Clinical outcomes and overestimation of oxygen saturation in patients hospitalized with COVID-19

JAMA Network Open

2023-08-24

(Press-News.org) About The Study: Overestimation of oxygen saturation by pulse oximetry led to delayed delivery of COVID-19 therapy and higher probability of readmission regardless of race in this study of 24,000 patients. Black patients were more likely to have unrecognized need for therapy with potential implications for population-level health disparities.

Authors: Tianshi David Wu, M.D., M.H.S., of the Baylor College of Medicine in Houston, is the corresponding author.

To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/

(doi:10.1001/jamanetworkopen.2023.30856)

Editor’s Note: Please see the article for additional information, including other authors, author contributions and affiliations, conflict of interest and financial disclosures, and funding and support.

# # #

Embed this link to provide your readers free access to the full-text article This link will be live at the embargo time http://jamanetwork.com/journals/jamanetworkopen/fullarticle/10.1001/jamanetworkopen.2023.30856?utm_source=For_The_Media&utm_medium=referral&utm_campaign=ftm_links&utm_term=082423

About JAMA Network Open: JAMA Network Open is an online-only open access general medical journal from the JAMA Network. On weekdays, the journal publishes peer-reviewed clinical research and commentary in more than 40 medical and health subject areas. Every article is free online from the day of publication.

END

ELSE PRESS RELEASES FROM THIS DATE:

Excess all-cause mortality in China after ending the zero COVID policy

2023-08-24

About The Study: In this study across all regions in mainland China, an estimated 1.87 million excess deaths occurred among individuals 30 years and older during the first two months after the end of China’s zero COVID policy, a proactive strategy that deploys mass testing and strict quarantine measures to stamp out any outbreak before it can spread. Authors: Hong Xiao, Ph.D., and Joseph M. Unger, Ph.D., M.S., of the Fred Hutchinson Cancer Research Center in Seattle, are the corresponding authors. To access the embargoed study: Visit our For The Media website at this link https://media.jamanetwork.com/ (doi:10.1001/jamanetworkopen.2023.30877) Editor’s ...

Assessment of AI chatbot responses to top searched queries about cancer

2023-08-24

About The Study: The findings of this study suggest that artificial intelligence (AI) chatbots generally produce accurate information for the top cancer-related search queries, but the responses are not readily actionable and are written at a college reading level. These limitations suggest that AI chatbots should be used supplementarily and not as a primary source for medical information. Authors: Abdo E. Kabarriti, M.D., of the State University of New York Downstate Health Sciences University ...

Combining immunotherapy with KRAS inhibitor eliminates advanced KRAS-mutant pancreatic cancer in preclinical models

2023-08-24

HOUSTON ― Researchers at The University of Texas MD Anderson Cancer Center have uncovered a functional role for KRAS mutations in pancreatic cancer and rapidly translated these findings into a novel therapeutic approach combining a KRAS G12D inhibitor with immune checkpoint inhibitors for early- and late-stage KRAS G12D-mutant pancreatic cancer. The combination therapy led to durable tumor elimination and significantly improved survival outcomes in preclinical models, leading to the launch of a Phase I clinical trial. Two studies, published today in Developmental Cell and Cancer Cell, describe why KRAS-targeted monotherapy likely is not enough ...

Breakthrough in β-lactam synthesis using nickel catalysts

2023-08-24

Led by Director CHANG Sukbok, scientists from the Center for Catalytic Hydrocarbon Functionalizations within the Institute for Basic Science (IBS) have made a significant advancement in the synthesis of β-lactam scaffolds, which are structural components frequently found in essential antibiotics such as penicillins and carbapenems. This breakthrough overcomes challenges in β-lactam synthesis to promise streamlined pathways for drug development. The core chemical structure that makes up penicillins is a four-membered cyclic amide scaffold called chiral ...

Lignocellulose bio-refinery developed for value-added chemical overproduction in yeast

2023-08-24

Lignocellulosic biomass is a renewable feedstock for 2nd-generation biomanufacturing. In particular, efficient co-fermentation of mixed glucose and xylose in lignocellulosic hydrolysates is a key issue in reducing product costs. However, co-utilization of xylose and glucose in microbes is challenging due to limited xylose assimilation and the glucose repression effect. Recently, a research group led by Prof. ZHOU Yongjin from the Dalian Institute of Chemical Physics (DICP) of the Chinese Academy ...

ChatGPT shows limited ability to recommend guidelines-based cancer treatments

2023-08-24

Correct and incorrect recommendations inter-mingled in one-third of the chatbot’s responses, making errors more difficult to detect For many patients, the internet serves as a powerful tool for self-education on medical topics. With ChatGPT now at patients’ fingertips, researchers from Brigham and Women’s Hospital, a founding member of the Mass General Brigham healthcare system, assessed how consistently the artificial intelligence chatbot provides recommendations for cancer treatment that align with National Comprehensive Cancer Network ...

Topography of the genome influences where cancer mutations thrive, study shows

2023-08-24

Researchers at the University of California San Diego have uncovered a connection between the topography of the human genome and the presence of mutations in human cancer. They found that certain regions of the genome, which exhibit unique features, act as hotspots for the accumulation of mutations. The findings, published recently in Cell Reports, shed light on how the 3D architecture of the human genome may play a role in the development of various forms of cancer. The human genome is often visualized as the iconic DNA double helix, composed of long sequences of the letters A, C, G and T. “However, the genome ...

Pioneering treatment highly effective for rare kidney disease

2023-08-24

A pioneering drug for a rare kidney disease prevents organ failure and significantly improves the outcome for patients, new research has confirmed. Atypical Haemolytic Uraemic Syndrome (aHUS) is a genetic life-threatening condition caused by a defect in the immune system which leads to kidney failure. Newcastle University, UK, carried out clinical trials into the drug, eculizumab, which eventually led to the NHS approving the treatment for use in patients from 2015. Now, a study by Newcastle experts, published in Blood, ...

Getting protein factories to run – How deubiquitinating enzymes moonlight as Fubi proteases

2023-08-24

Fubi is produced by cells as a fusion protein with the ribosomal protein S30, and must be separated from S30 by proteases for functioning ribosomes. In immune cells, this by-product of ribosome production is utilized as a secreted signalling molecule, for example to locally reduce the activity of the maternal immune system in the uterus and to thus enable embryos to implant. How Fubi is specifically recognized by proteases and how they distinguish it from ubiquitin was previously unknown. First author Rachel O’Dea and Malte Gersch explain their research in detail: What is the discovery that you made and why is it exciting? Our team revealed ...

Eureka win for researchers behind new anti-cancer strategy

2023-08-24

Associate Professor Tim Thomas and Professor Anne Voss from WEHI (Melbourne, Australia) have been awarded the 2023 UNSW Eureka Prize for Scientific Research. The prize recognises their groundbreaking research in developing a new class of drugs that can put cancer cells ‘to sleep’ without triggering the harmful side effects caused by conventional cancer treatments, like chemotherapy and radiation. The Australian Museum Eureka Prizes are among Australia’s most distinguished science awards, honouring excellence across the areas of research and innovation, leadership, science engagement, and school science. At a glance Associate Professor Tim Thomas and Professor ...

1 in 3 university students surveyed from a Parisian suburb report being unable to access desired food, with this food insecurity associated with academic dropout

Clinical outcomes and overestimation of oxygen saturation in patients hospitalized with COVID-19

ELSE PRESS RELEASES FROM THIS DATE:

LAST 30 PRESS RELEASES: