Bacterial consortium therapy for prevention of recurrent c difficile infection

JAMA

2023-04-15

(Press-News.org) About The Study: Among adults with laboratory-confirmed Clostridioides difficile infection (CDI) with one or more prior CDI episodes in the last six months and those with primary CDI at high risk for recurrence, high-dose VE303 (a novel oral microbiome-directed therapy composed of nonpathogenic, nontoxigenic, commensal strains of Clostridia) prevented recurrent CDI compared with placebo. A larger, phase 3 study is needed to confirm these findings.

Authors: Jeffrey L. Silber, M.D., of Vedanta Biosciences Inc., in Cambridge, Massachusetts, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jama.2023.4314)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

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Media advisory: The study is being released to coincide with presentation at the European Congress of Clinical Microbiology & Infectious Diseases.

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Bacterial consortium therapy for prevention of recurrent c difficile infection

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