Mea6 deficiency in oligodendrocytes affects white matter formation in the brain
2023-03-27
(Press-News.org)
More than half amount in adult human brain is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white matter. Abnormal myelin sheath is associated with many neurological diseases. Mea6/ cTAGE5C is essential for vesicle trafficking from ER to Golgi. However, its biological function in oligodendrocyte and white matter development remains unclear.
Scientists from Institute of Genetics and Developmental Biology of Chinese Academy of Sciences generated mice with conditional knockout (cKO) of Mea6 in oligodendrocytes. Using different models of diffusion magnetic resonance imaging, they detected the dramatically affected gross and microstructure of white matter, as well as its lipid and water diffusion capacity, in Mea6-cKO brains. A significant decrease in whole-brain cholesterol and triglycerides was detected in cKOs. In addition, they performed the first lipidomic analysis of purified myelin sheath and found that Mea6 elimination significantly altered the proportion of lipid components in myelin lipidome, especially very long-chain fatty acids (VLCFAs). In particular, the levels of most VLCFA-containing phosphatidylcholines were significantly lower in cKOs. The reduction of VLCFAs is likely due to the reduced expression of ELOVLs (elongation of very long chain fatty acids proteins). This study entitled “Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content” is published on 23 March 2023 online in Life Metabolism.
This study of an animal model with white matter malformation and the comprehensive lipid profiling would provide clues for future studies of myelin lipids and new insight into the pathogenesis of white matter diseases.
###
Reference: Tiantian Ma et al. (2023) Ablation of Mea6/cTAGE5 in oligodendrocytes significantly impairs white matter structure and lipid content. Life Metabolism. https://doi.org/10.1093/lifemeta/load010.
About Higher Education Press
Founded in May 1954, Higher Education Press Limited Company (HEP), affiliated with the Ministry of Education, is one of the earliest institutions committed to educational publishing after the establishment of P. R. China in 1949. After striving for six decades, HEP has developed into a major comprehensive publisher, with products in various forms and at different levels. Both for import and export, HEP has been striving to fill in the gap of domestic and foreign markets and meet the demand of global customers by collaborating with more than 200 partners throughout the world and selling products and services in 32 languages globally. Now, HEP ranks among China’s top publishers in terms of copyright export volume and the world’s top 50 largest publishing enterprises in terms of comprehensive strength.
About Life Metabolism
Life Metabolism is a fully open access, peer-reviewed journal that publishes one volume per year online, providing a platform for the publication of works of high significance and broad interest in all areas of metabolism. Life Metabolism welcomes several different article types, including original article, review article, research highlight, letter, editorial, perspective, and so on. Once a paper is accepted, Life Metabolism can publish a precopyedited, preproofed version of the paper online within 48 hours of receiving a signed licence, and this will be replaced by a copyedited, proofed version of the paper as soon as it is ready. The Editors-in-Chief are professors Peng Li at Tsinghua University and John R Speakman at University of Aberdeen, UK. In the first three years, there will be no publication costs for publishing in Life Metabolism, and Open Access fees will be waived.
END
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
2023-03-27
Recently, a research group lead by Prof. Shuting Wang from topology optimization of Huazhong University of Science and Technology has put forward a massively efficient filter utilizing the splitting of the tensor product structure. This study can be found in the journal Frontiers of Mechanical Engineering on 10 January, 2023.
With the aid of spitting technique, the traditional weight matrices of both B-splines and non-uniform rational B-splines implicit filters are equivalently decomposed into two or three submatrices, by which the sensitivity analysis is reformulated for the nodal design variables without altering ...
2023-03-27
A large observational study published in JAMA Internal Medicine suggests that most patients do not medically benefit from consultation with a medical specialist before their surgery.
In Canada, surgeons refer more than 40,000 patients each year for consultation with a medical specialist (such as a general internist, cardiologist, endocrinologist, geriatrician, or nephrologist) before surgery. Between 10 and 40% of elective surgery patients will have a preoperative medical consultation.
These preoperative medical consultations are meant to address health issues that could lead to complications during surgery, but the evidence to support them has been limited ...
2023-03-27
Public health experts at the University of Colorado Anschutz Medical Campus released a new research letter today in JAMA Pediatrics that examines how quickly Colorado’s children and teenagers can access a loaded gun and call attention to the critical importance of reducing access to guns when an adolescent is in crisis.
“There’s a high rate of firearm suicides in our youth and we know that for a large portion of those who attempt suicide, that ideation to action can happen under 10 minutes,” said principal investigator Ashley Brooks-Russell, ...
2023-03-27
After a child’s hospital stay, many families covered by private insurance may experience sticker shock – on average spending $1,300 out of pocket – a new study in JAMA Pediatrics suggests.
For one in seven families, the price tag is even higher, exceeding $3,000.
“Bills for a child’s hospitalization can be astonishingly high for some families depending on how their insurance plan is structured,” said lead author Erin Carlton, M.D., a pediatric intensivist at University of Michigan Health C.S. Mott Children's ...
2023-03-27
About The Study: In this study of 1,678 participants, expectations of low benefit and high adverse effects, the tendency to catastrophize instead of normalize benign bodily sensations, and prior negative experiences were associated with COVID-19 vaccination adverse effects. Clinician-patient interactions and public vaccine campaigns may both benefit from these insights by optimizing and contextualizing information provided about COVID-19 vaccines.
Authors: Ingmar Schafer, Ph.D., of the University Medical Center Hamburg-Eppendorf ...
2023-03-27
Lunar surface water has attracted much attention due to its potential for in-situ resource utilization by future lunar exploration missions and other space missions
Now, a research group led by Prof. HU Sen from the Institute of Geology and Geophysics (IGG) of the Chinese Academy of Sciences (CAS) has found that impact glass beads in Chang'e-5 (CE5) lunar soils contain some water.
Detailed studies show that these glass beads are likely a new water reservoir on the Moon, recording the dynamic ingress and egress of solar wind-derived water and acting ...
2023-03-27
A 2022 study from Oregon Health & Science University researchers confirmed that chronic use of cannabis may greatly impact male fertility and reproductive outcomes in nonhuman primates — but it was unclear whether the effects are permanent. Now, the OHSU research team has confirmed that discontinuing use of THC can at least partly reverse these effects, according to a new study published online today in Fertility & Sterility.
This is one of the first studies demonstrating that discontinuation ...
2023-03-27
**EMBARGOED TILL 11 A.M. ET MONDAY, MARCH 27
To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team led by Johns Hopkins Medicine scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.
Monocytes are short-lived circulating immune cells that are a precursor to macrophages, immune cells able to engulf and destroy viruses, bacteria ...
2023-03-27
Every year, hundreds of thousands of pairs of black holes merge in a cosmic dance that emits gravitational waves in every direction. Since 2015, the large ground-based LIGO, Virgo and KAGRA interferometers have made it possible to detect these signals, although only about a hundred such events, an infinitesimal fraction of the total, have been observed. Most of the waves remain 'indistinguishable', superimposed and added together, creating a flat, diffuse background signal that scientists call the 'stochastic gravitational wave ...
2023-03-27
The results of a study published in “Advances in Nutrition” that compared dietary and nutrition recommendations from dozens of clinical practice guidelines around the world for treating, managing and preventing major chronic diseases should increase clinician confidence on recommending consumption of fruits, vegetables, legumes and whole grains.
The meta-epidemiological study from the American College of Lifestyle Medicine (ACLM) reviewed 78 clinical practice guidelines published between 2010 and 2021 in North America, Europe and Asia and found close alignment in their recommendations for encouraging daily intake of plant food sources, while ...
LAST 30 PRESS RELEASES:
[Press-News.org] Mea6 deficiency in oligodendrocytes affects white matter formation in the brain
