PRESS-NEWS.org - Press Release Distribution
FREE PRESS RELEASES DISTRIBUTION

Mayo Clinic research suggests women over 65 be offered hereditary cancer genetic testing

2021-07-23
(Press-News.org) ROCHESTER, Minn. -- A new study by Fergus Couch, Ph.D., of Mayo Clinic Cancer Center, along with collaborators from the CARRIERS consortium, suggests that most women with breast cancer diagnosed over 65 should be offered hereditary cancer genetic testing. The study was published Thursday, July 22, in the Journal of Clinical Oncology.

Dr. Couch says that women over 65 rarely qualify for hereditary cancer genetic testing based on current testing guidelines because they are thought to exhibit low rates of genetic mutations in breast cancer genes.

"Most studies of breast cancer genes have not looked at older women, those who were diagnosed over the age of 65," says Dr. Couch. He says these studies have mainly tested women with a strong family history of breast or ovarian cancer rather than those in the general breast cancer population. By studying older women from the general breast cancer population, the investigators aimed to determine if these women should be routinely offered genetic testing.

"We were not sure what this study of the older breast cancer population would yield, but our results support broader testing, regardless of age or family history," says Dr. Couch.

The researchers evaluated women with breast cancer diagnosed after 65 and matched unaffected women from the large population in the CARRIERS study for age, race, and ethnicity.

"We found that mutations in actionable breast cancer risk genes were present in 3.2% of the women with breast cancer," says Dr. Couch.

When the researchers considered only high-risk breast cancer genes, including BRCA1, BRCA2 and PALB2, they found that 1.35% of women with breast cancer exhibited mutations and that more than 2.5% of women with estrogen receptor-negative breast cancer had high-risk mutations, regardless of their age.

"As 2.5% mutation frequency is often used to trigger genetic testing, these results suggest that all women with estrogen receptor-negative breast cancer ? and perhaps all women with breast cancer, including those diagnosed over age 65 ? should be offered hereditary breast cancer testing," says Dr. Couch.

Dr. Couch also notes that women over 65 with high-risk mutations may benefit from targeted therapies and improved risk assessment for secondary breast cancers. He adds that family members of these women also may benefit from risk assessment.

INFORMATION:

About Mayo Clinic Mayo Clinic is a nonprofit organization committed to innovation in clinical practice, education and research, and providing compassion, expertise and answers to everyone who needs healing. Visit the Mayo Clinic News Network for additional Mayo Clinic news. For information on COVID-19, including Mayo Clinic's Coronavirus Map tracking tool, which has 14-day forecasting on COVID-19 trends, visit the Mayo Clinic COVID-19 Resource Center.

Media contact:

Joe Dangor, Mayo Clinic Public Affairs, newsbureau@mayo.edu



ELSE PRESS RELEASES FROM THIS DATE:

Synlogic publishes papers in Nature journals demonstrating proof-of-mechanism and potential of synth

2021-07-22
- Data show dose-responsive, non-saturated increases in gastrointestinal consumption of Phe in humans by SYNB1618 - - SYNB1618 Phase 2 study in patients with PKU ongoing with proof-of-concept readout anticipated in 2H 2021 - - Phase 1 study of SYNB1934, an evolved strain of SYNB1618 in the PKU portfolio, initiated - CAMBRIDGE, Mass., July 22, 2021 /PRNewswire/ -- Synlogic, Inc. (Nasdaq: SYBX), a clinical stage company bringing the transformative potential of synthetic biology to medicine, announced today the publication of two papers in the journals Nature Metabolism and Communications Biology. The publications detail findings ...

Study: Young workers now value respect over 'fun' perks in the workplace

2021-07-22
Millennials, often referred to as the "job-hopping generation," represent a group of young workers who once grabbed the national spotlight with their publicized demands for "fun" work perks, such as happy hours. However, researchers at the Novak Leadership Institute at the University of Missouri and Kansas State University discovered today's young workers -- ages 21-34 -- represent a life-stage shift toward placing more value on having respectful communication in the workplace over trendy work perks. "Millennials have been called the 'entitled generation,' and they kind of give young workers a bad rap because their often-publicized interests ...

Early-life social connections influence gene expression, stress resilience

Early-life social connections influence gene expression, stress resilience
2021-07-22
Having friends may not only be good for the health of your social life, but also for your actual health--if you're a hyena, that is. Strong social connections and greater maternal care early in life can influence molecular markers related to gene expression in DNA and future stress response, suggests a new University of Colorado Boulder study of spotted hyenas in the wild. Researchers found that more social connection and maternal care during a hyena's cub and subadult, or "teenage," years corresponded with lower adult stress hormone levels and fewer modifications to DNA, including near genes involved in immune function, inflammation and ...

'Good cholesterol' may protect liver

Good cholesterol may protect liver
2021-07-22
The body's so-called good cholesterol may be even better than we realize. New research from Washington University School of Medicine in St. Louis suggests that one type of high-density lipoprotein (HDL) has a previously unknown role in protecting the liver from injury. This HDL protects the liver by blocking inflammatory signals produced by common gut bacteria. The study is published July 23 in the journal Science. HDL is mostly known for mopping up cholesterol in the body and delivering it to the liver for disposal. But in the new study, the researchers identified a special type of HDL called HDL3 that, when produced by the intestine, blocks gut bacterial signals ...

Big data-derived tool facilitates closer monitoring of recovery from natural disasters

2021-07-22
By analyzing peoples' visitation patterns to essential establishments like pharmacies, religious centers and grocery stores during Hurricane Harvey, researchers at Texas A&M University have developed a framework to assess the recovery of communities after natural disasters in near real time. They said the information gleaned from their analysis would help federal agencies allocate resources equitably among communities ailing from a disaster. "Neighboring communities can be impacted very differently after a natural catastrophic event," said Dr. Ali Mostafavi, associate professor in the ...

Perfecting collagen production in osteogenesis imperfecta

Perfecting collagen production in osteogenesis imperfecta
2021-07-22
Most people can expect to break close to two bones in their lifetime, but those with osteogenesis imperfecta -- also known as brittle bone disease -- can break hundreds of bones before they even hit puberty. And while healthy bones can break from a hard fall or a bad car wreck, there may not be an apparent reason at all with brittle bone disease. Classified as a rare disease, osteogenesis imperfecta, or OI, affects 6-7 people out of every 100,000 live births and can range in severity depending on the specific mutation. And while there are currently few treatment options and no cure, ...

New tests can detect tiny but toxic particles of coal ash in soil

2021-07-22
DURHAM, N.C. - Scientists at Duke University have developed a suite of four new tests that can be used to detect coal ash contamination in soil with unprecedented sensitivity. The tests are specifically designed to analyze soil for the presence of fly ash particles so small other tests might miss them. Fly ash is part of coal combustion residuals (CCRs) that are generated when a power plant burns pulverized coal. The tiny fly ash particles, which are often microscopic in size, contain high concentrations of arsenic, selenium and other toxic elements, many of which have been ...

Doctoral student bridges gap between electronics and optics

Doctoral student bridges gap between electronics and optics
2021-07-22
According to the United Nations' telecommunications agency, 93% of the global population has access to a mobile-broadband network of some kind. With data becoming more readily available to consumers, there is also an appetite for more of it, and at faster speeds. Ramy Rady, doctoral student in the Department of Electrical and Computer Engineering at Texas A&M University, is working with Dr. Kamran Entesari, his faculty advisor and professor, and Dr. Christi Madsen, professor, to design a chip that can revolutionize the current data rate for processors and technologies such as smartphones, laptops, etc. Dr. Sam Palermo, ...

The anatomy of a planet

The anatomy of a planet
2021-07-22
Since early 2019, researchers have been recording and analysing marsquakes as part of the InSight mission. This relies on a seismometer whose data acquisition and control electronics were developed at ETH Zurich. Using this data, the researchers have now measured the red planet's crust, mantle and core - data that will help determine the formation and evolution of Mars and, by extension, the entire solar system. Mars once completely molten We know that Earth is made up of shells: a thin crust of light, solid rock surrounds a thick mantle of heavy, viscous rock, which in turn envelopes a core consisting mainly of iron and ...

'Wrapping' anodes in 3D carbon nanosheets: The next big thing in li-ion battery technology

Wrapping anodes in 3D carbon nanosheets: The next big thing in li-ion battery technology
2021-07-22
Lithium-ion batteries (LIBs), which are a renewable source of energy for electrical devices or electric vehicles, have attracted much attention as the next-generation energy solution. However, the anodes of LIBs in use today have multiple inadequacies, ranging from low ionic electronic conductivity and structural changes during the charge/discharge cycle to low specific capacity, which limits the battery's performance. In search of a better anode material, Dr. Jun Kang of Korea Maritime and Ocean University, along with his colleagues from Pusan National University, Republic of Korea, END ...

LAST 30 PRESS RELEASES:

Scientists model 'true prevalence' of COVID-19 throughout pandemic

New breakthrough to help immune systems in the fight against cancer

Through the thin-film glass, researchers spot a new liquid phase

Administering opioids to pregnant mice alters behavior and gene expression in offspring

Brain's 'memory center' needed to recognize image sequences but not single sights

Safety of second dose of mRNA COVID-19 vaccines after first-dose allergic reactions

Changes in disparities in access to care, health after Medicare eligibility

Use of high-risk medications among lonely older adults

65+ and lonely? Don't talk to your doctor about another prescription

Exosome formulation developed to deliver antibodies for choroidal neovascularization therapy

Second COVID-19 mRNA vaccine dose found safe following allergic reactions to first dose

Plant root-associated bacteria preferentially colonize their native host-plant roots

Rare inherited variants in previously unsuspected genes may confer significant risk for autism

International experts call for a unified public health response to NAFLD and NASH epidemic

International collaboration of scientists rewrite the rulebook of flowering plant genetics

Improving air quality reduces dementia risk, multiple studies suggest

Misplaced trust: When trust in science fosters pseudoscience

Two types of blood pressure meds prevent heart events equally, but side effects differ

New statement provides path to include ethnicity, ancestry, race in genomic research

Among effective antihypertensive drugs, less popular choice is slightly safer

Juicy past of favorite Okinawan fruit revealed

Anticipate a resurgence of respiratory viruses in young children

Anxiety, depression, burnout rising as college students prepare to return to campus

Goal-setting and positive parent-child relationships reduce risk of youth vaping

New research identifies cancer types with little survival improvements in adolescents and young adul

Oncotarget: Replication-stress sensitivity in breast cancer cells

Oncotarget: TERT and its binding protein: overexpression of GABPA/B in gliomas

Development of a novel technology to check body temperature with smartphone camera

The mechanics of puncture finally explained

Extreme heat, dry summers main cause of tree death in Colorado's subalpine forests

[Press-News.org] Mayo Clinic research suggests women over 65 be offered hereditary cancer genetic testing