Bacterial consortium therapy for prevention of recurrent c difficile infection

JAMA

2023-04-15

(Press-News.org) About The Study: Among adults with laboratory-confirmed Clostridioides difficile infection (CDI) with one or more prior CDI episodes in the last six months and those with primary CDI at high risk for recurrence, high-dose VE303 (a novel oral microbiome-directed therapy composed of nonpathogenic, nontoxigenic, commensal strains of Clostridia) prevented recurrent CDI compared with placebo. A larger, phase 3 study is needed to confirm these findings.

Authors: Jeffrey L. Silber, M.D., of Vedanta Biosciences Inc., in Cambridge, Massachusetts, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2023.4314)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Media advisory: The study is being released to coincide with presentation at the European Congress of Clinical Microbiology & Infectious Diseases.

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time https://jamanetwork.com/journals/jama/fullarticle/10.1001/jama.2023.4314?guestAccessKey=78cc89bf-06db-4687-a463-da021a5f18dd&utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_content=tfl&utm_term=041523

END

ELSE PRESS RELEASES FROM THIS DATE:

Filtering pollution: A microfluidic device for collecting microplastics via acoustic focusing

2023-04-15

Plastic debris particles smaller than 5 mm in size, known as microplastics (MPs), are a serious environmental concern. Formed by the breaking down of plastic waste due to wear and tear and sunlight or produced by fiber waste in laundry wastewater and as microbeads in beauty products, they adsorb and introduce harmful chemicals that pollute the environment. By 2050, MPs might outnumber the fish in the oceans. Under these circumstances, the collection and removal of MPs from water are crucial. Conventionally, MPs are collected by filtering water through meshes. ...

Detailed guidance on natural pacemaker method published today

2023-04-15

Barcelona, Spain – 15 April 2023: An international consensus statement on the safest and most effective way to implant a pacing system that mimics the heart’s normal function is published today in EP Europace,1 a journal of the European Society of Cardiology (ESC). The document is being launched at the EHRA Conduction System Pacing (CSP) Summit2 and will be discussed during EHRA 2023, a scientific congress of the ESC.3 “It is estimated that 1.4 million patients worldwide will receive a pacemaker in 2023,” said first author ...

Clinical staff MRSA carriage and environmental contamination by other “superbugs” found in Portuguese veterinary practices

2023-04-15

**Note: the release below is from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the conference if you use this story** Examination tables, scales and other surfaces in small animal veterinary practices are frequently contaminated with multidrug-resistant “superbugs”, the results of a Portuguese study suggest. The research, which is being presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) ...

Multidrug-resistant bacteria found in 40% of supermarket meat samples

2023-04-15

**Note: the release below is from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the conference if you use this story** Multidrug-resistant E. coli were found in 40% of supermarket meat samples tested in a Spanish study. E. coli strains capable of causing severe infections in people were also highly prevalent, this year's European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April) will hear. Antibiotic resistance is reaching dangerously high levels around the world. Drug-resistant infections kill ...

Major genetic study reveals how antibiotic resistance varies according to where you live, demographics, and diet

2023-04-15

**Note: the release below is from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the conference if you use this story** A genetic study analysing the microbiome (bacteria in the gut) of a large nationally representative sample of the Finnish population finds that geographic, demographic, diet, and lifestyle factors are driving the spread of antibiotic resistance in the general population. The most comprehensive study of its kind by Dr Katariina Pärnänen ...

UK-Portuguese study shows antibiotic-resistant “superbugs” are being passed between dogs and cats and their owners, study strongly suggests

2023-04-15

**Note: the release below is from the European Congress of Clinical Microbiology & Infectious Diseases (ECCMID 2023, Copenhagen, 15-18 April). Please credit the conference if you use this story** Evidence that multidrug-resistant bacteria are being passed between pet cats and dogs and their owners will be presented at this year’s European Congress of Clinical Microbiology & Infectious Diseases (ECCMID) in Copenhagen, Denmark (15-18 April). Six pets in Portugal and one in the UK were carrying antibiotic-resistant bacteria similar to those found in their owners, a Portuguese study found. The finding underlines the importance ...

Study of cerebral blood vessels uncovers potential new drug targets for treating stroke

2023-04-14

Strokes cause numerous changes in gene activity in affected small blood vessels in the brain, and these changes are potentially targetable with existing or future drugs to mitigate brain injury or improve stroke recovery, according to a study led by Weill Cornell Medicine scientists. In the study, which appears Apr. 14 in the Proceedings of the National Academy of Sciences, the researchers performed a comprehensive survey, in a preclinical model, of gene activity changes in small blood vessels in the brain following stroke. Comparing these changes to those that have been recorded in stroke patients, they catalogued hundreds ...

Tracking a new path to octopus and squid sensing capabilities

2023-04-14

Along their eight arms, octopuses have highly sensitive suckers that allow methodical explorations of the seafloor as they search for nourishment in a “taste by touch” approach. Squids, on the other hand, use a much different tactic to find their next meal: patiently hiding until they ambush their prey in swift bursts. In a unique analysis that provides a glimpse into the origin stories of new animal traits, a pair of research studies led by University of California San Diego and Harvard University scientists has traced the evolutionary adaptations of octopus and squid sensing capabilities. The studies, featured on ...

Trees in savanna areas of Cerrado produce three times more bark than species in forest areas

2023-04-14

In tropical regions of the planet, savannas and forests often coexist in the same area and are exposed to the same climate. An example is the Cerrado, a Brazilian biome that includes several types of vegetation, from broad-leaved and sclerophyllous in dense woodland or shrubland (cerrado sensu stricto) to semi-evergreen in closed-canopy forest (cerradão), as well as grassland with scattered shrubs (campo sujo) and even semi-deciduous seasonal forest. Areas of cerradão develop in the absence of fire, in both poor and moderately fertile soil (dystrophic to mesotrophic). This coexistence intrigues botanists and ecologists ...

Wayne State researcher receives $1.95 million NIH grant to study impact of inositol homeostasis on essential cellular functions

2023-04-14

DETROIT – A researcher from Wayne State University’s Department of Biological Sciences has received a five-year, $1.95 million grant from the National Institute of General Medical Sciences of the National Institutes of Health to identify mechanisms that regulate inositol synthesis in mammalian cells and determine the cellular consequences of inositol depletion. Inositol is a type of sugar that is essential for the viability of eukaryotic cells. Myo-inositol is the precursor of all inositol compounds, which play pivotal roles in cell signaling and metabolism. Consistent with its importance, a disturbance of inositol homeostasis ...

LAST 30 PRESS RELEASES:

New study finds air pollution increases inflammation primarily in patients with heart disease

AI finds undiagnosed liver disease in early stages

The American Society of Tropical Medicine and Hygiene and the Bill & Melinda Gates Foundation announce new research fellowship in malaria genomics in honor of professor Dominic Kwiatkowski