PRESS-NEWS.org - Press Release Distribution
PRESS RELEASES DISTRIBUTION

External factors shape genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene

External factors shape genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene
2023-05-24
(Press-News.org)

“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]”

BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.”

In this new study, researchers Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, and Alexander M. Kulminski from Duke University, University of Pittsburgh and Washington University School of Medicine examined associations of single nucleotide polymorphisms (SNPs) of the MLXIPL lipid gene with Alzheimer’s (AD) and coronary heart disease (CHD) and potentially causal mediation effects of their risk factors, high-density lipoprotein cholesterol (HDL-C) and triglycerides (TG) in two samples of European ancestry from the United States (US) (22,712 individuals 587/2,608 AD/CHD cases) and the United Kingdom Biobank (UKB) (232,341 individuals; 809/15,269 AD/CHD cases).

“Our results suggest that these associations can be regulated by several biological mechanisms and shaped by exogenous exposures.”

Two patterns of associations (represented by rs17145750 and rs6967028) were identified. Minor alleles of rs17145750 and rs6967028 demonstrated primary (secondary) association with high TG (lower HDL-C) and high HDL-C (lower TG) levels, respectively. The primary association explained ~50% of the secondary one suggesting partly independent mechanisms of TG and HDL-C regulation. The magnitude of the association of rs17145750 with HDL-C was significantly higher in the US vs. UKB sample and likely related to differences in exogenous exposures in the two countries. rs17145750 demonstrated a significant detrimental indirect effect through TG on AD risk in the UKB only (βIE = 0.015, pIE = 1.9 × 10−3), which suggests protective effects of high TG levels against AD, likely shaped by exogenous exposures. 

Also, rs17145750 demonstrated significant protective indirect effects through TG and HDL-C in the associations with CHD in both samples. In contrast, rs6967028 demonstrated an adverse mediation effect through HDL-C on CHD risk in the US sample only (βIE = 0.019, pIE = 8.6 × 10−4). This trade-off suggests different roles of triglyceride mediated mechanisms in the pathogenesis of AD and CHD.

“Finally, the results of this study suggest that genetic associations of SNPs from the MLXIPL gene locus with lipids, AD, and CHD are shaped by exogenous exposures. Further study of the related biological mechanisms can help to elucidate the related, modifiable risk factors.”

 

Read the full study: DOI: https://doi.org/10.18632/aging.204665 

Corresponding Authors: Yury Loika, Alexander M. Kulminski

Corresponding Emails: yury.loika@duke.edu, alexander.kulminski@duke.edu 

Keywords: MLXIPL, lipids, triglycerides, coronary heart disease, Alzheimer's disease

Sign up for free Altmetric alerts about this article: https://aging.altmetric.com/details/email_updates?id=10.18632%2Faging.204665

 

About Aging-US:

Launched in 2009, Aging publishes papers of general interest and biological significance in all fields of aging research and age-related diseases, including cancer—and now, with a special focus on COVID-19 vulnerability as an age-dependent syndrome. Topics in Aging go beyond traditional gerontology, including, but not limited to, cellular and molecular biology, human age-related diseases, pathology in model organisms, signal transduction pathways (e.g., p53, sirtuins, and PI-3K/AKT/mTOR, among others), and approaches to modulating these signaling pathways.

Please visit our website at www.Aging-US.com​​ and connect with us:

SoundCloud Facebook Twitter Instagram YouTube LabTube LinkedIn Reddit Pinterest  

Click here to subscribe to Aging publication updates.

For media inquiries, please contact media@impactjournals.com.

 

Aging (Aging-US) Journal Office

6666 E. Quaker Str., Suite 1B

Orchard Park, NY 14127

Phone: 1-800-922-0957, option 1

###

END


[Attachments] See images for this press release:
External factors shape genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene External factors shape genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene 2

ELSE PRESS RELEASES FROM THIS DATE:

A student’s poor eating habits can lead to a lifetime of illness

2023-05-24
A UBC Okanagan researcher is cautioning that a person’s poor eating habits established during post-secondary studies can contribute to future health issues including obesity, respiratory illnesses and depression. Dr. Joan Bottorff, a Professor with UBCO’s School of Nursing, is one of several international researchers who published a multi-site study looking at the eating habits of university students. Almost 12,000 medical students from 31 universities in China participated in the study that aimed to determine the association between eating behaviours, obesity and various diseases. The point, ...

Recent UCLA computer grad constructs “Crown Jewel of Cryptography”

Recent UCLA computer grad constructs “Crown Jewel of Cryptography”
2023-05-24
ACM, the Association for Computing Machinery, today announced that Aayush Jain receives the 2022 ACM Doctoral Dissertation Award for his dissertation “Indistinguishability Obfuscation from Well-Studied Assumptions,” which established the feasibility of mathematically rigorous software obfuscation from well-studied hardness conjectures. The central goal of software obfuscation is to transform source code to make it unintelligible without altering what it computes.  Additional conditions may be added, such as requiring the transformed code to perform ...

Meet the 2023 ASBMB Advocacy Training Program delegates

2023-05-24
The American Society for Biochemistry and Molecular Biology announced the 12 delegates who will participate in the society’s Advocacy Training Program this summer. The ATP is a three-month summer externship that provides hands-on science policy and advocacy training and experience. After completing the educational component of the program, delegates will visit Capitol Hill to meet with policymakers in 2024. The ASBMB public affairs department runs the program. The society has trained 42 ASBMB members in four ATP cohorts, providing the foundational knowledge, skills ...

Does having Alzheimer’s genes increase your risk of epilepsy?

2023-05-24
MINNEAPOLIS – People with a genetic predisposition for Alzheimer’s disease may have an increased risk of epilepsy and people with a certain type of epilepsy may have an increased risk of developing Alzheimer’s disease, according to a study published in the May 24, 2023, online issue of Neurology®, the medical journal of the American Academy of Neurology. “Our research found that not only are people with Alzheimer’s disease more likely to develop epilepsy, but also that those with focal epilepsy, which accounts for ...

New study shows 1 in 5 “healthy” individuals actually have the metabolism of a prediabetic

2023-05-24
Scientists at Klick Labs have developed a new way to catch the earliest signs the human body is failing to control blood glucose levels, before it reaches prediabetic levels in patients.   In findings published today in Mayo Clinic Proceedings: Digital Health, researchers outlined a new method of analysis that flags a precursor to prediabetes called impaired glucose homeostasis (IGH). When they applied their patented mathematical method to data obtained from continuous glucose monitors (CGMs), scientists found about one in five study participants, considered healthy by medical standards, actually had glucose metabolism similar to those with prediabetes.   “For people ...

New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains

New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
2023-05-24
Irvine, CA – May 24, 2023 – A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems. The study, “Superior Global Cognition in Oldest-Old is Associated with Resistance to Neurodegenerative Pathologies: Results from the 90+ Study,” was published in the Journal of Alzheimer’s Disease. “People ...

Survival pathway and therapeutic target in metastatic colorectal and pancreatic cancer

Survival pathway and therapeutic target in metastatic colorectal and pancreatic cancer
2023-05-24
“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]” BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.” In this new study, researchers Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, and Alexander ...

Researchers identify strong T-cell response in first-in-human nanoparticle HIV vaccine

2023-05-24
SEATTLE – MAY 24, 2023 – Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine. Their work, published in Science Translational Medicine, signals a major step toward development of a vaccine approach to end the HIV/AIDS ...

Clinicians supporting cancer patients with taste loss need educational materials and training

2023-05-24
AMHERST, Mass. – While an overwhelming majority of cancer patients experience taste disruption from their disease or treatment, they have consistently reported a lack of support from their doctors about this troubling side effect, according to research. A new study by the University of Massachusetts Amherst, focusing for the first time on the issue from the cancer clinicians’ point of view, reveals not a lack of concern about their patients’ taste loss but a lack of access to educational materials, ...

Epigenetic landscape modulates pioneer transcription factor binding

Epigenetic landscape modulates pioneer transcription factor binding
2023-05-24
(Memphis, Tenn.—May 24, 2023) Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children’s Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work revealed how the epigenetic landscape influences transcription factor binding. Problems with transcription have been implicated in numerous cancers, so this more detailed understanding of the process may aid in developing future therapeutics. The study ...

LAST 30 PRESS RELEASES:

IOP Publishing and IPEM mandate reporting of sex and gender in research 

Dogs trained to detect trauma stress by smelling humans’ breath

Electronic device thermal management made simpler and slightly better!

Study: Dangerous surgical site infections can be reduced with simple prevention protocol

Genetic testing of patients with atrial fibrillation can alert clinicians to potential development of life-threatening conditions

Artificial Intelligence tool successfully predicts fatal heart rhythm

What progress has China made in agriculture green development over the past five years?

ALMA finds new molecular signposts in starburst galaxy

Open waste burning linked to air pollution in Northwestern Greenland

Google Street View reveals how built environment correlates with risk of cardiovascular disease

Connecting the dots to shape growth forces

Parental avoidance of toxic exposures could help prevent autism, ADHD in children, new study shows

Trends in the incidence of renal replacement therapy due to rapidly progressive glomerulonephritis in Japan, 2006–2021

Olympics not likely to swallow up skateboarding’s subversive nature into its corporate spectacle, study says

Looking after the NHS workforce must be a top priority, say experts

Prolonged use of certain hormone drugs linked to increased brain tumor risk

Delirium a ‘strong risk factor’ for dementia among older people

People experiencing homelessness more likely to develop dementia at younger ages, study finds

Can metalens be commercialized at a fraction of the cost?

Reclaim ‘wellness’ from the rich and famous, and restore its political radicalism, new book argues

Curtin research unlocks supernova stardust secrets

New documents reveal patient safety concerns over strike day cover

UTA hosts Solar-bration watch party for April 8 eclipse

Researchers discover molecule that promotes production of cancer cells in triple-negative breast cancer

New tool provides researchers with improved understanding of stem cell aging in the brain

Around half of people living with HIV in developed countries are now aged 50 years and over and at higher risk of becoming frail and having multiple comorbidities

You are never too old for an STI – more older adults being diagnosed with STIs such as gonorrhea and syphilis

University of Minnesota researchers introduce enhanced brain signal analysis technique

Aston University research center to focus on using AI to improve lives

Robot, can you say ‘cheese’?

[Press-News.org] External factors shape genetic predisposition to lipids, Alzheimer’s and heart disease in MLXIPL gene