on desert tortoise mitigation after initial numbers of the endangered animals were undercounted before its construction. A study published in the journal Ecological Applications from the University of California, Davis, and UC Santa Cruz warns against another potential desert timing mismatch amid the race against climate change and toward rapid renewable ...

Revealing the secret cocoa pollinators

Revealing the secret cocoa pollinators
2021-05-04
The importance of pollinators to ensure successful harvests and thus global food security is widely acknowledged. However, the specific pollinators for even major crops - such as cocoa - haven't yet been identified and there remain many questions about sustainability, conservation and plantation management to enhance their populations and, thereby, pollination services. Now an international research team based in Central Sulawesi, Indonesia and led by the University of Göttingen has found that in fact ants and flies - but not ceratopogonid midges as was previously thought - appear to have a crucial role to play. In addition, they found ...

Development of microsatellite markers for censusing of endangered rhinoceros

Development of microsatellite markers for censusing of endangered rhinoceros
2021-05-04
Today, the Sumatran rhinoceros (Dicerorhinus sumatrensis) is critically endangered, with fewer than 100 individuals surviving in Indonesia on the islands of Sumatra and Borneo. To ensure survival of the threatened species, accurate censusing is necessary to determine the genetic diversity of remaining populations for conservation and management plans. A new study reported in BMC Research Notes characterized 29 novel polymorphic microsatellite markers -- repetitive DNA sequences -- that serve as a reliable censusing method for wild Sumatran rhinos. The study was a collaborative effort involving the University ...

Plastic pollution in the deep sea: A geological perspective

Plastic pollution in the deep sea: A geological perspective
2021-05-04
Boulder, Colo., USA: A new focus article in the May issue of Geology summarizes research on plastic waste in marine and sedimentary environments. Authors I.A. Kane of the Univ. of Manchester and A. Fildani of the Deep Time Institute write that "Environmental pollution caused by uncontrolled human activity is occurring on a vast and unprecedented scale around the globe. Of the diverse forms of anthropogenic pollution, the release of plastic into nature, and particularly the oceans, is one of the most recent and visible effects." The authors cite multiple studies, including one in the May issue by Guangfa Zhong and Xiaotong ...

Consumers make decisions based on how and why products are recommended online

2021-05-04
UNIVERSITY PARK, Pa. -- As more people go online for shopping, understanding how they rely on e-commerce recommendation systems to make purchases is increasingly important. Penn State researchers now suggest that it's not just what is recommended, but how and why it's recommended, that helps to shape consumers' opinions. In a study, the researchers investigated how people reacted to two product recommendation systems. The first system generated recommendations based on the user's earlier purchases -- often referred to as content-based recommendation systems. ...

UTEP study examines movement in children with autism

UTEP study examines movement in children with autism
2021-05-04
EL PASO, Texas -- For more than a year, researchers at The University of Texas at El Paso's Stanley E. Fulton Gait Research & Movement Analysis Lab in the College of Health Sciences have been using real-time 3D animation to investigate motor impairments in children who have autism spectrum disorder (ASD). Their aim is to understand how children with autism can learn motor skills, so that they can receive effective therapies. The results of their study, titled "Children With Autism Exhibit More Individualized Responses to Live Animation Biofeedback Than Do Typically Developing Children," were recently published in the journal of Perceptual and Motor Skills. The paper's release coincides with National Autism Awareness Month in April. "The greatest takeaway from this study is that when teaching ...

Health ads in users' customized online sites may evoke negative reactions

2021-05-04
UNIVERSITY PARK, Pa. -- Tweaking the look of a social media profile may subtly alter a person's reaction to the health messages that appear on that site, according to researchers. They add that these reactions could influence whether the users heed the advice of those messages. In a study, the researchers found that people who gained a feeling of control when they customized an online website were more likely to perceive the health message as a threat to their freedom, lowering the chance that they will adopt the message's advice. On the other hand, when customization bolstered the users' sense of identity, they did not resent the message as much and were more willing to consider the ads' recommended behavioral changes, according to the researchers. "In ...

Housing subsidies reduce health care costs for vulnerable veterans

2021-05-03
Ensuring that veterans have stable housing not only reduces homelessness but also slashes the cost of providing them with publicly funded health care, according to a national study led by University of Utah Health scientists. The researchers found that veterans who received temporary financial assistance (TFA) from the Department of Veterans Affairs (VA) to acquire or retain housing had fewer hospital visits and an average reduction in health care costs of $2,800 over a two-year period than veterans who did not receive this benefit. The researchers say this model could help non-profit organizations and other federal, state, and local governments better serve homeless Americans who are not veterans. "Getting ...

33% of neighborhoods in largest US cities were 'pharmacy deserts'

2021-05-03
Black and Latino neighborhoods in the 30 most populous U.S. cities had fewer pharmacies than white or diverse neighborhoods in 2007-2015, USC research shows, suggesting that 'pharmacy deserts'- like so-called food deserts-may be an overlooked contributor to persistent racial and ethnic health disparities. Pharmacies are increasingly vital points of care for essential health services. In addition to filling prescriptions to treat chronic health conditions, pharmacists dispense emergency doses of naloxone to reverse opioid overdoses, contraceptives to prevent unplanned pregnancy and COVID-19 testing and vaccinations. But ...

New research shows benefits of deworming expectant mothers to their infants

2021-05-03
More than 25% of the world's population (greater than 1.5 billion people) face the burden of soil-transmitted helminth (STH) infections, a species of intestinal parasite whose eggs develop in the soil before finding a new host. The main cause of this high infection rate is lack of access to adequate sanitation facilities (toilets) and the consequent contamination of the environment with human feaces. While universal access to adequate sanitation is one of the sustainable development goals, parasite burdens are still causing harm. Fortunately, deworming medicines are highly effective and safe. Researchers from Syracuse University, the World Health Organization, ...

LAST 30 PRESS RELEASES:

Blackologists and the Promise of Inclusive Sustainability

Robot-assisted surgery: Putting the reality in virtual reality

Novel interactions between proteins that help in recovering from brain injury

Common antibiotic found useful in accelerating recovery in tuberculosis patients

The 'Mozart effect' shown to reduce epileptic brain activity, new research reveals

Study examines heart and kidney outcomes of adults with nephrotic syndrome

Study examines symptoms before and after kidney transplantation

New research adds a wrinkle to our understanding of the origins of matter in the Milky Way

Stronger together: how protein filaments interact

New study uncovers details behind the body's response to stress

Carcinogen-exposed cells provide clues in fighting treatment-resistant cancers

Memory helps us evaluate situations on the fly, not just recall the past

Animals' ability to adapt their habitats key to survival amid climate change

Undiagnosed and untreated disease identified in rural South Africa

Study reveals new therapeutic target for C. difficile infection

New artificial heart shows promising results in 'auto-mode' -- initial clinical experience reported in ASAIO Journal

Picky neurons

Does cannabis affect brain development in young people with ADHD? Too soon to tell, reports Harvard Review of Psychiatry

Researchers find optimal way to pay off student loans

Use rewards effectively to boost creativity

Researchers find losartan is not effective in reducing hospitalization from mild COVID-19

Scientists detect signatures of life remotely

Team describes science-based hiccups intervention

Princeton-led team discovers unexpected quantum behavior in kagome lattice

Overcoming a newly recognized form of resistance to modern prostate cancer drugs

Will reduction in tau protein protect against Parkinson's and Lewy body dementias?

The end of Darwin's nightmare at Lake Victoria?

Study: Men doing more family caregiving could lower their risk of suicide

Researchers dig deeper into how cells transport their waste for recycling

Organic farming could feed Europe by 2050

[Press-News.org] Increased use of minimally invasive non-endoscopic tests for Barrett's esophagus screening
Embargoed news from Annals of Internal Medicine