PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

Aging | Age-related methylation changes in the human sperm epigenome

Aging | Age-related methylation changes in the human sperm epigenome
2023-03-21
(Press-News.org)

“[...] we identified > 1,000 candidate genes with genome-wide significant age-related methylation changes in sperm.”

BUFFALO, NY- March 21, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 5, entitled, “Age-related methylation changes in the human sperm epigenome.”

Advanced paternal age is associated with increased risks for reproductive and offspring medical problems. Accumulating evidence suggests age-related changes in the sperm epigenome as one underlying mechanism. In a recent study, researchers Laura Bernhardt, Marcus Dittrich, Andreas Prell, Ramya Potabattula, Charis Drummer, Rüdiger Behr, Thomas Hahn, Martin Schorsch, Tobias Müller, and Thomas Haaf from Julius Maximilians University, Partner Site Göttingen and Fertility Center Wiesbaden performed reduced representation bisulfite sequencing (RRBS) on 73 sperm samples of males attending a fertility center in Germany.

“[...] we identified 1,162 (74%) regions which were significantly (FDR-adjusted) hypomethylated and 403 regions (26%) being hypermethylated with age.” 

There were no significant correlations with paternal BMI, semen quality, or ART outcome. The majority (1,152 of 1,565; 74%) of age-related differentially methylated regions (ageDMRs) were located within genic regions, including 1,002 genes with symbols. Hypomethylated ageDMRs were closer to transcription start sites than hypermethylated DMRs, half of which reside in gene-distal regions. 

In this and conceptually related genome-wide studies, so far 2,355 genes have been reported with significant sperm ageDMRs, however most (90%) of them in only one study. The 241 genes which have been replicated at least once showed significant functional enrichments in 41 biological processes associated with development and the nervous system and in 10 cellular components associated with synapses and neurons. 

This supports the hypothesis that paternal age effects on the sperm methylome affect offspring behavior and neurodevelopment. The researchers found it interesting to note that sperm ageDMRs were not randomly distributed throughout the human genome; chromosome 19 showed a highly significant twofold enrichment with sperm ageDMRs. Although the high gene density and CpG content have been conserved, the orthologous marmoset chromosome 22 did not appear to exhibit an increased regulatory potential by age-related DNA methylation changes.

“Collectively, our data support the conclusion that age-induced methylation changes in the sperm epigenome contribute to the increased offspring disease susceptibility for neurodevelopmental disorders.”

 

Read the Full Paper: DOI: https://doi.org/10.18632/aging.204546 

Corresponding Author: Thomas Haaf

Corresponding Email: thomas.haaf@uni-wuerzburg.de 

Keywords: ART outcome, DNA methylation, male germ cells, paternal age effect, human sperm epigenome

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204546

 

About Aging-US:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud Facebook Twitter Instagram YouTube LabTube LinkedIn Reddit Pinterest

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

END


[Attachments] See images for this press release:
Aging | Age-related methylation changes in the human sperm epigenome Aging | Age-related methylation changes in the human sperm epigenome 2 Aging | Age-related methylation changes in the human sperm epigenome 3

ELSE PRESS RELEASES FROM THIS DATE:

Study finds similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk

Study finds similar association of progestogen-only and combined hormonal contraceptives with breast cancer risk
2023-03-21
There is a relative increase of 20% to 30% in breast cancer risk associated with both combined and progesterone-only contraceptives, whatever the mode of delivery, though with five years of use, the 15-year absolute excess incidence is at most 265 cases per 100,000 users. The results appear in a new study publishing March 21st in the open access journal PLOS Medicine by Kirstin Pirie of University of Oxford, UK, and colleagues. Use of combined oral contraceptives, containing both estrogen and progestogen, has previously been associated with a small increase in breast cancer risk but there is limited data about the ...

Exercise therapy is safe, may improve quality of life for many people with heart failure

2023-03-21
CONTENT UPDATED 3/17 - note new references to cardiac rehabilitation. Statement Highlights: A new scientific statement indicates supervised exercise therapy may help improve symptoms for people with one of the most common types of heart failure, known as heart failure with preserved ejection fraction (HFpEF), in which the heart muscle’s pumping strength is intact. Exercise therapy had comparable or better results on improving exercise capacity for people with preserved EF compared to those who have heart failure with reduced ...

COVID-19 unemployment stigma is real and could threaten future job prospects: uOttawa study

COVID-19 unemployment stigma is real and could threaten future job prospects: uOttawa study
2023-03-21
Regina Bateson, an Assistant Professor in the Faculty of Social Science’s Graduate School of Public and International Affairs, details the findings of her study, which shows the significant social and economic impacts to individuals who were out of work during the COVID-19 pandemic. Below she answers questions about her study. Question: How was this research performed? Regina Bateson: “In this study, I conducted a pre-registered survey experiment with a nationally representative sample of 974 U.S. adults. ...

Ultra-lightweight multifunctional space skin created to withstand extreme conditions in space 

2023-03-21
A new nano-barrier coating could help protect ultra-lightweight carbon composite materials from extreme conditions in space, according to a study from the University of Surrey and Airbus Defence and Space.   The new functionality added to previously developed ‘space skin’ structures adds a layer of protection to help maintain space payloads while travelling in space, similar to having its very own robust ultralight protective jacket.  The research team has shown that their innovative nano-barrier would help drastically increase the stability of carbon fibre materials, while reducing radiation ...

Researchers identify new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer’s disease

2023-03-21
An international study led by the Molecular Physiology Laboratory at the UPF Department of Medicine and Life Sciences (MELIS) identifies new genes that modulate the toxicity of the protein β-amyloid, responsible for causing Alzheimer’s disease. Combining molecular biology, genomics and bioinformatics techniques, 238 amyloid toxicity protective or activator genes have been identified. Among them, the gene Surf4 stands out. It is involved in the control of intracellular calcium and, by increasing the toxicity of the β-amyloid protein, contributes to the disease.   The research has been carried out thanks to the support ...

Smart light traps

Smart light traps
2023-03-21
Plants use photosynthesis to harvest energy from sunlight. Now researchers at the Technical University of Munich (TUM) have applied this principle as the basis for developing new sustainable processes which in the future may produce syngas (synthetic gas) for the large-scale chemical industry and be able to charge batteries. Syngas, a mixture of carbon monoxide and hydrogen, is an important intermediate product in the manufacture of many chemical starter materials such as ammonia, methanol and synthetic hydrocarbon fuels. "Syngas is currently made almost exclusively using fossil raw materials," ...

Visualization of electron dynamics on liquid helium for the first time

Visualization of electron dynamics on liquid helium for the first time
2023-03-21
An international team led by Lancaster University has discovered how electrons can slither rapidly to-and-fro across a quantum surface when driven by external forces. The research, published in Physical Review B, has enabled the visualisation of the motion of electrons on liquid helium for the first time. The experiments, carried out in Riken, Japan, by Kostyantyn Nasyedkin (now at Oak Ridge National Laboratory, USA) in the lab of Kimitoshi Kono (now in Taiwan at Yang Ming Chiao Tung University) detected unusual oscillations whose frequencies varied in time. Although it was unclear how ...

Argonne is helping U.S. companies advance battery recycling technology and strengthen the nation’s battery supply chain

2023-03-21
Argonne received $3.5 million in funding to help accelerate battery production in America, lower costs, provide a domestic source of materials and reduce the environmental impact of electric vehicle batteries. Batteries are critical to powering a clean energy economy. This is especially true in the transportation sector, where electric vehicles (EVs) are on track to make up half of all new vehicle sales by 2030. In order to meet this rapidly increasing demand, the U.S. Department of Energy (DOE) is distributing funding to advance domestic recycling and reuse of electric vehicle batteries. Managed by DOE’s Vehicle ...

Machine learning programs predict risk of death based on results from routine hospital tests

2023-03-21
If you’ve ever been admitted to hospital or visited an emergency department, you’ve likely had an electrocardiogram, or ECG, a standard test involving tiny electrodes taped to your chest that checks your heart’s rhythm and electrical activity.  Hospital ECGs are usually read by a doctor or nurse at your bedside, but now researchers are using artificial intelligence to glean even more information from those results to improve your care and the health-care system all at once. In recently published findings, the research team built and trained machine learning programs based on 1.6 ...

Imaging the proton with neutrinos

Imaging the proton with neutrinos
2023-03-21
The Science Protons and neutrons, the building blocks of atomic nuclei, are themselves made up of strongly interacting quarks and gluons">quarks and gluons. Because the interactions are so strong, the structure of protons and neutrons is difficult to calculate from theory. Instead, scientists must measure it experimentally. Neutrino experiments use targets that are nuclei made of many protons and neutrons bound together. This complicates interpreting those measurements to infer proton structure. ...

LAST 30 PRESS RELEASES:

Fig trees convert atmospheric CO2 to stone

Intra-arterial tenecteplase for acute stroke after successful endovascular therapy

Study reveals beneficial microbes that can sustain yields in unfertilized fields

Robotic probe quickly measures key properties of new materials

Climate change cuts milk production, even when farmers cool their cows

Frozen, but not sealed: Arctic Ocean remained open to life during ice ages

Some like it cold: Cryorhodopsins

Demystifying gut bacteria with AI

Human wellbeing on a finite planet towards 2100: new study shows humanity at a crossroads

Unlocking the hidden biodiversity of Europe’s villages

Planned hydrogen refuelling stations may lead to millions of euros in yearly losses

Planned C-sections increase the risk of certain childhood cancers

Adults who have survived childhood cancer are at increased risk of severe COVID-19

Drones reveal extreme coral mortality after bleaching

New genetic finding uncovers hidden cause of arsenic resistance in acute promyelocytic leukemia

Native habitats hold the key to the much-loved smashed avocado’s future

Using lightning to make ammonia out of thin air

Machine learning potential-driven insights into pH-dependent CO₂ reduction

Physician associates provide safe care for diagnosed patients when directly supervised by a doctor

How game-play with robots can bring out their human side

Asthma: patient expectations influence the course of the disease

UNM physician tests drug that causes nerve tissue to emit light, enabling faster, safer surgery

New study identifies EMP1 as a key driver of pancreatic cancer progression and poor prognosis

XPR1 identified as a key regulator of ovarian cancer growth through autophagy and immune evasion

Flexible, eco-friendly electronic plastic for wearable tech, sensors

Can the Large Hadron Collider snap string theory?

Stuckeman professor’s new book explores ‘socially sustainable’ architecture

Synthetic DNA nanoparticles for gene therapy

New model to find treatments for an aggressive blood cancer

Special issue of Journal of Intensive Medicine analyzes non-invasive respiratory support

[Press-News.org] Aging | Age-related methylation changes in the human sperm epigenome