Insights from color-blind octopus help fight human sight loss
2021-05-04
(Press-News.org) University of Bristol research into octopus vision has led to a quick and easy test that helps optometrists identify people who are at greater risk of macular degeneration, the leading cause of incurable sight loss.
The basis for this breakthrough was published in the latest issue of the Journal of Experimental Biology and describes new technology developed by lead researcher, Professor Shelby Temple, to measure how well octopus- which are colour-blind - could detect polarized light, an aspect of light that humans can't readily see. Using this novel technology, the research team showed that octopus have the most sensitive polarization vision system of any animal tested to date. Subsequent research used the same technology in humans and led to the development of a novel medical device that assesses the risk factor for sight loss later in life.
Prof Shelby Temple, who holds honorary positions at the School of Biological Sciences, University of Bristol and the School of Optometry, Aston University, explained the impact of the team's findings. He said: "We knew that octopus, like many marine species, could see patterns in polarized light much like we see colour, but we had no idea that they could do so when the light was only 2% polarized - that was an exciting surprise, but even more surprising was when we then tested humans and found that they were able to see polarization patterns when the light was only 24% polarized.
"Humans can perceive polarized because macular pigments in our eyes differentially absorb violet-blue light depending on its angle of polarization, an effect known as Haidinger's brushes. It's like a super sense most of us don't even know we have, revealing a faint yellow bow-tie shape on the retina. The more of these pigments a person has, the better protected they are against sight-loss.
"By inventing a method to measure polarization vision in octopuses, we were able to use the core technology to develop a novel ophthalmic device that can quickly and easily screen people for low macular pigments, a strong risk factor for increased susceptibility to macular degeneration."
Macular pigments are the body's natural protection against damaging violet-blue light. This new testing approach enables optometrists to provide preventative advice to patients. Empowering patients to make simple lifestyle choices, like wearing sunglasses or eating more dark green and brightly coloured fruits and vegetables that can help them protect their sight through life.
Prof Temple said, "I am so happy this work has been published, as it was the foundation upon which we developed our exciting new technology for measuring macular pigments."
Macular pigments are the carotenoids lutein, zeaxanthin and meso-zeaxanthin that we can only acquire from our diet. They provide long term protection to the retina and this helps prevent age-related macular degeneration by acting as antioxidants and by strongly absorbing the most damaging high energy visible (violet-blue) wavelengths (380-500 nm) of light that reach our retina. A challenge to the eye care industry is that it is not possible to determine someone's macular pigment levels without measurement, and until now most techniques have been too time consuming, difficult, or expensive to become part of regular eye exams. The new technology developed by Prof Temple through his start-up company Azul Optics Ltd, enables rapid screening of macular pigment levels and can be used on patients from 5 -95 years of age. Prof Temple added: "We are all living longer and expecting to do more in our older age, so I hope this serendipitous invention will help empower people to do more to look after our eyes, so they don't suffer from this devastating disease."
INFORMATION:
Paper:
'Thresholds of polarization vision in octopuses' by Shelby Temple, Martin How, Nicholas Roberts et al, published in Journal of Experimental Biology
Notes for Editor
Age-related macular degeneration (AMD): is the leading cause of incurable blindness globally with over 288M predicted to be affected by 2050. AMD is caused by the long-term accumulation of damage with strong risk factors being age, genetics and smoking, violet-blue light exposure and low macular pigments.
What is polarized light? Light travels as a wave. The length of the waves we perceive as colour, and the orientation of the plane of vibration of the waves is their polarization. If light waves are randomly oriented, the light is unpolarized (0%), but if all of the waves are vibrating in the same plane, then the light is 100% polarized. Manmade light sources and filters often produce nearly 100% polarized light (e.g. LCD computer screens and polarized lenses in sunglasses and camera filters) but natural light rarely exceeds 70% polarization.
How humans and cephalopods detect polarised light differently: Octopus and cuttlefish use their photoreceptors, which are adapted to detect the orientation of polarized light, and are oriented vertically and horizontally across their retinas, whereas humans use the shadow formed on the retina by the absorption of violet-blue light by macular pigments that differentially absorb polarized light depending on orientation. This shadow forms faint yellow bowtie/hourglass like shape first described by Karl von Haidinger in 1844 and now bears his name (Haidinger's brushes).
Azul Optics Ltd: Is a start-up company based in Bristol UK, that took Prof Temple's fundamental research idea and translated it into a Class 1, CE marked medical device called the MP-eye. This simple to use tool empowers people to protect their eyes by giving eye care professionals a measurement of a patient's natural protective pigment levels that reinforces advice around how to protect against sight loss (e.g. wearing sunglasses, photochromic and blue filtering lenses, quitting smoking, increased consumption of lutein and zeaxanthin rich foods or supplements and weight management). For more information visit http://www.azuloptics.com
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[Press-News.org] Insights from color-blind octopus help fight human sight loss
