(Press-News.org) A new study published in the peer-reviewed OMICS: A Journal of Integrative Biology identified differentially expressed host and viral microRNAs (miRNAs) in six Epstein-Barr virus (EBV) associated tumors. The study reports several drug candidates for repurposing and targeting EBV latent infection: Glyburide, Levodopa, Nateglinide, and Stiripentol, among others. Click here to read the article now.
The authors, Anamika Thakur and Manoj Kumar, PhD, from the Institute of Microbial Technology, Council of Scientific and Industrial Research (CSIR), Chandigarh, India, note: “This is the first integrative analysis, to the best of our knowledge, in regard to the potential therapeutic targets and drug repurposing candidates against the EBV tumors.” EBV is associated with several types of malignancies, such as gastric carcinoma, Burkitt lymphoma, nasopharyngeal carcinoma, and Hodgkin’s lymphoma.
“Epstein-Barr virus is a major planetary health burden especially in the oncology clinic. The study makes a contribution toward antiviral drug innovation for treatment of EBV infection and prevention of EBV-related tumors,” says Vural Özdemir, MD, PhD, DABCP, Editor-in-Chief of OMICS.
About the Journal
OMICS: A Journal of Integrative Biology is an authoritative and highly innovative peer-reviewed interdisciplinary journal published monthly online, addressing the latest advances at the intersection of postgenomics medicine, biotechnology and global society, including the integration of multi-omics knowledge, data analyses and modeling, and applications of high-throughput approaches to study complex biological and societal problems. Public policy, governance and societal aspects of the large-scale biology and 21st century data-enabled sciences are also peer-reviewed. Complete tables of content and a sample issue may be viewed on the OMICS: A Journal of Integrative Biology website.
About the Publisher
Mary Ann Liebert, Inc., publishers is known for establishing authoritative peer-reviewed journals in many areas of science and biomedical research. Its biotechnology trade magazine, Genetic Engineering & Biotechnology News (GEN), was the first in its field and is today the industry’s most widely read publication worldwide. A complete list of the firm’s 90 journals, books, and newsmagazines is available on the Mary Ann Liebert, Inc., publishers website.
END
Epstein-Barr virus associated tumors and drug repurposing
2023-03-27
[Attachments] See images for this press release:
ELSE PRESS RELEASES FROM THIS DATE:
Researchers identify 6 challenges humans face with artificial intelligence
2023-03-27
ORLANDO, March 27, 2023 - A University of Central Florida professor and 26 other researchers have published a study identifying the challenges humans must overcome to ensure that artificial intelligence is reliable, safe, trustworthy and compatible with human values.
The study, “Six Human-Centered Artificial Intelligence Grand Challenges,” was published in the International Journal of Human-Computer Interaction.
Ozlem Garibay ’01MS ’08PhD, an assistant professor in UCF’s Department ...
Mea6 deficiency in oligodendrocytes affects white matter formation in the brain
2023-03-27
More than half amount in adult human brain is made up of white matter. Lipid-rich myelin is a special structure formed by oligodendrocytes wrapping neuronal axons to form the major components of white matter. Abnormal myelin sheath is associated with many neurological diseases. Mea6/ cTAGE5C is essential for vesicle trafficking from ER to Golgi. However, its biological function in oligodendrocyte and white matter development remains unclear.
Scientists from Institute of Genetics and Developmental Biology of Chinese Academy of Sciences generated mice with conditional knockout (cKO) of Mea6 in oligodendrocytes. Using ...
Massively effective filter for topology optimization based on the splitting of tensor product structure
2023-03-27
Recently, a research group lead by Prof. Shuting Wang from topology optimization of Huazhong University of Science and Technology has put forward a massively efficient filter utilizing the splitting of the tensor product structure. This study can be found in the journal Frontiers of Mechanical Engineering on 10 January, 2023.
With the aid of spitting technique, the traditional weight matrices of both B-splines and non-uniform rational B-splines implicit filters are equivalently decomposed into two or three submatrices, by which the sensitivity analysis is reformulated for the nodal design variables without altering ...
Routine preoperative medical consultations don’t improve surgery outcomes
2023-03-27
A large observational study published in JAMA Internal Medicine suggests that most patients do not medically benefit from consultation with a medical specialist before their surgery.
In Canada, surgeons refer more than 40,000 patients each year for consultation with a medical specialist (such as a general internist, cardiologist, endocrinologist, geriatrician, or nephrologist) before surgery. Between 10 and 40% of elective surgery patients will have a preoperative medical consultation.
These preoperative medical consultations are meant to address health issues that could lead to complications during surgery, but the evidence to support them has been limited ...
CU Anschutz experts call attention to unsupervised youth gun access in Colorado
2023-03-27
Public health experts at the University of Colorado Anschutz Medical Campus released a new research letter today in JAMA Pediatrics that examines how quickly Colorado’s children and teenagers can access a loaded gun and call attention to the critical importance of reducing access to guns when an adolescent is in crisis.
“There’s a high rate of firearm suicides in our youth and we know that for a large portion of those who attempt suicide, that ideation to action can happen under 10 minutes,” said principal investigator Ashley Brooks-Russell, ...
Study: Average privately insured family spends $1,300 for child’s hospitalization
2023-03-27
After a child’s hospital stay, many families covered by private insurance may experience sticker shock – on average spending $1,300 out of pocket – a new study in JAMA Pediatrics suggests.
For one in seven families, the price tag is even higher, exceeding $3,000.
“Bills for a child’s hospitalization can be astonishingly high for some families depending on how their insurance plan is structured,” said lead author Erin Carlton, M.D., a pediatric intensivist at University of Michigan Health C.S. Mott Children's ...
Expectations, prior experiences associated with adverse effects of COVID-19 vaccination
2023-03-27
About The Study: In this study of 1,678 participants, expectations of low benefit and high adverse effects, the tendency to catastrophize instead of normalize benign bodily sensations, and prior negative experiences were associated with COVID-19 vaccination adverse effects. Clinician-patient interactions and public vaccine campaigns may both benefit from these insights by optimizing and contextualizing information provided about COVID-19 vaccines.
Authors: Ingmar Schafer, Ph.D., of the University Medical Center Hamburg-Eppendorf ...
Researchers find new water reservoir on Moon
2023-03-27
Lunar surface water has attracted much attention due to its potential for in-situ resource utilization by future lunar exploration missions and other space missions
Now, a research group led by Prof. HU Sen from the Institute of Geology and Geophysics (IGG) of the Chinese Academy of Sciences (CAS) has found that impact glass beads in Chang'e-5 (CE5) lunar soils contain some water.
Detailed studies show that these glass beads are likely a new water reservoir on the Moon, recording the dynamic ingress and egress of solar wind-derived water and acting ...
Ending THC use may reverse its impacts on male fertility
2023-03-27
A 2022 study from Oregon Health & Science University researchers confirmed that chronic use of cannabis may greatly impact male fertility and reproductive outcomes in nonhuman primates — but it was unclear whether the effects are permanent. Now, the OHSU research team has confirmed that discontinuing use of THC can at least partly reverse these effects, according to a new study published online today in Fertility & Sterility.
This is one of the first studies demonstrating that discontinuation ...
New study: HIV genomes that hide in white blood cells offer new target to eliminate infections
2023-03-27
**EMBARGOED TILL 11 A.M. ET MONDAY, MARCH 27
To develop treatments that may one day entirely rid the body of HIV infection, scientists have long sought to identify all of the places that the virus can hide its genetic code. Now, in a study using blood samples from men and women with HIV on long-term suppressive therapy, a team led by Johns Hopkins Medicine scientists reports new evidence that one such stable reservoir of HIV genomes can be found in circulating white blood cells called monocytes.
Monocytes are short-lived circulating immune cells that are a precursor to macrophages, immune cells able to engulf and destroy viruses, bacteria ...