Good news for those with MS—fertility treatments not linked to increase in relapses
EMBARGOED FOR RELEASE UNTIL 4 P.M. ET, WEDNESDAY, MARCH 15, 2023
MINNEAPOLIS – There’s good news for those with multiple sclerosis (MS). A new study has found that female participants were no more likely to have a flare-up of the disease after receiving fertility treatments than they were before their treatments. The study is published in the March 15, 2023, online issue of Neurology® Neuroimmunology & Neuroinflammation, an official journal of the American Academy of Neurology. Earlier studies had shown conflicting results. The study also found a link between the use of MS medications and a lack of increase in relapses during fertility treatments.
“These results are exciting, as MS is common among females of childbearing age, and those with MS are more likely to be diagnosed with infertility but have been less likely to receive fertility treatment than those who do not have MS,” said study author Edith L. Graham, MD, of Northwestern University in Chicago, Illinois, and a member of the American Academy of Neurology. “Fertility treatments for people with MS are not as risky as we once thought. We did not see many relapses in our cohort, probably due to the fact that most of the patients were treated with disease-modifying therapies in the year prior.”
The study involved 65 female participants with an average age of 37 who had at least one fertility treatment. A total of 56 had a diagnosis of MS and nine had clinically isolated syndrome, which is the first episode of MS symptoms. Overall, participants had been diagnosed for an average of eight years. None had progressive MS.
Participants had 124 cycles of fertility treatments, including in vitro fertilization and oral medications to induce ovulation. Researchers reviewed medical records to see how many relapses people had in the year before having fertility treatments and then also in the three months after each treatment.
A total of 43% of the participants were actively receiving disease-modifying therapy for their MS during fertility treatments, and the majority had received treatment within the year prior.
Researchers found no increase in the relapse rate after fertility treatment. The result was the same when researchers looked at specific types of fertility treatments including in vitro fertilization, egg banking for fertility preservation, embryo transfer from donor eggs and intrauterine insemination.
Researchers concluded that being on MS treatments at time of fertility stimulation was associated with lower rates of relapse. None of the people on disease-modifying therapy relapsed in the three months post-stimulation.
The researchers also assessed if the relapse rate was affected by whether or not the fertility treatment resulted in a pregnancy, as earlier studies had suggested that could influence the relapse rate. They found that the relapse rate after a fertility treatment with no resulting pregnancy was no different than the rate prior to the treatment.
“We hope our findings provide reassurance to those with MS as well as fertility experts that these treatments are not associated with elevated risks of relapses,” Graham said. “It’s important for people to remember that continuing appropriately timed disease-modifying treatments during fertility treatment can reduce the risk of relapse.”
A limitation of the study was that it looked back in time. It is possible that information about relapses was not collected in all cases. In addition, confirmation of relapses via brain scans was not available in all cases.
The study was supported by Northwestern University.
Learn more about MS at BrainandLife.org, home of the American Academy of Neurology’s free patient and caregiver magazine focused on the intersection of neurologic disease and brain health. Follow Brain & Life® on Facebook, Twitter and Instagram.
When posting to social media channels about this research, we encourage you to use the hashtags #Neurology and #AANscience.
The American Academy of Neurology is the world’s largest association of neurologists and neuroscience professionals, with over 40,000 members. The AAN is dedicated to promoting the highest quality patient-centered neurologic care. A neurologist is a doctor with specialized training in diagnosing, treating and managing disorders of the brain and nervous system such as Alzheimer’s disease, stroke, migraine, multiple sclerosis, concussion, Parkinson’s disease and epilepsy.
For more information about the American Academy of Neurology, visit AAN.com or find us on Facebook, Twitter, Instagram, LinkedIn and YouTube.
ELSE PRESS RELEASES FROM THIS DATE:
A University of Texas at Arlington civil engineering researcher received a one-year, $300,000 competitive grant from the Water Research Foundation to evaluate a trenchless process to renew sanitary sewer pipes in Soapstone Valley Park, a popular Washington, D.C., attraction.
Mohammad Najafi, associate professor in the Department of Civil Engineering, is leading the project.
Najafi said the project will use a trenchless cured-in-place-pipe (CIPP) method that relines the old sewer pipe with new plastic material. That material then is cured in place with hot water.
“We will ...
PHILADELPHIA – The Pezcoller Foundation–American Association for Cancer Research (AACR) International Award for Extraordinary Achievement in Cancer Research will be presented to Tak W. Mak, PhD, Fellow of the AACR Academy, during the AACR Annual Meeting 2023, April 14-19 at the Orange County Convention Center in Orlando, Florida.
Mak is a senior scientist at the Princess Margaret Cancer Centre, University Health Network, as well as a university professor in the departments of medical biophysics and immunology at the Temerty Faculty of Medicine ...
Sharareh “Sherri” Kermanshachi, a University of Texas at Arlington associate professor of civil engineering, has received the 40 Under 40 Award from Mass Transit magazine, which recognizes individuals who have shown a capacity for innovation and demonstrated leadership and a commitment to making an impact in transit.
“I am honored and humbled to receive this award and be named to the 40 Under 40 Mass Transit award list,” said Kermanshachi, who is also director of the Resilient Infrastructures and Sustainable Environment ...
PHILADELPHIA – The American Association for Cancer Research (AACR) will honor Nobel Laureate Carolyn R. Bertozzi, PhD, with the 2023 AACR Award for Outstanding Achievement in Chemistry in Cancer Research during the AACR Annual Meeting 2023, April 14-19 in Orlando, Florida.
Bertozzi is the Anne T. and Robert M. Bass Professor of Chemistry in the School of Humanities and Sciences and a professor (by courtesy) of chemical and systems biology and of radiology at Stanford University, an investigator with the Howard Hughes Medical Institute, and the Baker Family Director of Sarafan ChEM-H. Bertozzi is being recognized for advancing basic ...
PHILADELPHIA – A new approach that delivers a “one-two punch” to help T cells attack solid tumors is the focus of a preclinical study by researchers from the Perelman School of Medicine at the University of Pennsylvania. The findings, published in the Proceedings of the National Academy of Sciences (PNAS), showed that targeting two regulators that control gene functions related to inflammation led to at least 10 times greater T cell expansion in models, resulting in increased antitumor immune activity and durability.
CAR T cell therapy was pioneered at Penn Medicine by ...
A comprehensive analysis of an archaeological site in Saudi Arabia sheds new light on mustatils—stone monuments from the Late Neolithic period thought to have been used for ritual purposes. Melissa Kennedy of the University of Western Australia, Perth, and colleagues, in conjunction with The Royal Commission for AlUla present these findings in the open-access journal PLOS ONE on March 15, 2023.
Built around 7,000 years ago, mustatils are rectangular, low-walled, stone structures that range from 20 to 600 meters in length. Researchers first discovered them in the 1970s, and more than 1,600 mustatils have now been discovered, primarily concentrated in northern ...
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282239
Article Title: Eight years of community structure monitoring through recreational citizen science at the “SS Thistlegorm” wreck (Red Sea)
Author Countries: Italy
Funding: STE project was funded by Project AWARE Foundation, ASTOI Association, Ministry of Tourism of the Arab Republic of Egypt, Settemari S.p.A Tour Operator, Scuba Nitrox Safety International, Viaggio nel Blu Diving Center. The funders had no role in study design, data collection ...
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0282323
Article Title: Connecting higher education to workplace activities and earnings
Author Countries: USA
Funding: This research is supported in part by the University of Pittsburgh Pitt Momentum Fund and the Center for Research Computing. This work has been supported (in part) by # 2109-33808 from the Russell Sage Foundation. Any opinions expressed are those of the principal investigator(s) alone and should not be construed as representing the opinions of the Foundation. The funders had no role in study design, data collection ...
The sex hormone estrogen has a negative impact on heartbeat regulation, according to an experimental study from Linköping University, Sweden, published in Science Advances. Estrogen impact seems to interact with hereditary changes causing a heart disease disturbing the heart’s rhythm, while other endogenous substances may have a protecting effect.
In a lifetime, the heart beats around 2.5 billion times. Each heartbeat is triggered by an electrical impulse that causes the heart muscle to contract in a very well-coordinated movement. ...
Researchers have identified evidence they interpret as active volcanism on the surface of Venus, according to a new analysis of radar images from the Magellan spacecraft. The images reveal a vent that changed shape on Venus, which they believe points to ongoing volcanic activity there. Many volcanoes have been identified on the surface of Venus, but evidence of recent volcanic activity on the planet has been lacking. As a result, it was unknown whether the prominent volcanic features of Venus’ geologically young surface are a product of ongoing active volcanism ...
LAST 30 PRESS RELEASES:
[Press-News.org] Good news for those with MS—fertility treatments not linked to increase in relapses