(Press-News.org) Cancer has been recently shown to be affected by protein clusters, particularly by the aggregation of mutant variants of the tumor suppressor protein p53, which are present in more than half of malignant tumors. However, how the aggregates are formed is not yet fully understood. The understanding of this process is expected to provide new therapeutic tools able to prevent proteins to clump and cancer progression.
In Brazil, researchers at the Federal University of Rio de Janeiro have identified a key mechanism behind the mutant p53 aggregation process, linked to cancer pathology, opening new paths for the development of novels drugs against the disease.
The latest findings have been published in advance in the scientific journal END
Phase transition inside the nucleus provides oncogenic function to mutant p53 in cancer
Researchers at the Federal University of Rio de Janeiro discover a crucial link between phase transition (aggregation) and cancer pathology
2021-05-04
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[Press-News.org] Phase transition inside the nucleus provides oncogenic function to mutant p53 in cancerResearchers at the Federal University of Rio de Janeiro discover a crucial link between phase transition (aggregation) and cancer pathology