(Press-News.org) Irvine, CA – May 24, 2023 – A University of California, Irvine-led team of researchers have discovered that the oldest-old, those who live to be 90+ and have superior cognitive skills, have similar levels of brain pathology as Alzheimer’s patients, however, they also have less brain pathology of other neurodegenerative diseases that cause memory and thinking problems.
The study, “Superior Global Cognition in Oldest-Old is Associated with Resistance to Neurodegenerative Pathologies: Results from the 90+ Study,” was published in the Journal of Alzheimer’s Disease.
“People who are 90+ and still have good memory and thinking abilities tend to have similar levels of Alzheimer’s pathology in their brains,” Roshni Biswas, post-doctoral scholar with The 90+ Study. “Our findings indicate that while Alzheimer's Disease neuropathological changes and vascular changes are common in their brains, these individuals are less susceptible to other types of neurodegenerative changes such as Lewy body disease.”
Age is the primary risk factor for cognitive issues, such as Alzheimer’s, Lewy body disease and other related dementias. Over the past 30 years, the number of people aged 90 and older in the U.S. has nearly tripled, and this number is projected to quadruple in the next four decades.
With this rise in age, many people see increased problems with memory and brain function. However, little data is available on the changes in the brains of 90+ people who maintain superior cognitive abilities, despite their age.
The objective of the study was to examine the brain features of people without cognitive impairment and their relation to superior cognitive skills and reasoning in those that are 90+.
“There are some individuals who can maintain high levels of cognitive function well into advanced ages,” said María M. Corrada, ScD, co-principal investigator of the study and professor in the Department of Neurology at UCI School of Medicine. “Further research into the factors that enable these individuals to maintain their cognitive function could provide insights into how to preserve cognitive health despite advanced age.”
The study results were derived by analyzing autopsy data from 102 cognitively normal individuals who died at a mean age of 97.6 years. They also used cognitive test scores from people taken between two to twelve months before death. The average age of study participants at the time of their last visit was 97.1 years of age.
“In our future research, we will examine how lifestyle habits and health conditions are associated with superior cognition in individuals who are 90+ and the factors that contribute to maintaining stable cognitive function over time,” said Biswas.
The 90+ Study is a longitudinal study on aging and dementia that was initiated in 2003 to study the oldest-old population, which is the fastest growing age group in the United States.
With more than 2000 participants enrolled, it is now one of the largest studies of its kind in the world. The project has produced several significant findings regarding cognitive function, health and lifestyle habits in the oldest-old population information obtained during life.
This work was supported by the National Institutes of Health.
UCI School of Medicine:
Each year, the UCI School of Medicine educates more than 400 medical students and nearly 150 PhD and MS students. More than 700 residents and fellows are trained at the UCI Medical Center and affiliated institutions. Multiple MD, PhD and MS degrees are offered. Students are encouraged to pursue an expansive range of interests and options. For medical students, there are numerous concurrent dual degree programs, including an MD/MBA, MD/MPH, or an MD/MS degree through one of three mission-based programs: the Health Education to Advance Leaders in Integrative Medicine (HEAL-IM), the Program in Medical Education for Leadership Education to Advance Diversity-African, Black and Caribbean (PRIME LEAD-ABC), and the Program in Medical Education for the Latino Community (PRIME-LC). The UCI School of Medicine is accredited by the Liaison Committee on Medical Accreditation and ranks among the top 50 nationwide for research. For more information, visit medschool.uci.edu.
New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
These oldest-old are also less susceptible to other types of neurodegenerative changes
ELSE PRESS RELEASES FROM THIS DATE:
Survival pathway and therapeutic target in metastatic colorectal and pancreatic cancer
“Recent findings suggest that neurodegenerative and cardiovascular diseases may have overlapping etiologies [...]” BUFFALO, NY- May 24, 2023 – A new research paper was published in Aging (listed by MEDLINE/PubMed as "Aging (Albany NY)" and "Aging-US" by Web of Science) Volume 15, Issue 9, entitled, “Exogenous exposures shape genetic predisposition to lipids, Alzheimer’s, and coronary heart disease in the MLXIPL gene locus.” In this new study, researchers Yury Loika, Elena Loiko, Fan Feng, Eric Stallard, Anatoliy I. Yashin, Konstantin Arbeev, Allison L. Kuipers, Mary F. Feitosa, Michael A. Province, and Alexander ...
Researchers identify strong T-cell response in first-in-human nanoparticle HIV vaccine
SEATTLE – MAY 24, 2023 – Researchers from Fred Hutchinson Cancer Center in Seattle, Scripps Research in La Jolla, California, IAVI and other collaborating institutions have characterized robust T-cell responses in volunteers participating in the IAVI G001 Phase 1 clinical trial to test the safety and immune response of a self-assembling nanoparticle HIV vaccine. Their work, published in Science Translational Medicine, signals a major step toward development of a vaccine approach to end the HIV/AIDS ...
Clinicians supporting cancer patients with taste loss need educational materials and training
AMHERST, Mass. – While an overwhelming majority of cancer patients experience taste disruption from their disease or treatment, they have consistently reported a lack of support from their doctors about this troubling side effect, according to research. A new study by the University of Massachusetts Amherst, focusing for the first time on the issue from the cancer clinicians’ point of view, reveals not a lack of concern about their patients’ taste loss but a lack of access to educational materials, ...
Epigenetic landscape modulates pioneer transcription factor binding
(Memphis, Tenn.—May 24, 2023) Like thread tightly wrapped around a spool, DNA is wrapped around histones and packaged into structures called nucleosomes. Scientists at St. Jude Children’s Research Hospital are exploring how a type of transcription factor called a pioneer transcription factor accesses DNA even when it is tightly wound. Their work revealed how the epigenetic landscape influences transcription factor binding. Problems with transcription have been implicated in numerous cancers, so this more detailed understanding of the process may aid in developing future therapeutics. The study ...
A popular compostable plastic doesn’t break down in the ocean
A widely used compostable plastic persists unchanged in marine environments for at least 14 months, according to a new study in the open-access journal PLOS ONE by Sarah-Jeanne Royer and colleagues from Scripps Institution of Oceanography at the University of California, San Diego. The study highlights the distinction between textile materials that can be composted in a controlled, industrial setting (PLA), and the ones that can undergo biodegradation in natural environments (cellulose-based textiles). The accumulation and persistence of oil-based plastic waste ...
Physical activity linked to higher pain tolerance
A new analysis of data from more than 10,000 adults shows that people who were physically active had higher pain tolerance than those who were sedentary, and that those with a higher level of activity had a higher level of pain tolerance. Anders Årnes of the University Hospital of North Norway, Tromsø, and colleagues present these findings in the open-access journal PLOS ONE on May 24, 2023. Prior research has suggested the possibility that a habit of engaging in a higher level of physical activity might help ease or prevent chronic pain by boosting pain tolerance. However, most studies on this topic have been small or focused on narrow groups of people. To help clarify the ...
U.S. teens who are food insecure are more likely to engage in emotional eating and consume sugar-sweetened beverages and junk foods
Article URL: https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0285446 Article Title: Psychosocial correlates in patterns of adolescent emotional eating and dietary consumption Author Countries: USA Funding: The authors received no specific funding for this work. END ...
Scientists provide first field observations of coccolithophore osmotrophy
Coccolithophores, a globally ubiquitous type of phytoplankton, play an essential role in the cycling of carbon between the ocean and atmosphere. New research from Bigelow Laboratory for Ocean Sciences shows that these vital microbes can survive in low-light conditions by taking up dissolved organic forms of carbon, forcing researchers to reconsider the processes that drive carbon cycling in the ocean. The findings were published this week in Science Advances. The ability to extract carbon from the direct absorption of dissolved organic carbon is known as osmotrophy. ...
Not so biodegradable: new study finds bio-based plastic and plastic-blend textiles do not biodegrade in the ocean
Plastic pollution is seemingly omnipresent in society, and while plastic bags, cups, and bottles may first come to mind, plastics are also increasingly used to make clothing, rugs, and other textiles. A new study from UC San Diego’s Scripps Institution of Oceanography, published May 24 in the journal PLOS One, for the first time tracked the ability of natural, synthetic, and blended fabrics to biodegrade directly in the ocean. Lead author Sarah-Jeanne Royer conducted an experiment off the Ellen Browning Scripps Memorial Pier and found that natural and wood-based cellulose fabrics degraded within a month. Synthetic textiles, including so-called compostable ...
Increasing heat likely a major factor in human migration
Rising temperatures due to climate change are likely influencing human migration patterns, according to a new study by Rita Issa of University College London and colleagues, published May 24 in the open-access journal PLOS Climate. In the last decade, heatwaves were frequent, and surface temperatures were the warmest on record. As the planet warms, many people are expected to leave their homes to escape extreme temperatures. However, the exact role of heat in human migration is not yet understood. To illuminate this relationship, Issa’s team conducted a review of research documents, ...
LAST 30 PRESS RELEASES:
Using AI to create better, more potent medicines
Quest for alien signals in the heart of the Milky Way takes off
Deconstructing the role of MALAT1 in MAPK-Signaling in melanoma
Obstructive sleep apnea disrupts gene activity throughout the day in mice
Researchers use ‘natural’ system to identify proteins most useful for developing an effective HIV vaccine
Researchers identify link between alternative gene splicing and risk of alcohol use disorder
Novel approach significantly improves access, decreases wait times for autism screening
Illinois professor examines lasting legacy of al-Andalus for Arabs, Muslims today
Astronomers discover planets in NASA Kepler's final days of observations
Matthew Bailes, Duncan Lorimer and Maura McLaughlin receive the 2023 Shaw Prize in Astronomy
Are pandemic lockdowns and vaccinations complements or substitutes? Lessons learned from COVID-19 should be considered in future pandemics
To boost health care teams’ effectiveness, integrate organizational sciences research with technology development
Reusable packaging revolution is close - experts say
Silent zoo tours can generate new perspectives on animals, study suggests
World leading health experts say aviation industry must act on cabin fumes as they launch new medical guidance
Healthy kidneys despite hypertension
Webb Telescope finds towering plume of water escaping from Saturn moon
Ghahari studying correlated and topological phases in Graphene Van der Waals (vdW) heterostructures
A telescope’s last view
An algorithm for sharper protein films
4,000-year-old plague DNA found – the oldest cases to date in Britain
The making of a Mona Lisa hologram
How insects track odors by navigating microscale winds
Sleep health before SARS-CoV-2 infection and risk of long COVID
Association between heart attack and cognition
Volunteering, health, and well-being of children and adolescents
Use of metabolic and bariatric surgery among youth
Racial, ethnic, and language disparities in identifying and mitigating central line–associated bloodstream infections
Philosophy aligns with economics on how to value future generations in climate policy
Researchers proposed a deep neural network-based 4-quadrant analog sun sensor calibration[Press-News.org] New UCI-led research shows people who live to be 90+ with superior thinking skills are resilient to Alzheimer’s pathology in their brains
These oldest-old are also less susceptible to other types of neurodegenerative changes