(Press-News.org) Dysregulation of microRNAs, which are molecules involved in controlling gene expression, can promote tumor formation and progression. A study in The FASEB Journal found that the miR-145 microRNA can suppress the growth of cervical cancer cells.
miR-145 was expressed at lower than normal levels in human cervical cancer cells, and lower levels correlated with more advanced clinical stages of cervical cancer in patients.
Experiments in cells and mice revealed the mechanisms behind miR-145 effects and pointed to potential targets that could be manipulated to benefit patients with cervical cancer.
“Cervical cancer is the fourth leading cause of cancer-related death in women worldwide, and microRNA dysregulation plays an important role in its pathogenesis,” said co–corresponding author Kun Yang, PhD, of The Fourth Military Medical University, in China. “This study explored the potential mechanism of miR-145 in cervical cancer, suggesting that targeting miR-145 is expected to be an effective strategy for cervical cancer treatment.”
URL upon publication: https://onlinelibrary.wiley.com/doi/10.1096/fj.202201189RR
Additional Information
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About the Journal
The FASEB Journal publishes high quality and impactful multidisciplinary research covering biology and biomedical sciences at every level of organization: atomic, molecular, cell, tissue, organ, organismic, and population. The journal’s scope includes the spectrum of biological and biomedical sciences as well as interdisciplinary research cutting across multiple fields and extending in related areas.
About Wiley
Wiley is one of the world’s largest publishers and a global leader in scientific research and career-connected education. Founded in 1807, Wiley enables discovery, powers education, and shapes workforces. Through its industry-leading content, digital platforms, and knowledge networks, the company delivers on its timeless mission to unlock human potential. Visit us at Wiley.com. Follow us on Facebook, Twitter, LinkedIn and Instagram.
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Boosting the effects of a particular microRNA may benefit patients with cervical cancer
2023-03-22
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